Apoptotic reperfusion injury. Medical search. Frequent questions

It has been proved that inhalation of methane also modulates leukocyte activation, affects key events of ischemia-reperfusion-induced oxidative stress, and has anti-inflammatory effects against ischemia-reperfusion damage [ 12 ]. (hindawi.com)
oxidative stress marker), caspase-3 (apoptotic executor), and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) activity (apoptotic indicator). (elsevierpure.com)
One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
Livers treated with NMP combined with BMMSCs showed better liver function, relieved histopathological damage, reduced oxidative stress injury and ferroptosis, and the mechanism of reduction was associated with downregulation of intracellular reactive oxygen species (ROS) and free Fe²⁺ levels. (medscimonit.com)
oxidative stress that occurs during reperfusion injury has been shown to induce apoptosis, over and above that induced by ischemia. (latestfashiontips.com)

It has been demonstrated that I/R-induced hepatic injury is initially triggered by reactive oxygen species (ROS), which induce oxidative damage and apoptosis, an important mechanism for cell death following hepatic I/R injury ( 2 ). (spandidos-publications.com)
Apoptosis is one of the major mechanisms that lead to neuronal death after cerebral ischemia and reperfusion. (springer.com)
We found remifentanil postconditioning markedly improved the spatial learning and memory as well as attenuated neuronal apoptosis in hippocampus caused by cerebral ischemia/reperfusion injury. (springer.com)
The results suggest that remifentanil postconditioning exhibits neuroprotective effects against global cerebral ischemia/reperfusion injury in rats, and its mechanisms might involve inhibition of neuronal apoptosis through the PI3K pathway. (springer.com)
Yuan Y, Guo Q, Ye Z et al (2011) Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway. (springer.com)
DLC1β-OE resulted in downregulated pro-apoptotic mRNA expression (Bax/Cycs/Casp3), upregulated protective mRNA targets (BCl2/Akt1) and less late/early apoptosis via flow cytometry. (uwo.ca)
At the end of reperfusion, Immunohistochemical detection of apoptotic cells was performed by using an in situ apoptosis detection kit. (vin.com)
Dexmedetomidine pretreatment can obviously relieve myocardial ischemia-reperfusion injury and cardiomyocyte apoptosis in rats probably by activating the Janus kinase 2/signal transducers and activators of transcription 3 signaling pathway. (ijpsonline.com)
Complement activation induces synthesis of pro-inflammatory cytokines and the membrane attack complex directly causes cell injury, apoptosis and necrosis, which in turn cause further complement activation and a vicious circle of inflammation and cell damage 4 . (nature.com)
SC was susceptible to oxidative injury and apoptosis in experimental diabetic neuropathy when subjected to mild IR injury. (elsevierpure.com)
miR-127-5p regulates FAIM2-mediated cell apoptosis and participates in cerebral ischemia-reperfusion injury. (bvsalud.org)
Apoptosis is an important way of neuronal death after cerebral ischemia-reperfusion injury. (crimsonpublishers.com)
Neuronal apoptosis is closely associated with brain damage induced by ischemia/reperfusion injury [ 3 - 5 ]. (einj.org)
Trim8 knockout relieved hepatocyte injury triggered by I/R. Silencing of Trim8 expression alleviated hepatic inflammation responses and inhibited apoptosis in vitro and in vivo . (ijbs.com)
The morphologic changes seen in apoptosis include cell shrinkage, loss of cell-cell contacts, membrane blebbing, and nuclear condensation, terminating in the breakdown of the cell into apoptotic bodies that are phagocytosed by surrounding cells. (latestfashiontips.com)
Activation of the mitochondrial apoptotic process is regarded as the point of no return in apoptosis. (latestfashiontips.com)
The p38 survival signal was transiently lost during both spontaneous and Fas-induced apoptosis, favoured induction of the apoptotic process. (lu.se)

Ischemia due to early hypoperfusion followed by ischemia reperfusion injury (IRI) results in renal tissue damage 4 . (nature.com)

Pentoxifylline treatment improved short-term memory by suppressing apoptotic cell death in the hippocampus with elevated cAMP levels. (einj.org)

The balance between pro-apoptotic and antiapoptotic Bcl-2 family members determines the mitochondrial response to apoptotic stimuli [ 11 ]. (einj.org)
The Bcl-2 proteins influence cell survival primarily by controlling the mitochondrial response to apoptotic signals, although direct inhibition of caspase activity may occur. (latestfashiontips.com)

Perinatal hypoxic-ischemia is accompanied by neurodegeneration, including necrotic and apoptotic neuronal death [ 1 , 2 ]. (einj.org)
Mitochondrial dysfunction plays a central role in mediating both the necrotic and apoptotic components of reperfusion injury. (elsevierpure.com)

In addition, certain pro-inflammatory chemokines and cytokines are key during the initial period of reperfusion, whereas the late period of hepatic injury is neutrophil-mediated ( 3 ). (spandidos-publications.com)

Qi et al ( 9 ) reported that GP protected against DNA damage in neurons in I/R-induced cerebral injury. (spandidos-publications.com)
Global cerebral ischemia followed by reperfusion, which leads to extensive neuronal damage, particularly the neurons in the hippocampal CA1 region. (springer.com)
The neuroprotective effects of remifentanil preconditioning against cerebral ischemia/reperfusion injury have been recently reported. (springer.com)
Here we investigated whether remifentanil postconditioning exerts neuroprotective effects against global cerebral ischemia/reperfusion injury in rats and its potential mechanisms. (springer.com)
Wang JY, Shen J, Gao Q et al (2008) Ischemic postconditioning protects against global cerebral ischemia/reperfusion-induced injury in rats. (springer.com)
Huang Y , Tan F , Zhuo Y , Liu J , He J , Duan D , Lu M , Hu Z , . Hypoxia-preconditioned olfactory mucosa mesenchymal stem cells abolish cerebral ischemia/reperfusion-induced pyroptosis and apoptotic death of microglial cells by activating HIF-1α. (aging-us.com)
Microglial cells are the first line immune cells that initiate inflammatory responses following cerebral ischemia/reperfusion(I/R) injury. (aging-us.com)
Taken together, these findings reveal that hypoxia-preconditioned OM-MSC inhibits pyroptotic and apoptotic death of microglial cell in response to cerebral ischemia/reperfusion insult by activating HIF-1α in vitro . (aging-us.com)
With prolonged hypoxic-ischemic insult and failure of compensatory mechanisms, cerebral blood flow falls, leading to ischemic brain injury. (medscape.com)
Mechanical thrombectomy (MT) has become an effective re- airway method for cerebral ischemia - reperfusion injury (CI/RI). (bvsalud.org)
Ischemia reperfusion injury is one of the important injury factors in the process of cerebral infarction, and its pathological process is very complicated. (crimsonpublishers.com)
In the treatment of acute cerebral infarction, it is possible to remove the arterial thrombosis as early as possible, make the occlusion of the cerebral artery repasses, restore or improve the blood supply of the infarct area, prevent the ischemia reperfusion injury, save the ischemic penumbra, prevent the irreversible injury of ischemic brain tissue, and reduce the mortality and the rate of disability. (crimsonpublishers.com)
Safflower injection can correct the imbalance of thromboxane (TXA2) HJNKM / prostacyclin (PGI2) and abnormal changes of the ultrastructure of brain tissue in circulating blood after cerebral ischemia-reperfusion, and reduce the injury of cerebral ischemia reperfusion. (crimsonpublishers.com)
According to the data, safflower injection has an obvious anti apoptotic effect on hippocampus in rats with cerebral infarction. (crimsonpublishers.com)

Gypenoside (GP), the predominant component of Gynostemma pentaphyllum, exhibits a therapeutic effect on chronic hepatic injury, fibrosis and fatty liver disease via its anti-inflammatory and anti‑oxidant activity. (spandidos-publications.com)
However, the effect of GP on ischemia/reperfusion (I/R)-induced hepatic injury has, to the best of our knowledge, not previously been investigated. (spandidos-publications.com)
In the present study, a hepatic I/R‑injury model was successfully established using C57BL/6 mice. (spandidos-publications.com)
In conclusion, the present study indicated that GP effectively protected against I/R-induced hepatic injury via its anti-oxidative and anti-apoptotic bioactivity. (spandidos-publications.com)
Ischemia/reperfusion (I/R) is a predominant cause of hepatic injury, which is of clinical significance following liver surgery, hemorrhagic shock and liver transplantation ( 1 ). (spandidos-publications.com)
Therefore, developing effective preventive and therapeutic strategies for I/R-induced hepatic injury is required. (spandidos-publications.com)
Furthermore, GP exhibits a therapeutic effect on chronic hepatic injury, fibrosis, as well as fatty liver disease, which were induced by a high fat, high cholesterol diet and alcohol in mice ( 5 , 8 ). (spandidos-publications.com)
To the best of our knowledge, the role of GP in hepatic I/R injury and the underlying molecular mechanism, have not yet been investigated. (spandidos-publications.com)
Therefore, in the present study the protective effects of GP against I/R-induced hepatic injury in mice was studied. (spandidos-publications.com)
In the present study, the team was able to show that Liproxstatin-1 suppresses ferroptosis both in human kidney cells, Gpx4 deletion-induced acute renal failure and in a pre-clinical model of hepatic ischemia reperfusion injury. (sciencedaily.com)
Tao Q, Tianyu W, Jiangqiao Z, Zhongbao C, Xiaoxiong M, Long Z, Jilin Z. Tripartite Motif 8 Deficiency Relieves Hepatic Ischaemia/reperfusion Injury via TAK1-dependent Signalling Pathways. (ijbs.com)
However, the function of Trim8 in hepatic ischaemia/reperfusion (I/R) injury remains largely unknown. (ijbs.com)
The aim of this study is to explore the role of Trim8 in hepatic I/R injury. (ijbs.com)
The effect of Trim8 on hepatic I/R injury was analysed via pathological and molecular analyses. (ijbs.com)
The results indicated that Trim8 was significantly upregulated in liver of mice subjected to hepatic I/R injury. (ijbs.com)
TAK1 was required for Trim8 function in hepatic I/R injury as TAK1 activation abolished Trim8 function in vitro . (ijbs.com)
In conclusion, our study demonstrates that Trim8 deficiency plays a protective role in hepatic I/R injury by inhibiting the activation of TAK1-dependent signalling pathways. (ijbs.com)
Ischaemic reperfusion (I/R) occurs during surgical procedures, including hepatic resection and liver transplantation (LT) [ 1 ]. (ijbs.com)
Hepatic I/R injury can result in loss of viability of a liver graft, which is directly correlated with the recipient's survival [ 2 ]. (ijbs.com)
Unfortunately, there are no good treatments to improve hepatic I/R injury. (ijbs.com)
Hepatic I/R injury is characterized by endothelial and Kupffer cell swelling, vasoconstriction, leukocyte infiltration, and platelet aggregation in sinusoids [ 3 ]. (ijbs.com)

Vascular endothelial cell (EC)-derived factors play an important role in endothelial-cardiomyocyte crosstalk and could save cardiomyocytes (CMs) from injury. (mdpi.com)
In vitro, HL-1 cells (mouse cardiomyocytes) received chamber hypoxia-oxygenation reperfusion (H/R) for 24H4R with/without DLC1β plasmid, before collection for protein/mRNA analyses. (uwo.ca)
Considering these results, we conclude that L-carnitine has a protective effect against cardiac ischemic reperfusion injuries as a reduction of apoptotic cardiomyocytes. (vin.com)

Apoptotic epithelial tubular cells release pro-fibrinogenic factors, which, combined with complement-mediated inflammatory cell recruitment, promote fibrosis. (nature.com)
Only the outer serosa layer and the inner columnar luminal epithelial cells were affected by the reperfusion. (nih.gov)
This was indicated by major accumulation of extracellular fluid, presence of apoptotic-labeled glandular epithelial layer and vascular endothelium. (nih.gov)
Acts upstream of with a negative effect on epithelial cell apoptotic process. (nih.gov)

abstract = "Mild ischemia-reperfusion (IR) injury to diabetic peripheral nerve is known to cause severe ischemic fiber degeneration. (elsevierpure.com)

Apoptotic cardiomyocyte death is an increasingly recognized feature of congestive heart failure and acute myocardial infarction. (latestfashiontips.com)
Despite inducing ultrastructural damage, Caspase3 does not trigger a full apoptotic response in the cardiomyocyte. (uniroma5.it)
We also implicate Caspase3 in determining myocardial infarct size after ischemia-reperfusion injury, because its cardiomyocyte-specific overexpression increases infarct size. (uniroma5.it)

The PKCδ/p53 apoptotic signaling pathway was the pharmacological target of baicalin. (medscimonit.com)
Zhou Y, Fathali N, Lekic T et al (2012) Remote limb ischemic postconditioning protects against neonatal hypoxic-ischemic brain injury in rat pups by the opioid receptor/Akt pathway. (springer.com)
Hence, treatment strategies for orchitis should focus on the balance of inflammatory cytokines, removal of oxidative and apoptotic injury, and regulation of the PK2/PKR1 pathway. (hindawi.com)

Perinatal hypoxic-ischemic injury increased apoptotic cell death in the hippocampus, resulting in impaired short-term memory with decreased cAMP levels. (einj.org)

We investigated the effects of pentoxifylline, a methylxanthine derivative and type-4 phosphodiesterase inhibitor, on short-term memory and apoptotic neuronal cell death in the hippocampus following perinatal hypoxic-ischemia in newborn rats. (einj.org)

In the present work, a hypoxia/reoxygenation (H/R) model in NRK-52E cells and ischemia-reperfusion model in rats were used. (mdpi.com)
The results showed that the TFs significantly attenuated cell injury and markedly decreased serum creatinine (Cr) and blood urea nitrogen (BUN) levels in rats. (mdpi.com)
To evaluate the effects of dexmedetomidine on myocardial ischemia-reperfusion injury in rats and its anti-apoptotic role, as well as the mechanism by which it regulates Janus kinase 2/signal transducers and activators of transcription 3 signal. (ijpsonline.com)
Rats were randomly divided into 3 groups: control group (n=3), myocardial ischemia without reperfusion (PI group, n=3), and myocardial ischemia with reperfusion (IR group, n=4). (elsevierpure.com)

Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). (mdpi.com)
Renal ischemia-reperfusion injury (IRI) is considered as a major cause of acute kidney injury. (frontiersin.org)
Renal ischemia-reperfusion injury (IRI) is a common pathophysiological phenomenon in clinical settings. (frontiersin.org)
A total of 24 Adult males of Swiss albino mice were randomized to four groups: I/R group (n = 6), mice underwent 30 minute bilateral renal ischemia and 48 hr reperfusion. (biomedcentral.com)
The mice were treated with 45 min unilateral renal ischemia and reperfusion (I/R) to induce an acute renal injury. (oncotarget.com)

Moreover, immunohistochemical experiments showed that DOEO remarkably increased the protein levels of NF-E2-related nuclear factor 2 (Nrf2) and heme oxygenase-1 (HO-1) and reduced the expression of apoptotic caspases, including caspase 3 and caspase 9. (wjtcm.net)
Standard histologic, immunohistochemical and Elisa techniques were used to study the histopathologic, oxidative, apoptotic and inflammatory changes in MI and IR. (aku.edu)

Dysregulation of succinate synthesis, and therefore ATP synthesis, happens in some genetic mitochondrial diseases, such as Leigh syndrome, and Melas syndrome, and degradation can lead to pathological conditions, such as malignant transformation, inflammation and tissue injury. (wikipedia.org)

The microvascular and parenchymal organ damage induced upon ischemia tissue reperfusion is mainly attributed to the reactive oxygen-free radicals, and it has been demonstrated in many organs. (frontiersin.org)
The production of antioxidant enzymes that scavenge free radicals in ischemic tissue is then impaired, thereby exacerbating the damage caused by these free radicals in the post ischemic reperfusion tissue. (frontiersin.org)
Reperfusion injury refers to the tissue damage inflicted when blood flow is restored after an ischemic period of more than about ten minutes. (benbest.com)
Neutrophils are the first immune cells that infiltrate the damaged tissue as early as 24 h after injury. (springer.com)
The process is present during normal myocyte development and is activated in response to cell injury and results in the removal of the injured cell without damaging surrounding tissue. (latestfashiontips.com)

In addition, the present study indicated that treatment with GP suppressed the I/R-induced increase in the pro-apoptotic protein levels of Bax and cytochrome c and the activity of caspase-3/8, as well as the I/R-induced decrease in the levels of anti-apoptotic protein Bcl‑2. (spandidos-publications.com)
Bcl-2 proteins are classified into 2 groups: the antiapoptotic protein Bcl-2 and the pro-apoptotic protein Bax [ 10 ]. (einj.org)

Therefore, in the present study, we evaluated the effect of mitochondrial complex 1 inhibition by rotenone on the chronic renal damage induced by acute ischemia-reperfusion. (oncotarget.com)

Compared to the myocardial ischemia group, the DOEO pretreatment groups had lower levels of myocardial injury, creatinine kinase, lactate dehydrogenase, alanine transaminase, aspartate transaminase, hydrogen peroxide, and nitric oxide, and higher levels of glutathione and superoxide dismutase. (wjtcm.net)
Another set of 8 rabbits was subjected to 60 min of ischemia and administered antioxidants (acetylsalicylic acid, ascorbic acid, allopurinol, quercetin, superoxide dismutase) before reperfusion. (edu.gh)

Cardiac ischemia-reperfusion injury (IRI) occurs intra-operatively during heart transplantation (HTx), underpinning graft survival. (uwo.ca)
Cardiac ischemia-reperfusion injury (IRI) occurs when transplanting a heart from donor to recipient. (uwo.ca)
Cardiac surgery-associated acute kidney injury (CSA-AKI) occurs in ≥50% of patients with chronic kidney disease (CKD) undergoing cardiac surgery with cardiopulmonary bypass (CPB) 2 . (nature.com)
This is an important feature of apoptotic cell death/removal that occurs during development and cellular injury. (latestfashiontips.com)

Apoptotic pathways in ischemic acute renal failure. (bmj.com)
Danger-associated molecular patterns (DAMPs) are endogenous ligands released from renal tubular cells following ischemia/reperfusion injury that activate the complement system through the classical, lectin and alternative pathways. (nature.com)

The role of complement dysregulation on vascular endothelial cells has been well established in atypical hemolytic uremic syndrome (aHUS), a thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and target organ injury. (jrheum.org)
1 - 3 Acute kidney injury is a common prominent feature of the disease, owing to the susceptibility of the glomerular circulation to endothelial damage. (jrheum.org)

Short-term cardiac stress, induced by ischemia-reperfusion (I/R) injury resulted in impaired left ventricular (LV) recovery and increased infarct size in heterozygous Hmox1-deficient (Hmox1 +/− ) mice [ 55 ]. (springer.com)
After the end of reperfusion phase mice were sacrificed, blood samples were collected directly from the heart for determination of serum TNF-a, IL-6, urea and Creatinine. (biomedcentral.com)
When subjected to myocardial ischemia-reperfusion injury, Caspase3 transgenic mice showed increased infarct size and a pronounced susceptibility to die. (uniroma5.it)
After three days of I/R injury, rotenone at a dose of 200 ppm in food was administered to the mice. (oncotarget.com)

Zhang Y, Irwin MG, Wong TM (2004) Remifentanil preconditioning protects against ischemic injury in the intact rat heart. (springer.com)
D. odorifera may be a potential candidate drug for treating myocardial ischemic injury. (wjtcm.net)
From the morphological and nano-mechanical changes in heart mitochondria, we suggested that the outer membranes of mitochondria were broken by myocardial ischemic injury before they became swollen, and the swelling might be correlated with the ischemic injury. (elsevierpure.com)

Activation of Kupffer cells and neutrophils leads to release of inflammatory cytokines and free radicals, which further aggravate liver injury [ 4 , 5 ]. (ijbs.com)

This study was aimed to investigate the protective role of baicalin on vascular endothelium exposed to ischemia reperfusion injury and the involved molecular mechanisms. (medscimonit.com)

8 , 11 - 14 Numerous stimuli can drive the activation of the complement system, including apoptotic debris, pathogens, and antibody-antigen complexes, in addition to ischemia-reperfusion injuries associated with organ transplantation. (jrheum.org)

Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling positive cells and expression of Bcl-2 and Bax in the hippocampal CA1 region were assessed after reperfusion. (springer.com)
It was found that methane significantly prolonged rat survival, decreased the W/D ratio, alleviated LPS-induced histological changes, and reduced apoptotic cells in the testes. (hindawi.com)
As time goes on, the number of apoptotic cells increases and the number of apoptotic cells increases. (crimsonpublishers.com)
An increase in the number of TUNEL-positive cells is reflective of apoptotic cell death [ 3 , 6 , 8 ]. (einj.org)
Further analyses have shown its anti-inflammatory and anti-apoptotic roles in human cells. (encyclopedia.pub)
Objective: To investigate the morphological effects of free radical injury on spermatogenic cells in both testes of the rabbit experimental model of testicular torsion. (edu.gh)
Results: In the 24-hour reperfusion group, apoptotic bodies and giant cells were more prominent in the seminiferous tubules of the left testes compared to the right, and were maximal after 90 min. (edu.gh)
In the 3-month reperfusion group, giant cells were absent, and apoptotic bodies were reduced in both testes. (edu.gh)
BMMSCs showed significant protective effects on the ultrastructure of DCD donor livers and ROS-induced injury to IAR-20 cells under electron microscopy. (medscimonit.com)
Heart failure is characterized by a significant increase in apoptotic myocyte death in spite of the enhanced expression of antiapoptotic gene products in the cells. (latestfashiontips.com)

In this way, caspases recruit and activate proteins involved in the apoptotic process (eg, caspase-dependent endonuclease), inactivate survival proteins (eg, the extracellularly responsive kinases and the DNA repair enzyme poly-ADP-ribosyl polymerase), and act directly on cytoskeletal proteins, resulting in plasma membrane changes. (latestfashiontips.com)

DOEO has a therapeutic effect on MI by inhibiting the oxidant and apoptotic effects. (wjtcm.net)

During the transient loss of p38 activity there was a temporary Fas-induced increase in phosphatidylinositol 3-kinase (PI3K) activity, which also had a pro-apoptotic impact on the neutrophils. (lu.se)
Consequently, PP2A can increase the activity of caspase 3 by dual mechanisms and thereby promote the apoptotic response in human neutrophils. (lu.se)

Inhaled methane limits mitochondrial electron transport chain dysfunction and confers protection against mitochondrial dysfunction during experimental liver ischemia-reperfusion injury [ 11 ]. (hindawi.com)
The experimental setup is a platform that can be used to conduct further studies on uterine ischemia- and reperfusion injury that may lead to improved human uterus transplantation protocols. (nih.gov)
Hashmi, S & Al-Salam, S 2015, ' Acute myocardial infarction and myocardial ischemia-reperfusion injury: A comparison ', International Journal of Clinical and Experimental Pathology , vol. 8, no. 8, pp. 8786-8796. (uaeu.ac.ae)

Because mitochondrial swelling is one of the most important indicators of the beginning of mitochondrial permeability transition, quantification of morphological changes in mitochondria would be useful in evaluating the degree of IR injury, as well as the protective effects of various therapies. (elsevierpure.com)

The degree of apoptotic cell death following ischemia/reperfusion may be reduced by the use of caspase inhibitors, antioxidants, and ischemic preconditioning. (latestfashiontips.com)
Our IR model showed enhanced pro-apoptotic mediators like cleaved caspase-3 (P=0.005) and cytochrome c in the myocardium as compared to the MI model. (aku.edu)
Meanwhile, the enhanced inflammatory markers of TNF-α, IL-1β, IL-6, and IL-18 and apoptotic markers of Bax and caspase-3 were all significantly blunted by inhibiting mitochondrial complex-1. (oncotarget.com)

Materials and Methods: The left testes of 8 peripubertal NZW rabbits (3-6 months) were subjected to 0, 15, 30, 60, 90, 120, and 180 min of ischemia by applying a clamp to the spermatic cord, followed by reperfusion. (edu.gh)
Testicular MDA showed an increase only in the left testes in the 24-hour reperfusion group, while the 3-month group showed increased MDA levels in both testes, but more on the left. (edu.gh)
The Johnsen score fell only to 8.0 in the left testes in the 24-hour reperfusion group, but dropped to 2.3 in the 3-month reperfusion group. (edu.gh)
Only in the 3-month reperfusion group, did antioxidant-treated animals show a fall in Johnsen scores in the left testes, regardless of the type of antioxidant. (edu.gh)

Therefore, we hypothesized that DLC1β overexpression (OE) had anti-apoptotic effects. (uwo.ca)

Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay can detect DNA fragmentation, which is a characteristic of apoptotic cell death. (einj.org)
Apoptotic cell death follows well-defined time-depend-ent processes, which result in changes in the plasma membrane, proteolysis of intracellular proteins, loss of mitochondrial function, and characteristic DNA cleavage. (latestfashiontips.com)
This anatomic condition is characterized by diastolic overloading, sarcomere stretching, apoptotic cell death, and side-to-side slippage of myocytes within the wall. (latestfashiontips.com)

Thrombotic microangiopathy (TMA) is a well-known clinicopathologic entity characterized by microangiopathic hemolytic anemia, thrombocytopenia, and organ injury. (jrheum.org)
This model proved to be able to distinguish reperfusion injury-related differences associated to organ preservation. (nih.gov)

Management of acute kidney injury: core curriculum 2018. (bmj.com)

Strikingly, after three weeks treatment with rotenone, we found that the unilateral I/R-induced tubular damage, tubulointerstitial fibrosis were all attenuated by rotenone as determined by the tubular injury score, Masson staining, and the levels of collagen-I, collagen-III, fibronectin, PAI-1, and TGF-β. (oncotarget.com)

I/R is a common pathological disorder leading to acute liver injury, a potentially life-threatening clinical condition with high morbidity, mortality, and prolonged patient hospitalization. (ijbs.com)

However, if we can understand how this damage happens, we may be able to develop strategies to avoid this injury in future. (uwo.ca)
Ischemia and reperfusion can cause serious brain damage in stroke or cardiac arrest. (benbest.com)
However, a much faster and severe reperfusion damage of all uterine layers were evident during the reperfusion experiment following 48 hours of cold ischemia. (nih.gov)

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