Loading...
  • solute
  • Excessive ADH causes an inappropriate increase in the reabsorption in the kidneys of solute-free water ("free water"): excess water moves from the distal convoluted tubules (DCT)s and collecting tubules of the nephrons - via activation of aquaporins, the site of the ADH receptors - back into the circulation. (wikipedia.org)
  • regulates
  • One of the proposed mechanisms of IL-6 in disease pathogenesis is that it regulates the transition of leukocyte recruitment. (biomedcentral.com)
  • neuromyelitis optica
  • Currently two principal causes are accepted: In NMO-IgG positive patients, the cause of the neuromyelitis optica (understood as the syndrome) is an autoimmune aquaporin-4 channelopathy, due to these specific autoantibodies. (wikipedia.org)
  • molecules
  • NMOSD monocytes showed a remarkable increase in the production of pro-inflammatory cytokines (IL-6, IL-1β) and increased expression of cell-surface molecules (CD80, HLA, ICAM-1, CD16), as well as a decrease in the levels of anti-inflammatory cytokine IL-10, compared to healthy control (HC) monocytes. (biomedcentral.com)
  • For example, the aquaporin 3 channel has a pore width of 8-10 Ångströms and allows the passage of hydrophilic molecules ranging between 150 and 200 Da. (wikipedia.org)
  • lens
  • In the native form, it is an aquaporin, but during lens development, it becomes proteolytically truncated. (tcdb.org)