Analysis of Protein Array containing more than 19,000 full-length human proteins using Clusterin / APOJ Mouse Monoclonal Antibody (CLU/4730) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. (neobiotechnologies.com)
The antibody was raised in rabbits by immunization with the recombinant Rat Clusterin. (biovendor.com)
The best quality, top Clusterin/ Apolipoprotein J RMab Antibody, Clusterin/ Apolipoprotein J RMab Antibody, Clusterin/ Apolipoprotein J RMab Antibody, Clusterin/ Apolipoprotein J RMab Antibody, Clusterin/ Apolipoprotein J RMab Antibody products prices, the best delivery. (monclonals.com)
Regulates clusterin2
18. GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer. (nih.gov)
Transforming growth factor beta regulates clusterin gene expression via modulation of transcription factor c-Fos. (musc.edu)
APOE5
In this study, we reviewed the loci related to phenotypes of AD, MCI and SCD from literature and performed the first meta-analyses evaluating the role of apolipoprotein E (APOE) in the risk of conversion from a healthy status to MCI and SCD. (nih.gov)
In MCI syndrome, APOE is confirmed as a pheno-conversion factor leading from MCI to AD, and clusterin is a promising candidate. (nih.gov)
Recent genome wide association (GWA) studies reported that the allele 4 of apolipoprotein E (APOE) and single nucleotide polymorphisms (SNPs) in other genes that regulate inflammatory pathways, such as the gene coding for clusterin (CLU), are associated with AD. (unibo.it)
Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. (icr.ac.uk)
Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells (By similarity). (icr.ac.uk)
Extracellular chaperone2
One tempting hypothesis says that clusterin is an extracellular chaperone protecting cells from stress induced by degraded and misfolded protein precipitates.Clus-terin is up- or downregulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others. (biovendor.com)
The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide. (nih.gov)
Protein6
Clusterin (apolipoprotein J) is a 75-80 kDa disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apoptosis. (wikipedia.org)
It was shown that dermcidin is the most abundant sweat protein, and along with apolipoprotein D, clusterin, prolactin-inducible protein and serum albumin, they make up 91% of secreted sweat proteins. (nih.gov)
5. IR-inducible clusterin gene expression: a protein with potential roles in ionizing radiation-induced adaptive responses, genomic instability, and bystander effects. (nih.gov)
8. Repression of IR-inducible clusterin expression by the p53 tumor suppressor protein. (nih.gov)
Clusterin is a 75-80 kD disulfide-linked heterodimeric protein containing about 30% of N-linked carbohydrate rich in sialic acid, but truncated forms targeted to the nucleus have also been identified. (biovendor.com)
Clusterin is a heavily N-glycosylated protein. (biovendor.com)
Proteins6
6. Regulation of clusterin/apolipoprotein J, a functional homologue to the small heat shock proteins, by oxidative stress in ageing and age-related diseases. (nih.gov)
Specific proteins responsible for stealth effect, such as apolipoprotein A-I, apolipoprotein A-IV, and clusterin, are present in large amounts on the PEGylated NCs. (rsc.org)
Combination of plasma tumor necrosis factor receptors signaling proteins, beta-amyloid and apolipoprotein E for the detection of Alzheimer's disease. (cdc.gov)
While the role of apolipoproteins and low-density lipoproteins (LDL) in cardiovascular disease (CVD) has been understood for some time, emerging research is revealing that these proteins may prove to be valuable biomarkers beyond CVD. (bioradiations.com)
Along with other proteins, apolipoproteins bind lipids to form lipoproteins such as high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL). (bioradiations.com)
Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. (icr.ac.uk)
Complement1
Clusterin has been ascribed a plethora of functions such as phagocyte recruitment, aggregation induction, complement attack prevention, apoptosis inhibition, membrane remodelling, lipid transport, hormone transport and/or scavenging, matrix metalloproteinase inhibition. (biovendor.com)
Immunoaffinity chromatography on a column with immobilized recombinant Rat Clusterin. (biovendor.com)
Variants1
4. Non-secreted clusterin isoforms are translated in rare amounts from distinct human mRNA variants and do not affect Bax-mediated apoptosis or the NF-κB signaling pathway. (nih.gov)
Allele1
Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline. (nih.gov)
Apoptosis2
Glicoproteína heterodimérica, muy estable, que se expresa en muy diversos trastornos fisiológicos graves, como el CÁNCER, la APOPTOSIS y algunas TRASTORNOS NEUROLÓGICOS. (bvsalud.org)
Also known as clusterin, Apo J is associated with the clearance of cellular debris and apoptosis. (bioradiations.com)
Biomarkers2
However, recent studies indicate that apolipoproteins are critical biomarkers in many other diseases, from autoimmunity to cancer (Table 2). (bioradiations.com)
While cholesterol levels are still used to measure cardiovascular risk, apolipoproteins have emerged as relevant biomarkers for assessing the risk of various CVD and initiating prophylactic and therapeutic strategies. (bioradiations.com)
Cardiovascular diseases2
13. The physiological roles of apolipoprotein J/clusterin in metabolic and cardiovascular diseases. (nih.gov)
A component of HDL that has no marked similarity to other apolipoprotein sequences. (bioradiations.com)
Alzheimer's2
Two independent genome-wide association studies found a statistical association between a SNP within the clusterin gene and the risk of having Alzheimer's disease. (wikipedia.org)
Further studies have suggested that people who already have Alzheimer's disease have more clusterin in their blood, and that clusterin levels in blood correlate with faster cognitive decline in individuals with Alzheimer's disease, but have not found that clusterin levels predicted the onset of Alzheimer's disease. (wikipedia.org)
Chaperone3
1. The chaperone activity of clusterin is dependent on glycosylation and redox environment. (nih.gov)
3. The molecular chaperone apolipoprotein J/clusterin as a sensor of oxidative stress: implications in therapeutic approaches - a mini-review. (nih.gov)
Clusterin is ubiquitously expressed and appears to function as a secreted MOLECULAR CHAPERONE . (bvsalud.org)
Regulation1
7. Chapter 4: Regulation of Clusterin activity by calcium. (nih.gov)
19. Chapter 9: Oxidative stress in malignant progression: The role of Clusterin, a sensitive cellular biosensor of free radicals. (nih.gov)
Concentration1
Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment. (nih.gov)
Prostate2
15. Clusterin isoforms differentially affect growth and motility of prostate cells: possible implications in prostate tumorigenesis. (nih.gov)
17. mda-7/IL-24 differentially regulates soluble and nuclear clusterin in prostate cancer. (nih.gov)
Role2
According to Roxana Carare, MD PhD, at the University of Southampton, apolipoprotein J (also called clusterin) is being investigated for its role in chaperoning Amyloid Beta for brain waste clearance along the intramural periarterial pathway (IPAD). (amyloidangiopathy.com)
Background: Apolipoprotein J is the major secreted product of Sertoli cells and is thought to play a critical role in spermatogenesis. (idhinhibitor.com)
Brain1
20. Transcriptomes of Clusterin- and S100B-transfected neuronal cells elucidate protective mechanisms against hypoxia and oxidative stress in the hooded seal (Cystophora cristata) brain. (nih.gov)
Human2
10. Apolipoprotein J/Clusterin is a novel structural component of human erythrocytes and a biomarker of cellular stress and senescence. (nih.gov)
12. Novel nucleolar localization of clusterin and its associated functions in human oral cancers: An in vitro and in silico analysis. (nih.gov)
Clusterin was first identified in ram rete testis fluid where it showed signs of clustering with rat sertoli cells and erythrocytes, hence its name. (wikipedia.org)