Atlas cells. Medical search. Frequent questions

The Translational Genomics Research Institute received a grant to develop a standard for the "processing and storage of solid tissues for single-cell RNA sequencing", compared to the typical practice of relying on the average of sequencing multiple cells. (wikipedia.org)
The researchers are looking forward to improving upon their current atlas by sequencing additional human tissues. (genengnews.com)
The work, Deepcell said, will help to create a detailed portrait of cell types, as well as a view of their distribution and variation across tissues and within the endothelial, epithelial, stromal, and immune compartments. (genomeweb.com)
A new human atlas initiative has been launched to create a unified database of molecular network of all the tissues in the human body and to derive a holistic picture of working of human body. (thehindubusinessline.com)
Currently the project is in its beta testing mode where students are being trained at NCCS, Pune campus to annotate and curate the molecular data related to research on human skin and assign them to various cells, tissues and organs via the newly created annotation platform. (thehindubusinessline.com)
Researchers at the Wellcome Sanger Institute and Newcastle University have collected genomic data from over 250,000 cells from a range of donated developing human tissues including liver, skin, kidney, and placenta. (broadinstitute.org)
Among all cancerous cells, a few act as stem cells that reproduce and sustain the tumor, much like stem cells normally renew and sustain our organs and tissues. (atlasantibodies.com)
Using advanced single cell technologies, she and her colleagues study human and mouse tissues at single cell resolution. (sdu.dk)
Dr Teichmann, head of cellular genetics at the Sanger Institute, a director of research in the Department of Physics at the University of Cambridge, and a senior research fellow of Churchill College, Cambridge , said: "The data that will be collected for the atlas, when complete, will provide an entry point for deeper study of cells' functions and interactions, both within their home tissues and more broadly throughout the body. (cambridgeindependent.co.uk)
It states that for the first draft of the atlas, the consortium will study and map between 30 and 100 million cells from several organs and tissues. (cambridgeindependent.co.uk)
The long-term goal of the group - led by an organising committee of 27 scientists from 10 countries - is to profile an astonishing 10 billion cells covering all tissues, organs and systems. (cambridgeindependent.co.uk)
We do not yet comprehensively know our cells - how they are defined by their molecular products, how they vary across tissues, systems, and organs, and how they influence health and disease. (cambridgeindependent.co.uk)
Single-cell technologies, developed in the past decade, enable researchers to study tissues at the resolution of individual cells, giving insight into the different functions of cells that make a whole organ do its job. (myscience.de)
This is accomplished by combining high-throughput generation of affinity-purified antibodies with protein profiling in a multitude of tissues and organs assembled in tissue microarrays, to explore protein expression patterns on a cell type-specific level. (scilifelab.se)
The program hosts the Human Protein Atlas portal with expression profiles of human proteins in tissues and cells. (scilifelab.se)
This collection highlights recent papers published in Nature Portfolio journals on topics across embryonic development & stem cells, reproductive biology, synthetic tissues & embryo models, clinical & translational research and tissue stem cells. (nature.com)
The bionetwork is using new single-cell and spatial multiomics approaches first to understand the cellular and molecular makeup of oral and craniofacial tissues and then to address common and rare diseases. (ada.org)
This approach will be key to achieving an inclusive, ancestrally diverse, open-access, multiomic reference atlas of oral and craniofacial tissues and fluids across the life span. (ada.org)
We investigated the expression of immune checkpoints (ICs) on lymphoid populations within the CRC TME and compared with cells from normal colon tissues using samples from 50 patients with varying disease stages. (mdpi.com)

In June 2023, the International Society for Stem Cell Research (ISSCR) released a report detailing standards for human stem cell research . (nature.com)

Its scope is to categorize the 37 trillion cells of the human body to determine which genes each cell expresses by sampling cells from all parts of the body. (wikipedia.org)
However, it remains unclear which genes and cell types of the TG are involved. (genengnews.com)
Now, by analyzing mouse and human TG, researchers from Brigham and Women's Hospital and Massachusetts General Hospital profiled, at single-cell resolution, the genes expressed in each TG cell type. (genengnews.com)
We now have an atlas of the genes that are expressed in each of the cell types in the TG, the key relay center for migraine and facial pain, and we are now using this tool to identify potential therapeutic targets that are selectively expressed in cell types that drive head pain. (genengnews.com)
Importantly, they found that while cell types between mice and humans are largely conserved, some of the genes known to be involved in pain are expressed in different subsets of cells in mice versus humans. (genengnews.com)
This trigeminal ganglion cell atlas improves our understanding of the cell types, genes, and epigenomic features involved in headache pathophysiology and establishes a rich resource of cell-type-specific molecular features to guide the development of more selective treatments for headache and facial pain," concluded the researchers. (genengnews.com)
This data will show which genes are switched on in each individual cell, and help explain vital processes in development. (broadinstitute.org)
CancerSEA provides an atlas of cancer single-cell functional states and associates protein-coding genes (PCGs) and lncRNAs with these functional states at single-cell level. (go.jp)
Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
The new atlas, reported in Cell , provides a window into the brain's remarkable diversity of cells, a starting point for studying how genes and genetic variants contribute to neurological and psychiatric disorders, and insights into how different kinds of neurons achieve their highly specialized functions. (broadinstitute.org)
Genetic studies of psychiatric and neurological disorders are now implicating many specific genes, but we need to be able to make the scientific connections from genes to cell populations and circuits," said study senior author and Broad institute member Steven McCarroll , the director of genetics at the Stanley Center for Psychiatric Research and the Dorothy and Milton Flier Professor of Biomedical Science and Genetics at Harvard Medical School. (broadinstitute.org)
Historically, months of experiments were often required to figure out which cell populations express even one of these genes. (broadinstitute.org)
Elementary school teachers and their pupils are invited to join a journey into ATLAS Center Director Susanne Mandrup's research area and get an introduction to fat cells, genes, and the code of life. (sdu.dk)
Susanne Mandrup has contributed to this material with insights into the code of life, genes, and cells, in particular fat cells, communicated through an introductory magazine and six inspirational catalogues targeted at different grades in primary school. (sdu.dk)
The catalogues contain background materials as well as ideas for how to introduce the pupils to cells, DNA, genes, the role of fat cells in health and lifestyle diseases. (sdu.dk)
By pooling and integrating all the bits of knowledge and data that had been generated previously, the researchers created the first integrated Human Lung Cell Atlas: For each of the 2.4 million cells in this atlas, they know which genes were active in which cell, thereby learning about the functionality of those cells. (myscience.de)
For example, first author Lisa Sikkema from the Institute of Computational Biology and the scientific team saw that monocyte-derived macrophages (a specific type of immune cell) showed activity of similar genes in cancer, COVID-19, and lung fibrosis, likely playing a role in scar formation in the lung in all three diseases. (myscience.de)
One of the ten emerging technologies selected was the Human Cell Atlas, which aims to integrate research exploring all the "omes": the genome (the full set of genes), the transcriptome (the RNA made from all genes), the proteome (the proteins), the metabolome (small molecules, such as sugars, fatty acids and amino acids, involved or generated by cellular processes), and the fluxome (metabolic reactions whose rates can vary under different conditions). (scilifelab.se)
In the nucleus, β-catenin recruits either CBP or p300 to express various genes involved in stem cell regulation. (atlasofscience.org)
Cancers occur when genetic mutations build up in critical genes, specifically those that control cell growth and division (proliferation) or the repair of damaged DNA. (medlineplus.gov)
Somatic mutations in many different genes have been found in lung cancer cells. (medlineplus.gov)
The EGFR and KRAS genes each provide instructions for making a protein that is embedded within the cell membrane. (medlineplus.gov)

Among malignant neoplasms of the penis, squamous cell carcinoma (SCC) is the most common. (medscape.com)
The cause of penile squamous cell carcinoma (SCC) is unclear, although human papillomavirus (HPV) appears to play a major role in many cases. (medscape.com)
Non-small cell lung cancer is divided into three main subtypes: adenocarcinoma, squamous cell carcinoma, and large cell lung carcinoma. (medlineplus.gov)

The rapid emergence of large-scale atlas-level single-cell RNA-seq datasets presents remarkable opportunities for broad and deep biological investigations through integrative analyses. (nature.com)
However, harmonizing such datasets requires integration approaches to be not only computationally scalable, but also capable of preserving a wide range of fine-grained cell populations. (nature.com)
Single-cell RNA-Seq datasets were manually curated with 14 cancer-related functional states. (go.jp)
An international team of researchers now created a single-cell atlas of the human lung by combining 49 different published and newly generated datasets. (myscience.de)
Dr Malte L cken, Group leader at the Institute of Computational Biology and the Institute of Lung Health & Immunity at Helmholtz Munich adds: "A comprehensive organ atlas requires many datasets to capture the diversity between both cells and individuals, but combining different datasets is a huge challenge. (myscience.de)
We developed a benchmarking pipeline to find the optimal method to integrate all datasets into the atlas, using artificial intelligence, and combined knowledge and data from almost 40 previous lung studies. (myscience.de)
While the core of the Human Lung Cell Atlas is data from healthy lungs, the team also took datasets from more than 10 different lung diseases and used machine learning to project these onto the healthy data, in order to understand disease states. (myscience.de)
On this website you will find the different published liver single cell RNA-sequencing datasets generated in the labs of Charlotte Scott and Martin Guilliams from the VIB-UGent Centre for Inflammation Research, Belgium. (livercellatlas.org)
By integrating these multi-omic datasets, we provide validated strategies to reliably discriminate and localize all hepatic cells including a population of bile-duct lipid-associated macrophages (LAMs). (livercellatlas.org)
When tracking cells between graphs in bigger datasets this is necessary to avoid too many lines being drawn and introducing lag. (lu.se)

Researchers unmask unique genetic signatures of more than 560 cell populations across nine brain regions, and lay the groundwork for deeper insights into the biology of brain disorders. (broadinstitute.org)
Diversity of the different cell types that make up our brains can only be fully understood in light of their developmental history," said NYU Biology Professor Claude Desplan, the study's senior author. (medicalxpress.com)
While we do not yet understand the functions of these previously unknown neurons, neurons with very similar properties-called Cajal-Retzius cells-also exist in mammalian brains, and they are critical for proper brain development ," said Felix Simon, a biology doctoral student at NYU and the other lead author of the study. (medicalxpress.com)
This atlas elucidates the diversity of single lung cell types and allows learning about lung biology in health and disease. (myscience.de)
Prof. Fabian Theis, Head of the Computational Health Center, Director of the Institute of Computational Biology at Helmholtz Munich and Professor at the Technical University of Munich (TUM), explains the project: "We have created a first integrated reference atlas of the human lung, which includes data from more than a hundred healthy people and reveals how the cells from individuals vary with age, sex, and smoking history. (myscience.de)
This Collection highlights selected articles from across the Nature Portfolio that document the recent progress in understanding the biology of Extracellular Vesicle-mediated cell-cell communication and advances in clinical translation of EVs. (nature.com)
These results confirm that our previously described CBP/p300 coactivactor switching model that plays a very fundamental role in stem cell biology. (atlasofscience.org)
Development: For advances in developmental biology and stem cells. (lu.se)

This gave the researchers new ideas about which cells to study further. (genengnews.com)
Earlier this year, Menlo Park, California-based Deepcell began working with researchers at the University of California, Los Angeles to identify and sort cancer cells from clinical cytology samples of body fluids. (genomeweb.com)
Researchers from the global Human Cell Atlas (HCA) Consortium are taking the first steps toward using powerful single-cell genome analysis tools to understand early human development and how this can affect health or lead to disease. (broadinstitute.org)
Researchers expect to find even more types of cells, and they don't fully understand some of the ones they've already found, like splatter neurons. (kenw.org)
The recent development of a human kidney cell atlas will help researchers better understand the factors contributing to disease states and provide a critical foundation to help discover new treatments for acute kidney injury and chronic kidney disease. (hospitalhealthcare.com)
In the study, published in the journal Nature , a team of US researchers developed a kidney tissue atlas consisting of 51 main cell types including rare and novel cell populations and 28 cellular states indicative of injury or disease. (hospitalhealthcare.com)
Researchers applied multiple single-cell and single-nucleus assays and spatial imaging technologies to both healthy and diseased kidneys. (hospitalhealthcare.com)
Researchers have generated a cellular atlas of the mouse brain, based on the gene expression profiles of nearly 700,000 individual cells covering nine major brain regions. (broadinstitute.org)
New York University researchers have created a "developmental atlas" of gene expression in neurons, using gene sequencing and machine learning to categorize more than 250,000 neurons in the brains of fruit flies. (medicalxpress.com)
To understand the diversity of brain cells , researchers have long studied fruit flies , whose brains, although much simpler than those of humans, can be used as a model system. (medicalxpress.com)
Researchers previously identified the roughly 60,000 cells and 200 neuronal types that make up fruit flies' optic lobes , the areas of the brain that process visual information , including color vision and detection of objects and motion. (medicalxpress.com)
In their new study in Nature , researchers in Desplan's lab sought to thoroughly characterize the diversity of neurons in the optic lobe and build a "developmental atlas" of gene expression , comparing cells in the brains of adult flies and exploring differences during development. (medicalxpress.com)
The researchers created their "atlas" by taking advantage of a form of a recently invented technique known as single-cell mRNA sequencing, which allowed them to capture and sequence mRNA from more than 250,000 single cells. (medicalxpress.com)
While building their "developmental atlas," the researchers made several discoveries. (medicalxpress.com)
In addition, the researchers found that neurons exhibit the highest levels of molecular diversity during development compared to adult neurons, allowing cells during development to form connections with specific partner cells-and avoid the wrong ones. (medicalxpress.com)
Researchers at the Centro Nacional de Análisis Genómico ( CNAG-CRG ), based in the Barcelona Science Park, have created the first cellular atlas of the immune cells infiltrating tumours. (ub.edu)
The researchers tested the atlas' potential through various tests, showing it can help identify the type of immune cells residing within a patient's tumour and pinpoint their location. (ub.edu)
The researchers created the atlas by studying the tumour microenvironment. (ub.edu)
The researchers have also revealed that the gene expression profiles from the first one million immune cells towards this initial milestone, collected under the HCA from bone marrow and cord blood from healthy human donors, will be available in a public online resource by early November. (cambridgeindependent.co.uk)
International researchers have taken up this challenge and developed the Human Lung Cell Atlas, using artificial intelligence (AI)-based techniques. (myscience.de)
The Lung Atlas Integration project was a large collaborative effort with nearly 100 partners from more than 60 departments involved internationally, including key researchers from the University Medical Center Groningen and Northwestern University. (myscience.de)
The team plans to try to answer that question by looking level atlas of the human brain to determine the The researchers conducting the study were operating under Project setup at dopamine and the brain's theta rhythm. (medlineplus.gov)

The Human Tumor Atlas Network (HTAN) was created to change that. (mskcc.org)
In recent years, short-read single-cell RNA sequencing (scRNA-seq) has been instrumental in deciphering tumor cell heterogeneities. (biorxiv.org)
Cancer stem cells (CSCs) are small cells, 1% to 3% of all cells in a tumor, that drive the tumor's initiation, growth, and metastasis and may cause relapse. (atlasantibodies.com)
The use of CD133 (PROM1) to identify CSCs in glioma is still in question because tumorigenic cells are equally found in both CD133+ and CD133− cells in some gliomas, while some CD133+ brain tumor cells may not possess tumor-initiating capacity 23 . (atlasantibodies.com)
A single-cell tumor immune atlas for precision oncology. (ub.edu)
Using a high-quality testing and innovative multimodal and integrative approach, the first Veracyte Biopharma Atlas for DLBCL evaluated thousands of parameters across more than 150 pre-treatment DLBCL lesions and enabled us to precisely map the spectrum of tumor microenvironments across samples and to establish a robust unsupervised descriptive model. (bmj.com)
By projecting new specimens associated to relevant clinical information and sample data onto the referential map, Atlas analysis provides a detailed description of the tumor microenvironment and facilitates the development of predictive and prognostic tools. (bmj.com)
Methods Veracyte Biopharma Atlas characterizes the tumor microenvironment by analyzing information from 3 different modalities: (i) proteomics (Brightplex® panels), (ii) transcriptomics (RNA sequencing and hybridization using Nanostring technology), (iii) genomics (somatic mutations by exome sequencing and/or the rearrangement of the V(D)J regions of the CDR3 receptor of T cells). (bmj.com)
Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor . (medlineplus.gov)
These changes allow cells to grow and divide uncontrollably to form a tumor . (medlineplus.gov)

The decision for a stem cell to make an exact copy of itself and maintain the same level of potency versus initiate a differentiation program is critical both during development and normal tissue maintenance. (atlasofscience.org)
Interestingly, ICG-001 induces differentiation in various stem/progenitor cells including cancer stem cells. (atlasofscience.org)
YH249/250 also blocked the differentiation of muscle stem cells even under conditions that normally cause differentiation. (atlasofscience.org)
In dramatic contrast, ICG-001 forced the differentiation of these cells even under conditions that normally prevent differentiation. (atlasofscience.org)
YH249/250 also have potential therapeutic value to expand ex vivo stem cell populations (ESC and somatic stem cells e.g. cord blood stem cells) and somatic stem cells in vivo, without differentiation. (atlasofscience.org)
SCC of the prostate is a rare malignant epithelial neoplasm arising in the prostate, with squamous differentiation of the neoplastic cells. (medscape.com)
During vertebrate embryogenesis , fetal hematopoietic stem and progenitor cells (HSPCs) exhibit expansion and differentiation properties in a supportive hematopoietic niche. (bvsalud.org)
PKC is an important signaling molecule in numerous cell pathways, including cell differentiation, proliferation and apoptosis. (medscape.com)

The cells from these samples will be profiled at a genetic, epigenetic, transcriptomic, and proteomic level to generate the first and most comprehensive open-access resource atlas of cells in the childhood respiratory tract. (edu.au)
In this study, we surveyed the single-cell transcriptomic landscape to dissect the cellular and molecular changes associated with the aging of oMCs in mice. (sens.org)

Cancer stem cells (CSCs) are generated by a combination of DNA mutations, epigenetic events, and tissue microenvironment factors from normal stem cells or precursor/progenitor cells, to which they are closely related and share many of the behaviors and features 1 . (atlasantibodies.com)
Our results showed that the oMCs were composed of five ovarian differentiated MC (odMC) populations and one ovarian mesenchymal progenitor (oMP) cell population. (sens.org)
p300/β-catenin antagonists maintain stem cell potency, e.g. in mouse or human ESC and multipotency in other stem/progenitor cells. (atlasofscience.org)
A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish. (bvsalud.org)

Osteopontin Expression Identifies a Subsetof Recruited Macrophages Distinctfrom Kupffer Cells in the Fatty Liver. (livercellatlas.org)
This accumulation causes formation of globoid cells (hematogenous often-multinucleated macrophages containing undigested galactosylceramide), which is the histologic hallmark of Krabbe disease. (medscape.com)

The grant, titled "A strategy for mapping the human spinal cord with single cell resolution", will fund research to identify and catalogue gene activity in all spinal cord cells. (wikipedia.org)
BAKKEN: What we found in this study is that there really is a conserved set of cell types that we share with chimpanzees and gorillas, but the gene expression has changed in those cells. (kenw.org)
The atlas also serves as a repository of raw gene data and interactive 3D models of cells and microenvironment relationships. (hospitalhealthcare.com)
The research team generated the atlas by analyzing gene expression in 690,000 individual cells isolated from nine brain regions, including the frontal and posterior cortex, hippocampus, cerebellum, thalamus, striatum, and substantia nigra. (broadinstitute.org)
NYU biologists created a "developmental atlas" of gene expression in the neurons of fruit flies. (medicalxpress.com)
The 'atlas' constitutes an enormous resource for the research community: we can now simply look up whether a particular gene is active or not in any cell type of our choice and at any point during its development. (medicalxpress.com)
They studied the gene expression of more than 500,000 individual immune cells - selecting 317,111 to analyse - from 217 patients with 13 different types of primary tumours. (ub.edu)
They first took gene expression data from four different types of tumours and compared it to their cell atlas. (ub.edu)
They used a technique called SPOTlight, also developed by the CNAG-CRG, to visualise the gene expression of cells in tumour cross-sections. (ub.edu)
This group of tracks shows data from A human cell atlas of fetal gene expression . (ucsc.edu)
The TP53 gene provides instructions for making a protein, called p53, that is located in the nucleus of cells throughout the body, where it attaches (binds) directly to DNA. (medlineplus.gov)

This provided a high-resolution cellular atlas of 51 main cell types, which included rare and previously undescribed cell populations. (hospitalhealthcare.com)
By creating a data resource like this - in which scientists can simply look these things up online - we hope to enable a stronger understanding of how brain illness arises in specific cell populations. (broadinstitute.org)

Under the terms of the deal, Deepcell will use its AI-based technology for label-free cell isolation and collection to help Stanford generate single-cell morphology data for the Tabula Sapiens program, which aims to build a benchmark human cell atlas of 2 million cells collected from 25 organs of eight people. (genomeweb.com)
The project would utilize large biological community, both students and scientists, for extracting and adding the information from scientific literature at the level of cells and organs. (thehindubusinessline.com)
It was created from 45 healthy donor organs and 48 kidney disease biopsies and allows for the comparison of healthy and injured cells. (hospitalhealthcare.com)
This is a collection of single cell and single nucleus combinatorial indexing-based RNA-seq data covering 4 million cells from 15 organs obtained during mid-gestation. (ucsc.edu)

The HDCA is one part of the ambitious Human Cell Atlas, a global consortium that aims to transform biological research and medicine by mapping every cell in the human body. (broadinstitute.org)
earlyAIR is a paediatric component of the global Human Cell Atlas consortium that aims to create comprehensive reference maps of all human cells as a basis for both understanding human health and diagnosing, monitoring, and treating disease. (edu.au)
One of the technologies selected was the Human Cell Atlas, which aims to integrate research exploring the building-blocks of human cells using new emerging technologies. (scilifelab.se)
Work is underway to map every oral and craniofacial cell as part of the Human Cell Atlas, an international project that aims to catalog all the cells in the human body. (ada.org)

In April 2018, the first data set from the project was released, representing 530,000 immune system cells collected from bone marrow and cord blood. (wikipedia.org)
Progress on the HDCA and other aspects of the Human Cell Atlas will be discussed at the international HCA meetin g at the Wellcome Genome Campus, Cambridge on March 8 th 2018. (broadinstitute.org)
The Cancer Genome Atlas Research Network 2018, ' The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma ', Cell reports , vol. 23, no. 1, pp. 313-326.e5. (umn.edu)

To profile the developmental landscape of fetal HSPCs and their local niche, here, using single- cell RNA -sequencing, we deciphered a dynamic atlas covering 28,777 cells and 9 major cell types (23 clusters) of zebrafish caudal hematopoietic tissue (CHT). (bvsalud.org)
Studies indicate that early unrelated hematopoietic stem cell transplantation in both the infantile and late-onset forms is associated with at least short-term benefits on neurocognitive parameters, lifespan, and quality of life. (medscape.com)

Large cell carcinoma arises from epithelial cells that line the lungs. (medlineplus.gov)

They lay the groundwork for multiple atlases the Consortium could complete together, and they validate approaches for creating other spatiotemporal atlases. (asianetnews.net)

The Human Cell Atlas is a project to describe all cell types in the human body. (wikipedia.org)
The Tabula Sapeins data was published on a dedicated website List of distinct cell types in the adult human body Human Genome Project ENCODE - Encyclopedia of DNA Elements (ENCODE) Human Protein Atlas Preidt 2016. (wikipedia.org)
Their findings are published in the journal Neuron , in a paper titled, " Human and mouse trigeminal ganglia cell atlas implicates multiple cell types in migraine . (genengnews.com)
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes and progenitors. (nature.com)
This project is designed to generate data pertaining to cellular and molecular activities of various cell types in the body in both its normal and disease state using techniques such as single cell genomics. (thehindubusinessline.com)
Together, the papers map out the location, structure and function of at least 3,000 types of brain cells. (kenw.org)
It's a splatter of these types of cells. (kenw.org)
HAMILTON: So as part of the atlas project, Ren and his team have been creating a dictionary that links genetic changes to specific types of brain cells. (kenw.org)
HAMILTON: Ren says this sort of information could lead to treatments that target specific types of cells. (kenw.org)
However, understanding which variants matter in which cell types, and how they relate to healthy and disease states, remain among the greatest challenges in neuroscience and neuropsychiatric research. (broadinstitute.org)
And while scientists have a general idea of the different types of cells that make up some brain regions, the detailed identities, molecular repertoires, and functional roles of cells at a brain-wide level have yet to be fully cataloged, further complicating efforts to link variant to cell to function. (broadinstitute.org)
The existence of stem cells in hematological tissue prompted research in other tissue cancer types. (atlasantibodies.com)
The findings, published in Genome Research, reveal that different types of tumours in the human body show surprisingly similar patterns of immune cells residing within. (ub.edu)
Being able to assess the types, states and location of immune cells infiltrated within a tumour, also known as its immune profile, could significantly help predict whether a patient benefits from immunotherapy. (ub.edu)
The authors of the study did this by creating the first cell atlas of immune cells from different types of cancer. (ub.edu)
The analysis revealed that different types of cancer share common immune cell compositions. (ub.edu)
An overview in a white paper from the HCA Consortium, co-authored by Dr Teichmann, explains: "For the past 150 years scientists have classified cells by their structures, functions, locations, and, more recently, molecular profiles, but the characterization of cell types and states has remained surprisingly limited. (cambridgeindependent.co.uk)
This provided insight into the wide variety of cells and cell types existing in our lungs. (myscience.de)
The sheer numbers of cells and individuals involved now gives us the power to see rare cell types and identify new cell states that have not previously been described. (myscience.de)
The integrated results will lead to a tool that will simulate all the types and states of cells in our body and provide new understandings of disease processes. (scilifelab.se)
The Fetal Lineage subtrack shows similar data, but with the cell types subdivided more finely and by organ. (ucsc.edu)
Without maps of different cell types. (bvsalud.org)
Lung cancer is generally divided into two types, small cell lung cancer and non-small cell lung cancer, based on the size of the affected cells when viewed under a microscope. (medlineplus.gov)
Mycosis fungoides and Sézary syndrome are the 2 main types of cutaneous T-cell lymphomas. (msdmanuals.com)

Cell Tissue Res 257:459-470. (nih.gov)
First, however, the team had to collect individual cells from the adult mouse brain in a way that reflects the cellular diversity of native, intact tissue. (broadinstitute.org)
Identifying the characteristics of specific cells within a tissue has significant applications for understanding physiology, how organisms develop, and which cells are causes or indicators of disease, potentially leading to future gains in human disease research. (asianetnews.net)
This is the collection of blood cells, immune cells and connective tissue in the immediate vicinity of a tumour, which plays a critical role in the development, progression and control of cancer. (ub.edu)
By combination, they are able to form up to 24 different integrins, which are differentially expressed depending on the tissue and the physiological state of the cell. (uvigo.es)

Ovarian mesenchymal cells (oMCs) constitute a distinct microenvironment that supports folliculogenesis under physiological conditions. (sens.org)
They were particularly interested in the role of immune cells in the tumour microenvironment, as it influences the effectiveness of immunotherapy, treatments that use a person's immune system to find and destroy cancer cells. (ub.edu)

We expect this fundamental research to deliver a wide range of important insights - from a better understanding of why miscarriages and genetic developmental disorders happen, through to understanding childhood cancers that have their root in development and the developmental pathways that cancer cells take advantage of in adults. (broadinstitute.org)
When these proteins are turned on (activated) by binding to other molecules, signaling pathways are triggered within cells that promote cell proliferation. (medlineplus.gov)

COVID - 19 immune features revealed by a large-scale single - cell transcriptome atlas . (nih.gov)
In the last few years, there has been a lot of progress of mapping the genome and transcriptome in single cells. (asianetnews.net)

Their first studies resulted in state-of-the-art panoramic spatial atlases of life, published in Cell and Developmental Cell on May 4. (asianetnews.net)
But this has been without the context of the spatial aspect of neighbourhoods of cells, ecosystem of cells, and therefore there is a whole layer of information that has been missing, which I think will now become accessible. (asianetnews.net)
The scientists will use a suite of genomic techniques known as 'massively-parallel single-cell RNA sequencing', related technologies to characterise other molecules and spatial methods to map cell locations and interactions. (cambridgeindependent.co.uk)
Here, we present a spatial proteogenomic atlas of the healthy human and murine liver combining single-cell CITE-seq, single-nuclei sequencing, spatial transcriptomics and spatial proteomics. (livercellatlas.org)

Molecular classification of glioma stem cells Comprehensive genetic analysis of glioblastomas by The Cancer Genome Atlas (TCGA) has proposed a new classification based on genetic abnormalities. (atlasofscience.org)

We are excited about the efforts to create a Human Cell Atlas and the addition of new emerging tools to create a knowledge-based platform for understanding the human cell" says Mathias Uhlen, Director of the international Human Protein Atlas consortium. (scilifelab.se)
The Human Protein Atlas project, funded by the Knut and Alice Wallenberg Foundation, has been set up to allow for a systematic exploration of the human proteome using antibody-based proteomics. (scilifelab.se)

Importantly, we identified an endothelial cell -specific G protein -coupled receptor 182, followed by in vivo and in vitro functional validation of its evolutionally conserved role in supporting HSPC expansion in zebrafish and mice . (bvsalud.org)

Neuronal diversity and convergence in a visual system developmental atlas, Nature (2020). (medicalxpress.com)

Cell, 2022. (livercellatlas.org)
paraCell is a Single-cell analysis framework primarily developed since 2022 by Edward Agboraw at the Otto Lab, University of Glasgow. (gla.ac.uk)

A dysfunctional immune response in coronavirus disease 2019 ( COVID - 19 ) patients is a recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent immune cells is not complete. (nih.gov)

Non-Hodgkin Lymphomas Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the. (msdmanuals.com)

Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. (umn.edu)
In nearly all cases of lung cancer, these genetic changes are acquired during a person's lifetime and are present only in certain cells in the lung. (medlineplus.gov)
In rare cases, the genetic change is inherited and is present in all the body's cells (germline mutations). (medlineplus.gov)

Acute (AML) and chronic (CML) myeloid leukemia are cancers of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production. (atlasantibodies.com)

The altered protein cannot regulate cell proliferation effectively and allows DNA damage to accumulate in cells. (medlineplus.gov)

A similar Human Cell Atlas project was launched in 2016 as a collaborative effort between scientists. (thehindubusinessline.com)
CSCs were first identified in hematological cancer such as acute myeloid leukemia in the late '90s when scientists isolated a subpopulation of leukemia cells that expressed the surface marker CD34 but not CD38. (atlasantibodies.com)
But an international consortium of scientists, co-chaired by Sarah Teichmann of the Wellcome Trust Sanger Institute in Hinxton, have marked a key stage in the creation of the first Human Cell Atlas (HCA). (cambridgeindependent.co.uk)
Aviv Regev, director of the Klarman Cell Observatory and Cell Circuits Program at the Broad Institute of MIT and Harvard, said: "Over the past year, the international scientific community, from physicians to computer scientists, has engaged in an open process to plan how to go about making this revolutionary atlas. (cambridgeindependent.co.uk)

A research program at the Max Planck Institute of Immunobiology and Epigenetics published an atlas of the cells of the liver, using single-cell RNA sequencing on 10,000 normal cells obtained from nine donors. (wikipedia.org)
We thus developed a cell atlas in which human and mouse trigeminal ganglia are transcriptionally and epigenomically profiled at single-cell resolution. (genengnews.com)
Data from the collaboration will also be used to expand the company's Deep Cell Atlas, an atlas of single human cells that so far includes more than 1 billion cell images. (genomeweb.com)
Did you mean a single cell atlas of other peripheral immune response to severe covid 19 (3 results)? (nih.gov)
We haven't had a global framework for understanding, at the molecular, single-cell level, the cells that make up the core components of the brain," said Arpiar Saunders, a postdoctoral researcher in the McCarroll laboratory and co-first author of the study with Stanley Center associate member and Massachusetts General Hospital psychiatrist Evan Macosko. (broadinstitute.org)
To analyze so many cells, the team used Drop-Seq , a high-throughput, microfluidics-based, single-cell RNA-sequencing method developed by Macosko and collaborators in 2015 when he was a postdoctoral fellow in McCarroll's laboratory. (broadinstitute.org)
Each dot represents single cells that are organized into color-coded clusters according to their cell type. (medicalxpress.com)
This cell atlas of immune cells helps us visualise tumours in ways we have never been able to before," says Holger Heyn , leader of the Single Cell Genomics Team at the CNAG-CRG and final author of the study. (ub.edu)
Can a human organ be mapped on a single-cell level, to learn about the functionality of each individual cell? (myscience.de)
However, generating a single-cell dataset is time-consuming and expensive, and generally, only a few individuals are included in each study. (myscience.de)
The project, has been made technically feasible by a array of technological achievements for profiling single human cells at any given time. (scilifelab.se)
We also performed single cell RNA sequencing analysis of the CD45 - cells isolated from the livers of the mice fed the SD or WD for 24 and 36 weeks. (livercellatlas.org)

The HDCA program will create genomic reference maps of all the cells that are important for human development, which will revolutionize our understanding of health and disease, from miscarriages and children's developmental disorders, through to cancer and aging. (broadinstitute.org)
LEIN: You can use this map to understand what actually happens in disease and what kinds of cells may be vulnerable or affected. (kenw.org)
REN: For example, we found that late-onset Alzheimer's disease are particularly associated with a type of cell we call microglia. (kenw.org)
He added: 'With the atlas, we've created an interactive, hypothesis-generating resource for kidney disease investigators and clinicians around the world. (hospitalhealthcare.com)
This study will develop a reference atlas of healthy cells in the paediatric airway in order to understand the changes caused by childhood lung disease. (edu.au)
This healthy atlas will be used to enhance our understanding of childhood lung disease, develop new diagnosis and treatment options, and ultimately improve outcomes for children with lung diseases. (edu.au)
Establishing a reference atlas of cells from the healthy paediatric airway will allow us to understand what is normal, what is changing with disease, and develop better diagnostic and treatment options for children with respiratory diseases. (edu.au)
These lay an important foundation for STOC's research initiatives, which aim to create diverse sets of spatiotemporal atlases to broaden our knowledge of disease treatment, organ structures, development and aging, and to improve our understanding of biological evolution. (asianetnews.net)
A comprehensive collection of reference maps of the human body, the atlas is designed to enable a deeper understanding of human health, helping us to diagnose, monitor and treat disease. (cambridgeindependent.co.uk)
Finding these shared disease-associated cells is really exciting, and reveals a totally different way of looking at lung diseases, opening possibilities for novel treatment targets and developing treatment response biomarkers. (myscience.de)
This enabled studies of how the cells from individuals vary with age, sex, or disease. (myscience.de)
Krabbe disease, also known as globoid cell leukodystrophy or galactosylceramide lipidosis, is an autosomal-recessive sphingolipidosis caused by deficient activity of the lysosomal hydrolase galactosylceramide beta-galactosidase (GALC). (medscape.com)
The Seattle Alzheimer's Disease Brain Cell dementia. (medlineplus.gov)
Health care services for severe NCDs such as type 1 diabetes, advanced rheumatic heart disease, and sickle cell disease, are usually provided at tertiary facilities in most countries. (who.int)

Microscope images of brain cells collected for Drop-Seq analysis: neurons (pink), astrocytes (green), oligo- and polydendrocytes (blue). (broadinstitute.org)
First, they found a completely new type of neurons in fruit flies, which is present only on the surface of the optic lobe during development but is removed through programmed cell death right before the flies hatch. (medicalxpress.com)
We observed intranuclear inclusions in neurons and glial cells of swine fetuses with encephalitis. (cdc.gov)

Other primary areas of focus for the HDCA include an improved understanding of how blood cells form and how the immune system functions. (broadinstitute.org)

The mechanisms controlling lysosome abundance in cells and how changes in lysosome pool size impact physiological and pathophysiological processes are discussed. (nature.com)

for human brain cells from ref. 36 ( GSE164485 ) and ref. 37 ( https://github.com/LieberInstitute/10xPilot_snRNAseq-human#work-with-the-data ). (nature.com)
Preliminary projects for the Human Developmental Cell Atlas (HDCA) have sequenced a quarter of a million separate cells so far and the first tranche of data analysis is underway. (broadinstitute.org)
Different research groups used different names for the same cell type, or the same name for different cells, so as a team we worked to standardize them using the data in the atlas. (myscience.de)
The Veracyte Biopharma Atlas innovative approach combines linear (multimodal factor analysis) and non-linear (self-organizing map) approaches with graphical representation of the data. (bmj.com)
Projection of ZUMA-1 immune contexture data onto the Atlas map revealed actionable information related to patients receiving CAR-T-cell treatment. (bmj.com)
Conclusions Projection of CAR-T clinical trial data highlighted the Veracyte Biopharma Atlas as a powerful tool to stratify patients and identify key immune biomarkers linked to response to CAR T-cell therapy. (bmj.com)
The Fetal Cells subtrack contains the data organized by cell type, with RNA signals from all cells of a given type pooled and averaged into one bar for each cell type. (ucsc.edu)
A key aspect of the research will be increasing the diversity of donor data sets to ensure they are heterogeneous in terms of sex, age, ancestry and more, as these traits are known to influence cell-specific physiology. (ada.org)

Additional bar chart subtracks pool the cell by other characteristics such as by sex ( Fetal Sex ), assay ( FetalAssay ), donor ( Fetal Donor ID ), experiment ( Fetal Exp ), organ ( Fetal Organ ), and reverse transcription group ( Fetal RT Group ). (ucsc.edu)

In addition, CSCs might give rise to metastases, acting as a reservoir of cancer cells, causing relapse after the surgery or treatment has eliminated the visible signs of cancer. (atlasantibodies.com)
They are commonly expressed in pluripotent embryonic stem cells, germ cells, certain committed progenitors, and cancer cells 18 . (atlasantibodies.com)
The authors of the study believe this information make the atlas a powerful new complementary tool to personalise cancer treatments for the best possible outcome. (ub.edu)
Our study not only supports the presence of lung fibrosis in COVID-19, it allows us to identify and define a shared cell state between lung fibrosis, COVID-19 and lung cancer patients. (myscience.de)
Non-small cell lung cancer accounts for 85 percent of lung cancer, while small cell lung cancer accounts for the remaining 15 percent. (medlineplus.gov)

On the other hand, in brain tumors, such as glioma and glioblastoma, CSCs have instead been identified using cell surface markers, including SSEA-1 20 , EGFR 21 , and CD44 22 . (atlasantibodies.com)

3. Cell membrane. (uvigo.es)
Cell adhesion relies on transmembrane proteins, known as adhesion proteins , found in the plasma membrane. (uvigo.es)
For example, cells can change the type and amount of adhesion molecules in the plasma membrane by synthesis, degradation, or hidden them temporarily in internal compartments by endocytosis and exocytosis. (uvigo.es)
The strength of the adhesion of a cell to the extracellular matrix depends on the number, the active state and type of integrins that are expressed in the plasma membrane. (uvigo.es)
A study by White et al (2009) found that psychosine's cytotoxic effects on oligodendroglia and Schwann cells was mediated through disruption of the architecture and composition of lipid rafts (cell membrane regions characterized by high cholesterol and sphingolipid concentration), followed by altered protein kinase C (PKC) function. (medscape.com)

We demonstrate that bile-duct LAMs are induced by local lipid exposure, leading to their induction in steatotic regions of the murine and human liver, while Kupffer cell development crucially depends on their crosstalk with hepatic stellate cells via the evolutionarily-conserved ALK1-BMP9/10 axis. (livercellatlas.org)
1990. Cell replication and unscheduled DNA synthesis (UDS) activity of low molecular weight chlorinated paraffins in the rat liver in vivo. (cdc.gov)

Members of the research group who produced the panoramic atlases used a new enabling technology Stereo-seq, developed by BGI-Research, to produce the most insightful spatiotemporal cellular maps to date of mice, small fruit flies (Drosophila), zebrafish, and the Arabidopsis plant, making a breakthrough in resolution and panoramic field of view and enabling analysis of the distribution and placement of molecules and cells in situ, and over time. (asianetnews.net)
For traveling, cells first need to be attached to some element of the environment, a cell or some molecules of the extracellular matrix, and then drag the nucleus and the rest of the cytoplasm in the direction of moving. (uvigo.es)
One adhesion molecule does not make a strong bond, but cell adhesion is performed by many adhesion molecules that altogether make a strong linking, as if they were a molecular Velcro. (uvigo.es)
Some adhesion molecules may interact laterally between each other and form molecular complexes that increase the adhesion strength in some local points of the cell surface. (uvigo.es)
T here are adhesion molecules involved in the attachment of cells to the extracellular matrix and others in linking one cell to another. (uvigo.es)
PKC isozymes are LR-dependent molecules that link psychosine-induced LR disruption to reduced PKC function and altered cell signaling activity, possibly driving demyelination and apoptosis in oligodendrocytes and Schwann cells. (medscape.com)

The Human Cell Atlas will catalogue a cell based on several criteria, specifically the cell type, its state, its location in the body, the transitions it undergoes, and its lineage. (wikipedia.org)

These biological specimens will then be analysed using novel laboratory techniques to develop the first reference dataset of immune cells in the respiratory system of children. (edu.au)

Anatomy8

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