ProteinsTumor-associatedTransmembraneProstate-specific membrane antigenProteinAntibodiesSurfaceLysosomal membrane glycoproteinMonocytesPlasma membraneIIIaDifferentiation antigensExtracellular regionCD14MonoclonalReceptorsLipidPSMAMacrophagesCell membranesGolgiPlateletsReceptor complexPlatelet adhesionDendriticCellsIsolationSubunitsWillebrandCD47EctonucleotideAmino acidsHumanType
Proteins13
- View our protocol for Staining Membrane-associated Proteins . (rndsystems.com)
- The Rh blood group antigens (MIM 111700) are associated with human erythrocyte membrane proteins of approximately 30 kD, the so-called Rh30 polypeptides. (novusbio.com)
- Heterogeneously glycosylated membrane proteins of 50 and 45 kD, the Rh50 glycoproteins, are coprecipitated with the Rh30 polypeptides on immunoprecipitation with anti-Rh-specific mono- and polyclonal antibodies. (novusbio.com)
- Ankyrins link integral membrane proteins to the spectrin-based membrane skeleton. (dana-farber.org)
- Hereditary defects in membrane skeleton proteins. (dana-farber.org)
- This indicates that AE1 and probably other integral membrane proteins have a 'lipid-anchoring' function. (dana-farber.org)
- Sequence similarity to proteins bearing onco-differentiation antigens. (bdbiosciences.com)
- Selection involves B cells competing for T cell help based on the amount of antigen they capture and present on their MHC class II (MHCII) proteins. (ox.ac.uk)
- CD1 molecules are cell-surface glycoproteins with strong structural similarities to major histocompatibility complex (MHC) class I molecules, and studies in humans and mice have demonstrated that CD1 proteins perform the unique role of presenting lipid antigens to T lymphocytes. (elsevierpure.com)
- Our results indicated that multiple members of the guinea-pig CD1 family, including members that are homologous to the human CD1b and CD1c proteins, are expressed at the protein level in transfected cells and in specialized antigen-presenting cells such as monocyte-derived dendritic cells. (elsevierpure.com)
- The purpose of this study was to identify membrane proteins of PMNs, and/or glomerular cells, as additional autoantigenic ANCA targets. (rupress.org)
- Using these probes, evidence was provided that gp170/80-110 is identical with human lysosomal-associated membrane protein 2 (h-lamp-2), because both proteins were immunologically cross-reactive and screening of a cDNA expression library from human promyelocytic leukemia cells with anti-gp130 Ab yielded a clone derived from h-lamp-2. (rupress.org)
- Transmembrane proteins that form the alpha subunits of the HLA-DQ antigens. (musc.edu)
Tumor-associated1
- Human TROP-2, also known as Tumor Associated Calcium Signal Transducer 2 (TACSTD2), GA733-1, gp50 and T16, is a type I cell surface glycoprotein that is highly expressed on human carcinomas. (rndsystems.com)
Transmembrane8
- This transmembrane glycoprotein complex is composed of four subunits: GPIbα, GPIbβ, GPV and GPIX. (wikipedia.org)
- Glycoprotein VI is one of the immunoglobulin superfamily type I transmembrane glycoproteins. (wikipedia.org)
- Integrin alpha 2b (ITGA2b), also known as CD41 and GPIIb, is a transmembrane glycoprotein that is expressed by megakaryocytes and platelets. (rndsystems.com)
- The mouse monoclonal antibody CRIS1 reacts with an extracellular epitope of CD5, a 67kDa single-chain transmembrane glycoprotein expressed on mature T lymphocytes, most of thymocytes and B lymphocytes subset (B-1a lymphocytes). (exbio.cz)
- 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. (exbio.cz)
- Prostate-specific membrane antigen (PSMA) is a 100-kD transmembrane glycoprotein that is overexpressed on nearly all prostate cancers, particularly poorly differentiated and metastatic lesions ( 1 - 3 ). (snmjournals.org)
- Cancer antigen 27-29 (or CA 27-29) is an epitope of a large transmembrane mucin glycoprotein named MUC1 that is expressed on the cell surfaces of most glandular epithelia. (medscape.com)
- [ 1 ] This protein, also known as polymorphic epithelial mucin or epithelial membrane antigen, has a large extracellular region, a transmembrane sequence, and a cytosolic domain. (medscape.com)
Prostate-specific membrane antigen2
- The purpose of this work was to evaluate the effect of androgen receptor (AR) inhibition on prostate-specific membrane antigen (PSMA) uptake imaged using 68 Ga-PSMA-11 PET in a mouse xenograft model and in a patient with castration-sensitive prostate cancer. (snmjournals.org)
- 131 I-RPS-001 is targeting the prostate-specific membrane antigen (PSMA) receptor. (oncidiumfoundation.org)
Protein5
- The H4A3 monoclonal antibody specifically binds to CD107a which is also known as Lysosomal-associated membrane protein 1 (LAMP-1). (bdbiosciences.com)
- Type I membrane protein. (lu.se)
- A novel class of autoantigens of anti-neutrophil cytoplasmic antibodies in necrotizing and crescentic glomerulonephritis: the lysosomal membrane glycoprotein h-lamp-2 in neutrophil granulocytes and a related membrane protein in glomerular endothelial cells. (rupress.org)
- When membrane protein fractions were prepared from PMNs and isolated human glomeruli, and immunoblotted with ANCA sera of NCGN patients, two bands with apparent molecular masses of 170 and 80-110 kD (gp170/80-110) were labeled in PMNs, and a 130-kD glycoprotein (gp130) in glomeruli. (rupress.org)
- Each of the cell lines also reacted with antibodies against neural cell adhesion molecules, but none of them were positive for antibodies against glial fibrillary acidic protein, keratin, microtubule-associated protein tau and microtubule-associated protein 2, human lymphocyte antigen-DR, epidermal growth factor receptor, and T-cell antigen. (duke.edu)
Antibodies5
- The two monoclonal antibodies MAX.1 and MAX.11 recognize cell surface antigens that are almost undetectable on monocytes but highly expressed on differentiated macrophages. (uni-regensburg.de)
- Biochemical characterization revealed that both antibodies detect the same 58-64-kDa glycoprotein anchored to the plasma membrane by glycosyl-phosphatidylinositol linkage. (uni-regensburg.de)
- The NH2-terminal amino acid sequence was determined and turned out to be identical to the NH2-terminal sequence of the membrane-bound carboxypeptidase M. By precipitation with antibodies MAX.1 and MAX.11, membrane preparations of macrophages and placental microvilli were almost completely depleted of enzyme activity, indicating that the two antibodies indeed recognize carboxypeptidase M. Immunoreactivity of both antibodies correlates with the reported tissue distribution of enzyme activity. (uni-regensburg.de)
- MIM:300622), characterised by the polyagglutination of erythrocytes by naturally occurring anti Tn antibodies following exposure of the Tn antigen on their surface. (reactome.org)
- Anti-human lymphocyte antigen-A,B and anti-beta 2-microglobulin antibodies reacted with xenografts of D384 Med and D425 Med and were weakly positive for a small population of D384 Med cultured cells. (duke.edu)
Surface16
- Platelet membrane glycoproteins are surface glycoproteins found on platelets (thrombocytes) which play a key role in hemostasis. (wikipedia.org)
- These subunits form Ca2+ - dependent complex on the surface of platelet membrane in a 1:1 ratio. (wikipedia.org)
- Using pulse-chase radiolabeling, the kinetics of appearance of the class I histocompatibility antigens, H-2K(k) and H-2D(k), at the cell surface were compared and found to be remarkably different. (johnshopkins.edu)
- The rates of surface appearance for the two antigens closely resemble the rates at which their Asn-linked oligosaccharides mature from endoglucosaminidase H (endo-H)-sensitive to endo H-resistant forms, a process that occurs in the Golgi apparatus. (johnshopkins.edu)
- Williams, DB, Swiedler, SJ & Hart, GW 1985, ' Intracellular transport of membrane glycoproteins: Two closely related histocompatibility antigens differ in their rates of transit to the cell surface ', Journal of Cell Biology , vol. 101, no. 3, pp. 725-734. (johnshopkins.edu)
- Glycoprotein antigens on the extracellular surface of the RBC membrane determine an individual's blood group. (cap.org)
- Identification and characterization of LAMP-1 as an activation-dependent platelet surface glycoprotein. (bdbiosciences.com)
- Sawada R, Lowe JB, Fukuda M. E-selectin-dependent adhesion efficiency of colonic carcinoma cells is increased by genetic manipulation of their cell surface lysosomal membrane glycoprotein-1 expression levels. (bdbiosciences.com)
- The CD14 antigen is a glycosyl-phosphatidylinositol-linked single-chain surface membrane glycoprotein with a molecular weight of 53-55 kDa. (beckman.com)
- The alpha subunit is the CD11C ANTIGEN, a surface antigen expressed on some myeloid cells. (bvsalud.org)
- As opposed to prostate-specific antigen levels, PSMA expression on the cell surface increases with AR inhibition ( 10 - 12 ). (snmjournals.org)
- By contrast, gp130 was localized in the surface membranes of endothelial cells of human glomerular and renal interstitial capillaries, rather than in lysosomes, as found for h-lamp-2. (rupress.org)
- The mouse monoclonal antibody 5E10 recognizes CD90/Thy-1, a GPI-anchored cell surface glycoprotein expressed predominantly on thymocytes, hematopoietic stem cells and neurons. (exbio.cz)
- C-CAM (Cell-CAM 105) is a cell surface glycoprotein that is involved in cell-cell adhesion of rat hepatocytes in vitro. (lu.se)
- Hemagglutinin (H) is a glycoprotein on the influenza viral surface that allows the virus to bind to cellular sialic acid and fuse with the host cell membrane. (msdmanuals.com)
- Neuraminidase (NA), another surface glycoprotein, enzymatically removes sialic acid, promoting viral release from the infected host cell. (msdmanuals.com)
Lysosomal membrane glycoprotein1
- Isolation and sequencing of a cDNA clone encoding lysosomal membrane glycoprotein mouse LAMP-1. (bdbiosciences.com)
Monocytes2
- CD14 antigen is strongly expressed on monocytes, macrophages, and weakly on neutrophils. (beckman.com)
- Expression of carboxypeptidase M on mRNA level and enzymatic activity markedly increase during in vitro differentiation of monocytes, according to the described increase in MAX.1 and MAX.11 antigen expression. (uni-regensburg.de)
Plasma membrane1
- CD90 (Thy-1) is an 18-35 kDa GPI-anchored plasma membrane glycoprotein expressed in many cell types, such as in hematopoietic cells and neurons, connective tissues, various fibroblast and stromal cell lines, tumor endothelial cell lines and other. (exbio.cz)
IIIa3
- In consequence, this complex activates GPIIb / IIIa membrane glycoproteins, allowing them to bind fibrinogen. (wikipedia.org)
- The IIb / IIIa complex is a major platelet membrane component. (wikipedia.org)
- Fibrinogen sites recognized by glycoprotein IIb / IIIa complex: dodecapeptide located in the C-terminal of the fibrinogen γ chain (the most important) RGD sequence of the α chain → the Arginine-Glycine-Aspartate amino acid sequence This complex also binds vWF, fibronectin and vitronectin. (wikipedia.org)
Differentiation antigens1
- Leucocyte typing V : white cell differentiation antigens : proceedings of the fifth international workshop and conference held in Boston, USA, 3-7 November, 1993. (bdbiosciences.com)
Extracellular region2
- It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. (exbio.cz)
- CA 27-29 represents a sequence of mucins on the extracellular region of this glycoprotein. (medscape.com)
CD141
- CD14 is a 53-55 kD glycosylphosphatidylinositol (GPI)-linked membrane glycoprotein that is also known as the LPS receptor. (biolegend.com)
Monoclonal2
- Nitrocellulose membrane was probed with 2 µg/ml of mouse anti-CD5 monoclonal antibody followed by IRDye800-conjugated anti-mouse secondary antibody. (exbio.cz)
- We purified the MAX.1/11 antigen by immunoaffinity chromatography using monoclonal antibody MAX.11. (uni-regensburg.de)
Receptors3
- Autologous as well as allogeneic CD8 + T cells transduced with tumor antigen specific T cell receptors (TCR) may cause significant tumor lysis upon adoptive transfer. (oncotarget.com)
- Membrane glycoproteins GPIa/IIa, GPVI and probably GPIV as well, function as collagen receptors, engaged in platelet adhesion to collagen. (wikipedia.org)
- Rather, it suggests that one or more receptors localized to the ER membrane may mediate the selective transport of membrane glycoproteins out of the ER to the Golgi apparatus. (johnshopkins.edu)
Lipid2
- During the past decade our laboratory and others have shown that hereditary spherocytosis is caused by defects in the connections that attach the membrane skeleton to the overlying lipid bilayer. (dana-farber.org)
- In general, the formation of acanthocytes depends on alteration of the lipid composition and fluidity of the red cell membrane. (medscape.com)
PSMA1
- PSMA is a membrane-bound glycoprotein expressed mainly in the prostate epithelium. (oncidiumfoundation.org)
Macrophages1
- Glycoproteins with a wide distribution on hematopoietic and non-hematopoietic cells and strongly expressed on MACROPHAGES. (bvsalud.org)
Cell membranes2
- Various authors have studied amino acid transport in cell membranes obtained from the proximal renal tubule of humans, rats, and rabbits. (medscape.com)
- Red cell membranes: fact and fancy. (wikidata.org)
Golgi1
- There is increasing evidence from our laboratory and others that some organelles (e.g., lysosomes, Golgi) also have membrane skeletons. (dana-farber.org)
Platelets3
- Human alloantigens expressed only on platelets, specifically on platelet membrane glycoproteins. (clustermed.info)
- Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)
- In addition, when platelets are activated, negatively charged phospholipids move from the inner to the outer leaflet of the membrane bilayer. (medscape.com)
Receptor complex1
- CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). (exbio.cz)
Platelet adhesion1
- Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury . (online-medical-dictionary.org)
Dendritic1
- Dendritic cells (DCs), which are the most important antigen-presenting cells (APCs) that send signals to the T cells, mainly participate in the pathogenesis of many diseases with immunoregulatory mechanisms, such as AR. (frontiersin.org)
Cells4
- We hypothesized lysosome-associated membrane glycoprotein 1 (LAMP1, CD107a) to be a marker for fratricide in TCR transgenic CD8 + T cells. (oncotarget.com)
- Although much experimental evidence indicates that AE1 is required for membrane skeleton assembly, AE1-/- red blood cells have a normal membrane skeleton. (dana-farber.org)
- This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with cell membrane glycoproteins of lymphoblastic leukemia cells. (reliatech.de)
- The Tn antigen is tumour associated, found in a majority of human carcinomas, and is not normally expressed in peripheral tissues or blood cells (Crew et al. (reactome.org)
Isolation1
- Isolation and characterization of a glycoprotein from human group O erythrocyte membrane. (wikidata.org)
Subunits1
- Antigenic shift refers to the relatively rare development of new combinations of H and/or NA antigens, which result from reassortment of subunits of the viral genome. (msdmanuals.com)
Willebrand1
- Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin . (online-medical-dictionary.org)
CD474
- The Rh antigens appear to exist as a multisubunit complex of CD47 (MIM 601028), LW (MIM 111250), glycophorin B (MIM 111740), and play a critical role in the Rh50 glycoprotein. (novusbio.com)
- Antigens, CD47" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
- This graph shows the total number of publications written about "Antigens, CD47" by people in this website by year, and whether "Antigens, CD47" was a major or minor topic of these publications. (rush.edu)
- Below are the most recent publications written about "Antigens, CD47" by people in Profiles. (rush.edu)
Ectonucleotide1
- A number of laboratories have observed that membrane glycoprotein plasma cell antigen 1 (PC-1) [ ectonucleotide pyrophosphatase phosphodiesterase 1] is either overexpressed or overactive in muscle, adipose tissue, fibroblasts, and other tissues of insulin-resistant individuals, both nondiabetic and diabetic. (cnr.it)
Amino acids1
- The high-affinity system mediates uptake of 10% of L-cystine and the dibasic amino acids at the apical membrane of the straight third segment (S3) of the proximal tubule. (medscape.com)
Human5
- Find the definition of the medical term Antigens, Human Platelet. (clustermed.info)
- Antigens, Human Platelet defined and explained for easy understanding at the Medical Conditions from ClusterMed.info. (clustermed.info)
- It was originally identified as an antigen present on human gastrointestinal tumors and is the second of two members of this family. (rndsystems.com)
- Studies on the major sialoglycoprotein of the human red cell membrane. (wikidata.org)
- Human erythrocyte membrane glycoprotein: a re-evaluation of the molecular weight as determined by SDS polyacrylamide gel electrophoresis. (wikidata.org)
Type4
- The H-antigen with the fucosyl galactose end chain is present on type O blood and is the base structure of the ABO blood group system. (cap.org)
- Other blood types differ from type O in the presence of an additional sugar antigen, α- N-acetyl galactose for type A, α-galactose for type B, or both for type AB, on the core of the nonimmunogenic H-antigen (Figure 1). (cap.org)
- α-N-acetyl-galactosaminidase allowed for the conversion of A-antigen to H-antigen (type-O RBC). (cap.org)
- Classed as a type I integral membrane glycoprotein, in its capacity as a receptor, LYVE1 can bind to soluble and immobilised HA. (prospecbio.com)