CytotoxicTransplantationPeripheral bloodReady-to-infuseAntigensProliferationTILsImmunotherapyMelanomaAllogeneicDendritic cellsPatient'sCancersChemotherapyStemInfusionsTumorsTregsCellularAntigenMaternalLymphomaAdoptive transferAllogenicFunctionallyTherapyAntibodiesCancerCellsPatientsGeneHumanConclusionSurfaceTreatmentType of white blooEffectsPrimarilyApplicationDisease
Cytotoxic4
- The role of uncultured melanoma cells in the proliferation of autologous tumor-specific cytotoxic T lymphocytes (CTLs) was investigated. (johnshopkins.edu)
- The vaccine induces cytotoxic T lymphocytes to disrupt cancer stem cell antigens. (cedars-sinai.edu)
- The clinical trial is the first to use products consisting of autologous cytotoxic T lymphocytes that target tumor antigens using Immatics' target warehouse, according to a press release. (pharmacytimes.com)
- Immunotherapy is emerging as a new form to treat cancer by harnessing the activity of cytotoxic CD8 + T lymphocytes (CTLs) that specifically recognize tumor-associated antigens. (lifeboat.com)
Transplantation6
- In transplantation, autologous lymphocytes refers to a person's own white blood cells. (wikipedia.org)
- Treatment includes chemotherapy and often stem cell transplantation , either from the patient's own bone marrow (autologous) or sometimes from another person's bone marrow (allogeneic). (dana-farber.org)
- Herpes simplex virus thymidine kinase (HSV-tk) is a well-established suicide gene that has been successfully used to control GvHD following donor lymphocyte infusions (DLI) after allogeneic stem cell transplantation. (haematologica.org)
- Carfilzomib or bortezomib in combination with lenalidomide and dexamethasone for patients with newly diagnosed multiple myeloma without intention for immediate autologous stem-cell transplantation (ENDURANCE): a multicentre, open-label, phase 3, randomised, controlled trial Lancet Oncology 21 (10): 1317-1330,2020. (pennmedicine.org)
- After the transplantation, the patient's new lymphocytes or immune cells are self-tolerant and do not attack the immune system. (scienceblog.com)
- 3 Autologous stem cell transplantation almost exclusively uses peripheral blood, while for allogeneic SCT, T-lymphocytes in the peripheral blood could pose some danger. (bdbiosciences.com)
Peripheral blood3
- Clinical studies are also underway to evaluate TIL in earlier stage cancers in combination with currently approved treatments, and to investigate Iovance peripheral blood lymphocyte (PBL) T cell therapy for blood cancers. (biospace.com)
- Autologous mature dendritic cells derived from peripheral blood monocytes were pulsed with the HLA-A2-binding MUC1 peptides (M1.1 and M1.2). (aacrjournals.org)
- These cells inhibited T cell proliferation in a standard in vitro mixed lymphocyte assay and, moreover, attenuated the development of vasculopathy mediated by autologous peripheral blood mononuclear cells in a functionally relevant humanized mouse transplant model. (lu.se)
Ready-to-infuse3
- LN-145 is a ready-to-infuse, autologous TIL therapy that utilizes an autologous TIL manufacturing process, as originally developed by the NCI and further optimized by Iovance for the treatment of patients with metastatic NSCLC. (moffitt.org)
- Genesis Biopharma is developing Cōntego™, a ready-to-infuse adoptive cellular immunotherapy (ACT) using tumor infiltrating lymphocytes (TILs) for the treatment of Stage IV metastatic melanoma. (aol.com)
- The Company's lead product candidate, Cōntego™, is a ready-to-infuse autologous cellular immunotherapy utilizing tumor infiltrating lymphocytes for the treatment of patients with Stage IV metastatic melanoma. (aol.com)
Antigens2
- The T lymphocyte-mediated immune lung disease hypersensitivity pneumonitis (HP) in machinists is poorly understood for disease mechanisms and diagnosis due in part to lack of information on causative T-cell antigens of the etiological agent Mycobacterium immunogenum (MI). (cdc.gov)
- These antigens also activated the human naïve CD4+ T cells in presence of autologous DCs as measured using ELISPOT for IFN-gamma. (cdc.gov)
Proliferation7
- Uncultured autologous tumor cells by themselves induced modest, but significant, proliferation in 10 of 13 (77%) CTL clones and in only two of nine non-CTL clones. (johnshopkins.edu)
- Autologous tumor-induced CTL proliferation declined with increasing age of the culture. (johnshopkins.edu)
- In all these five CTL clones, autologous tumor cells suppressed IL-2-induced proliferation. (johnshopkins.edu)
- The remaining four CTL clones, however, required both uncultured autologous melanoma cells and IL-2 for the proliferation. (johnshopkins.edu)
- Autologous T-lymphocytes stimulate proliferation of orbital fibroblasts derived from patients with Graves ophthalmopathy. (thieme-connect.de)
- However, only two of the five proteins (AgA, AgD) showed significant T-cell response (T lymphocyte proliferation and IFN-gamma secretion) when tested using sensitized T-cells from MI-induced HP mouse model. (cdc.gov)
- B and T lymphocytes, CD4+ B lymphocytes versus CD8+ T lymphocytes), and tests that measure T-cell proliferation or function in response to specific or nonspecific stimuli (e.g., lymphocyte proliferation assays) ( 4,5 ). (cdc.gov)
TILs4
- Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in melanoma, but has not been previously evaluated in metastatic non-small cell lung cancer. (nature.com)
- Autologous TILs were expanded ex vivo from minced tumors cultured with interleukin-2. (nature.com)
- Cell therapy with autologous TILs is generally safe and clinically active and may constitute a new treatment strategy in metastatic lung cancer. (nature.com)
- The therapeutic candidate comprises an enzyme (fucosyltransferase), a substrate (GDP), and autologous tumor infiltrating lymphocytes (TILs). (globaldata.com)
Immunotherapy4
- New cancer immunotherapy using autologous lymphocytes activated with trastuzumab. (nih.gov)
- Now-a-days, the market of immunotherapy is more attributed towards developing Tumor-Infiltrating Lymphocytes for causing complete remission of the tumor cells from the cancer patients. (researchandmarkets.com)
- As per "Global Tumor Infiltrating Lymphocytes Immunotherapy Market Opportunity & Clinical Trials Insight 2025" report findings, it is estimated that the innovative research and development sector has excited the oncology researchers for driving the overall oncology pharmaceutical industry. (researchandmarkets.com)
- Immunotherapy based on the adoptive transfer of ex vivo expanded and activated autologous tumor-reactive lymphocytes can mediate tumor regression in cancer patients. (unimedizin-mainz.de)
Melanoma2
- 3 Autologous lymphocytes genetically modified with the TCR for MART-1/Melan-A have been adoptively transferred to patients with advanced melanoma. (haematologica.org)
- Transfusion of autologous tumor-specific CTLs 1-4 and blockade of T cell inhibitory receptors 5-7 have demonstrated to elicit durable clinical benefit in a significant proportion of patients with melanoma, leukemia, lymphoma and other cancers, who failed to respond to conventional treatments. (lifeboat.com)
Allogeneic2
- The Dana-Farber/Boston Children's Stem Cell Transplant Center offers autologous and allogeneic stem cell transplants and is active in researching new stem cell techniques. (dana-farber.org)
- G-CSF is a commonly used mobilizing agent for practically all autologous and a majority of allogeneic HSCTs and is known to increase CD34+ concentration. (bdbiosciences.com)
Dendritic cells2
- For the activation of CD4 + T-helper lymphocytes, dendritic cells were further incubated with the PAN-DR-binding peptide PADRE. (aacrjournals.org)
- The GBM cancer stem cell vaccine is cellular and consists of patients' autologous dendritic cells infused with tumor lysate from an allogenic glioblastoma cancer stem cell line. (cedars-sinai.edu)
Patient's1
- Tumor infiltrating lymphocyte (TIL) therapy uses a patient's own immune cells to attack cancer. (biospace.com)
Cancers2
- Genesis Biopharma, Inc. is engaged in the development and commercialization of autologous cell therapies for the treatment of various cancers. (aol.com)
- These are a collection of aggressive cancers of mature T-lymphocytes. (dana-farber.org)
Chemotherapy3
- No treatment such as chemotherapy and be expected to recover fully from the previous treatment at the time of the lymphocytes collection for manufacturing 10. (mycancergenome.org)
- Case presentation Here, we report a case of a refractory MCL in a patient who had relapsed after conventional chemotherapy and autologous CAR T cell therapy. (bmj.com)
- This is followed by an autologous stem cell transplant (using your own stem cells) to rescue the bone marrow after the high-dose chemotherapy. (medlineplus.gov)
Stem2
- The procedure is called autologous non-myeloablative haematopoietic stem-cell transplantion. (scienceblog.com)
- 202. Autologous stem cell transplant within 6 weeks of planned KTE-X19 or axicabtagene ciloleucel infusion. (who.int)
Infusions1
- Objective To determine whether autologous infusions of expanded regulatory T lymphoctyes (Tregs) into patients with amyotrophic lateral sclerosis (ALS) are safe and tolerable during early and later stages of disease. (neurology.org)
Tumors1
- In collaboration with Hi-TIDe's Tumor microenvironment & biomarkers group and T cell discovery group , we capture tumor-infiltrating lymphocytes in human tumors in action, at the steady state or following adoptive T-cell therapy and other therapeutic perturbations, and interrogate them exhaustively to unveil the underlying T cell intrinsic signaling regulatory networks. (unil.ch)
Tregs2
- While the autoreactive cells displayed significantly reduced Tregs numbers, the alloreactive transplacentally acquired maternal lymphocytes had high functional Tregs. (hindawi.com)
- However, a diminished suppressive function on autologous lymphocytes was found in SSc-derived Tregs. (uni-wuerzburg.de)
Cellular2
- The identification of lymphocytes as the main cell type responsible for both cellular and humoral immunity started in the early 1950s with the emergence of cell culture techniques. (frontiersin.org)
- Tests that demonstrate the status of cellular immunity include lymphocyte numbers (i.e., a complete blood count with differential), a test that delineates concentrations and proportions of lymphocyte subsets (i.e. (cdc.gov)
Antigen2
- Definition of the receptor and ligand molecules as CD2 and lymphocyte function-associated antigen 3 (LFA-3). (ox.ac.uk)
- Although human CD20 has previously been described as functional selection marker and suicide gene after retroviral transfer to T lymphocytes, 9 , 10 the specificities of these T cells were unknown, and therefore a potential effect of CD20 on antigen-specific T-cell functions could not be investigated. (haematologica.org)
Maternal4
- We suggest that a high-tolerance capacity of the alloreactive transplacentally acquired maternal lymphocytes represents a toleration advantage, yet still associated with severe immunodeficiency. (hindawi.com)
- In some cases, T cells may present, as a result of residual autologous cells or transplacentally acquired maternal lymphocytes [ 1 ]. (hindawi.com)
- The origin of the reactive cells in such patients are either thymic release of T-cells that expand at the periphery or transplacentally transfers of maternal T lymphocytes. (hindawi.com)
- A distinctive feature of SCID patients, which sometimes can clinically resemble Omenn, [ 6 ] is the presence of alloreactive cells originated from transplacentally maternal T lymphocytes. (hindawi.com)
Lymphoma4
- Conclusions This case suggests that haplo-CAR T cell therapy can be effective in controlling lymphoma that failed to respond to autologous CAR T cell therapy and overcome limitation of autologous CAR T cells, thus may be one possible regimen before the era of off-the-shelf "universal" CAR T cell therapy. (bmj.com)
- Lymphoma is a type of cancer that affects your blood cells called lymphocytes. (lymphoma.org.au)
- Hodgkin Lymphoma - all Hodgkin Lymphomas are lymphomas of B-cell lymphocytes. (lymphoma.org.au)
- Non-Hodgkin Lymphoma (NHL) - these are lymphomas of all other B-cells or T-cell lymphocytes, including NK cells. (lymphoma.org.au)
Adoptive transfer1
- A phase 1 trial of adoptive transfer of vaccine-primed autologous circulating T cells in ovarian cancer. (unil.ch)
Allogenic1
- this is used in both autologous and allogenic HSCT. (bdbiosciences.com)
Functionally1
- CD2, also known as LFA-2, T11, and the E rosette receptor, is a T lymphocyte surface protein functionally important in adhesion to target cells and T cell triggering. (ox.ac.uk)
Therapy3
- The cell transfer therapy used in this study involves patients receiving an NMA lymphocyte depleting preparative regimen, followed by infusion of autologous TIL, then finally followed by the administration of IL-2. (moffitt.org)
- The treatment regimen associated with the TIL therapy comprises of collection of lymphocytes that have the ability to engage themselves in the tumor cells destruction. (researchandmarkets.com)
- The aim of this study was to investigate whether DAbR1 can be expressed on lymphocytes and used as a reporter gene as well as a suicide gene for therapy of immune-related adverse effects. (snmjournals.org)
Antibodies2
- Lymphocytes have a number of roles in the immune system, including the production of antibodies and other substances that fight infections and other diseases. (wikipedia.org)
- Our lymphatic system is also where our B-cell lymphocytes make disease fighting antibodies. (lymphoma.org.au)
Cancer1
- Therapeutic effects of autologous lymphocytes activated with trastuzumab for xenograft mouse models of human breast cancer. (nih.gov)
Cells7
- Residual autologous T cells are usually emerging from partial thymic maturation impairment such as in the case of Major histocompatibility complex class II (MHC-II) deficiency. (hindawi.com)
- The LLNA has been evaluated extensively in the context nocytes, Langerhans cells, and T-lymphocytes, have been of both national and international interlaboratory trials. (cdc.gov)
- White blood cells, called lymphocytes, are found in lymph tissue. (medlineplus.gov)
- Occasional patients may develop some autologous T and/or NK cells . (lu.se)
- Our lymphocytes are white blood cells that are a big part of our immune system. (lymphoma.org.au)
- Unlike our other blood cells, lymphocytes usually live in our lymphatic system rather than in our blood stream. (lymphoma.org.au)
- Some rare lymphomas are Natural Killer cell (NK) lymphomas - NK cells are a type of T-cell lymphocyte. (lymphoma.org.au)
Patients1
- METHODS The stability of essential components (EGF, vitamin A, and TGF-β) in preserved serum were examined following preservation at 4°C and −20°C. In a primary clinical trial, 12 patients with Sjögren's syndrome were treated with autologous serum (diluted to 20% with sterile saline) for 4 weeks, and vital staining of the ocular surface was compared before and after treatment. (bmj.com)
Gene2
- A novel immunotherapeutic combination-this one targeting the LAG-3 (lymphocyte-activation gene 3) and PD-1 immune checkpoints-delayed time to disease progression significantly more. (ascopost.com)
- We investigated the use of human CD20 as suicide gene in T-lymphocytes. (haematologica.org)
Human2
- Rosetting of activated human T lymphocytes with autologous erythrocytes. (ox.ac.uk)
- We find that LFA-3 is expressed on human E, and that CD2 is a receptor for LFA-3 that mediates T cell adhesion to human E. Pretreatment of T lymphocytes with CD2 mAb or of E with LFA-3 mAb inhibits rosetting. (ox.ac.uk)
Conclusion1
- CONCLUSION Autologous serum application is a safe and efficient way to provide essential components to the ocular surface in the treatment of dry eye associated with Sjögren's syndrome. (bmj.com)
Surface1
- 14 Our recent experience with frequent use of autologous serum in the reconstruction of the ocular surface in severe dry eye such as ocular pemphigoid or Stevens-Johnson syndrome supports the concept that the lack of biologically active tear components can be replaced by autologous serum application. (bmj.com)
Treatment2
- AIM To evaluate the efficacy of autologous serum application for the treatment of dry eye in Sjögren's syndrome. (bmj.com)
- The present study was designed to determine the efficacy and safety of autologous serum application in the treatment of epithelial disorders associated with SS dry eye. (bmj.com)
Type of white bloo2
- Most lymphomas start in a type of white blood cell called the B lymphocyte, or B cell. (medlineplus.gov)
- Lymphocytes are a type of white blood cell that support our immune system by fighting infection and disease. (lymphoma.org.au)
Effects1
- In 1984 Fox et al reported the beneficial effects of autologous serum application to dry eye in Sjögren's syndrome. (bmj.com)
Primarily1
- The adaptive immune response, primarily comprised of T and B lymphocytes, has important implications in the fracture healing process as well [ 3 , 4 ]. (hindawi.com)
Application1
- The application of autologous serum offers an advantage over the simple use of artificial tears which lack such essential components. (bmj.com)
Disease1
- Because our lymphocytes fight infection and disease, they are part of our immune system. (lymphoma.org.au)