- Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) binds to death receptors and induces apoptosis in various cancer cell lines while sparing normal cells. (oncotarget.com)
- The protein encoded by this gene is a member of the TNF-receptor superfamily. (wikipedia.org)
- In an HCT116 xenograft model ADI-TRAIL localized to the tumor and induced dose-dependent tumor regression, the fusion protein was superior to rhTRAIL administered at the same molar amounts. (oncotarget.com)
- TRAIL (also known as Apo2 ligand), is a trimeric protein, a TNF superfamily member, expressed as a type-II transmembrane protein and plays a physiological role in anti-tumor immune surveillance [ 1 - 6 ]. (oncotarget.com)
- Decoy receptor 1 (DCR1), also known as TRAIL receptor 3 (TRAILR3) and tumor necrosis factor receptor superfamily member 10C (TNFRSF10C), is a human cell surface receptor of the TNF-receptor superfamily. (wikipedia.org)
- These cellular processes are self-sufficiency in growth signals (oncogene addiction), insensitivity to growth-inhibitory signals (loss of tumor suppressors), evading programmed cell death (anti-apoptosis), limitless replication potential (aberrant cell cycle), sustained angiogenesis, and invasion/metastasis. (medscape.com)
- 10] Interestingly, breast basal-like tumors shared a number of molecular characteristics common to ovarian cancer such as the types and frequencies of genomic mutations, suggesting a related etiology and potentially similar responsiveness to some of the same therapies. (medscape.com)
- Decoy receptor 1 (DCR1), also known as TRAIL receptor 3 (TRAILR3) and tumor necrosis factor receptor superfamily member 10C (TNFRSF10C), is a human cell surface receptor of the TNF-receptor superfamily. (wikipedia.org)
- Many human tumor types with distinct genotypes have 6 essential alterations in cell physiology that appear to collectively dictate the malignant phenotype. (medscape.com)
- Many oncogenes (RAS, PI3K, KIT) and tumor suppressors (P53, RB, PTEN) are frequently mutated in different human malignancies. (medscape.com)