Aspirin salicylates. Medical search. Frequent questions

Prostaglandin E2 (PGE2), thromboxane B2 (TXB2), and salicylic acid were measured in blood samples from 10 healthy men after administration of antiinflammatory doses of aspirin (3.9 g/day) or salsalate (3.0 g/day). (nih.gov)
Plasma salicylate concentrations were slightly, but generally insignificantly, higher during aspirin dosing, although both drugs produced salicylic acid levels in the antiinflammatory range. (nih.gov)
He had discovered salicylic acid, the principal metabolite of aspirin. (wikipedia.org)
A less corrosive compound of salicylic acid, acetylsalicylic acid, produced by reacting sodium salicylate with acetyl chloride, was developed from 1897 by Felix Hoffmann and Arthur Eichengrün. (wikipedia.org)
The fresh bark of all members of this genus contains salicin[226], which probably decomposes into salicylic acid (closely related to aspirin) in the human body[213]. (pfaf.org)
Mechanism of Action: Aspirin is a more potent inhibitor of both prostaglandin synthesis and platelet aggregation than other salicylic acid derivatives. (theodora.com)
The differences in activity between aspirin and salicylic acid are thought to be due to the acetyl group on the aspirin molecule. (theodora.com)
Following absorption, aspirin is hydrolyzed to salicylic acid with peak plasma levels of salicylic acid occurring within 1-2 hours of dosing (see Pharmacokinetics --Metabolism). (theodora.com)
Metabolism: Aspirin is rapidly hydrolyzed in the plasma to salicylic acid such that plasma levels of aspirin are essentially undetectable 1-2 hours after dosing. (theodora.com)
If your frequent use skin care or personal care products contain any synthetic or natural form of salicylic acid, over time, you could develop salicylate sensitivity and eventually a variety of symptoms associated with salicylic acid allergies. (cleure.com)
Many major brands of mouthwash contain essential oils and therefore salicylic acid, or it may list it as methyl salicylate, menthol, or other plant extracts. (cleure.com)
According to Mayo Clinic, some of the triggering causes include salicylic acid ingredients found in such products as aspirin taken by children and teens. (cleure.com)
Chemically, aspirin is salicylic acid acetate. (prescriptiondrugs.com)
Aspirin is rapidly absorbed and almost totally hydrolyzed to salicylic acid following oral administration. (prescriptiondrugs.com)
Although aspirin has a half-life of only about 15 minutes, the apparent biologic half-life of salicylic acid in the therapeutic plasma concentration range is between 6 and 12 hours. (prescriptiondrugs.com)

Background and purpose: Aspirin or its metabolite sodium salicylate is widely prescribed and has many side effects. (johnshopkins.edu)
In the current study, aging Fischer 344 rats (18 months old) were treated with sodium salicylate at a dose of 100 mg/kg for 2 times per day for 5 days per week for 3 weeks. (cdc.gov)

Ingestion of 5 mL of oil of wintergreen ( methyl salicylate , a component of some liniments and solutions used in hot vaporizers) can kill a young child. (msdmanuals.com)
Methyl salicylate (oil of wintergreen) is a chemical that smells like wintergreen. (medlineplus.gov)
Methyl salicylate overdose occurs when someone swallows a dangerous amount of a product containing this substance. (medlineplus.gov)
Methyl salicylate can be poisonous in large amounts. (medlineplus.gov)
Other products may also contain methyl salicylate. (medlineplus.gov)
Below are symptoms of a methyl salicylate overdose in different parts of the body. (medlineplus.gov)
Methyl salicylate is the most poisonous form of the salicylate type of chemicals. (medlineplus.gov)
Methyl salicylates and menthol are found in many over-the-counter pain-relieving creams. (nih.gov)
In 2007, a teen was reported as dead due to overdosing on methyl salicylate after rubbing her sore thigh muscle with a pain reducing cream, Bengay. (cleure.com)
Glycoside, gaultherin (which is comprised of about 99% methyl salicylate) an enzyme gaultherase, aldehyde 1 alcohol, 1 ester, tannin, wax and mucilage. (emedicinal.com)
The oil consists mostly of methyl salicylate, a close relative of aspirin. (emedicinal.com)
Essential oil (methyl salicylate) in leaves is synthetically produced for "wintergreen" flavor. (emedicinal.com)

Nuts and seeds also contain salicylates. (livestrong.com)
The berries contain salicylates, which your body sees as similar to aspirin. (greatist.com)
White willow , cayenne and other herbs contain salicylates, compounds like those in aspirin. (anniesremedy.com)

Aspirin (acetylsalicylic acid) is an easily obtainable and inexpensive pharmaceutical medicine that is widely used to treat a number of conditions [ 6 ]. (ecancer.org)
The chemical of acetylsalicylic acid was first synthesized in 1899 by Bayer Pharmaceuticals in Germany [ 7 ] and mass produced under the commercial name of aspirin. (ecancer.org)
Ecotrin enteric coated aspirin (acetylsalicylic acid) tablets available in 81mg, 325mg and 500 mg tablets for oral administration. (theodora.com)
Aspirin is the trade name of acetylsalicylic acid , but other chemicals such as sodium or bismuth salicylate may also cause the onset of Reye's syndrome. (everything2.com)
The chemical name of aspirin is acetylsalicylic acid. (lamfacialplastics.com)

The interest in this potential extends back over more than a decade and aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) were the subject of the first International Agency for Research on Cancer (IARC) scientific evaluation on cancer chemoprevention [ 9 ]. (ecancer.org)
aspirin or any other NSAIDs. (mydr.com.au)
If you have an allergy to aspirin or NSAIDs . (drugs.com)

Dehydration, hyperthermia, and chronic ingestion increase salicylate toxicity because they result in greater distribution of salicylate to tissues. (msdmanuals.com)
Coadministration of dichlorphenamide with high-dose aspirin may increase salicylate levels. (medscape.com)

This is a combination product containing Carisoprodol, a centrally-acting muscle relaxant, plus aspirin, an analgesic with antipyretic and anti-inflammatory properties. (globalrph.com)
Aspirin is a nonnarcotic analgesic with antiinflammatory and antipyretic activity. (prescriptiondrugs.com)

Prescription aspirin is used to relieve the symptoms of rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by breakdown of the lining of the joints), systemic lupus erythematosus (condition in which the immune system attacks the joints and organs and causes pain and swelling) and certain other rheumatologic conditions (conditions in which the immune system attacks parts of the body). (nih.gov)
Symptoms of a broccoli allergy usually mean that you're sensitive to salicylates , which is a natural chemical that can be found in plants like broccoli. (healthline.com)
People who are allergic or sensitive to broccoli and salicylates in foods may have to avoid a long list of plant foods in order to lessen their symptoms. (healthline.com)
Although symptoms usually subside over the course of the next several hours, discontinue Carisoprodol and Aspirin Tablets and initiate appropriate supportive and symptomatic therapy, which may include epinephrine and/or antihistamines. (prescriptiondrugs.com)

Diagnosis is clinical, supplemented by measurement of the anion gap, arterial blood gases, and serum salicylate levels. (msdmanuals.com)
Serum levels of PGE2 and TXB2, which reflected synthesis of cyclo-oxygenase products by platelets, were minimally affected by salsalate but profoundly suppressed by aspirin. (nih.gov)
When medication was discontinued, the effects of salsalate on serum PGE2 and TXB2 were readily reversible within 36 h, whereas the recovery from aspirin was still incomplete after 13 days of observation. (nih.gov)
Serum salicylate levels should not exceed 30 mg/dl routinely. (nih.gov)
Salicylate metabolism is saturable and total body clearance decreases at higher serum concentrations due to the limited ability of the liver to form both salicyluric acid and phenolic glucuronide. (theodora.com)
Tinnitus is a sign of high serum salicylate levels (see OVERDOSAGE ). (globalrph.com)

ingestion of 5 mL is equivalent to about 7000 milligrams (twenty-two 325-mg tablets) of aspirin , which can kill a young child. (msdmanuals.com)
Chewable aspirin tablets may be chewed, crushed, or swallowed whole. (nih.gov)
If you have an allergy to bismuth, salicylates , or any other part of Pepto-Bismol (bismuth subsalicylate chewable tablets). (drugs.com)
Carisoprodol and Aspirin Tablets are indicated as an adjunct to rest, physical therapy, and other measures for the relief of pain, muscle spasm, and limited mobility associated with acute, painful musculoskeletal conditions. (globalrph.com)
If severe reactions occur, discontinue Carisoprodol and Aspirin Tablets and initiate appropriate symptomatic and supportive therapy. (globalrph.com)
If allergic reactions occur, discontinue Carisoprodol and Aspirin Tablets and treat symptomatically. (globalrph.com)
The gastric accumulation of enteric-coated aspirin tablets due to gastric outlet scarring and impaired gastric emptying has been reported [6]. (who.int)

Each tablet contains: Calcium 140mg, magnesium 9mg, salicylate 99mg, low sodium, avoid excessive heat(over 104"F or 40"C). (herbspro.com)
dichlorphenamide increases levels of magnesium salicylate by unspecified interaction mechanism. (medscape.com)
They may contain ingredients similar to salsalate (such as aspirin, choline salicylate, or magnesium salicylate). (everydayhealth.com)

Allergy alert: Contains salicylate. (nih.gov)
In the case of a life-threatening allergy to salicylates, ideally you should keep an epinephrine pen in your home, car, bag, and at your place of work or school. (healthline.com)
Salicylate free" and "salicylate allergy" may not be terms you're familiar with, unless you're a patient of Paul St. Amand, M.D. , the author of What Your Doctor May Not Tell You About Fibromyalgia . (cleure.com)
You may not even be aware that you have salicylate sensitivity, salicylate intolerance or salicylate allergy. (cleure.com)
Salicylates are a natural chemical produced by plants, believed to be used as a pest repellent, according to the Auckland Allergy Clinic. (livestrong.com)

Comparison of salsalate and aspirin on mucosal injury and gastroduodenal mucosal prostaglandins. (nih.gov)
Salsalate is a non-steroidal anti-inflammatory drug (NSAID) in a group of drugs called salicylates (sa-LIS-il-ates). (everydayhealth.com)

Aspirin may cause Reye's syndrome (a serious condition in which fat builds up on the brain, liver, and other body organs) in children and teenagers, especially if they have a virus such as chicken pox or the flu. (nih.gov)
Salicylates can cause Reye's syndrome, a serious and sometimes fatal condition, if you have any of these conditions. (everydayhealth.com)

In the intervening century, aspirin has become one of the most widely used medicines around the world and it is also showing cancer chemopreventive potential [ 8 ]. (ecancer.org)
Furthermore, aspirin is already well known and widely used in the general population as well as providing a benchmark to measure the effectiveness of other medicines, such as statins [ 13 ]. (ecancer.org)
High doses of salicylates are also found in medicines including aspirin and Pepto-Bismol . (healthline.com)
Because some over-the-counter (OTC) medicines contain aspirin, always read labels and check with your doctor before using them. (kidshealth.org)
Some aspirin-containing medicines use words other than aspirin (such as salicylate or acetylsalicylate), so avoid those too. (kidshealth.org)

Salicylates simultaneously and independently cause primary metabolic acidosis. (msdmanuals.com)

Enteric coated aspirin products are erratically absorbed from the GI tract. (theodora.com)

Edward Stone (1702-1768) was a Church of England cleric who discovered the active ingredient of aspirin. (wikipedia.org)
A recent promising finding is that chronic treatment with high-dose salicylate (the active ingredient of aspirin) for several weeks enhances expression of the outer hair cell (OHC) motor protein (prestin), resulting in strengthened OHC electromotility and enhanced distortion product otoacoustic emissions (DPOAE). (greenmedinfo.com)

Avoid concurrent administration with other aspirin-like drugs. (pfaf.org)
However, some people have difficulty tolerating large amounts of salicylates and have to avoid foods containing high amounts. (livestrong.com)

Reye's syndrome and salicylate use. (cdc.gov)
96 percent of Reye's syndrome cases are found to have used a medication containing aspirin before or during the first three days of the viral illness. (everything2.com)
Hence, aspirin is usually the second ingredient to the onset of Reye's syndrome. (everything2.com)

Nonprescription aspirin comes as a regular tablet, a delayed-release (releases the medication in the intestine to prevent damage to the stomach) tablet, a chewable tablet, powder, and a gum to take by mouth. (nih.gov)
Certain very common human drugs like aspirin and especially tylenol (acetominophen) are deadly to cats, so don't give them any kind of medication unless recommended by the vet (note that aspirin can be given in very small doses, but you need to check correct dosage and frequency of administration). (faqs.org)
This product contains natural salicylates, do not use if pregnant, nursing, allergic to aspirin, or on blood thinning medication. (vitacost.com)

Bismuth subsalicylate (8.7 mg salicylate/mL) is another potentially unexpected source of large amounts of salicylate. (msdmanuals.com)

Notably, pepto-bismol 's active ingredient is bismuth salicylate , so it should be avoided along with aspirin. (everything2.com)

People who are younger than 20 years of age and receiving long-term aspirin therapy. (mayoclinic.org)
People younger than 19 years old on long-term aspirin- or salicylate-containing medications. (cdc.gov)

a history of severe allergic reaction after taking aspirin, an NSAID, or other salicylates. (everydayhealth.com)

There is one health condition in children and teens in particular that can be fatal, due to taking salicylate ingredients. (cleure.com)
If you have sensitive skin you should only use products with non-irritating ingredients that are also salicylate free. (cleure.com)

To follow up on these observations, we carried out two studies, one planned study of age-related hearing loss restoration and a second unrelated study of salicylate-induced tinnitus. (greenmedinfo.com)
Our findings may increase our understanding of the receptors involved in the side effects of salicylate on the central nervous system, such as seizures and tinnitus. (johnshopkins.edu)
We hypothesized that loss of GLAST function could sensitize the ear to tinnitus-inducing agents, such as salicylate. (frontiersin.org)
Using shorter ISI to obtain a greater dynamic range to assess tinnitus-like effects, we found that disruption of gap detection by salicylate was exacerbated across various intensities of a 32-kHz narrow band noise gap carrier in GLAST knockout (KO) mice when compared to their wild-type (WT) littermates. (frontiersin.org)

Some people may be sensitive to even small amounts of salicylates. (healthline.com)
Fruits tend to contain the highest amounts of salicylates, according to Food-Info.net. (livestrong.com)
Fruits with negligible amounts of salicylates include bananas and pears. (livestrong.com)
Vegetables with negligible amounts of salicylates include green peas, green beans, cabbage and celery. (livestrong.com)
Nuts and seeds suspected to have moderate amounts of salicylates include Brazilnuts, pecans, peanut butter, sesame seeds, hazelnuts and sunflower seeds. (livestrong.com)
Cashews contain negligible amounts of salicylates. (livestrong.com)
In fact, it is believed that tomato sauce has high amounts of salicylates because of its seasonings. (livestrong.com)

At somewhat higher doses, aspirin reversibly inhibits the formation of prostaglandin 1 2 (prostacyclin), which is an arterial vasodilator and inhibits platelet aggregation. (theodora.com)
At higher doses aspirin is an effective anti-inflammatory agent, partially due to inhibition of inflammatory mediators via cyclooxygenase inhibition in peripheral tissues. (theodora.com)

Furthermore, there are a number of matters that arise including the potential for the public health field to further advocate the self-care preventive agenda, which might include aspirin. (ecancer.org)

Because the use of salicylates such as aspirin for children with influenza and chickenpox has been associated with Reye syndrome, the Surgeon General advises against use of salicylate and salicylate-containing medications for children with these diseases. (cdc.gov)
advises against the use of salicylates and salicylate-containing medications for children with influenza and chickenpox. (cdc.gov)
Aspirin is in a group of medications called salicylates. (nih.gov)
Aspirin is also available in combination with other medications such as antacids, pain relievers, and cough and cold medications. (nih.gov)

Chief hazards of chronic salicylate administration other than salicylism (which should be uniformly preventable) include gastric irritation with questionable relationship to peptic ulcer disease, and rare serious hepatotoxicity, bleeding diatheses, or hypersensitivity reactions. (nih.gov)

Dried fruits tend to have higher concentrations of salicylates because of the removal of water. (livestrong.com)

Alkalinization of the urine is a key concept in the management of salicylate overdose. (theodora.com)

CDC, on the basis of its review of the available data and the recommendations of an advisory panel on February 12, 1982, stated that 'until definitive information is available, CDC advises physicians and parents of the possible increased risk of Reye syndrome associated with the use of salicylates for children with chickenpox and influenza-like illness' (3). (cdc.gov)
The American Academy of Pediatrics' Committee on Infectious Diseases also has reviewed the data, and in the June 1982 issue of Pediatrics issued a statement advising that the use of salicylates should be avoided for children suffering from influenza or chickenpox (4). (cdc.gov)

dichlorphenamide increases levels of aspirin by unknown mechanism. (medscape.com)

Non-acetylated salicylates do not inhibit this enzyme and have no effect on platelet aggregation. (theodora.com)
Comment: Carbonic anhydrase inhibitors (CAIs) and salicylates inhibit each other's renal tubular secretion, resulting in increased plasma levels. (medscape.com)

You can have a food intolerance to broccoli and other foods with salicylates. (healthline.com)

These studies conducted by state health departments suggest an association between prior ingestion of aspirin and other salicylates and Reye syndrome. (cdc.gov)

Aspirin and nonsteroidal agents. (medlineplus.gov)

These results indicate that the two orally administered salicylates have differential effects on prostaglandin synthesis in platelets and may also differ in their therapeutic and adverse effects. (nih.gov)

Hypersensitivity to salicylates (e.g. aspirin). (nealsyardremedies.com)

Ask a doctor before you give aspirin to your child or teenager. (nih.gov)
Never give aspirin to kids or teens, especially during viral illnesses. (kidshealth.org)

Drug interactions associated with salicylates applicable [301]. (pfaf.org)

150 mg/kg of salicylate can cause severe toxicity. (msdmanuals.com)

Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity. (nih.gov)

Unexpectedly, while an enhanced or sustained DPOAE was seen, permanent reductions in the amplitude of the cochlear compound action potential (CAP) and the auditory brainstem response (ABR) were often observed after the chronic salicylate treatment. (greenmedinfo.com)

The Surgeon General notes that the FDA will notify health professionals through its Drug Bulletin, will develop lay-language information for widespread distribution, and will take the steps necessary to establish new labeling requirements for drugs containing salicylates. (cdc.gov)
Interacts with many drugs, particularly those that also bind to blood proteins such as aspirin, sulfonamides, tetracyclines, and phenytoin. (drugs.com)

The most common adverse reactions associated with the use of aspirin have been gastrointestinal, including nausea, vomiting, gastritis, occult bleeding, constipation and diarrhea. (globalrph.com)
Allergic type reactions in aspirin-sensitive individuals may involve the respiratory tract or the skin. (globalrph.com)
allergic or idiosyncratic reactions to carisoprodol, aspirin, or related compounds. (prescriptiondrugs.com)

Hepatotoxicity during treatment of juvenile rheumatoid arthritis and rheumatic diseases using salicylates]. (nih.gov)
Aspirin is also sometimes used to treat rheumatic fever (a serious condition that may develop after a strep throat infection and may cause swelling of the heart valves) and Kawasaki disease (an illness that may cause heart problems in children). (nih.gov)

Acute application of salicylate may cause reversible hearing loss, reduction of distortion product otoacoustic emission (DPOAE), and loss of outer hair cell (OHC) electromotility. (cdc.gov)

Pharmacodynamics: Aspirin affects platelet aggregation by irreversibly inhibiting prostaglandin cyclo-oxygenase. (theodora.com)

Salicylate (aspirin) is a widely used drug in clinics. (cdc.gov)

Nonprescription aspirin is used to reduce fever and to relieve mild to moderate pain from headaches, menstrual periods, arthritis, toothaches, and muscle aches. (nih.gov)
Nonprescription aspirin is usually taken every 4 to 6 hours as needed to treat fever or pain. (nih.gov)
Stop taking aspirin and call your doctor if your fever lasts longer than 3 days, if your pain lasts longer than 10 days, or if the part of your body that was painful becomes red or swollen. (nih.gov)

Salicylates are naturally related to the chemical compound, salicylcic acid, found in aspirin. (livestrong.com)

Prescription aspirin comes as an extended-release (long-acting) tablet. (nih.gov)
Each tablet for oral administration contains Carisoprodol 200 mg and Aspirin 325 mg. (globalrph.com)

High salicylate foods contain over 1.5 milligrams of salicylates per 100-gram serving, according to Saraband Health. (livestrong.com)
Moderate salicylate foods contain between 0.5 milligrams and 1.5 milligrams of salicylates per 100-gram serving. (livestrong.com)
A low salicylate food contains below 0.5 milligrams of salicylates per 100-gram serving. (livestrong.com)

Anatomy3

Organisms2

Diseases5

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes6

Health Care1

Salicylic acid15

Sodium salicylate2

Methyl12

Contain salicylates3

Acetylsalicylic5

NSAIDs3

Increase salicylate2

Analgesic2

Symptoms4

Serum6

Tablets7

Magnesium3

Allergy5

Salsalate2

Cause Reye's syndrome2

Medicines5

Metabolic acidosis1

Enteric coated aspirin1

Active ingredient of aspirin2

Avoid2

Reye's3

Medication3

Large amounts1

Pepto-Bismol1

Long-term aspirin2

NSAID1

Ingredients2

Tinnitus4

Amounts7

Doses2

Include aspirin1

Medications4

Salicylism1

Concentrations1

Overdose1

Chickenpox2

Levels of aspirin1

Inhibit2

Intolerance1

Ingestion1

Nonsteroidal1

Prostaglandin synthesis1

Hypersensitivity1

Give aspirin2

Interactions1

Toxicity1

Pharmacokinetics1

Chronic1

Drugs2

Reactions3

Rheumatic2

Acute1

Platelet aggregation1

Widely1

Fever3

Acid1

Tablet2

Milligrams3