Hereditary Breast and Ovarian Cancer SyndromeOvarian NeoplasmsGenes, BRCA1JewsBRCA2 ProteinGenes, BRCA2BRCA1 ProteinGenetic TestingGerm-Line MutationNeoplastic Syndromes, HereditaryBreast NeoplasmsGenetic CounselingPedigreeSyndromeGenes, DominantGenetic Predisposition to DiseaseMutationFounder EffectBreastHeterozygoteDNA Mutational AnalysisPolycystic Kidney, Autosomal DominantFamily HealthNeoplasm ProteinsBreast Neoplasms, MaleGenetic LinkageNeoplasms, Glandular and EpithelialAge of OnsetTay-Sachs DiseaseExonsColorectal Neoplasms, Hereditary NonpolyposisGenotypeGene Expression Regulation, NeoplasticRisk Factorsvon Hippel-Lindau DiseasePolymerase Chain ReactionDNA, NeoplasmPhenotypeMutation, MissenseCell Line, TumorCarcinoma, Ductal, BreastMastectomyIsraelBreast Diseases