• According to the researchers, this drug inhibits a gene called HIF-2α, which they discovered earlier promotes the progressive thickening of the lung artery walls - a key feature of pulmonary arterial hypertension called "vascular remodeling," which leads to right-sided heart failure, the main cause of death in patients with this condition. (nih.gov)
  • In recent research, they have demonstrated that inhibiting HIF-2α with a compound reverses pulmonary arterial hypertension, suppresses vascular remodeling and right heart failure, and increases the survival rate among these patients. (nih.gov)
  • Chapter One addresses the pulmonary vascular resistance (PVR) and total pulmonary vascular capacitance (Cp) product of the pulmonary circulation as a global estimate of right ventricular (RV) afterload, the assessment of the local arterial stiffness indices and its relationship with PVR and Cp, and finally, reviews the cause-effect relationships between large/conduit stiffening and distal/resistive vascular disease. (novapublishers.com)
  • Chapter Three reviews the processes involved in the pathogenesis of arterial stiffness in COPD, and the possible role of COPD therapy in vascular alterations. (novapublishers.com)
  • Chapter Four reviews links between bone turnover, vascular calcifications and arterial stiffness. (novapublishers.com)
  • Your vascular surgeon will only recommend peripheral arterial stenting if you are significantly limited by your symptoms, and conservative management is no longer effective. (nuffieldhealth.com)
  • A malfunction of the vascular endothelium arises at an early stage in the development of pulmonary arterial hypertension. (medicalnewstoday.com)
  • With pulmonary arterial hypertension, the malfunctioning of the vascular epithelium results in the contraction and narrowing of the blood vessels. (medicalnewstoday.com)
  • Peripheral arterial disease is also called peripheral vascular disease. (coxhealth.com)
  • In pulmonary arterial hypertension (PAH), the increased pulmonary vascular resistance and pulmonary artery pressure impose pressure overload on the right ventricle (RV). (frontiersin.org)
  • Wnt7a expression is six fold higher in healthy control vascular cells than in cells from individuals with pulmonary arterial hypertension (PAH). (stanford.edu)
  • Peripheral vascular/arterial disease (PVD/PAD) refers to any disorder or disease of the network of blood vessels that carry blood throughout the body. (whhs.com)
  • Arterial vascular abnormality accompanying cerebral cortical dysplasia. (ajnr.org)
  • The vascular and biochemical effects of cilostazol in patients with peripheral arterial disease. (medscape.com)
  • Lifestyle changes, such as dietary changes and stopping smoking, are critical to the long-term success of peripheral arterial bypass surgery. (medlineplus.gov)
  • Griffin MP, Siadaty MS. Papaverine prolongs patency of peripheral arterial catheters in neonates. (medscape.com)
  • The purpose of this study was to present 11 patients operated on owing to rare forms of peripheral arterial embolism at the Institute for Cardiovascular Diseases of the Serbian Clinical Center over a period of 20 years. (medscape.com)
  • Cite this: Rare Forms of Peripheral Arterial Embolism: Review of 11 Cases - Medscape - Jun 01, 2005. (medscape.com)
  • Peripheral arterial disease (PAD) is a condition in which there is narrowing of the blood vessels (arteries) leading to reduced blood flow. (mydr.com.au)
  • Tests for peripheral arterial disease may include the following. (mydr.com.au)
  • Peripheral arterial stenting uses a stent to widen an artery. (nuffieldhealth.com)
  • What is peripheral arterial stenting? (nuffieldhealth.com)
  • Peripheral arterial disease (PAD) occurs when plaque (a fatty deposit) builds up on your artery walls causing a restriction in the flow of blood and oxygen to your limbs. (nuffieldhealth.com)
  • Many people with peripheral arterial disease experience no symptoms. (nuffieldhealth.com)
  • Left untreated peripheral arterial disease could cause permanent damage to your limbs. (nuffieldhealth.com)
  • If conservative methods to treat your PAD are not successful, your consultant may recommend peripheral arterial stenting. (nuffieldhealth.com)
  • Peripheral arterial stenting is a minimally invasive procedure during which a small mesh tube called a stent is inserted into an artery. (nuffieldhealth.com)
  • What are the benefits of peripheral arterial stenting? (nuffieldhealth.com)
  • Peripheral arterial stenting should provide relief of the symptoms caused by the blocked artery. (nuffieldhealth.com)
  • Is peripheral arterial stenting right for me? (nuffieldhealth.com)
  • What happens during peripheral arterial stenting? (nuffieldhealth.com)
  • Peripheral arterial stenting can take from 30 minutes up to several hours depending on the amount of narrowing you have. (nuffieldhealth.com)
  • Peripheral arterial disease (PAD) is a narrowing or blockage of arteries that causes poor blood flow to your arms and legs. (coxhealth.com)
  • Many people who have peripheral arterial disease don't have any symptoms. (coxhealth.com)
  • An absent or weak pulse in these spots is a sign of peripheral arterial disease. (coxhealth.com)
  • Treatment for peripheral arterial disease relies mainly on healthy lifestyle changes and taking care to manage high blood pressure and cholesterol. (coxhealth.com)
  • In rare cases, advanced peripheral arterial disease can cause tissues in your leg or foot to die because they don't get enough oxygen as a result of poor blood flow. (coxhealth.com)
  • Peripheral arterial disease, specifically lower limb peripheral arterial disease, can be defined as atheromatous narrowing or occlusion of an artery or arteries in the lower limb. (intechopen.com)
  • Diagnosis and prompt treatment are key as the effects of untreated peripheral arterial disease can be dire. (intechopen.com)
  • There are several instances in which non-invasive imaging can be used in patients with, or suspected of having, peripheral arterial disease (PAD). (intechopen.com)
  • Peripheral arterial disease (PAD) is a condition involving clogging of the arteries around the body, most commonly in the legs. (medbroadcast.com)
  • Peripheral arterial disease is when an artery, usually in your leg, becomes partly or completely blocked. (msdmanuals.com)
  • What increases the risk of peripheral arterial disease? (msdmanuals.com)
  • Because it takes a long time for the arteries to get narrow, most people don't have peripheral arterial disease before age 55. (msdmanuals.com)
  • What are the symptoms of peripheral arterial disease? (msdmanuals.com)
  • Peripheral arterial disease is rare in the arms. (msdmanuals.com)
  • How can doctors tell if I have peripheral arterial disease? (msdmanuals.com)
  • Various disease processes mimic claudication symptoms and must be excluded before a diagnosis of peripheral arterial occlusive disease (PAOD) can be made. (medscape.com)
  • Confounding of the relation between homocysteine and peripheral arterial disease by lead, cadmium , and renal function. (cdc.gov)
  • Homocysteine levels are associated with peripheral arterial disease (PAD) in observational studies. (cdc.gov)
  • Pulmonary arterial hypertension is a progressive disorder characterized by abnormally high blood pressure ( hypertension ) in the pulmonary artery, the blood vessel that carries blood from the heart to the lungs. (medlineplus.gov)
  • Pulmonary arterial hypertension is one form of a broader condition known as pulmonary hypertension. (medlineplus.gov)
  • Signs and symptoms of pulmonary arterial hypertension occur when increased blood pressure cannot fully overcome the elevated resistance. (medlineplus.gov)
  • Shortness of breath (dyspnea) during exertion and fainting spells are the most common symptoms of pulmonary arterial hypertension. (medlineplus.gov)
  • In the United States, about 1,000 new cases of pulmonary arterial hypertension are diagnosed each year. (medlineplus.gov)
  • Mutations in the BMPR2 gene are the most common genetic cause of pulmonary arterial hypertension. (medlineplus.gov)
  • Mutations in several additional genes have also been found to cause pulmonary arterial hypertension, but they are much less common causes of the disorder than are BMPR2 gene mutations. (medlineplus.gov)
  • Variations in other genes may increase the risk of developing pulmonary arterial hypertension or modify the course of the disease (usually making it more severe). (medlineplus.gov)
  • Although pulmonary arterial hypertension often occurs on its own, it can also be part of syndromes that affect many parts of the body. (medlineplus.gov)
  • Researchers have also identified nongenetic factors that increase the risk of developing pulmonary arterial hypertension. (medlineplus.gov)
  • Pulmonary arterial hypertension is also a rare complication of certain infectious diseases, including HIV and schistosomiasis. (medlineplus.gov)
  • Pulmonary arterial hypertension is usually sporadic, which means it occurs in individuals with no known family history of the disorder. (medlineplus.gov)
  • These non-familial cases are described as idiopathic pulmonary arterial hypertension. (medlineplus.gov)
  • Inherited cases of this disorder are known as familial pulmonary arterial hypertension. (medlineplus.gov)
  • Researchers partly funded by NHLBI have identified a drug that could treat, and perhaps reverse, pulmonary arterial hypertension, a severe lung disease with a five-year survival rate of 50 percent. (nih.gov)
  • In a preliminary study, the orally administered dual endothelin-receptor antagonist bosentan improved exercise capacity and cardiopulmonary hemodynamics in patients with pulmonary arterial hypertension. (nih.gov)
  • In this double-blind, placebo-controlled study, we randomly assigned 213 patients with pulmonary arterial hypertension (primary or associated with connective-tissue disease) to receive placebo or to receive 62.5 mg of bosentan twice daily for 4 weeks followed by either of two doses of bosentan (125 or 250 mg twice daily) for a minimum of 12 weeks. (nih.gov)
  • The endothelin-receptor antagonist bosentan is beneficial in patients with pulmonary arterial hypertension and is well tolerated at a dose of 125 mg twice daily. (nih.gov)
  • Endothelin-receptor antagonism with oral bosentan is an effective approach to therapy for pulmonary arterial hypertension. (nih.gov)
  • Max Planck scientists find a way of treating pulmonary arterial hypertension . (medicalnewstoday.com)
  • Patients with pulmonary arterial hypertension struggle with severe symptoms, which include shortness of breath, exhaustion and a lack of vitality. (medicalnewstoday.com)
  • According to Pullamsetti, these combined effects caused a reduction in the arterial hypertension. (medicalnewstoday.com)
  • Here we report application of human umbilical cord mesenchymal stem cell (HUCMSC)-derived therapy for pulmonary arterial hypertension (PAH). (nature.com)
  • This is the first link between a specific collection of bacteria and pulmonary arterial hypertension. (scienceblog.com)
  • Pulmonary arterial hypertension (PAH) alters the geometries of both ventricles of the heart. (frontiersin.org)
  • Pulmonary arterial hypertension is a chronic disease in which individuals find it harder and harder to breathe - eventually leading to right heart failure and death. (stanford.edu)
  • Between 500 to 1000 new cases of pulmonary arterial hypertension, or PAH, are diagnosed in the US every year. (stanford.edu)
  • Pulmonary arterial hypertension (PAH) is one form of a broader condition known as pulmonary hypertension , which is high blood pressure in the lungs. (lung.org)
  • It took about a year for them to say it was pulmonary arterial hypertension. (lung.org)
  • All hospitalisations for pulmonary arterial hypertension (PAH) in the Scottish population were examined to determine the epidemiological features of PAH. (ersjournals.com)
  • Hospitalisation data from the Scottish Morbidity Record scheme gave higher prevalences of pulmonary arterial hypertension than data from the expert centres (Scotland and France). (ersjournals.com)
  • The hospitalisation data may overestimate the true frequency of pulmonary arterial hypertension in the population, but it is also possible that the expert centres underestimate the true frequency. (ersjournals.com)
  • Incidence of pulmonary arterial hypertension in Scotland and France from three sources. (ersjournals.com)
  • It has been shown that traditional cardiovascular risk factors such as hypertension, obesity, diabetes, dyslipidemia and metabolic syndrome modify the structural and functional characteristics of arteries reducing their compliance and increasing arterial stiffness. (dovepress.com)
  • NEW YORK (GenomeWeb News) - A team led by researchers at Columbia University Medical Center uncovered a new gene linked with pulmonary arterial hypertension, and as the group reported in The New England Journal of Medicine this week, the effects of some mutations in this gene may be mitigated by drug treatment. (genomeweb.com)
  • Pulmonary arterial hypertension is a rare, progressive, and fatal disorder marked by increased pulmonary artery pressure, which leads to decreased blood flow from the heart to the lungs. (genomeweb.com)
  • Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by vasoconstriction and remodeling of the pulmonary vessels. (lu.se)
  • The aim was identify the social representation of arterial hypertension and your treatment for people with this diagnosis. (bvsalud.org)
  • Classics in arterial hypertension / by Arthur Ruskin. (who.int)
  • Imatinib in pulmonary arterial hypertension: c-Kit inhibition. (bvsalud.org)
  • Pulmonary arterial hypertension (PAH) is a progressive disease characterized by severe remodeling of the pulmonary artery resulting in increased pulmonary artery pressure and right ventricular hypertrophy and, ultimately, failure. (bvsalud.org)
  • Blood pressure pulse waves for quality control - further pulse wave analysis provides additional cardiovascular parameters such as stroke volume , cardiac output and arterial stiffness . (wikipedia.org)
  • This book provides current research advances on arterial stiffness. (novapublishers.com)
  • Chapter Two discusses local and regional arterial stiffness measurement in clinical practice. (novapublishers.com)
  • Chapter Five examines ambulatory arterial stiffness index during pregnancy in Type 1 diabetes mellitus. (novapublishers.com)
  • Chapter Seven focuses on the higher arterial stiffness related to blood pressure overresponse to arm and leg resistance exercises in elderly individuals. (novapublishers.com)
  • In conclusion, in the elderly, the presence at the same time of high leptin levels and low adiponectin levels seems to have synergic effects on arterial stiffness. (dovepress.com)
  • Arterial embolization can also enhance a patient's quality of life by reducing the symptoms caused by a tumor that cannot be surgically removed. (moffitt.org)
  • In addition to the usual clinical signs of acute limb ischemia, in the rare forms of arterial embolism, the presence of certain uncommon clinical symptoms was also observed. (medscape.com)
  • Arterial gas may refer to: Physiologic arterial blood gas Air embolism This disambiguation page lists articles associated with the title Arterial gas. (wikipedia.org)
  • Further follow-up revealed a poor prognosis in patients with malignant arterial embolism. (medscape.com)
  • [ 2 ] Cholesterol emboli from atherosclerotic arteries, cardiac myxoma, venous thrombus that passes into the arterial system via a right-to-left atrial or ventricular shunt (paradoxal embolism), bacterial endocarditis, and malignant tumors are some rare causes of arterial embolism. (medscape.com)
  • Arterial gas embolism (AGE) is a complication of lung barotrauma of ascent. (standardofcare.com)
  • Obstructing bubbles in arterial gas embolism may resolve or be redistributed into the venous circulation spontaneously or in response to recompression. (standardofcare.com)
  • Experiments on explanted hearts suggested a trigger for coronary artery inflammation: Where flow is perturbed, hemodynamic stress results in local mechanical injury allowing the entry of blood cells into the arterial intima, triggering inflammation-driven atherogenesis . (medpagetoday.com)
  • Due to variations of the arterial anatomy and limited number of anatomic studies of the saphenous flap, we studied the topography and anatomy of the saphenous artery for increasing reliability of the saphenous flap. (unboundmedicine.com)
  • Arterial embolization is a nonsurgical treatment that may be recommended for a patient who has been diagnosed with advanced renal cell carcinoma. (moffitt.org)
  • Because a blockage created by arterial embolization can prevent a tumor from receiving oxygen and other vital substances that it needs to grow, the tumor cells can begin to die off, causing the tumor to shrink. (moffitt.org)
  • Similarly, arterial embolization can facilitate ablation (laser- or cold-based destruction) of larger tumors because inhibiting the blood supply to a tumor can make certain ablation procedures (radiofrequency ablation or cryoablation) safer and more effective. (moffitt.org)
  • To learn more about arterial embolization and other treatments for kidney cancer, call 1-888-663-3488 or complete a new patient registration form online. (moffitt.org)
  • The most common type of arterial embolus is the thromboembolus, which most frequently originates from the heart as a result of various pathologic conditions, such as myocardial infarction, cardiac arrhythmias, valvular diseases, congestive myocardiopathy, and ventricular aneurysms of the heart. (medscape.com)
  • Comparison of noninvasive blood pressure monitoring with invasive arterial pressure monitoring in medical ICU patients with septic shock. (medscape.com)
  • Kim WY, Jun JH, Huh JW, Hong SB, Lim CM, Koh Y. Radial to femoral arterial blood pressure differences in septic shock patients receiving high-dose norepinephrine therapy. (medscape.com)
  • Femoral-radial arterial pressure gradients in critically ill patients. (medscape.com)
  • Double-blind, randomized, controlled trial of papaverine-containing infusions to prevent failure of arterial catheters in pediatric patients. (medscape.com)
  • A test called an arterial Doppler ultrasound may also be done to check the blood flow in your arteries. (coxhealth.com)
  • Continuous noninvasive arterial blood pressure measurement (CNAP) combines the advantages of the following two clinical "gold standards": it measures blood pressure (BP) continuously in real-time like the invasive arterial catheter system (IBP) and it is non-invasive like the standard upper arm sphygmomanometer (NBP). (wikipedia.org)
  • Lesser incidence of accidental catheter removal with femoral versus radial arterial access. (medscape.com)
  • Large intra-arterial bubbles can cause arterial occlusion, ischemia, and infarction. (standardofcare.com)
  • Continuous noninvasive arterial pressure ( CNAP ) is the method of measuring beat-to-beat arterial blood pressure in real-time without any interruptions (continuously) and without cannulating the human body ( noninvasive ). (wikipedia.org)
  • However, a similar congestion report for the arterial system has not been developed, although signalized arterial roads carry a large percentage of traffic in the Twin Cities metropolitan area. (umn.edu)
  • and of course the reverse arterial perfusion on the Doppler study. (thefetus.net)
  • Bubbles are introduced into the arterial circulation where they can cause multifocal ischemia, and may occur after diving related, iatrogenic, or accidental pulmonary barotrauma or by direct iatrogenic introduction of gas into the vasculature. (standardofcare.com)
  • Ultrasound Guidance Versus Landmark-Guided Palpation for Radial Arterial Line Placement by Novice Emergency Medicine Interns: A Randomized Controlled Trial. (medscape.com)
  • Arterial line placement can be performed via multiple methods. (medscape.com)
  • The Vent-Axia Arterial range combines the advantages of semi-rigid and traditional rigid ducting in one simple system. (vent-axia.com)
  • Surgical and Patient Risk Factors for Severe Arterial Line Complications in Adults. (medscape.com)
  • It occurs when breathing gas is introduced to the circulation on the arterial side via lung over-pressure trauma. (standardofcare.com)
  • Arterial blood pressure is the force exerted by the blood on the wall of a blood vessel as the heart pumps (contracts) and relaxes. (cdc.gov)
  • Trunk Highway 13, Trunk Highway 55, Trunk Highway 7 and Trunk Highway 10)--researchers developed an innovative approach to generate an arterial traffic congestion report for the MnDOT Metro District. (umn.edu)
  • Twin reversed arterial perfusion (TRAP) occurs in identical twin pregnancies when one twin has an absent or non-functioning heart and receives all of its blood from the normally functioning and developing "pump twin. (childrenshospital.org)
  • Discover 31 products from Arterial Line Filter manufacturers, suppliers, distributors, and dealers across India. (tradeindia.com)
  • Arterial Line Filter product price in India ranges from 1,200 to 14,500 INR and minimum order requirements from 1 to 100. (tradeindia.com)
  • For use with MVHR systems, the Arterial air distribution system provides a flexible, highly robust solution, which can significantly reduce the installation time when compared to a standard system. (vent-axia.com)
  • The secret to the Arterial System is the unique low-resistance distribution plenum (Patent Pending) which is sited between joists allowing connection between semi-rigid and rigid sections. (vent-axia.com)
  • In this project--based on the archived high-resolution traffic data from four major arterials equipped with the SMART-Signal system in the metro area (i.e. (umn.edu)