DopamineReceptorsInhibitoryAntagonists of presynapticMidbrainNeuronsNeurotransmitterSerotonin autoreceptorMuscarinic autoreceptorsPresynaptic autoreceptorsRapheInhibitionNeuronalRegulateSympatheticAlpha2AGABATerminalStimulationBupropionKidneyPeripheralDecreaseCombinationsBrainNegative feedbackExpressionCellsRoleAnalysisCellMouseTreatmentHumanStudies
Dopamine10
- In their review of TAAR1 in monoaminergic systems, Xie and Miller proposed this schematic: synaptic dopamine binds to the dopamine autoreceptor, which activates the DAT. (wikipedia.org)
- Dopamine autoreceptors modulate the in vivo release of dopamine in the frontal, cingulate and entorhinal cortices. (aspetjournals.org)
- Stimulation of midbrain M4 autoreceptors are thought to decrease the activity of dopaminergic neurons in ventral tegmental area neurons, leading to reduced dopamine release in the nucleus accumbens. (nih.gov)
- Michele's doctoral research, also performed at the University of Pittsburgh in the laboratory of Dr. Tony Grace, investigated the regulation of midbrain dopamine neurons by somatodendritic autoreceptors in a mouse model of Parkinson's disease. (nih.gov)
- However, identifying the role of these receptors is complicated by the existence of both postsynaptic D2 receptors and presynaptic autoreceptors, which inhibit dopamine release. (nih.gov)
- The goal of the current study was to determine which of the D2-1ike receptors (D2, D3 or D4) are involved in autoreceptor regulation of dopamine synthesis. (wustl.edu)
- Taken together, these data confirm the hypothesis that dopamine D2 and D3 receptors can perform dual roles in autoreceptor regulation. (wustl.edu)
- In view of the known loss of nigrostriatal dopamine neurons and decreases in striatal dopamine that occur with ageing, we predicted a decrement in apomorphine-induced yawning and penile grooming , responses that are thought to result from stimulation of autoreceptors located on dopamine nerve terminals. (baillement.com)
- Our observations suggest that there is an age-related decline in the functional response to stimulation of dopamine autoreceptors and postsynaptic D2 receptors, although postsynaptic responses to mixed D1/D2 stimulation are increased. (baillement.com)
- 2022 13 (19), 2863-2873), they examined how the D3 autoreceptor, which binds to dopamine and acts as a feedback mechanism to inhibit its release, functions in zebrafish. (ku.edu)
Receptors6
- Autoreceptors are usually G protein-coupled receptors (rather than transmitter-gated ion channels) and act via a second messenger. (wikipedia.org)
- Using positron emission tomography and the selective 5-HT1A receptor radioligand [11C]WAY100635, we previously demonstrated a preferential occupancy of 5-HT1A autoreceptors, compared to postsynaptic receptors by pindolol in healthy volunteers. (ox.ac.uk)
- 14. Crosstalk between presynaptic angiotensin receptors, bradykinin receptors and alpha 2-autoreceptors in sympathetic neurons: a study in alpha 2-adrenoceptor-deficient mice. (nih.gov)
- Serotonin 5-HT1B and 5-HT1D receptors, inhibitory autoreceptors that regulate serotonin release, exhibit considerable constitutive in vitro activity. (the-scientist.com)
- Modulation of sympathetic neuron signaling occurs by feedback inhibition of neurotransmitter release (autoreceptors), mediated in part via alpha2A and/or alpha2C adrenergic receptors. (stanford.edu)
- The results also show an increased sensitivity to presynaptic inhibition by both glutamate (autoreceptors) and GABA (heteroreceptors) metabotropic receptors, suggesting that glutamate release would be depressed during acute opioid withdrawal. (jneurosci.org)
Inhibitory3
- The effect of heparin and poly-L-glutamate on the function of inhibitory M2 muscarinic autoreceptors on parasympathetic nerves in the lung was tested in antigen-challenged guinea pigs. (nih.gov)
- 19. Involvement of G-protein βγ subunits on the influence of inhibitory α2-autoreceptors on the angiotensin AT1-receptor modulation of noradrenaline release in the rat vas deferens. (nih.gov)
- This appeared to be due to a lower expression of inhibitory D2 autoreceptors and their downstream target, G-protein-coupled K + channels, in mesoprefrontal neurons compared with mesolimbic neurons. (nature.com)
Antagonists of presynaptic2
- In a previous meta-analysis , first author Jonathan Henssler, MD, and colleagues reported on the merits of combining monoamine reuptake inhibitors (selective serotonin reuptake inhibitor, serotonin-norepinephrine reuptake inhibitor [SNRI], or tricyclic antidepressant) and antagonists of presynaptic alpha2-autoreceptors (mianserin, mirtazapine, trazodone). (medscape.com)
- A recent systematic review and meta-analysis was done of randomized clinical trials comparing combined therapy with antidepressants and antagonists of presynaptic alpha-2 autoreceptors (eg, mirtazapine, trazodone) vs analogous bupropion combinations and antidepressant monotherapy in adults with acute depression. (medscape.com)
Midbrain2
- In parallel, intracerebroventricular C-1A-siRNA infusion markedly decreased presynaptic 5 HT1A-autoreceptor expression in the midbrain dorsal raphe (DR) without affecting postsynaptic 5-HT1AR expression in hippocampus (HPC), eliciting robust antidepressant effects. (csic.es)
- A possible mechanism underlying preferential occupancy and the attenuation of this phenomenon in depressed patients on SSRIs may include changes in the proportion of high affinity 5-HT1A sites in the autoreceptor region of the midbrain raphe. (ox.ac.uk)
Neurons3
- 4. All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. (nih.gov)
- 20. Noradrenaline release from cultured mouse postganglionic sympathetic neurons: autoreceptor-mediated modulation. (nih.gov)
- Whole-transcriptome analysis of cholinergic interneurons and medium spiny projection neurons laser-microdissected from the human putamen confirmed selective expression of GNRH1 and GNRHR1 autoreceptors in cholinergic cells and uncovered the detailed transcriptome profile and molecular connectome of these two cell types. (biorxiv.org)
Neurotransmitter4
- Autoreceptors on the presynaptic neuron will also detect this neurotransmitter and often function to control internal cell processes, typically inhibiting further release or synthesis of the neurotransmitter. (wikipedia.org)
- The feedback cell releases a neurotransmitter to which the autoreceptor of the presynaptic neuron is receptive. (wikipedia.org)
- Presynaptic alpha2-autoreceptors might also boost monoaminergic neurotransmission "by interrupting the inhibition feedback loop initiated when reuptake inhibitors increase neurotransmitter concentrations in the synaptic cleft," he added. (medscape.com)
- If your brain needs to downregulate a neurotransmitter, it'll start by upregulating a completely different neurotransmitter, which upregulates the first neurotransmitter, which hits autoreceptors that downregulate the first neurotransmitter, which then cancel the upregulation, and eventually the neurotransmitter gets downregulated. (lesswrong.com)
Serotonin autoreceptor2
- It also appears to serve as a presynaptic serotonin autoreceptor. (wikipedia.org)
- Moret C (1985) Pharmacology of the serotonin autoreceptor. (springer.com)
Muscarinic autoreceptors1
- 9. Heterogeneity of release-inhibiting muscarinic autoreceptors in heart atria and urinary bladder: a study with M(2)- and M(4)-receptor-deficient mice. (nih.gov)
Presynaptic autoreceptors1
- Chronic treatment with amitriptyline desensitizes presynaptic autoreceptors and heteroreceptors, producing long-lasting changes in monoaminergic neurotransmission. (gfrpartners.com)
Raphe1
- Administration of SSRIs is associated with activation of 5-HT 1A and 5-HT 7 autoreceptors located on raphe nucleus neuronal cell bodies. (pharmacology2000.com)
Inhibition2
- The autoreceptor causes the inhibition of calcium channels (slowing calcium ion influx) and the opening of potassium channels (increasing potassium ion efflux) in the presynaptic membrane. (wikipedia.org)
- The 5-HT 1A autoreceptor-mediated inhibition did not develop until P21. (jneurosci.org)
Neuronal1
- It's the same for receptor up- and down-regulation, pharmacological effects including drug tolerance, neuronal 'self-regulation' through autoreceptors, long-term potentiation, etc. (blogspot.com)
Regulate3
- The D2sh autoreceptor has been shown recently to interact with the trace amine-assorted receptor 1 (TAAR1), a G-Coupled Protein Receptor GPCR, to regulate monoaminergic systems in the brain. (wikipedia.org)
- Presynaptically localized D2Rs regulate synthesis and release of DA as the main autoreceptor of the dopaminergic system. (genome.jp)
- Collectively, their data show that, as in mammals, zebrafish D3 autoreceptors regulate DA release in part by inhibiting uptake. (ku.edu)
Sympathetic1
- An atypical example is given by the β-adrenergic autoreceptor in the sympathetic peripheral nervous system, which acts to increase transmitter release. (wikipedia.org)
Alpha2A3
- 1. A study of presynaptic alpha2-autoreceptors in alpha2A/D-, alpha2B- and alpha2C-adrenoceptor-deficient mice. (nih.gov)
- 2. Occurrence, pharmacology and function of presynaptic alpha2-autoreceptors in alpha2A/D-adrenoceptor-deficient mice. (nih.gov)
- 15. Prejunctional alpha2A-autoreceptors in the canine saphenous vein. (nih.gov)
GABA1
- The increased excitability was due to depolarized resting membrane potential, increased resistance, increased firing rate, lack of 5-HT 1A autoreceptor response, and lack of GABA synaptic activity. (jneurosci.org)
Terminal4
- 5-HT 1D autoreceptors localized on serotonergic terminal boutons are also stimulated. (pharmacology2000.com)
- release-regulating autoreceptor sensitivity in A9/A10 cell body and terminal areas after withdrawal of rats from continuous infusion of cocaine. (adicciones.es)
- Receptores de transmisión en los terminales presinápticos (o varicosidades) o en su proximidad, que son sensibles a la liberación de los transmisores liberados por la propia terminal. (bvsalud.org)
- These autoreceptors lower the release of 5-HT in the terminal forebrain areas. (fileshampoo.com)
Stimulation1
- van der Werf JF, Bast A, Bijloo GJ, Van der Vliet A, Timmerman H (1987) HA autoreceptor assay with superfused slices of rat brain cortex and electrical stimulation. (springer.com)
Bupropion1
- Separate investigations of combinations using presynaptic alpha2-autoreceptor antagonists or bupropion also took place. (medscape.com)
Kidney2
Peripheral1
- Göthert M (1985) Role of autoreceptors in the function of the peripheral and central nervous system. (springer.com)
Decrease1
- Autoreceptor activity may also decrease paired-pulse facilitation (PPF). (wikipedia.org)
Combinations1
- It's possible that in combinations, "alpha2-autoreceptors effectively counteract, through sedation, the restlessness and agitation that many patients find troublesome when taking monoamine-reuptake inhibitors. (medscape.com)
Brain2
Negative feedback1
- Our group report on a new treatment strategy based on the administration of small interference RNA (siRNA) to suppress 5-HT1A-autoreceptor-mediated negative feedback mechanisms. (csic.es)
Expression1
- Here, we demonstrate that region-specific contributions of D 2 autoreceptors (D2AR) to presynaptic DA homeostasis dictate the consequences of Val559 expression in adolescent male mice. (nih.gov)
Cells1
- An autoreceptor is a type of receptor located in the membranes of nerve cells. (wikipedia.org)
Role1
- The goal of this study is to determine the specific role of D2 autoreceptors in drug-seeking behavior and motor learning. (nih.gov)
Analysis2
- In clinical management of depression, combining a reuptake inhibitor with presynaptic alpha2-autoreceptors significantly improves treatment outcomes, compared with monotherapy, a meta-analysis found. (medscape.com)
- In the separate analysis, presynaptic alpha2-autoreceptors did a better job than monotherapy as a first-line treatment and when applied to nonresponder populations. (medscape.com)
Cell2
- A given receptor can act as either an autoreceptor or a heteroreceptor, depending upon the type of transmitter released by the cell on which it is embedded. (wikipedia.org)
- Autoreceptors may be located in any part of the cell membrane: in the dendrites, the cell body, the axon, or the axon terminals. (wikipedia.org)
Mouse1
- 16. Presynaptic alpha 2-autoreceptors in mouse heart atria: evidence for the alpha 2D subtype. (nih.gov)
Treatment1
Human1
- 13. Subtype determination of presynaptic alpha 2-autoreceptors in the rabbit pulmonary artery and human saphenous vein. (nih.gov)
Studies1
- In slice electrophysiological studies, GnRH inhibited these interneurons via GnRHR1 autoreceptors. (biorxiv.org)