PCNAExtractable nuclearEBNAProliferatingAutoantibodiesProteinsMembraneAntibodyRibonucleoproteinSurface antigenLatent nuclearENAsProliferation-relatedEpstein-BarrViralMicroscopyCellsProteinCytoplasmicAutoimmune diseasesRepertoireClinicalPacientesImmune responsesTissueHumanSEARCHExperienced nuclear medicineMoleculesPresentationTestCellResultsSmall
PCNA6
- Proliferating cell nuclear Ag (PCNA) is overexpressed in cancer cells. (bgu.ac.il)
- This retrospective immunohistochemical study compares the expression of five stress-response (heat-shock) proteins (srp's) [srp 90, srp 72, srp 27, alpha B-crystallin and ubiquitin], p53 protein and proliferating cell nuclear antigen (PCNA) in 118 primary brain tumors and 21 carcinoma metastases to the central nervous system. (elsevierpure.com)
- Proliferating cell nuclear antigen (PCNA) and Ki-67 are such kind of molecular markers which may have prognostic significance in RCC and need to be studied about. (ijsurgery.com)
- Reference: Immunocytochemical identification of proliferative hepatocytes using monoclonal antibody to proliferating cell nuclear antigen (PCNA/cyclin). (neb.com)
- The authors investigated whether immunocytochemical staining with a monoclonal antibody to proliferating cell nuclear antigen (PCNA/cyclin) could be used to identify proliferative hepatocytes in frozen sections fixed in a mixture of periodate, lysine, and 2% paraformaldehyde. (neb.com)
- Tissue repair was assessed by proliferating cell nuclear antigen (PCNA) immunoreactivity and by expression of keratinocyte growth factor (KGF) mRNA by real-time PCR. (cdc.gov)
Extractable nuclear2
- An extractable nuclear antigen panel, or an ENA panel, tests for presence of autoantibodies in the blood that react with proteins in the cell nucleus. (wikipedia.org)
- Anti-RNP antibodies are directed against the U1 particle of an extractable nuclear antigen (ENA) named ribonucleoprotein,[9] which is made up of a complex of proteins and a small nuclear RNA named U1. (medscape.com)
EBNA2
- Here we use an integrative genomics approach in order to localize genetic factors influencing levels of Epstein Barr virus (EBV) nuclear antigen-1 (EBNA-1) IgG antibodies, as a measure of history of infection with this pathogen, in large Mexican American families. (edu.au)
- The presence or absence of EBV viral capsid antigen (VCA) IgG, VCA IgM and EBV nuclear antigen (EBNA) IgG antibodies was recorded. (who.int)
Proliferating5
- Brain tumor: immunohistochemical studies on the stress-response proteins, p53 protein and proliferating cell nuclear antigen. (elsevierpure.com)
- Dive into the research topics of 'Brain tumor: immunohistochemical studies on the stress-response proteins, p53 protein and proliferating cell nuclear antigen. (elsevierpure.com)
- In vivo studies demonstrated that the PFK15+bc2 treatment group had lower thickening of the ankle, less antigen specific autoantibodies and an increased population of proliferating Tregs. (aiche.org)
- Additionally, the PFK15+bc2 prevention group had an increased population of antigen specific Tregs and number of proliferating Tregs in the popliteal LNs. (aiche.org)
- Epithelial proliferating cell nuclear antigen staining was increased at 1 and 3 days post exposure and was similar in the two groups. (cdc.gov)
Autoantibodies8
- Autoantibodies to these antigens are associated with particular connective tissue disorders. (wikipedia.org)
- The diagnosis of autoimmune connective tissue diseases (CTDs) is done through analysis of clinical symptoms and signs, but also through the identification of the autoantibodies directed against nuclear antigens. (wikipedia.org)
- In this paper we report the use of Sm autoantibodies to isolate a cDNA clone for the mRNA of one of these nuclear antigens. (elsevierpure.com)
- This cloned Sm antigen comigrated with the small nuclear RNA-associated protein known as 'E' and reacted with four out of four Sm autoantibodies that precipitate E protein from total mRNA translation products. (elsevierpure.com)
- To study the frequency of different autoantibodies to extractable nuclear antigens (ENAs) in rheumatoid arthritis (RA) patients and to correlate findings with clinical manifestations, disease activity and radiological damage. (reumatologiaclinica.org)
- Here we show a method where local delivery of an antigen specific therapy can generate antigen-specific Tregs and reduce antigen-specific Th17, Th1 and autoantibodies in a collagen-induced arthritis (CIA) mouse model of RA. (aiche.org)
- These mice were then sacrificed on day 30, and the blood, spleen and lymph nodes (LNs) were harvested to analyze the presence of antigen specific autoantibodies, T cells, and antigen specific T cells. (aiche.org)
- Positive autoantibodies (anti-nuclear antigens, rheumatoid factor) 17. (who.int)
Proteins7
- Sera from patients with systemic lupus erythematosus and other autoimmune disorders contain antibodies against nuclear proteins. (elsevierpure.com)
- In light of existing evidence that the mammalian Sm antigen E is a weaker autoantigen than other small nuclear RNA-associated proteins, these results suggest a possible correlation between a protein's capacity to serve as an autoantigen during breakdown of the host's immunological tolerance and its extent of evolutionary conservation, whereas the inverse relationship applies to conventional immunity. (elsevierpure.com)
- The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). (nih.gov)
- My research focuses on understanding the intricate molecular mechanisms that determine the vast repertoire of peptide antigens displayed by the proteins of the Major Histocompatibility Complex for immune surveillance by T cells and Natural Killer cells. (upenn.edu)
- Our detailed biophysical characterization of the molecular chaperone TAPBPR provided us with a high-resolution view of peptide exchange on MHC-I proteins and led to the development a high-throughput methodology for generating barcoded MHC tetramer libraries encompassing hundreds of unique antigen specificities. (upenn.edu)
- Poly(ADP-ribose) polymerase-1 (PARP-1) is an abundant and ubiquitous nuclear protein that uses NAD + to synthesize a multibranched polyanion composed of ADP-ribose moieties, giving rise to poly(ADP-ribose) (PAR), onto itself or a variety of target proteins. (nature.com)
- [ 9 ] which is made up of a complex of proteins and a small nuclear RNA named U1. (medscape.com)
Membrane3
- Evangelista L, Cuppari L, Zattoni F, Mansi L, Bombardieri E. The future of choline PET in the era of prostate specific membrane antigen. (minervamedica.it)
- Both prostate-specific membrane antigen (PSMA) PET/CT and ferumoxtran-10 nanoparticle-enhanced MRI (nano-MRI) are imaging modalities with high potential to identify LN metastases in PCa patients. (snmjournals.org)
- Background: In prostate cancer (PCa), questions remain on indications for prostate-specific membrane antigen (PSMA) positron emission tomography (PET) imaging and PSMA radioligand therapy, integration of advanced imaging in nomogram-based decision-making, dosimetry, and development of new theranostic applications. (lu.se)
Antibody5
- For example, Scl-70 antigen is less negatively charged, which can result in the antigen traveling in the same direction as the antibody. (wikipedia.org)
- Formalin-fixed, paraffin-embeddedhuman tonsil stained with Pan-Nuclear AntigenRecombinant Mouse Monoclonal Antibody (rNM106). (neobiotechnologies.com)
- The extractable nuclear antigens test or the ENA test is prescribed as a follow-up test when the antinuclear antibody tests yield a positive report. (flebo.in)
- Mib-1 monoclonal antibody recognizes the proliferation-related antigen Ki-67. (lu.se)
- 10] Ribonucleoprotein is part of the splicosome and also includes Smith (Sm) antigen, which is the target of the anti-Smith antibody and is frequently positive in SLE. (medscape.com)
Ribonucleoprotein4
- Most ENAs are part of spliceosomes or nucleosomes complexes and are a type of small nuclear ribonucleoprotein (snRNPS). (wikipedia.org)
- Small nuclear ribonucleoprotein D3 polypeptide 18kDa, Sm-D3, snRNP core protein D3. (prospecbio.com)
- SNRPD3 is a small nuclear ribonucleoprotein (snRNPs) that contains the spliceosome in eukaryotes. (prospecbio.com)
- SNRPD3 is essential for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. (prospecbio.com)
Surface antigen1
- 5. That a Hepatitis B surface antigen test not be performed if the person requesting the test indicates that the test is for a prenatal assessment. (ontario.ca)
Latent nuclear1
- Kaposi's sarcoma is the most common neoplasia diagnosed in AIDS patients and the expression of the human herpesvirus-8 (HHV-8) latent nuclear antigen-1 has been useful for its histological diagnosis. (fiocruz.br)
ENAs1
- Extractable nuclear antigens (ENAs) are over 100 different soluble cytoplasmic and nuclear antigens. (wikipedia.org)
Proliferation-related1
- Assignment of the gene(s) involved in the expression of the proliferation-related Ki-67 antigen to human chromosome 10. (ijsurgery.com)
Epstein-Barr3
- ZHAN De-Jin, CHEN Jian-Jing.Study on expression of Epstein-Barr virus nuclear antigens in various infected states of cells .VIROLOGICA SINICA, 1994, 9(1): 13. (virosin.org)
- Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle. (ox.ac.uk)
- The Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is a sequence-specific DNA-binding protein that plays an essential role in viral episome replication and segregation, by recruiting the cellular complex of DNA replication onto the origin (oriP) and by tethering the viral DNA onto the mitotic chromosomes. (ox.ac.uk)
Viral1
- A Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen Micropolymorphism. (expasy.org)
Microscopy1
- Epstein, A.L. and Clevenger, C.V., Identification of nuclear antigens in human cells by immunofluorescence, immunoelectron microscopy, and immuno-biochemical methods using monoclonal antibodies. (neobiotechnologies.com)
Cells13
- These included presumptive amacrine cells of the inner nuclear layer and either displaced amacrine cells or ganglion cells of the ganglion cells of the ganglion cell layer. (nih.gov)
- Therefore, Fos or a related antigen is expressed in a subset of retinal neurons in response to light and is presumably involved in regulating gene expression of these cells to respond to alterations in synaptic activity. (nih.gov)
- This MAb recognizes an antigen associated with the nuclei in all cells. (neobiotechnologies.com)
- To this end, we assessed the relative frequency of mitotic phases and nuclear damage (detected by in situ end-labeling of DNA strand breaks) in CD30+ large cells of nodular sclerosis and mixed cellularity HD. (nih.gov)
- Our results show that a) most CD30+ cells in HD exhibit abortive mitoses, with a highly significant arrest at the metaphase-ana/telophase transition, and b) many of these elements, i.e. mainly H-RS cells, show fragmentation of nuclear DNA, suggesting imminent or actual death. (nih.gov)
- Antigen-specific enrichment of immunosuppressive regulatory T-cells (Tregs) and reduction of antigen-specific T-effector cells (Teff) can prevent the progression of RA. (aiche.org)
- Notably, dendritic cells (DCs) are effective modulators of antigen-specific T-cell responses. (aiche.org)
- Notably, the no treatment group and PFK15+bc2 treatment groups had elevated levels of antigen specific Th1 and Th17 pro-inflammatory cells compared to the prevention group, which had undetectable levels. (aiche.org)
- Yet, if and how the tissue environment shapes the antigen specificity of iNKT cells remains unknown. (elifesciences.org)
- By analysing iNKT cells from lymphoid tissues of mice and humans we demonstrate that their T cell receptor (TCR) repertoire is highly diverse and is distinct for cells from various tissues resulting in differential lipid-antigen recognition. (elifesciences.org)
- This suggests that unique tissue-specific factors (including local lipid antigens, cytokines and/or hormones) may shape the population of iNKT cells resident in those tissues, ultimately regulating local immune responses. (elifesciences.org)
- iNKT cells have been traditionally defined by the expression of an invariant TCR α-chain (Vα14-Jα18 in mice or Vα24-Jα18 in humans) and their capacity to recognise the glycolipid antigen α-galactosylceramide (αGalCer) presented on CD1d. (elifesciences.org)
- Initially described in Japan, KFD was first reported almost simultaneously by Kikuchi and by Fujimoto and associates in 1972 as a lymphadenitis with focal proliferation of reticular cells accompanied by numerous histiocytes and extensive nuclear debris. (medscape.com)
Protein1
- Functional genomics data indicate that 2 of the suggestive SNPs (rs2446823 and rs2446824) are located within putative binding sites for the CCAAT/Enhancer Binding Protein (CEBP) and Hepatocyte Nuclear Factor 4, Alpha transcription factors (TFs), respectively. (cdc.gov)
Cytoplasmic2
- An autoimmune response to nuclear and cytoplasmic autoantigens is detected in about 60-80% of patients with polymyositis and dermatomyositis. (medscape.com)
- RCC1, associated with chromatin, is involved in the formation of RanGTP gradients critical for nucleo-cytoplasmic transport, mitotic spindle formation and nuclear envelope reassembly following mitosis. (ox.ac.uk)
Autoimmune diseases1
Repertoire2
- Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection. (upenn.edu)
- Despite this prototypical TCR repertoire gene usage, in recent years it has become apparent that there are variations within the iNKT cell repertoire that ultimately impact the antigen recognition capacity and consequently the functional outcomes during an immune response. (elifesciences.org)
Clinical3
- Additionally, its clinical performance was compared to two assays for the detection of ANA/ENA from different manufacturers that have a similar antigen composition. (cerbaresearch.com)
- Correlation between extractable nuclear antigens and clinical features, laboratory findings and disease activity indices in RA patients. (reumatologiaclinica.org)
- We focus on F-18-labeled agents for PET, as they begin to redefine-along with the corresponding Ga-68-labeled agents discussed elsewhere in this supplement to The Journal of Nuclear Medicine-the management of prostate cancer across a variety of clinical contexts. (uni-koeln.de)
Pacientes1
- O sarcoma de Kaposi é a neoplasia mais diagnosticada em pacientes com SIDA e a expressão do antígeno nuclear latente-1 do herpesvírus humano tipo-8 (HHV-8) tem se mostrado útil no seu diagnóstico histológico. (fiocruz.br)
Immune responses2
Tissue1
- It can be used to stain the nuclei in cell or tissue preparations and can be used as a nuclear marker in subcellular fractions. (neobiotechnologies.com)
Human3
- 1992) Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha. (guidetopharmacology.org)
- 2014) Purification, characterization and docking studies of the HIN domain of human myeloid nuclear differentiation antigen (MNDA). (guidetopharmacology.org)
- Genome-wide evidence of both significant linkage and association was obtained on chromosome 6 in the human leukocyte antigen (HLA) region and replicated in an independent Mexican American sample of large families (minimum p-value in combined analysis of both datasets is 1.4×10(-15) for SNPs rs477515 and rs2516049). (edu.au)
SEARCH1
- Design, setting, and participants: The results of a systematic literature search informed a two-round Delphi process with a panel of 28 PCa experts in medical or radiation oncology, urology, radiology, medical physics, and nuclear medicine. (lu.se)
Experienced nuclear medicine1
- All scans were analyzed independently by experienced nuclear medicine physicians and radiologists. (snmjournals.org)
Molecules1
- One such autoantibody system, known as Sm, reacts with antigens associated with small nuclear RNA molecules. (elsevierpure.com)
Presentation1
- Pathway analysis indicated that these genes are associated with antigen processing and presentation, and other immune pathways. (cdc.gov)
Test5
- The test is also known as Antibodies to Saline-extracted Antigens, Anti-RNP, and ENA Panel. (flebo.in)
- Why is the Extractable Nuclear Antigens test done? (flebo.in)
- What does the Extractable Nuclear Antigens test measure? (flebo.in)
- The extractable nuclear antigens test or the ENA test looks for the presence of antigens in the blood. (flebo.in)
- The extractable nuclear antigens test is done by testing the blood of the patient. (flebo.in)
Cell3
- The extractable nuclear antigens are easily removed from the cell and that helps determine the exact nature of the condition. (flebo.in)
- The pathogenesis of polymyositis points toward a T-cell-mediated cytotoxic process directed against unidentified muscle antigens. (medscape.com)
- Absent in melanoma (AIM)-like receptors (ALRs): myeloid cell nuclear differentiation antigen. (guidetopharmacology.org)
Results1
- Both of these techniques require the precipitation of antigens for valid results. (wikipedia.org)
Small1
- RCC1 is the major nuclear guanine nucleotide exchange factor for the small GTPase Ran enzyme. (ox.ac.uk)