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  • DOACs
  • In a paper recently published in the British Medical Journal, Vonpgradova reported findings from a prospective open-cohort study investigating the correlation between DOACs and risks of bleeding as compared with the relationship between warfarin and the same endpoints. (eso-stroke.org)
  • The present study provides data indicating that in comparison to warfarin, DOACs are a reasonable choice with better safety profiles in both patients with and without AF. (eso-stroke.org)
  • Therefore, the present data will be important in guiding physicians in considering DOACs as the preferred anticoagulant option. (eso-stroke.org)
  • Using the Japanese Diagnosis Procedure Combination database, we identified 16 977 patients who underwent 13 types of high-risk endoscopic procedures and took preoperative warfarin or DOACs from 2014 to 2015. (ovid.com)
  • Propensity
  • One-to-one propensity score matching was performed to compare postendoscopy GI bleeding and thromboembolism between the warfarin and DOAC groups. (ovid.com)
  • therapeutic
  • The therapeutic effect of warfarin exists within a narrow therapeutic window as dictated by the INR. (docplayer.net)
  • Type A: Augmented pharmacologic effects - dose dependent and predictable Type A reactions, which constitute approximately 80% of adverse drug reactions, are usually a consequence of the drug's primary pharmacological effect (e.g. bleeding when using the anticoagulant warfarin) or a low therapeutic index of the drug (e.g. nausea from digoxin), and they are therefore predictable. (wikipedia.org)
  • clinical
  • The increased anticoagulant response to warfarin seen with increasing patient age persisted even after simultaneously controlling for relevant demographic and clinical variables in a multivariate model. (umassmed.edu)
  • People using anticoagulants to treat this condition should avoid using bed rest as a complementary treatment because there are clinical benefits to continuing to walk and remaining mobile while using anticoagulants in this way. (wikipedia.org)
  • Toxgnostic biomarker tests currently available for use in clinical practice include markers for irinotecan, thioguanine, warfarin and 5FU. (wikipedia.org)
  • 2016
  • Using data from two large United Kingdom primary care databases, between 2011 and 2016 a total of 196,061 anticoagulant users who had no anticoagulant prescriptions in the year prior to study entry were identified. (eso-stroke.org)
  • closely
  • These workers believe the rat to be the preferred experimental animal in the study of 4-hydroxycoumarin anticoagulants, as the response of the rat is most closely parallel to that of the human. (jamanetwork.com)
  • He remained closely involved in the biochemistry of warfarin and related compounds. (wikipedia.org)
  • compounds
  • Warfarin, one of the several compounds synthesised as part of the coumarin research, was patented in 1945 with the Wisconsin Alumni Research Foundation, Link and researchers Stahmann and Ikawa jointly owning the patent. (wikipedia.org)
  • effects
  • Dermatotoxic effects of epicutaneous application of a first-generation anticoagulant, warfarin (WF) were examined in rats. (ac.rs)
  • Binding to human serum albumin induces Cotton effects in the enantiomers of phenprocoumon and warfarin, which superimpose upon the intrinsic Cotton effects of the drugs. (aspetjournals.org)
  • The induced Cotton effects are similar in sign for the two phenprocoumon isomers, but dissimilar for the warfarin isomers. (aspetjournals.org)
  • poison
  • In 1948 a potent synthetic form of dicumarol was originally introduced as an extremely effective rodent (small mammals of the order Rodentia, which includes rats, squirrels, and beavers) poison called warfarin (named for the patent holder, Wisconsin Alumni Research Foundation). (discoveriesinmedicine.com)
  • dosage
  • Their intake should be avoided whilst taking anticoagulants or, if coagulability is being monitored, their intake should be kept approximately constant so that anticoagulant dosage can be maintained at a level high enough to counteract this effect without fluctuations in coagulability. (wikipedia.org)
  • protein
  • In contrast, increased formation of malondialdehyde (MDA), with a decrease in protein and non-protein thiols in homogenates of warfarin-treated skin was demonstrated, pointing to prooxidant activity in warfarin-treated skin. (ac.rs)
  • The principal plasma proteins for drug binding are: albumin α1-acid glycoprotein lipoproteins Some drug interactions with warfarin are due to changes in protein binding. (wikipedia.org)
  • Therefore
  • Therefore it is concluded that the orientation of the 4-hydroxycoumarin nucleus is the same for the phenprocoumon isomers, but different for the warfarin isomers, when bound to human serum albumin. (aspetjournals.org)
  • differences
  • No evident differences in skin histology between control and warfarin-treated skin were found at that time point, while striking changes in tissue integrity, cellularity and appearance 72h following WF application were noted. (ac.rs)
  • rats
  • Presented data demonstrate the potential of epicutaneously applied warfarin to modulate local skin activity in rats. (ac.rs)