Aripiprazole antipsychotic agents. Medical search. Frequent questions

Among atypical antipsychotics, olanzapine can be provided in both oral and intramuscular forms and is also effective in treating psychosis with acute agitation. (medscape.com)
If psychosis persists beyond elimination of the offending substance, an atypical antipsychotic drug (eg, risperidone, olanzapine, quetiapine) may be considered. (medscape.com)
[ 33 ] Minimal weight gain with aripiprazole compared with olanzapine has also been commented upon, as has the absence of any QTc prolongation associated with aripiprazole. (medscape.com)
Although prescribing rates for the newer atypical agents (paliperidone, ziprasidone and aripiprazole) remained low relative to their older counterparts (risperidone, olanzapine and quetiapine), rates of aripiprazole use rose to 1.0 user per 1000 older adults by the end of the study period. (ices.on.ca)
This study compared healthcare costs in patients treated with a mood stabilizer and adjunctive aripiprazole versus adjunctive olanzapine, quetiapine, risperidone or ziprasidone. (unboundmedicine.com)
Generalized gamma regressions were used to compare the total healthcare costs of adjunctive aripiprazole treatment and treatment with adjunctive olanzapine, quetiapine, risperidone or ziprasidone. (unboundmedicine.com)
Adjunctive aripiprazole may have economic benefits over other atypicals in terms of lower psychiatric treatment costs than adjunctive olanzapine, quetiapine, risperidone or ziprasidone, and lower total healthcare costs than adjunctive olanzapine, risperidone or ziprasidone. (unboundmedicine.com)
Atypical antipsychotics with D2 antagonism and partial agonism combined with 5HT2A antagonism have greater efficacy for mania, and these include aripiprazole, quetiapine, olanzapine, risperidone, and asenapine. (statpearls.com)
Quetiapine, clozapine, and olanzapine have high anticholinergic properties, whereas other atypical antipsychotics very weakly bind to muscarinic cholinergic receptors. (statpearls.com)
The long-acting injectables include aripiprazole, olanzapine, paliperidone, and risperidone, which are administered at two to four-week intervals. (statpearls.com)
The orally disintegrating tablets include aripiprazole, asenapine, clozapine, olanzapine, and risperidone, which are identical to the standard tablets in terms of absorption and bioavailability. (statpearls.com)
The mean increase in weight over a ten-week period for patients treated with standard doses of atypical antipsychotics was 4.45 kg with clozapine and 4.15 kg with olanzapine. (statpearls.com)
More helpful is likely switching to another atypical antipsychotic agent such as olanzapine, quetiapine, clozapine, aripiprazole, or ziprasidone. (valladolidvacceosbox.com)
AUTHORS' CONCLUSIONS: The available evidence is of poor quality but there is some evidence aripiprazole is effective compared to placebo and haloperidol, but not when compared to olanzapine. (ox.ac.uk)
Olanzapine was administered instead of aripiprazole and while his psychotic symptoms improved, the dystonic symptoms were continued. (psychiatryinvestigation.org)
After admission, aripiprazole was switched to olanzapine and the dosage was titrated up to 20 mg/day on the 7th hospital day. (psychiatryinvestigation.org)
In addition, the appearance of the atypical antipsychotic drugs (amisulpride, aripiprazole, clozapine, olanzapine, quetiapine, risperidone, and ziprasidone) with different therapeutic and side-effect profiles, has promoted a greater interest in assessing the quality of life of schizophrenic patients. (nih.gov)
L'émergence de médicaments antipsychotiques atypiques (amisulpride, aripiprazole, cloza-pine, olanzapine, quétiapine, rispéridone et zipra-sidone) dotés de profils d'effets thérapeutiques et d'effets secondaires différents a favorisé l'intérêt croissant dans l'évaluation de la qualité de vie des patients schizophrènes. (nih.gov)
The most commonly used second-generation antipsychotics in the exposed group were quetiapine, aripiprazole, and olanzapine. (womensmentalhealth.org)
In our study, long-term hospitalized chronic schizophrenia patients with co-T2DM who were prescribed olanzapine or risperidone as the primary antipsychotic medication were enrolled. (frontiersin.org)
Among the many atypical antipsychotics, risperidone is considered to have one of the most significant effects on elevating prolactin (PRL) levels in psychiatric patients, and the PRL- increasing pharmacological effects of olanzapine should not be underestimated ( 1 ). (frontiersin.org)
What's more, risperidone and olanzapine are two of the top-ranked antipsychotic drugs in terms of prescription rates, according to reports of prescribing patterns for psychiatric patients from around the world, including China ( 5 - 8 ). (frontiersin.org)
It is therefore not surprising to observe that HPRL brought on by atypical antipsychotics, such as risperidone and olanzapine, continue to be widespread and require proper clinical attention. (frontiersin.org)
Methods: Seventy-nine youth aged 6-19 years, with schizophrenia spectrum disorders, treated naturalistically with aripiprazole, olanzapine, quetiapine, risperidone, or ziprasidone and evaluated monthly, were divided into ER/ENR groups at week 4, using at least "minimally improved" on the CGI-I scale. (elsevierpure.com)
Conventional antipsychotic drugs, used for a half century to treat a range of major psychiatric disorders, are being replaced in clinical practice by modern "atypical" antipsychotics, including aripiprazole, clozapine, olanzapine, quetiapine, risperidone and ziprasidone among others. (jddt.in)

The atypical antipsychotics started with clozapine, these are classified as multireceptor interacting compounds, acting as an agonist towards 5-HT1A and an antagonist towards D2 receptors among other 5-HT and DA receptors. (wikipedia.org)
Conversely, however, there are multiple reports 5 , 6 highlighting the benefits of aripiprazole in the treatment of enuresis induced by other antipsychotics, especially clozapine. (psychiatrist.com)
There is growing interest in N-desmethylclozapine (NDMC), the major metabolite of clozapine, as a unique antipsychotic because it acts in vitro as a 5-HT(2) antagonist and as a partial agonist to dopamine D(2) and muscarinic receptors. (nih.gov)
To explore this, we compared NDMC to a typical (haloperidol), atypical (clozapine), and partial-agonist atypical (aripiprazole) antipsychotic in preclinical models. (nih.gov)
Second-generation antipsychotics such as risperidone, ziprasidone, paliperidone, and aripiprazole are all potent antagonists of dopamine D2 receptors, while clozapine and quetiapine are weak D2 antagonists. (statpearls.com)
Alpha2 antagonism is the mechanism with quetiapine, clozapine, risperidone, and aripiprazole with variable degrees of potency. (statpearls.com)
Almost all atypical antipsychotics bind to alpha-adrenergic receptors, but the most potent are clozapine, risperidone, iloperidone, and clozapine. (statpearls.com)
Adjunctive aripiprazole decreased metabolic side effects of clozapine treatment. (nel.edu)
Clozapine is an atypical antipsychotic indicated for the treatment of refractory schizophrenia. (nel.edu)
Masopust J, Tůma I, Libiger J. Adjunctive aripiprazole decreased metabolic side effects of clozapine treatment. (nel.edu)

quetiapine and aripiprazole. (journalofpsychiatryreform.com)

In clinical trials involving patients with acute relapse of chronic schizophrenia, significant reductions from baseline in the mean Positive and Negative Syndrome Scale (PANSS) total score, which were comparable to those seen with haloperidol or risperidone, were observed with aripiprazole, [ 29 , 30 ] and efficacy was maintained long term. (medscape.com)
[ 32 ] Consistent with published trial results, a recent Cochrane review of clinical data noted that aripiprazole has comparable antipsychotic efficacy to conventional and other atypical antipsychotics for the treatment of schizophrenia. (medscape.com)
Short-term studies in patients with acute exacerbation of schizophrenia have shown that, compared with placebo, aripiprazole 10-30 mg/day is effective for the treatment of both positive and negative symptoms. (medscape.com)
Compared with placebo, improvements in symptoms of schizophrenia were evident as early as 1 week of treatment with aripiprazole. (medscape.com)
Atypical antipsychotics have transformed the treatment of psychoses as they are prescribed for acute psychoses and in the management of schizophrenia, affective disorders (depression and mania), and geriatric agitation. (statpearls.com)
To determine how often antipsychotics are prescribed off-label to adults without schizophrenia or bipolar disorder who are enrolled in Medicaid, which pays for more than 70% of antipsychotic prescriptions in the United States. (ajmc.com)
57.6% of patients given an antipsychotic had no diagnoses of schizophrenia or bipolar disorder during the year. (ajmc.com)
Antipsychotic medications have long been an important component of effective treatment for schizophrenia. (ajmc.com)
Once-monthly paliperidone palmitate (PP1M) is a long-acting injectable antipsychotic that may increase adherence rates, reduce hospitalizations, and lower medical costs compared to oral atypical antipsychotics (OAAs) among schizophrenia patients. (biomedcentral.com)
To evaluate the overall effectiveness of aripiprazole intramuscular (IM) depot as maintenance treatment in patients with schizophrenia. (novoclinica.com)
Subjects with schizophrenia that are considered resistant/refractory to antipsychotic treatment by history. (novoclinica.com)
The guidance says to avoid these agents except for FDA-approved indications such as schizophrenia , bipolar disorder , and adjuvant treatment of depression. (medscape.com)
Despite the increasing use of the newer "atypical" or second-generation antipsychotic agents to treat a spectrum of psychiatric disorders, including schizophrenia, bipolar disorder, major depression, PTSD and other anxiety disorders, we have relatively little data on the reproductive safety of these newer atypical agents. (womensmentalhealth.org)
For example, we would be more likely to maintain the use of an atypical antipsychotic in a patient with schizophrenia than in a patient who is using a low dose of an atypical agent to manage insomnia. (womensmentalhealth.org)
Despite possessing serotonin reuptake inhibitory activity in addition to D 2 receptor partial agonism, WS-50030 displays activity in preclinical models predictive of antipsychotic- and antidepressant efficacy similar to aripiprazole, suggesting potential efficacy of WS-50030 versus positive and negative symptoms of schizophrenia, comorbid mood symptoms, bipolar disorder, major depressive disorder, and treatment-resistant depression. (montclair.edu)
Antipsychotics have long been the mainstay for the treatment of schizophrenia and other psychotic disorders. (clinicalschizophrenia.net)
Aripiprazole not only worsened the severity of index disturbances associated to metabolism in long-term hospitalized chronic schizophrenia patients with co-T2DM on metformin-based hypoglycemic medications but also failed to lower PRL levels. (frontiersin.org)
The most significant and fundamental form of treatment for schizophrenia is antipsychotic medication, as we all know. (frontiersin.org)
Patients with newly diagnosed schizophrenia on antipsychotic monotherapy ( n = 1007, 817 men) were included and categorized into khat and non-khat users. (who.int)
Khat use hinders an individual's response to initial antipsychotic drug treatment for schizophrenia. (who.int)
Although and response to antipsychotic treatment in schizophrenia limited use may not be accompanied by serious conse- patients. (who.int)

Typical antipsychotics (eg, haloperidol) effectively treat psychosis with acute agitation, which is at least partially attributed to their benefit of rapid tranquilization. (medscape.com)
High-potency classic agents (eg, haloperidol) provide rapid, predictable, and effective sedation in the management of acutely psychotic patients. (medscape.com)
The typical antipsychotics, such as chlorpromazine and haloperidol, are potent D2 receptor antagonists. (wikipedia.org)
Although formal comparisons between aripiprazole and risperidone 6 mg/day [ 30 ] or haloperidol 10 mg/day [ 29 ] treatment groups were not performed in these trials, efficacy findings appeared to be comparable between treatment groups. (medscape.com)
Unlike haloperidol, there were no significant differences between aripiprazole and placebo in mean change from baseline in EPS rating scales. (medscape.com)

risperidone general medical costs were 18% higher versus aripiprazole (p=0.041). (unboundmedicine.com)

lower-potency antipsychotics (eg, chlorpromazine) might require higher doses. (medscape.com)
The most often ordered antipsychotic medication, which included 102 (23.18%) medications, was chlorpromazine. (bvsalud.org)

Pooled analysis of two similarly designed 52-week trials has shown aripiprazole to be an effective maintenance treatment for patients undergoing an acute psychotic episode who had previously responded to antipsychotic medications. (medscape.com)
Doctors sometimes prescribe antipsychotic medications to treat neuropsychiatric symptoms (NPSs) of dementia, which can include aggression or psychosis. (medicalnewstoday.com)
Antipsychotic medications can help manage symptoms of severe mental illness and prevent repeat episodes. (medicalnewstoday.com)
There are two main types of antipsychotic medications. (medicalnewstoday.com)
In 2005, the Food and Drug Administration (FDA) issued a black box warning regarding the use of antipsychotic medications to treat older adults with dementia. (medicalnewstoday.com)
If these medications and behavioral interventions are ineffective, providers may try antipsychotic medications, which may reduce the frequency and intensity of symptoms. (medicalnewstoday.com)
The majority of patients prescribed antipsychotic medications in state Medicaid programs are taking these agents for off-label indications. (ajmc.com)
Off-label use of antipsychotic medications is common, particularly among the elderly and children/adolescents. (ajmc.com)
This study documented rates of off-label use of antipsychotic medications in 42 state Medicaid programs in 2003. (ajmc.com)
They also make up a large and growing share of Medicaid prescription drug programs, which covered nearly 75% of all prescriptions for antipsychotic medications in the United States in 2002, 1 although since 2006 the public share of financing for antipsychotic medications has been roughly equally divided between Medicaid and Medicare. (ajmc.com)
Introduction: due to the widespread prescription of antipsychotic medications, their usage is cumulative. (bvsalud.org)
Conclusion: the results of this investigation showed that psychiatrists preferred traditional psychotropic medications, such as Antipsychotic tricyclic, antidepressants (TCAs) and phenothiazines, in high amounts possibly because these medications were readily available in this hospital and their prices suited patients' needs. (bvsalud.org)
In response to this deficit, the National Pregnancy Registry for Atypical Antipsychotics was created to evaluate the safety of atypical antipsychotic medications taken by women during pregnancy. (womensmentalhealth.org)
Ideally we would like to have greater numbers of exposed infants so that the analysis can assess the risks associated with exposure to specific antipsychotic medications. (womensmentalhealth.org)
The National Pregnancy Registry for Atypical Antipsychotics continues to recruit pregnant women taking atypical antipsychotic medications. (womensmentalhealth.org)
Abilify and other antipsychotic medications have been associated with an increased risk of death in elderly patients with dementia-related psychosis. (canadapharmacy.com)
And one of the most prevalent and common adverse drug reactions to antipsychotic medications is hyperprolactinemia (HPRL) ( 1 ), but it is believed to have decreased with the broad and extensive clinical prescribing of second-generation antipsychotics as opposed to traditional antipsychotics ( 2 ). (frontiersin.org)
All of these contain a key agent called as aripiprazole, which is a part of a category of medications called as atypical antipsychotics. (healthcaress.com)
Antipsychotic medications were reviewed to determine their potential and the cause of substitution in association with khat use. (who.int)

Methodological restriction of patients to those newly initiated on an atypical antipsychotic and incomplete medication history limit the generalizability of the findings. (unboundmedicine.com)
Continuously enrolled patients with at least 1 prescription for an antipsychotic medication were identified. (ajmc.com)
Of the 372,038 individuals given an antipsychotic medication, 214,113 (57.6%) received these agents for off-label disorders. (ajmc.com)
During Phase 3 (the open-label maintenance phase) oral aripiprazole rescue medication will be allowed for subjects who do not meet stability criteria or meet the criteria for impending relapse/exacerbation of psychotic symptoms. (novoclinica.com)
Subjects who, in the investigator's judgment, require chronic treatment with an antipsychotic medication. (novoclinica.com)
It states that "In conclusion, this post hoc analysis extends previous findings demonstrating that aripiprazole is safe and generally well tolerated as an augmentation strategy to standard ADT in patients with MDD with a history of an inadequate response to antidepressant medication. (blogspot.com)
Furthermore, we must take into consideration the indication for the usage of the antipsychotic medication. (womensmentalhealth.org)
The active ingredient in Abilify medication is aripiprazole . (canadapharmacy.com)

In this edition of the journal we call attention to the accumulating evidence that Abilify/aripiprazole can cause tardive dyskinesia. (journalofpsychiatryreform.com)
When combined with other dopaminergic agents, Abilify can increase the risk of neuroleptic malignant syndrome. (canadapharmacy.com)

this included 353 women treated with second-generation antipsychotics and a comparison group of 134 women with histories of psychiatric morbidity who were not treated with antipsychotics. (womensmentalhealth.org)

A diagnosis of psychosis not otherwise specified was made according to ICD-10 criteria, and she was started on oral aripiprazole 10 mg/d. (psychiatrist.com)
Treatment with oral aripiprazole is recommended for the first twenty-one days after the first ALLAI injection, which is a potential disadvantage. (clinicalschizophrenia.net)

Bifeprunox and other novel atypical antipsychotics will instead of antagonizing D2 receptors, will act as partial agonists, as well as partial agonists towards 5-HT1A receptors. (wikipedia.org)
The first generation, or typical antipsychotics, are dopamine receptor blockers that work by blocking dopamine receptors in the brain. (medicalnewstoday.com)
The second generation, or atypical antipsychotics, are dopamine antagonists that block serotonin receptors and affect serotonin levels. (medicalnewstoday.com)
A ripiprazole, a partial agonist at central D 2 receptors, is a widely prescribed atypical antipsychotic drug. (psychiatrist.com)
Aripiprazole is an atypical antipsychotic that has partial agonist activity at D 2 receptors. (wustl.edu)
The first-generation antipsychotics ("typicals" or "traditional") and second-generation antipsychotics ("atypicals") block post-synaptic dopamine receptors in the mesolimbic system, which has been correlated with antipsychotic effect. (hopkinsguides.com)
The first-generation antipsychotics have minimal antagonism of serotonin receptors, whereas the second-generation antipsychotics have greater antagonism of serotonin receptors. (hopkinsguides.com)
Side effects of both first- and second-generation antipsychotics are due to antagonism at histamine, muscarinic, and alpha adrenergic receptors. (hopkinsguides.com)
Pimavanserin is a novel atypical antipsychotic with inverse agonist and antagonist activity at 5-HT 2A , with low/no affinity for 5-HT2C, sigma 1, 5-HT2B, dopaminergic, muscarinic, histaminergic or adrenergic receptors. (hopkinsguides.com)
Conclusion: In terms of dopamine pharmacological properties, aripiprazole and other antipsychotic agents differ mainly that aripiprazole is a partial dopamine agonist at D2 receptors and also acts on D3 receptors. (sop.org.tw)

and molecular markers predictive of antipsychotic action (striatal Fos induction). (nih.gov)
In a rat model predictive of antipsychotic-like activity, WS-50030 and aripiprazole reduced conditioned avoidance responding by 42 and 55% at 10 mg/kg, respectively. (montclair.edu)

[ 28 ] Rapid absorption (maximum plasma concentrations occurring within 3-5 hours of dosing) and a relatively long half-life (47-68 hours) mean that aripiprazole accumulates with multiple-dose administration, with steady-state plasma concentrations occurring by day 14. (medscape.com)
The only treatment-emergent adverse event for which a dose-response relationship may exist for aripiprazole is somnolence. (medscape.com)
He was taking aripiprazole from 5 years ago due to his schizoaffective disorder, and the dose was increased from 10 mg/day to 20 mg/day 3 years ago. (psychiatryinvestigation.org)
His torticollis improved slightly by increasing benzodiazepine (lorazepam to 3 mg/day) and anticholinergic (benztropine to 3 mg/day) while reducing the aripiprazole dose, but the movement disorder was not fully diminished and worsening of the psychotic symptoms occurred. (psychiatryinvestigation.org)
Co-prescribing aripiprazole had no impact on PRL levels in all patients with co-T2DM, and aripiprazole dose had no impact on PRL levels in the clinical subgroup of the co-Ari group. (frontiersin.org)
Aripiprazole was added to ongoing SSRI or clomipramine treatment with a starting dose of 5 mg/day and titrated up to a maximum of 20 mg/day (mean dose 12.62 mg ± 4.25). (clinical-practice-and-epidemiology-in-mental-health.com)

It seems unlikely that NDMC would show efficacy as a stand-alone antipsychotic, however, its freedom from catalepsy and prolactin elevation, and its unique pharmacological profile (muscarinic agonism) may make it feasible to use this drug as an adjunctive treatment to existing antipsychotic regimens. (nih.gov)
Efficacy was assessed with the Yale-Brown obsessive compulsive scale (Y-BOCS) and the Clinical Global Improvement-severity scale (CGI-S) at baseline and at week 12 of Aripiprazole augmentation. (clinical-practice-and-epidemiology-in-mental-health.com)

After acquiring the discrimination (ie ≥80% correct responding on four consecutive sessions), the effects of a range of doses of D-amphetamine (0, 2.5, 5, 10, and 15 mg), alone and in combination with aripiprazole (0 and 20 mg), were assessed. (wustl.edu)

Conventional antipsychotics are classed into typical and atypical. (wikipedia.org)
They are "atypical" as they are differentiated from "conventional" or first-generation antipsychotics based on their clinical profile. (statpearls.com)

In clinical practice, metformin is a frequently used hypoglycemic drug that has been shown to have pharmacological effects in attenuating antipsychotic-induced HPRL ( 14 ), but the specific mechanism of action is uncertain. (frontiersin.org)

Bifeprunox (INN) (code name DU-127,090) is an atypical antipsychotic which, similarly to aripiprazole, combines minimal D2 receptor agonism with serotonin receptor agonism. (wikipedia.org)
The most often administered classes of drugs remained antipsychotic, followed by tricyclic antidepressants, antiepileptics, anxiolytics/sedatives, anticholinergic and selective serotonin reuptake inhibitors. (bvsalud.org)
Aripiprazole is known to have a low risk of extrapyramidal symptoms, because of its partial agonistic activity at dopamine receptor D 2 and serotonin receptor 5HT 1A . (psychiatryinvestigation.org)
Despite aripiprazole's reported lack of effect on serotonin transporters, long-term treatment with aripiprazole or WS-50030 reversed olfactory bulbectomy-induced hyperactivity at doses that did not reduce activity in sham-operated rats, indicating antidepressant-like activity for both compounds. (montclair.edu)
Antipsychotic augmentation is an effective treatment intervention for Obsessive Compulsive Disorder (OCD) patients resistant to Selective Serotonin Reuptake Inhibitors (SSRI) agents. (clinical-practice-and-epidemiology-in-mental-health.com)

Longacting injectables (LAI) of antipsychotics-provided once every two weeks to once every three months-promise to reduce the incidence of nonadherence. (clinicalschizophrenia.net)

The most frequently reported adverse events collected in a pooled analysis of safety and tolerability data from short-term placebo-controlled trials of aripiprazole included headache, nausea, vomiting, lightheadedness, akathisia, insomnia and somnolence. (medscape.com)
This pilot study was conducted to evaluate the effectiveness and tolerability of Aripiprazole for the augmentation of standard treatments in patients with resistant OCD. (clinical-practice-and-epidemiology-in-mental-health.com)
In this brief critical overview, we consider the pharmacology, therapeutic effectiveness, tolerability, adverse effects and costs of individual modern agents versus older antipsychotic drugs. (jddt.in)
Because of typically minor differences between agents in clinical effectiveness and tolerability, and because of growing concerns about potential adverse long-term health consequences of some modern agents. (jddt.in)

In the depressive subtype, combinations of antidepressants plus an antipsychotic are used. (medscape.com)
Atypical antipsychotics also have antidepressant properties in combination with other antidepressants and when administered alone. (statpearls.com)
Furthermore, WS-50030 provides a tool to further explore how combining these mechanisms might differentiate from other antipsychotics or antidepressants. (montclair.edu)

Aripiprazole, which is administered once daily, has a linear pharmacokinetic profile at all doses between 5 and 30 mg/day. (medscape.com)
In greater doses it's an anti- hallucinogenic agent. (bionity.com)

One of the most frequent side effects of atypical antipsychotics is hyperprolactinemia (HPRL), and metformin or aripiprazole co-prescription is regarded as an effective therapy option for reducing prolactin (PRL) levels. (frontiersin.org)

In emergencies, select a high-potency antipsychotic available in PO (tablet, liquid) or IM form. (medscape.com)
First-generation antipsychotics can be classified as low potency, medium potency, or high potency ( Table 24.2 ). (clinicalgate.com)

Aripiprazole (intramuscular) for psychosis-induced aggression or agitation (rapid tranquillisation). (ox.ac.uk)
Antipsychotics, such as aripiprazole in intramuscular form, can be used in such situations. (ox.ac.uk)
OBJECTIVES: To evaluate the effects of intramuscular aripiprazole in the treatment of psychosis-induced aggression or agitation (rapid tranquillisation). (ox.ac.uk)
SELECTION CRITERIA: All randomised controlled trials (RCTs) that randomised people with psychosis-induced aggression or agitation to receive either intramuscular aripiprazole or another intramuscular intervention. (ox.ac.uk)

In the manic subtype, combinations of mood stabilizers plus an antipsychotic are used. (medscape.com)

This article explains what antipsychotic drugs are and which can help treat dementia. (medicalnewstoday.com)
What are antipsychotic drugs? (medicalnewstoday.com)
Interpretation - Although the overall prevalence of use of new atypical antipsychotic agents remains low, their introduction has led to increased prescribing of this class of drugs in older adults. (ices.on.ca)
Maintenance therapy with antipsychotic drugs reduces the risk for acute relapse but may fail to prevent long-term deterioration. (clinicalgate.com)
In recent years, atypical antipsychotics or second-generation antipsychotics have become the drugs of choice for acute psychoses. (statpearls.com)
Background: Previous research support the use of second-generation antipsychotic drugs to treat aggression in Asperger's disorder (AD), but few studies have investigated their effi cacy in stereotypical behavior. (sop.org.tw)
disappeared with the use of expensive, modern antipsychotic drugs (APDs). (journalofpsychiatryreform.com)
Olfson MBlanco CLiu LMoreno CLaje G National trends in the outpatient treatment of children and adolescents with antipsychotic drugs. (jamanetwork.com)

We sought to establish the impact of newer atypical antipsychotics on prescribing rates and costs. (ices.on.ca)
By the first quarter of 2013, newer atypical antipsychotic agents were used by 4.4% of atypical antipsychotic users but accounted for 14.1% ($1.2 million of $8.5 million) of atypical antipsychotic expenditures. (ices.on.ca)

They are less sedating and are more easily titrated but are more likely to cause extrapyramidal adverse effects than the lower-potency agents. (medscape.com)
Adverse effects include sensitivity to extrapyramidal symptoms, especially akathisia, which is well documented in other aripiprazole preparations. (clinicalschizophrenia.net)
In order to decrease the risk of adverse events and accidents in psychiatric patients and to promote patient compliance with treatment, it is vital for psychiatrists to find effective ways to diminish or neutralize antipsychotic-induced HPRL. (frontiersin.org)

Economic outcomes were also not reported in the trials.When compared with placebo, fewer people in the aripiprazole group needed additional injections compared to the placebo group (2 RCTs, n = 382, RR 0.69, 95% CI 0.56 to 0.85, very low-quality evidence). (ox.ac.uk)

Learn more about second-generation antipsychotics. (medicalnewstoday.com)
Treatment with second-generation antipsychotics can contribute to weight gain and, subsequently, metabolic syndrome with high blood sugar, hypertension, abnormal cholesterol, and triglyceride concentrations, posing a patient at risk for stroke, myocardial disease, and diabetes mellitus. (statpearls.com)
Unlike the first generation antipsychotics, the second generation antipsychotics are less likely to cause neuroleptic-induced movement disorder. (psychiatryinvestigation.org)
With the introduction of the second generation antipsychotics, the incidence of neuroleptic-induced movement disorders has been decreased dramatically. (psychiatryinvestigation.org)
Of 214 live births with first-trimester exposure to second-generation antipsychotics, three major malformations were confirmed. (womensmentalhealth.org)
Based on the 214 cases of first-trimester exposure to second-generation antipsychotics, it would be reasonable to conclude that these agents as a class are not major teratogens. (womensmentalhealth.org)
Reproductive Safety of Second-Generation Antipsychotics: Current Data From the Massachusetts General Hospital National Pregnancy Registry for Atypical Antipsychotics. (womensmentalhealth.org)
As the risk associated with second-generation APs is not lower than that of first-generation agents, sedation and resulting hypoventilation, anticholinergic effects, and their effects on immunity have been proposed as the main mechanisms, rather than their extrapyramidal effects. (rxisk.org)

7 However, aripiprazole was reported to be associated with tardive dyskinesia. (psychiatryinvestigation.org)
Earlier publications claimed that aripiprazole could be used to treat tardive dyskinesia (Margolese). (journalofpsychiatryreform.com)
Such claims were clearly suspect at the time as it is well known that any antipsychotic dopamine blocking agent can temporarily suppress signs of tardive dyskinesia that the cost of long-term exacerbation. (journalofpsychiatryreform.com)
Tardive Dyskinesia and Covert Dyskinesia with Aripiprazole: A Case Series. (journalofpsychiatryreform.com)

Aripiprazole was generally well tolerated and no changes were observed in vital signs. (clinical-practice-and-epidemiology-in-mental-health.com)

In contrast to other antipsychotics, NDMC was not very effective in reducing AIL or CAR and showed minimal induction of Fos in the nucleus accumbens. (nih.gov)

Antipsychotics for elderly people with dementia: Which are best? (medicalnewstoday.com)
However, typical antipsychotics may not be the best antipsychotics for older adults with dementia because of the risk of side effects. (medicalnewstoday.com)
The most common prescription typical antipsychotic for dementia. (medicalnewstoday.com)
Doctors can legally prescribe antipsychotics off-label to treat serious dementia symptoms, such as hallucinations and agitation. (medicalnewstoday.com)

Doctors prescribe atypical antipsychotics more often than typical antipsychotic agents due to their reduced risk of side effects. (medicalnewstoday.com)
Drug-induced urinary symptoms such as urinary retention, urgency, or incontinence or nocturnal enuresis have been reported rarely with various typical and atypical antipsychotic agents. (psychiatrist.com)
They have fewer side effects regarding extrapyramidal symptoms when compared to typical antipsychotics. (statpearls.com)
Trifluoperazine (sold as Eskazinyl , Eskazine , Jatroneural , Modalina , Stelazine , Terfluzine , Trifluoperaz ) is a typical antipsychotic drug of the phenothiazine group. (bionity.com)

Depot antipsychotics are not intended for use in the acute setting. (medscape.com)
[ 31 ] Aripiprazole was also associated with improvements in PANSS positive and negative symptom subscale scores in patients experiencing acute psychotic relapse. (medscape.com)
2 We report on a patient who developed acute urinary symptoms with aripiprazole, but tolerated amisulpride without developing any urinary symptoms. (psychiatrist.com)

However, participants allocated to aripiprazole experienced less somnolence (1 RCT, n = 80, RR 0.25, 95% CI 0.08 to 0.82, low-quality evidence). (ox.ac.uk)

Aripiprazole, augmentation, treatment resistant OCD. (clinical-practice-and-epidemiology-in-mental-health.com)

No single atypical antipsychotic drug has been proven most beneficial for treatment of persistent alcohol-related psychosis. (medscape.com)

Additional analyses using pooled data from 4- or 6-week trials revealed that, relative to placebo, patients receiving aripiprazole experienced significant reductions in symptoms of depression and anxiety, [ 37 ] and in symptoms of hostility and excitability. (medscape.com)
In view of the harms induced by the use of antipsychotic agents (APs) for the symptomatic treatment of aggression and psychotic symptoms in elderly patients in residential facilities, [7] , [8] in 2008 the European national regulatory agencies recommended limiting their use to patients not responding to other interventions, and to reconsider their prescription at every follow up visit, with close patient follow up. (rxisk.org)

Clinically important improvement in agitation at two hours favoured the aripiprazole group (2 RCTs, n = 382, RR 1.50, 95% CI 1.17 to 1.92, very low-quality evidence). (ox.ac.uk)

The mechanism involved remains unclear, and the suitability of aripiprazole for treating the core pathophysiology of AD requires further investigation. (sop.org.tw)

Anatomy1

Organisms2

Diseases6

Chemicals and Drugs42

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Psychiatry and Psychology11

Phenomena and Processes5

Health Care4

Olanzapine25

Clozapine10

Quetiapine1

Schizophrenia21

Haloperidol5

Risperidone1

Chlorpromazine2

Medications19

Medication8

Abilify2

Treated with second-generation antipsychotics1

Oral aripiprazole2

Receptors10

Predictive of antipsychotic2

Dose6

Efficacy2

Combination with aripiprazole1

Conventional2

Pharmacological1

Serotonin5

Injectables1

Tolerability4

Antidepressants3

Doses2

Prolactin1

High-potency2

Intramuscular4

Mood stabilizers1

Drugs8

Newer atypical2

Adverse3

Compared with placebo1

Second-generation8

Tardive dyskinesia4

Generally well tolerated1

Minimal1

Dementia4

Typical4

Acute3

Somnolence1

Augmentation1

Psychosis1

Symptoms2

Agitation1

Mechanism1