• AQP2
  • From the Pf values and immunoblot signals of oocytes expressing AQP2-S256D-F, which is completely localized in the plasma membrane, the relation between Pf and AQP2 amount in the plasma membrane was obtained (Pf = [3.97 × amount of AQP2 protein expected in the membrane] − 9.7) (Fig. 6). (nih.gov)
  • solute
  • Excessive ADH causes an inappropriate increase in the reabsorption in the kidneys of solute-free water ("free water"): excess water moves from the distal convoluted tubules (DCT)s and collecting tubules of the nephrons - via activation of aquaporins, the site of the ADH receptors - back into the circulation. (wikipedia.org)
  • regulates
  • One of the proposed mechanisms of IL-6 in disease pathogenesis is that it regulates the transition of leukocyte recruitment. (biomedcentral.com)
  • neuromyelitis optica
  • Currently two principal causes are accepted: In NMO-IgG positive patients, the cause of the neuromyelitis optica (understood as the syndrome) is an autoimmune aquaporin-4 channelopathy, due to these specific autoantibodies. (wikipedia.org)
  • water molecules
  • The channel, which normally houses 6-9 water molecules, becomes constricted so only three remain, and these are trapped in a closed conformation. (wikipedia.org)
  • Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. (wikipedia.org)
  • molecules
  • NMOSD monocytes showed a remarkable increase in the production of pro-inflammatory cytokines (IL-6, IL-1β) and increased expression of cell-surface molecules (CD80, HLA, ICAM-1, CD16), as well as a decrease in the levels of anti-inflammatory cytokine IL-10, compared to healthy control (HC) monocytes. (biomedcentral.com)
  • For example, the aquaporin 3 channel has a pore width of 8-10 Ångströms and allows the passage of hydrophilic molecules ranging between 150 and 200 Da. (wikipedia.org)
  • aqueous
  • Much faster diffusion was found for a lipid probe (diOC(4)(3), 2.7 x 10(-)8 cm(2)/s) in the ER membrane and for unconjugated GFP in the aqueous ER lumen (6 x 10(-)8 cm(2)/s). (nih.gov)
  • Agre
  • Early work of Nobel Prize winner, Peter Agre and his group first clone a 269 amino acid protein from RBC and kidney libraries that has a 6 TMD (1). (acris-antibodies.com)
  • The 2003 Nobel Prize in Chemistry was awarded jointly to Peter Agre for the discovery of aquaporins, and Roderick MacKinnon for his work on the structure and mechanism of potassium channels. (wikipedia.org)
  • It was not until 1992 that the first aquaporin, 'aquaporin-1' (originally known as CHIP 28), was reported by Peter Agre, of Johns Hopkins University. (wikipedia.org)
  • In 1999, together with other research teams, Agre reported the first high-resolution images of the three-dimensional structure of an aquaporin, namely, aquaporin-1. (wikipedia.org)
  • Agre said he discovered aquaporins "by serendipity. (wikipedia.org)