CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the heterodimeric amino acid transporters (HATs). (exbio.cz)
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. (wikidoc.org)
SLC3A23
4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 (solute carrier family 3 member 2) gene. (wikipedia.org)
SLC3A2 comprises the heavy subunit of the large neutral amino acid transporter (LAT1) that is also known as CD98 (cluster of differentiation 98). (wikipedia.org)
A functional LAT1 transporter is composed of two proteins encoded by two distinct genes: 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene (this gene) CD98 light subunit protein encoded by the SLC7A5 gene SLC3A2 has been shown to interact with SLC7A7. (wikipedia.org)
The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. (wikidoc.org)
Protein kinase1
Cho JY, Skubitz KM, Katz DR, Chain BM: CD98-dependent homotypic aggregation is associated with translocation of protein kinase Cdelta and activation of mitogen-activated protein kinases. (exbio.cz)
Epithelial1
CD98, linked to various light chains by disulfide bond, is responsible for cell surface expression and basolateral localization of this transporter complex in polarized epithelial cells and also interacts with beta1 integrins and increases their affinity for ligand. (exbio.cz)
Heterodimer3
The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. (wikipedia.org)
The antibody MEM-108 reacts with an extracellular epitope of CD98, a 125 kDa disulfide-linked heterodimer (80 kDa glycosylated heavy chain + 45 kDa non-glykosylated light chain). (exbio.cz)
The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. (wikidoc.org)
Monoclonal1
Cancer-specific cell surface antigens are ideal therapeutic targets for monoclonal antibody (mAb)-based therapy. (bvsalud.org)
Cell4
Besides its roles in amino acid transport, CD98 is thus involved in cell fusion and activation. (exbio.cz)
Dalton P, Christian HC, Redman CW, Sargent IL, Boyd CA: Differential effect of cross-linking the CD98 heavy chain on fusion and amino acid transport in the human placental trophoblast (BeWo) cell line. (exbio.cz)
These glycoproteins include the CD98 heavy chain protein of Mus musculus (gbU25708) and the orthologous 4F2 cell surface antigen heavy chain of Homo sapiens (spP08195). (tcdb.org)
1 2 Cell surface antigens CD38 and CD138 can be used to distinguish normal cells from clonal plasma cells, but more extensive use of immunophenotyping has been limited by a lack of universally accepted markers of MM. 3-5 Once diagnosed, the current standard-of-care for MM includes immunomodulatory drugs, proteasome inhibitors, steroids, and antibody therapies. (bmj.com)
Characterization1
The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. (wakehealth.edu)
Amino1
Liu X, Charrier L, Gewirtz A, Sitaraman S, Merlin D: CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia. (exbio.cz)
In addidifferentia-tion, microR-NAs are coming to light as crucial regulators of innate and adaptive immune responses, and their abnormal expression and/or function in the immune system have been linked to multiple human diseases including inflammatory disorders, such as inflammatory bowel disease, and cancers. (123dok.net)
Regulation1
Regulation of immunities and maintenance of tolerance to self-antigens are critical to keep health. (creative-biolabs.com)
Major1
This graph shows the total number of publications written about "Antigens, CD98" by people in this website by year, and whether "Antigens, CD98" was a major or minor topic of these publications. (wakehealth.edu)
Human1
Flow cytometry analysis (surface staining) of human peripheral blood cells with anti-human CD98 (MEM-108) PE. (exbio.cz)
4F2hc3
A functional LAT1 transporter is composed of two proteins encoded by two distinct genes: 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene (this gene) CD98 light subunit protein encoded by the SLC7A5 gene SLC3A2 has been shown to interact with SLC7A7. (wikipedia.org)
3. The Heavy Chain 4F2hc Modulates the Substrate Affinity and Specificity of the Light Chains LAT1 and LAT2. (nih.gov)
[ 4 ] LAT1 requires another cell surface glycoprotein, the 4F2 heavy chain (4F2hc), for its functional expression and forming a heterodimeric complex. (medscape.com)
Cell-surface antigen heavy1
4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 (solute carrier family 3 member 2) gene. (wikipedia.org)
CD98hc1
2. Amino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) Is at the Cross-road of Oxidative Stress and Amino Acid Availability. (nih.gov)
Large neutral amino acids1
11. Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). (nih.gov)
Fusion Regulatory Protein1
A family of light chains that bind to FUSION REGULATORY PROTEIN 1, HEAVY CHAIN to form a heterodimer. (nih.gov)
Protein4
The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. (wikipedia.org)
Cluster of differentiation CD79A also known as B-cell antigen receptor complex-associated protein alpha chain and MB-1 membrane glycoprotein , is a protein that in humans is encoded by the CD79A gene . (wikidoc.org)
The CD79a protein together with the related CD79b protein, forms a dimer associated with membrane-bound immunoglobulin in B-cells , thus forming the B-cell antigen receptor (BCR). (wikidoc.org)
Association of the CD79a/b heterodimer with the immunoglobulin heavy chain is required for surface expression of the BCR and BCR induced calcium flux and protein tyrosine phosphorylation. (wikidoc.org)
Receptor1
This occurs in a similar manner to the association of CD3 with the T-cell receptor , and enables the cell to respond to the presence of antigens on its surface. (wikidoc.org)
Amino acid transp2
9. Expression profile of CD98 heavy chain and L-type amino acid transporter 1 and its prognostic significance in colorectal cancer. (nih.gov)
10. Identification and characterization of a novel member of the heterodimeric amino acid transporter family presumed to be associated with an unknown heavy chain. (nih.gov)
Marker1
4. The CD98 Heavy Chain Is a Marker and Regulator of Head and Neck Squamous Cell Carcinoma Radiosensitivity. (nih.gov)
Functional1
In this chapter, we describe the methodology to identify and validate specific microRNAs shuttled from T lymphocytes to B cells upon immune synapse formation, and to analyze their functional impact on post-synaptic antigen-presenting cells. (bvsalud.org)
Occurs1
During immune synapsis, transfer of small extracellular vesicles that contain bioactive molecules, including microRNAs, occurs from the T lymphocyte to the antigen-presenting cell. (bvsalud.org)
Cells2
Their main function is to present antigens to prime T cells and initiate and shape adaptive responses. (bvsalud.org)
Antigen presentation takes place through intimate contacts between the two cells, termed immune synapses (IS). (bvsalud.org)