ApoELipoproteinExpression of apolipoproteinApoE4PolymorphismAllelesLipoproteinsAtherosclerosisCholesterolELISAApoA1LipidsMonoclonal AntibodyMetabolismGeneSerumAntibodyKnockout miceAlleleApoB-48Neurodegenerative diseasesAlzheimer'sTriglyceridesHypercholesterolemiaIschemic strokeDeficiencyDetectsSignificantlyBiomarkersHumansApoA4AntigenAtheroscleroticProtein componentMolecular weightClinicalSolubleRiskVitaminPeptideRegulationConcentrationDetection
ApoE19
- Apolipoprotein E (apoE) plays an important role in the transport and uptake of cholesterol by way of its high affinity interaction with lipoprotein receptors, including the low-density lipoprotein (LDL) receptor. (wikipedia.org)
- Recent findings with apoA1 and apoE suggest that the tertiary structures of these two members of the human exchangeable apolipoprotein gene family are related. (wikipedia.org)
- Apolipoprotein E (APOE) gene variants have been reported to influence psoriasis risk. (hindawi.com)
- Lipid metabolism in the epidermis may be regulated by the expression of apolipoprotein E (APOE), a glycoprotein which is synthesized in a wide variety of extrahepatic tissues including skin [ 27 - 29 ]. (hindawi.com)
- Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. (dovepress.com)
- The apolipoprotein E (APOE) gene is located on chromosome 19 and encodes a glycoprotein that is 299 amino acids long. (dovepress.com)
- The relation of hypercholesterolemia and apolipoprotein E (ApoE) to cerebral aneurysm formation, has been unclear until now. (spandidos-publications.com)
- The apolipoprotein E (ApoE) polymorphism has been well studied in the adult human population, in part because the e4 allele is a known risk factor for Alzheimer's disease. (bmj.com)
- Genetic analysis of families with Alzheimer disease has revealed a disease-associated variant of the APOE gene, which encodes apolipoprotein E, a transporter of lipids in the blood and central nervous system. (columbia.edu)
- This study examines the distribution of apolipoprotein E (APOE) alleles in a population of healthy male and female Norwegians (n = 798) below the age of 40. (wayne.edu)
- Objective: To evaluate associations between established differences in ICH risk by race/ethnicity and the variability in the risks of apolipoprotein E (APOE) ε4 alleles, the most potent genetic risk factor for ICH. (ox.ac.uk)
- Methods: Aortic plaque deposition was assessed in streptozotocin-induced diabetic apolipoprotein E (Apoe) knockout (KO) and At 2 r (also known as Agtr2)/Apoe double-KO (DKO) mice. (monash.edu)
- Apolipoprotein E (ApoE) is expressed as Molecular Biology of Neurodegenerative Diseases. (web.app)
- APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. (web.app)
- Apolipoprotein E spielt im Katabolismus von Chylomikronen, IDL und VLDL-Remnants wie auch von ApoE-reichem HDL eine wichtige Rolle. (web.app)
- Apolipoprotein E (APOE) plays an important role in cholesterol transport and genetic variants in APOE have been linked to the risk of Alzheimer's disease. (web.app)
- 2020-08-16 · The APOE gene provides instructions for making a protein called apolipoprotein E. This protein combines with fats (lipids) in the body to form molecules called lipoproteins. (web.app)
- APOE / Apolipoprotein E Protein LS-G39871 is a Recombinant Human APOE / Apolipoprotein E produced in Human Cells Lys19-His317 with 6His, C-terminus tag(s). (web.app)
- Thank you for your interest in NeuroMab™ Mouse Anti-Apolipoprotein E/APOE Monoclonal Antibody (CBP2519) . (creative-biolabs.com)
Lipoprotein14
- However, because of their detergent-like (amphipathic) properties, apolipoproteins and other amphipathic molecules (such as phospholipids) can surround the lipids, creating a lipoprotein particle that is itself water-soluble, and can thus be carried through body fluids (i.e., blood, lymph). (wikipedia.org)
- In addition to stabilizing lipoprotein structure and solubilizing the lipid component, apolipoproteins interact with lipoprotein receptors and lipid transport proteins, thereby participating in lipoprotein uptake and clearance. (wikipedia.org)
- In lipid transport, apolipoproteins function as structural components of lipoprotein particles, ligands for cell-surface receptors and lipid transport proteins, and cofactors for enzymes (e.g. apolipoprotein C-II for lipoprotein lipase and apolipoprotein A-I (apoA1) for lecithin-cholesterol acyltransferase). (wikipedia.org)
- Apolipoprotein B plays a particularly important role in lipoprotein transport being the primary organizing protein of many lipoproteins. (wikipedia.org)
- Apolipoprotein M (apoM) participates in the lipid metabolism and exhibit anti‑atherosclerotic functions and it is presented in high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL). (wikipedia.org)
- Each lipoprotein is characterized by its lipid composition and by the type and number of apolipoproteins it possesses. (medscape.com)
- these apolipoproteins have lipid-soluble segments, the beta apolipoproteins, which remain part of the lipoprotein throughout its metabolism. (medscape.com)
- Apolipoprotein B binds to specific receptors on cell membranes and is involved in removal of LDL and very low density lipoprotein (VLDL) cholesterol from circulation. (thermofisher.com)
- Apolipoprotein B is mostly synthesized in the liver, and is a major apolipoprotein of very low density, intermediate density and low density lipoproteins (LDL) as well as being a major component of lipoprotein (a). (thermofisher.com)
- Apo E (Apolipoprotein E) plays an important role in the metabolism of lipids in the plasma, and is also is a constituent of various plasma lipoprotein-lipid particles. (thermofisher.com)
- ApoC-III (apolipoprotein C-III), an important regulator of lipoprotein metabolism, is strongly associated with hypertriglyceridaemia and the progression of CVD. (portlandpress.com)
- Apolipoprotein A-I (apo A-I), the main protein component of high-density lipoprotein (HDL), reduces the risk for atherosclerosis by removing cholesterol from the membrane of foam cells. (edpsciences.org)
- Apolipoprotein B (apoB) is a structural protein that constitutes a major component of the very-low-density lipoprotein (VLDL), the intermediate-density lipoprotein (IDL), and the low-density lipoprotein (LDL). (medscape.com)
- The present study aimed to examine the association between discordant apolipoprotein B ( Apo B ) with low-density lipoprotein cholesterol (LDL-C) or non- high-density lipoprotein cholesterol (non-HDL-C) and cardiovascular disease (CVD) risk in the Chinese population and to determine whether adding information on Apo B to LDL-C and HDL-C improves CVD risk prediction. (bvsalud.org)
Expression of apolipoprotein1
- Background: We have previously demonstrated that estrogen could significantly enhance expression of apolipoprotein M (apoM), whereas the molecular basis of its mechanism is not fully elucidated yet. (lu.se)
ApoE42
Polymorphism2
- In the article "Association between Apolipoprotein E Polymorphism and Clinical Outcome after Ischemic Stroke, Intracerebral Hemorrhage, and Subarachnoid Hemorrhage" [Cerebrovasc Dis 2022;51:313-322. (karger.com)
- The apolipoprotein E polymorphism and the cholesterol-raising effect of coffee. (web.app)
Alleles1
- Apolipoprotein E alleles, dyslipidemia, and coronary heart disease: the Framingham Off spring Study. (web.app)
Lipoproteins10
- Apolipoproteins are proteins that bind lipids (oil-soluble substances such as fats, cholesterol and fat soluble vitamins) to form lipoproteins. (wikipedia.org)
- citation needed] Different lipoproteins contain different classes of apolipoproteins, which influence their function. (wikipedia.org)
- Apolipoprotein A-I (apoA1) is the major structural protein component of high-density lipoproteins (HDL), although it is present in other lipoproteins in smaller amounts. (wikipedia.org)
- Apolipoprotein A-IV (apoA4) is present in chylomicrons, very-low-density lipoproteins (VLDL), and HDL. (wikipedia.org)
- Apolipoprotein C-III (apoC3) plays an important role in lipid metabolism specific in regulating the metabolism of triglyceride-rich lipoproteins (TRLs). (wikipedia.org)
- Regulation and clearance of apolipoprotein B-containing lipoproteins. (medlineplus.gov)
- Other apolipoproteins (A, C, D, E, and their subtypes) are soluble and are exchanged between lipoproteins during metabolism. (medscape.com)
- Apolipoprotein B (apo B) in human plasma is a major protein of low density lipoproteins (LDL) with a molecular mass of approximately 260-500 kDa. (thermofisher.com)
- Apolipoprotein AI (Apo AI) is one of the apoproteins of high-density lipoproteins (HDL). (southtees.nhs.uk)
- Apolipoprotein E is the recognition site for receptors involved in the clearance of remnants of very low density lipoproteins and chylomicrons (summary by Blum, 2016). (web.app)
Atherosclerosis2
- Apolipoprotein B is a ligand for the LDL receptor and elevated levels are associated with premature atherosclerosis. (thermofisher.com)
- Ala-Korpela, M 2019, ' The culprit is the carrier, not the loads: cholesterol, triglycerides and apolipoprotein B in atherosclerosis and coronary heart disease ', International Journal of Epidemiology , vol. 48, no. 5, pp. 1389-1392. (bris.ac.uk)
Cholesterol6
- Apolipoprotein B100 (apoB100) is a protein that plays a role in moving cholesterol around your body. (medlineplus.gov)
- These particles consist of a core of cholesterol esters and triglycerides surrounded by a monolayer of free cholesterol, phospholipids, and proteins (apolipoproteins). (medscape.com)
- Apolipoprotein E is a monomeric protein secreted by the liver and responsible for the transport of plasma cholesterol and triglycerides. (edu.au)
- Maintaining normal levels of cholesterol is essential for the Apolipoprotein E has been found in amyloid plaques in the cerebral cortex of patients with Alzheimer's disease as well as in other types of amyloid. (web.app)
- Subjects with hyperhomocysteinaemia had significantly elevated total cholesterol, LDL cholesterol, apolipoprotein A and apolipoprotein B and lower vitamin B levels compared with subjects with 12 normohomocysteinaemia. (who.int)
- Hcy levels correlated with total cholesterol ( r = 0.09), apolipoprotein A ( r = 0.012), and B ( r = 0.013) levels and total/HDL cholesterol ratio ( r = -0.085). (who.int)
ELISA2
- MIA1609 targets Apolipoprotein B in ELISA, IP and RIA applications and shows reactivity with Human samples. (thermofisher.com)
- Mouse Apolipoprotein B48 (apo-B48) ELISA Kit is Available at Gentaur Genprice with the fastest delivery. (joplink.net)
ApoA11
- Members of the apolipoprotein gene cluster (APOA1/C3/A4/A5) on human chromosome 11q23 play an important role in lipid metabolism. (doe.gov)
Lipids3
- Major lipids, apolipoproteins, and risk of vascular disease. (ox.ac.uk)
- CONTEXT: Associations of major lipids and apolipoproteins with the risk of vascular disease have not been reliably quantified. (ox.ac.uk)
- OBJECTIVE: To assess major lipids and apolipoproteins in vascular risk. (ox.ac.uk)
Monoclonal Antibody1
- The following product was used in this experiment: Apolipoprotein B Monoclonal Antibody (F2C9) from Thermo Fisher Scientific, catalog # MIA1609, RRID AB_11152638. (thermofisher.com)
Metabolism1
- Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism, neurobiology, and neurodegenerative diseases. (web.app)
Gene3
- The intestinal and the hepatic forms of Apolipoprotein B are encoded by a single gene from a single, very long mRNA. (thermofisher.com)
- The apolipoprotein A-I gene is actively expressed in the rapidly myelinating avian peripheral nerve. (rupress.org)
- The expression of the apolipoprotein A-I (apo A-I) gene was investigated in the myelinating sciatic nerve. (rupress.org)
Serum3
- In an immunochemical reaction, Apolipoprotein B in the human serum sample form immune complexes with specific antibodies. (cdc.gov)
- Thus, we established an MRM method to quantify 9 adipokines and 10 apolipoproteins in human serum. (uni-ulm.de)
- In 50 serum samples from participants with either normal weight or obesity, we quantified 8 adipokines and 10 apolipoproteins. (uni-ulm.de)
Antibody2
- The following product was used in this experiment: Apolipoprotein E Polyclonal Antibody from Thermo Fisher Scientific, catalog # BS-4892R. (thermofisher.com)
- PVDF membrane was probed with 0.25 µg/mL of Sheep Anti-Mouse/Rat Apolipoprotein H/ApoH Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6575) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016 ). (rndsystems.com)
Knockout mice1
- Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout mice. (cdc.gov)
Allele3
- 1997) No association between apolipoprotein E epsilon4 allele and the age of onset in type I familial amyloid polyneuropathy. (web.app)
- 1-3 Although individuals carrying the ε4 allele have higher and those carrying the Apolipoprotein (apo) E is a 299‐residue protein which functions as a key regulator of plasma lipid levels. (web.app)
- 2011. The apolipoprotein E ε4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase. (creative-biolabs.com)
ApoB-481
- Normal plasma apolipoprotein B levels are around 800mg/L. Apolipoprotein B occurs in plasma as two main isoforms, apoB-48 and apoB-100. (thermofisher.com)
Neurodegenerative diseases1
- Apolipoprotein E Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases. (web.app)
Alzheimer's1
- 2011. High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease. (creative-biolabs.com)
Triglycerides1
- Apolipoprotein F (apoF) is one of the minor apolipoprotein in blood plasma and it is a lipid transfer inhibit protein to inhibit cholesteryl ester transfer protein-mediated transfers of cholesteryl esters and triglycerides. (wikipedia.org)
Hypercholesterolemia1
- Familial hypercholesterolemia (FH) due to a founder variant in Apolipoprotein B (ApoB R3500Q ) is reported in 12% of the Pennsylvania Amish community. (clinicforspecialchildren.org)
Ischemic stroke1
- Benn M, Nordestgaard BG, Jensen JS, Tybjaerg-Hansen A. Polymorphisms in apolipoprotein B and risk of ischemic stroke. (prosci-inc.com)
Deficiency2
- Aoki T, Moriwaki T, Takagi Y, Kataoka H, Yang J, Nozaki K and Hashimoto N: The efficacy of apolipoprotein E deficiency in cerebral aneurysm formation. (spandidos-publications.com)
- Low apoB levels may indicate Bassen-Kornzweig syndrome (abetalipoproteinemia), a very rare genetic condition characterized by apolipoprotein B deficiency. (medscape.com)
Detects2
- MIA1609 detects Apolipoprotein B which has a predicted molecular weight of approximately 502 kDa. (thermofisher.com)
- Detects mouse and rat Apolipoprotein H/ApoH in Western blots and detects recombinant mouse Apolipoprotein H/ApoH in direct ELISAs. (rndsystems.com)
Significantly2
- In addition, apolipoprotein B significantly decreased only in females (p = 0.002). (nih.gov)
- Significantly different abundances were observed for five adipokines (adipsin, adiponectin, chemerin, leptin, vaspin) and four apolipoproteins (apo-B100/-C2/-C4/-D) between the body mass index (BMI) groups. (uni-ulm.de)
Biomarkers1
- Adipokines and apolipoproteins are key regulators and potential biomarkers in obesity and associated diseases and their quantitative assessment is crucial for functional analyses to understand disease mechanisms. (uni-ulm.de)
Humans1
- Apolipoprotein A4's (APOA4's) functions on HDL in humans are not well understood. (jci.org)
ApoA41
- A unique feature of APOA4 is that it is an intestinal apolipoprotein secreted on HDL and chylomicrons. (jci.org)
Antigen1
- Macrophage-derived apolipoprotein (apo) E and multimers of a synthetic apo E-peptide display monokine-like functions by inhibiting mitogen- or antigen-driven lymphocyte proliferation. (jci.org)
Atherosclerotic1
- Apolipoprotein AI is used in the evaluation of risk for atherosclerotic disease and the detection of Tangier disease. (southtees.nhs.uk)
Protein component1
- Apolipoprotein B is the main protein component of LDL and accounts for approximately 95% of the total protein content of LDL. (cdc.gov)
Molecular weight1
- Apolipoprotein H (ApoH), also known as beta 2‑Glycoprotein I/ beta 2-GPI, is a variably glycosylated member of the complement control superfamily of proteins with a molecular weight of aproximately 50 kDa (1, 2). (rndsystems.com)
Clinical1
- In summary, this multiplexed assay facilitated the investigation of relationships between adipokines or apolipoproteins and phenotypes or clinical parameters in large cohorts, which may contribute to disease prediction approaches in the future. (uni-ulm.de)
Soluble1
- Apolipoprotein D (apoD) is a soluble carrier protein of lipophilic molecules in neurons and glial cells within the central and peripheral nervous system and apoD can also modulate the stability and oxidation status of these molecules. (wikipedia.org)
Risk5
- Apolipoprotein measurements may provide more detail about your risk for heart disease, but the added value of this test beyond a lipid panel is unknown. (medlineplus.gov)
- Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity: A Meta-analysis. (ox.ac.uk)
- Apolipoprotein B (apoB) levels are used to evaluate the risk for cardiovascular disease. (medscape.com)
- Some evidence has shown that the capacity of the apoB/apoA-I ratio in assessing cardiovascular risk is strong and may be better than the use of apolipoprotein B alone. (medscape.com)
- Apolipoprotein Particle and Cardiovascular Risk Prediction (from a Prospective Cohort Study). (bvsalud.org)
Vitamin1
- The sexual dimorphism observed in circulating levels of measured apolipoproteins following vitamin D correction may explain, in part, known sexual disparity in the events of cardiometabolic health. (nih.gov)
Peptide1
- The objective of this study was to develop an atheroprotective vaccine by targeting a peptide of the LDL protein constituent apolipoprotein B-100 (apoB-100) to the nasal mucosa to induce a protective mucosal immune response. (lu.se)
Regulation1
- Epistatic Interactions between apolipoprotein E and hemoglobin S Genes in regulation of malaria para. (edu.au)
Concentration1
- The intensity of the scattered light is proportional to the concentration of Apolipoprotein B in the sample. (cdc.gov)
Detection1
- Detection of Rat and Mouse Apolipoprotein H/ApoH by Western Blot. (rndsystems.com)