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  • As with all chronic medical conditions, effective management of obesity must be based on a partnership between a highly motivated patient and a committed team of health professionals. (medscape.com)
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  • Screening, the general medical approach to the management of obesity, and clinical practice guidelines from the American College of Physicians for management of obesity in primary care settings are discussed elsewhere. (medilib.ir)
  • Few medications are available for the management of obesity. (medscape.com)
  • The need for any pharmaceutical regimen to be combined with a sustained exercise, dietary adjustment, and behavioral-change regimen to sustain weight loss further complicates the successful management of obesity. (medscape.com)
  • Obesity has reached epidemic levels, with a total of 500 million adults classed as obese globally in 2008, which is expected to rise to 700 million by 2015 (WHO). (medscape.com)
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  • inTrODUCTiOn One common treatment of the obesity epidemic involves the use of drugs (Hampp et al. (researchgate.net)
  • Catecholamine releasing agents such as amphetamine, phentermine, and related substituted amphetamines (e.g., bupropion) act as appetite suppressants. (wikipedia.org)
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  • Despite this focus, there are no current anti-obesity treatments targeting these circuits. (medscape.com)
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  • Cannabinoid receptor antagonists were developed to treat obesity because researchers noticed that cannabinoid agonists (such as THC, the main pharmacologically active component of cannabis), increased appetite. (wikipedia.org)
  • Notoginsenosides can treat obesity by reducing lipid synthesis, inhibiting adipogenesis, promoting white adipose tissue browning, increasing energy consumption, and improving insulin sensitivity. (frontiersin.org)
  • VI-0521, Vivus) and a naltrexone-bupropion combination (Contrave®, Orexigen Therapeutics Inc.) have been rejected and previously effective agents (phentermine, rimonabant and sibutramine) have been withdrawn due to safety concerns. (medscape.com)
  • reported that obesity specialists widely prescribe Phen plus 5-HTP/CB surpassing other combinations (e.g., caffeine + ephedrine or sibutramine + orlistat) to reduce feeding. (researchgate.net)
  • Research has indicated that appetite inhibiting hormones from the gut may have a therapeutic potential in obesity. (ku.dk)
  • For example, CBD and THC may work together to enhance therapeutic effects, such as pain relief and anti-inflammatory properties. (melincookie.com)
  • Thus, HDL rising in obesity is an attractive therapeutic target. (benthamscience.com)
  • Fecal microbiome therapy☜Modification of gut microbiota appears to be a promising therapeutic intervention for obesity and other metabolic disorders. (debategraph.org)
  • Improved understanding of the neurocircuitry of the feeding-satiety cycle has provided many potential targets for designer therapeutic agents under development. (medscape.com)
  • Obesity is a chronic medical condition, and as with similar chronic conditions (eg, diabetes, hypertension), after therapeutic agents are stopped, the relapse rate is high. (medscape.com)
  • Progress in this field is underscored by Belviq (lorcaserin) and Qsymia (phentermine/topiramate), the first agents in more than 10 years to achieve regulatory approval for chronic weight management in obese patients. (eddoctor24h.com)
  • Aside from advice (stop eating) and stomach surgery for the severely obese (say, 5-foot-8, 265 pounds), there are just two anti-obesity medications approved for long-term use, and the pounds come right back on as soon as you stop taking them. (popsci.com)
  • The problem is that once you're obese, your brain doesn't know it's obese," says neurologist Barry Levin, an obesity researcher at the VA Medical Center in East Orange, New Jersey. (popsci.com)
  • A 2019 study found spearmint essential oil to be an anti-obesity agent that might be safer than synthetic drugs. (medicalnewstoday.com)
  • In examining what went wrong with these drugs, it is important to consider whether their failings are indicative of all drugs of their specific classes or indeed likely to be drawbacks of all centrally acting agents. (medscape.com)
  • Therefore, it is necessary to find more effective and safer anti-obesity drugs. (frontiersin.org)
  • Although notoginsenosides are potential drugs for the treatment of obesity, their effects and mechanisms have not been analyzed in depth. (frontiersin.org)
  • However, currently, there are very few drugs available for obesity treatment. (frontiersin.org)
  • Therefore, the development of safe and effective new anti-obesity drugs has great clinical significance and economic value. (frontiersin.org)
  • These are drugs that decrease appetite, leading to lower consumption of food and hence loss of weight. (zovon.com)
  • The record of anti-obesity drugs has been poor so far and the only efficient treatment today is bariatric surgery. (ku.dk)
  • In the last decade, it has been shown that metformin, thiazolidinediones, vitamin E, ezetimibe, n-3 polyunsaturated fatty acids, renin-angiotensin system (RAS) blockers, and antiobesity drugs may improve hepatic pathophysiological disorders as well as clinical parameters. (hindawi.com)
  • Accordingly, insulin sensitizers, antioxidative agents, Niemann-Pick C1-like 1 (NPC1L1) inhibitors, RAS blockers, and drugs that target the central nervous system may represent candidate pharmacotherapies for NAFLD and possibly NASH. (hindawi.com)
  • As a rule any weight loss drugs are safe for adults with obesity. (yourbody-expert.com)
  • However, the current generation of drugs, which act on the central nervous system to suppress appetite, have raised significant health concerns-including psychiatric disorders, such as suicidal behaviour, depression, and cardiovascular problems. (debategraph.org)
  • In addition to Primidone-containing medications, drugs containing Phenobarbital anti-seizure agent can be used for epilepsy treatment in dogs. (ahefv.com)
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  • Weight Gain on Psychotropic Drugs: Has the Obesity Community been Paying Attention? (omicsonline.org)
  • Mirtazapine (Remeron) and paroxetine (Paxil) are two antidepressants with the greatest weight gain potential among the anti-depressants although except for buproprion (Wellbutrin) weight gain has been reported among all of the other drugs in this category [ 4 ]. (omicsonline.org)
  • See "Bariatric procedures for the management of severe obesity: Descriptions" . (medilib.ir)
  • INDICATIONS - Indications for the surgical management of severe obesity were first outlined by the National Institutes of Health (NIH) Consensus Development Panel in 1991 [ 16 ]. (medilib.ir)
  • The cost of treating obesity and its complications in the United States (US) is over 200 billion US dollars per year and over 20 percent of the US's entire health expenditure [ 6,8 ]. (medilib.ir)
  • Additionally, obesity and its complications lead to other significant costs, such as missed days of work and decreased life expectancy [ 5 ]. (medilib.ir)
  • In the United States, obesity and its complications cause as many as 300,000 premature deaths each year, making it second only to cigarette smoking as a preventable cause of death. (msdmanuals.com)
  • needs update] In the United States, the Food and Drug Administration advocates that people with either a body-mass index of at least 30, or a body-mass index of at least 27 with at least one weight-related comorbidity, represent a patient population with sufficiently high baseline health risks to justify the use of anti-obesity medication. (wikipedia.org)
  • The discontinued drug 2,4-dinitrophenol works by increasing energy expenditure by decreasing the efficiency of mitochondria (uncoupling agent). (wikipedia.org)
  • Putative satiety hormones and neurotransmitters involved in energy regulation circuits have been key targets for obesity drug development over the last decade (Figure 1). (medscape.com)
  • Perhaps the most infamous is the combination drug Roux-en-Y gastric bypass, biliopancreatic diversion with duo- Fen-Phen. (eddoctor24h.com)
  • The same reasons it's hard for most people to slim down in any permanent fashion through diet and exercise account for the fact that we still don't have an anti-obesity drug that's safe, effective and tolerable. (popsci.com)
  • The anti-obesity drug Phentermine falls under the category of controlled medicines that you cannot buy over the counter. (outlookindia.com)
  • reported that obesity specialists frequently prescribed, in humans, a triple drug combination (Phen, 5-HTP, and CB) for the treatment of obesity. (researchgate.net)
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  • Duromine is a legal and time-tested anti-obesity drug (manufacturer: iNova). (yourbody-expert.com)
  • Atta-ur-Rahman, M. Iqbal Choudhary , " Anti-Obesity Drug Discovery and Development ", Bentham Science Publishers (2011). (benthamscience.com)
  • The use of anti-obesity drug has become increasingly common in the last 30 years. (benthamscience.com)
  • Researchers have yet to figure out how protein works to reduce appetite, but it is speculated that it may be because protein causes the brain to receive lower levels of appetite-stimulating hormones (WebMD, 2012). (directcurrentmusic.com)
  • They help prevent or increase the appetite and suppress insulin secretion. (marsfam.net)
  • Although clinical evidence for RAS blockers and incretin-based agents (GLP-1 analogs and dipeptidyl peptidase-4 inhibitors) is also lacking, these agents are promising in terms of their insulin-sensitizing and anti-inflammatory effects without causing weight gain. (hindawi.com)
  • Patients on combination therapy with a glucagon-like peptide 1 (GLP-1) receptor agonist/glucose-dependent insulinotropic polypeptide (GIP) will probably require dose reduction or withholding of glucose-lowering agents (sulfonylureas or insulin) to avoid low blood glucose. (medscape.com)
  • These medications alter one of the fundamental processes of the human body, weight regulation, by reducing appetite and consequently energy intake, increasing energy expenditure, redirecting nutrients from adipose to lean tissue, or interfering with the absorption of calories. (wikipedia.org)
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  • YourBody-Expert.com team and most obesity treatment specialists do not recommend a very fast weight loss rate, up to 1 kilogram per week is normal. (yourbody-expert.com)
  • Talk to your healthcare provider before taking any weight loss agents, if you are planning to become pregnant or are pregnant already. (yourbody-expert.com)
  • Given that lifestyle intervention alone has limited success in achieving 10%-15% weight loss, the ADA SOC support the additional use of antiobesity medication (AOM) or metabolic surgery. (medscape.com)
  • Decision-making regarding the choice of antidiabetes medications should focus on agents that are weight-neutral or promote weight loss and limit the use of those associated with weight gain. (medscape.com)
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  • A controlled, randomized, clinical trial to evaluate the safety and efficacy of this combination in treating obesity should be considered. (researchgate.net)
  • Consensus for obesity treatment is that clinical therapy should begin with lifestyle changes focusing on behavioral modification, diet, and exercise. (benthamscience.com)
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  • INTRODUCTION - Obesity, defined as a body mass index (BMI) ≥30 kg/m 2 , is a chronic illness identified in children, adolescents, and adults worldwide [ 1,2 ]. (medilib.ir)
  • According to the World Health Organization, worldwide there are approximately 650 million adults with obesity and 42 million children with obesity under the age of five years [ 3 ]. (medilib.ir)
  • In the United States, 35 percent of adults (roughly 100 million people) and 17 percent of children have obesity [ 4 ]. (medilib.ir)
  • See "Obesity in adults: Prevalence, screening, and evaluation" and "Obesity in adults: Overview of management" . (medilib.ir)
  • Obesity is a growing pandemic, and related health and economic costs are staggering. (eddoctor24h.com)
  • Over the past two decades, the prevalence of metabolic abnormalities such as type 2 diabetes and metabolic syndrome (MetS) has been increasing worldwide together with the escalating obesity pandemic [ 1 - 3 ]. (hindawi.com)
  • However, many other factors appear to increase a person's predisposition to obesity, including endocrine disruptors (eg, bisphenol A [BPA]), gut microbiome, sleep/wake cycles, and environmental factors. (msdmanuals.com)
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  • The westernization transition is usually accompanied by increases in obesity, decreases in physical activity and alterations in dietary intake toward more calories, fat and non-complex carbohydrates. (justia.com)
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  • Type 2 diabetes is increasingly common primarily because of increases in the prevalence of a sedentary lifestyle and obesity. (justia.com)
  • Obesity often increases the risk of lifestyle diseases, such as cardiovascular disease, diabetes, and cancer. (frontiersin.org)
  • Because of potential side effects, and limited evidence of small benefits in weight reduction for children and adolescents with obesity, it is recommended that anti-obesity medications only be prescribed for obesity where it is hoped that the benefits of the treatment outweigh its risks. (wikipedia.org)
  • Based on its effectiveness for hypothyroidism, thyroid hormone became a popular treatment for obesity in euthyroid people. (wikipedia.org)
  • thus laying emphasis on the timely prevention and treatment of obesity. (frontiersin.org)
  • EXPERT OPINION: The incretin impairment, which seems to exist in both obesity and diabetes, may link these two pathologies and underlines the potential of GLP-1-based therapies in the prevention and treatment of these diseases. (ku.dk)
  • Little is known about the prescribing habits of physicians specializing in the treatment of obesity. (researchgate.net)
  • The average maximal dose of phentermine was above that approved in the package insert, and these physicians disagreed with the National Institutes of Health (NIH) Obesity Treatment Guidelines. (researchgate.net)
  • As 5-HTP-carbidopa was a combination not previously reported for the treatment of obesity, a retrospective chart review was performed in a single obesity practice, which may not be representative. (researchgate.net)
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  • The ABOM stresses obesity be considered a chronic disorder that requires lifelong treatment and follow-up. (msdmanuals.com)
  • Research has shown that essential oils may exert anti-obesity effects. (medicalnewstoday.com)
  • GLP-1 analogues such as tirzepatide, semaglutide, and liraglutide slow gastric emptying and also have neurologically driven effects on appetite. (wikipedia.org)
  • They worked primarily by suppressing appetite, and had other beneficial effects such as increased alertness. (wikipedia.org)
  • F. H. Chen exhibits anti-obesity effects. (frontiersin.org)
  • Obesity has definitely become a growing problem, but a lot of anti-obesity educations, with fen-peen as the best example, have proven to have very damaging side-effects like lung hypertension and heart valve condition (Fen Peen, 2010). (directcurrentmusic.com)
  • With these information, the researchers hope that snow peas would prove to have significant anti-obesity effects. (directcurrentmusic.com)
  • Further, a recent report on the effects of EOPK indicated that the oil has anti-obesity and hypolipidemic activity in vitro and in vivo , using 3 T3-L1 cells and high fat diet-fed rats [ 16 ]. (biomedcentral.com)
  • Curcumin also has anti-inflammatory effects which can be good for arthritis and other inflammatory conditions. (reviewsgoal.com)
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  • We analyzed in parallel the effects of obesity status on the levels and binding capacity of circulating SHBG and their relationship with testosterone and estradiol. (bvsalud.org)
  • AREAS COVERED: The purpose of this review is to cover the background for the GLP-1-based therapies and their potential in obesity and pre-diabetes. (ku.dk)
  • Setmelanotide is an agonist of the melanocortin 4 receptor and is used in people with certain rare genetic conditions that cause obesity. (wikipedia.org)
  • It selectively blocks the cannabinoid receptor CB1, which belongs to the endogenous cannabinoid system found throughout the body involved in controlling different physiological processes, like appetite. (zovon.com)
  • The literature updated to August 2014 from PubMed was identified using the combinations: GLP-1, GLP-1 receptor agonists, incretins, obesity and pre-diabetes. (ku.dk)
  • The world has witnessed a huge increase in the number of people battling with obesity due, in part, to unhealthy lifestyles and erratic daily routines. (ipsnews.net)
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  • People use Fucus vesiculosus for thyroid disorders, obesity, aging skin, constipation, and many other conditions, but there is no good scientific evidence to support these uses. (medlineplus.gov)
  • The International Federation for the Surgery of Obesity and Metabolic Diseases estimates that there were about 394,431 bariatric procedures performed worldwide in 2018 [ 12 ]. (medilib.ir)
  • It is less effective and not approved for general obesity. (wikipedia.org)
  • This, if proven effective, could be a natural way of treating obesity. (directcurrentmusic.com)
  • Significance of the Study If proven effective, the research study can serve as one of the basis for future searches, since not much anti-obesity agents were studied by the students of the Department of Pharmacy of the University of San Carols, Zebu City. (directcurrentmusic.com)
  • However, a recent study showed that AASs are effective as anabolic agents at increasing strength and strength training, but not muscle mass, growth human hormone recombinant. (marsfam.net)
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  • Other homeopathic seizure meds for dogs - Cocculus, Aconite, Cicuta Virosa and Silica are also effective anti-convulsant means. (ahefv.com)
  • Causes of obesity are multifactorial and include genetic predisposition and behavioral, metabolic, and hormonal influences. (msdmanuals.com)
  • Tackling obesity☜Many policy interventions have been suggested to address the obesity crisis across multiple studies-and indeed many such measures have been implemented, and are being implemented, now. (debategraph.org)
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