• Loperamide, sold under the brand name Imodium, among others, is a medication of the opioid receptor agonist class used to decrease the frequency of diarrhea. (wikipedia.org)
  • The antidiarrheal medication loperamide (Imodium) can also be used. (medscape.com)
  • Loperamide ( Imodium ) can help slow or stop diarrhea. (healthline.com)
  • Drugs called antidiarrheal, such as loperamide (Imodiumâ„¢) are used. (groupeproxim.ca)
  • Consequently, the over-the-counter opioids loperamide (Imodium A-D) and mitragynine, the herbal ingredient in kratom, are increasing. (medworm.com)
  • Anti-diarrheals - Medications like loperamide (Imodium) help slow motility. (colorwithleo.com)
  • Antidiarrheal agents, such as loperamide (Imodium), should also be avoided. (cdc.gov)
  • BACKGROUND: Loperamide (Imodium®), a commonly used anti-diarrheal, is a mu opioid receptor agonist that, like all opioids, reduces gastrointestinal tract peristalsis. (bvsalud.org)
  • Amazon has the 24-Pack Amazon Basic Care 2mg Loperamide Hydrochloride Anti-Diarrheal Tablets for $2.93 - 5% off with Subscribe & Save (can cancel at any time) = $2.78 with free shipping on $25+ or with Prime. (shopmiee.com)
  • Each caplet of anti-diarrheal medicine contains 2 mg of loperamide hydrochloride with a proven formula that works with your body to slow down your system and restore its natural rhythm and balance. (food4less.com)
  • Loperamide is effective for the treatment of a number of types of diarrhea. (wikipedia.org)
  • Off-label uses for loperamide also include chemotherapy-induced diarrhea, especially related to irinotecan use. (wikipedia.org)
  • Loperamide should not be used as the primary treatment in cases of bloody diarrhea, acute exacerbation of ulcerative colitis, or bacterial enterocolitis. (wikipedia.org)
  • If a suspicion exists of diarrhea associated with organisms that can penetrate the intestinal walls, such as E. coli O157:H7 or Salmonella, loperamide is contraindicated as a primary treatment. (wikipedia.org)
  • The study reported that the use of loperamide should be contraindicated in children who are under 3, systemically ill, malnourished, moderately dehydrated, or have bloody diarrhea. (wikipedia.org)
  • Two of those alternatives-loperamide, an over-the-counter opioid used to treat diarrhea, and kratom, a widely available herbal substance containing the opioid mitragynine-were associated with disproportionate reports of ventricular arrhythmias and cardiac arrest in pharmacovigilance databases from the US and Canada between 2015 and 2021. (tctmd.com)
  • Loperamide may be used occasionally for acute management of severe diarrhea but avoid chronic use. (medscape.com)
  • For adults and children 12 years of age and older who have acute or chronic diarrhea, the recommended dose of loperamide is a starting dose of 4 mg, followed by a 2 mg dose after each loose bowel movement (or bout of diarrhea). (medbroadcast.com)
  • Loperamide is an anti-diarrheal agent that is useful for giving effective relief of intestinal cramping and diarrhea. (fsu.edu)
  • Loperamide has been a safe and effective treatment for diarrhea for many years. (medworm.com)
  • Therapeutic efficacy of single-dose rifaximin (550 mg) with loperamide in treating acute watery diarrhea compared to single-dose azithromycin (500 mg) with loperamide. (who.int)
  • Results: We found that ultrasonography can quantitatively detect a decrease in colonic motility induced by loperamide, an antidiarrheal drug. (visualsonics.com)
  • Loperamide is an oral medication that typically only has to be taken after a diarrheal episode. (healthline.com)
  • Loperamide is available as a generic medication. (wikipedia.org)
  • Loperamide tablets and capsules are not suitable for children under the age of 6 years old. (medbroadcast.com)
  • The goals of pharmacotherapy are to reduce morbidity and to prevent complications.The treatment of ulcerative colitis relies on initial medical management with corticosteroids and anti-inflammatory agents, such as sulfasalazine, in conjunction with symptomatic treatment with antidiarrheal agents and rehydration. (medscape.com)
  • 1. Allergy to rifamycins, macrolides, or loperamide (not including mild gastrointestinal upset). (who.int)
  • Loperamide may interact with certain prescription drugs. (nih.gov)
  • Some of the most commonly used Anti-Diarrheal Drugs include Bismuth Subsalicylate, Loperamide, and Kaolin-Pectin. (emailwire.com)
  • Loperamide is one of the best-known anti-diarrheal medicines. (healthline.com)
  • Loperamide treatment is not used in symptomatic C. difficile infections, as it increases the risk of toxin retention and precipitation of toxic megacolon. (wikipedia.org)
  • The most frequent symptoms of loperamide overdose are drowsiness, vomiting, and abdominal pain, or burning. (wikipedia.org)
  • Within FAERS, the largest database, the researchers uncovered 1,163 reports of ventricular arrhythmia/cardiac arrest involving methadone, 1,008 involving loperamide, and 46 involving kratom (mitragynine) between 2015 and 2021. (tctmd.com)
  • A review of loperamide in children under 12 years old found that serious adverse events occurred only in children under three years old. (wikipedia.org)
  • Though loperamide, when taken at high doses, has been linked to dangerous arrhythmias before-with the FDA issuing a safety alert in 2016-these data newly call into question previous assertions that kratom may be relatively safe because it has not been associated with many reports of QTc prolongation. (tctmd.com)
  • However, reports of individuals misusing loperamide through the use of super-therapeutic doses, alone or in combination with P-glycoprotein and/or CYP450 enzyme inhibitors, is increasing. (bvsalud.org)
  • The antidiarrhoeal activity of the extract (200 and 400 mg/kg) was assessed on experimental animal and a dose dependent decrease in the total number of faecal dropping was obsereved in castor oil induced diarrhoea in mice. (banglajol.info)
  • For liquid forms of loperamide, use a syringe to measure each dose as this gives a more accurate measurement than household teaspoons. (medbroadcast.com)
  • The increasing popularity of kratom led the investigators to wonder whether it might carry a risk of arrhythmias similar to those seen previously with loperamide and methadone, an opioid used for the treatment of morphine or heroin addiction. (tctmd.com)
  • Loperamide also was tied to increased reporting of QTc prolongation/torsade de pointes, which could lead to sudden cardiac death, according to researchers led by Mori Krantz, MD, who conducted the study while working for Clario, a healthcare research technology company involved in clinical trials. (tctmd.com)
  • The potential mechanisms behind loperamide-induced cardiac arrhythmias associated with human abuse and extreme overdose - Lu HR, Damiano BP, Kreir M, Rohrbacher J, van der Linde H, Saidov T, Teisman A, Gallacher DJ. (medworm.com)
  • We evaluated loperamide in in vitro and in vivo cardiac safety. (medworm.com)
  • Fentanyl immunoassay screen-positive results at one institution were examined by high-resolution mass spectrometry (MS) for the presence of loperamide and quantified by liquid chromatography- tandem MS when positive. (bvsalud.org)
  • These results suggest that the extract possesses antidiarrhoeal and CNS depressant activity. (banglajol.info)
  • One controlled, prospective study of 89 women exposed to loperamide during their first trimester of pregnancy showed no increased risk of malformations. (wikipedia.org)
  • However, many cases of cardiotoxicity with intentional abuse of loperamide ingestion have recently been reported. (medworm.com)
  • This study aimed to assess the ability of community pharmacists to recognize cases of loperamide abuse at the point of sale, their perspective of and experience toward potential abuse cases. (medworm.com)
  • Loperamide is considered to have low abuse potential as it does not produce an analgesic or euphoric effect due to low bioavailability and first-pass metabolism. (bvsalud.org)
  • Loperamide can be present in breast milk, and is not recommended for breast-feeding mothers. (wikipedia.org)
  • Prescription-opioid alternatives like kratom and loperamide will likely remain a public health threat for the foreseeable future. (tctmd.com)
  • The use of loperamide in children under two years is not recommended. (wikipedia.org)
  • In 1990, all formulations for children of the antidiarrheal loperamide were banned in Pakistan. (wikipedia.org)
  • The National Health Service in the United Kingdom recommends that loperamide should only be given to children under the age of twelve if prescribed by a doctor. (wikipedia.org)
  • The objective of this study is to investigate the characteristics and trends of loperamide cases reported to United States (US) poison centers and to evalu. (medworm.com)