During this time, the perception of CD has changed from a rather uncommon enteropathy to a common multi- organ disease with a strong genetic predisposition that is associated mainly with human leukocyte antigen (HLA)-DQ2 and HLA-DQ8. (vdocuments.net)
DRB17
HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. (wikipedia.org)
HLA-DRB1*04:01 gene variant is found three times more often in asymptomatic carriers of SARS-CoV-2 than in patients with symptoms of COVID-19. (wikipedia.org)
It is known that the prevalence of the HLA-DRB1*04:01 variant directly correlates with the latitude and longitude of the population. (wikipedia.org)
DRB1*04:DQA1*03:03-DQB1*04:01 haplotype: type III autoimmune polyglandular syndrome, autoimmune hepatitis, autoimmune pancreatitis. (wikipedia.org)
DRB1*04:DQA1*03-DQB1*03:02 haplotype: Type 1 diabetes with DRB1*04:01, *04:05, *04:02 increasing risk when DQ8 is present. (wikipedia.org)
OBJECTIVE- HLA-DRB1* 03 -DQB1* 0201 /DRB1* 04 -DQB1* 0302 ( DR3/4-DQ8 ) siblings who share both major histocompatibility complex (MHC) haplotypes identical-by-descent with their proband siblings have a higher risk for type 1A diabetes than DR3/4-DQ8 siblings who do not share both MHC haplotypes identical-by-descent. (diabetesjournals.org)
Islet2
The Network for Pancreatic Organ donors with Diabetes (nPOD) is the largest biorepository of human pancreata and associated immune organs from donors with type 1 diabetes (T1D), maturity-onset diabetes of the young (MODY), cystic fibrosis-related diabetes (CFRD), type 2 diabetes (T2D), gestational diabetes, islet autoantibody positivity (AAb+), and without diabetes. (nature.com)
Proinflammatory islet antigen reactive CD4 T cells are linked with response to alefacept in type 1 diabetes. (immunetolerance.org)
Risk2
Data were technically validated using published algorithms to evaluate donor relatedness, ancestry, imputed HLA, and T1D genetic risk score. (nature.com)
Our goal was to search for non -DR/DQ MHC genetic determinants that cause the additional risk in the DR3/4-DQ8 siblings who share both MHC haplotypes. (diabetesjournals.org)
Islet cell2
In this low-risk population, autoantibodies to islet-cell antigens were associated with different HLA molecules. (nih.gov)
Glutamic acid decarboxylase 65 and islet cell antigen 512/IA-2 autoantibodies in relation to human leukocyte antigen class II DR and DQ alleles and haplotypes in type 1 diabetes mellitus. (nih.gov)
Susceptibility4
The HLA DQB1*0302 allele on DR4 haplotypes is a well-known marker for T1D susceptibility. (nih.gov)
On Asian DR4 haplotypes, not only DQB1*0302, but also DQB1*0401 confer susceptibility to T1D, which is mediated by DRB1*0405 on the same haplotype. (nih.gov)
The genes that confer actions, are likely to provide important information susceptibility to IDDM are located in the HLA region regarding the causes of IDDM and lead to approaches of chromosome 6. (nih.gov)
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 2007 Dec 450 (7171): 887-92. (cdc.gov)
Genotype1
Number of autoantibodies and HLA genotype, more than high titers of glutamic acid decarboxylase autoantibodies, predict insulin dependence in latent autoimmune diabetes of adults. (cdc.gov)
Epitopes1
HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos. (cdc.gov)
Haplotype2
DRB1*04:DQA1*03:03-DQB1*04:01 haplotype: type III autoimmune polyglandular syndrome, autoimmune hepatitis, autoimmune pancreatitis. (wikipedia.org)
DRB1*04:DQA1*03-DQB1*03:02 haplotype: Type 1 diabetes with DRB1*04:01, *04:05, *04:02 increasing risk when DQ8 is present. (wikipedia.org)
Serological1
A total of 104 consecutive patients with Hashimoto's thyroiditis underwent coeliac serological tests (antigliadins, transglutaminase and endomysium antibodies) and HLA-DQ typing. (wjgnet.com)
Association3
To analyze further the association of DQB1*0302 and DQB1*0401 haplotypes in Asian patients with T1D, we investigated HLA DR and DQ alleles with the presence or the persistence of GAD, ICA, and IA-2 autoantibodies in 121 Korean T1D patients. (nih.gov)
In Korean patients, there was an association of IA-2 autoantibodies with DR4 as well as DR3, but not with DQA1*0301-DQB1*0302. (nih.gov)
Design of the antigen-specific immunointervention trials should take into account such HLA DR and DQ association. (nih.gov)
Class3
In different populations, the immune response to different beta cell autoantigens is mediated via varying HLA class II molecules from different loci. (nih.gov)
HLA class I and class II frequencies in patients with cutaneous malignant melanoma from southeastern Spain: the role of HLA-C in disease prognosis. (cdc.gov)
Evidence for HLA class II susceptible and protective haplotypes for osteomyelitis in pediatric patients with sickle cell anemia. (cdc.gov)
Type1
Heterogeneity in the magnitude of the insulin gene effect on HLA risk in type 1 diabetes. (cdc.gov)
Disease2
Individuals who carry alleles con- for disease prevention. (nih.gov)
Distinct tumour necrosis factor alpha, interferon gamma, interleukin 10, and cytotoxic T cell antigen 4 gene polymorphisms in disease occurrence and end stage renal disease in Wegener's granulomatosis. (cdc.gov)
World1
The DR4 serogroup is large and has a number of moderate frequency alleles spread over large regions of the world. (wikipedia.org)