Antibodies receptors antigen t cell alpha beta. Medical search. Frequent questions

Monoclonal antibodies: designed to bind to specific targets on cancer cells, marking cancer cells so that they will be better seen and destroyed by the immune system. (wikipedia.org)
Current technologies for treatment of many lymphomas, leukemias, transplant rejection and some autoimmune disorders include monoclonal antibodies (mAb) that target and deplete B cell populations. (nationaljewish.org)
The iReceptor Plus Scientific Gateway is an excellent tool for detailed understanding of the basic biology underlying diseases of the adaptive immune system and is expected to lead to new vaccines, monoclonal antibodies for cancer and autoimmune treatment, and the many other diseases with a connection to the immune system. (ireceptor-plus.com)
Recent studies using cloned antigen-specific T lymphocytes and monoclonal antibodies directed at their various surface glycoprotein components have led to identification of the human T cell antigen receptor as a surface complex comprised of a clonotypic 90 kDa Ti heterodimer and the invariant 20 and 25 kDa T3 molecules. (ox.ac.uk)
During the last decade monoclonal antibodies have TH-302 been sought and engineered as candidates for molecular target drugs [12]. (researchatlanta.org)
For the last two decades, our understanding of immunology exploded with the advent of technologies that allowed high throughput screening and generation of large molecule biologics such as monoclonal antibodies (mAb) and small molecule compounds. (frontiersin.org)
New therapies used in these diseases, including biological agents (monoclonal antibodies or recombinant proteins), are also reviewed. (medlink.com)
This presentation will not include any discussion of the unlabeled use of a product or a product under investigational use except parts of the presentation will focus on monoclonal antibodies that are not FDA approved but are FDA authorized under emergency use authorizations EUA. (cdc.gov)
The US Food and Drug Administration has recently issued the emergency use authorization or EUA for monoclonal antibodies for both the treatment of COVID-19 and for post-exposure prophylaxis for certain patients, including patients with immunocompromising conditions. (cdc.gov)

This interaction is central to antigen specificity in the adaptive immune response. (rndsystems.com)
van den Berg HA, Wooldridge L, Laugel B, Sewell AK: Coreceptor CD8-driven modulation of T cell antigen receptor specificity. (exbio.cz)
Here, we recovered transcriptome and immune repertoire information for polyclonal T follicular helper cells following lymphocytic choriomeningitis virus (LCMV) infection, CD8+ T cells with binding specificity restricted to two distinct LCMV peptides, and B and T cells isolated from the nervous system in the context of experimental autoimmune encephalomyelitis. (nature.com)
This antibody has specificity for Human CD97. (thermofisher.cn)
The iReceptor Plus Gateway combines a range of new types of data (Single-Cell, Gene Expression, Clonotype, MHC/Immune Receptor Genotype, and Epitope Specificity data). (ireceptor-plus.com)
User searches for CDR3 sequences in the AIRR Data Commons will be supplemented with additional information on antigen/epitope specificity information from IEDB. (ireceptor-plus.com)

Cancer immunotherapy exploits the fact that cancer cells often have tumor antigens, molecules on their surface that can bind to antibody proteins or T-cell receptors, triggering an immune system response. (wikipedia.org)
T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). (genetex.com)
It plays a key function in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up‑regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. (rndsystems.com)
whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. (thermofisher.com)
Superantigens simultaneously bind to major histocompatibility complex class II molecules and T-cell receptor molecules bearing a particular V-β region. (cdc.gov)
These results suggest that T cells interact in a complex network, perhaps as complex as the regulatory interactions between antibody molecules and B cells. (ox.ac.uk)
In addition to peptide antigens bound to highly polymorphic MHC molecules, T cells have also evolved to recognize bacterial lipids when bound to non-polymorphic CD1 molecules. (bvsalud.org)
For efficient initiation of CD4+, T cell response requires T cell receptor (TCR) activation and costimulation provided by molecules on antigen-presenting cells (APC) and their counter receptors on T cells. (bvsalud.org)
This observation prompted us to study the expression of the costimulatory molecules (CD80, CD86, CD28, CD152), other accessory molecules (TCR alphabeta/gammadelta) and T cell lineage molecules (CD4+ and CD8+) during constitutive and activated state of peripheral blood mononuclear cells (PBMC) derived from normal and leprosy individuals using different formulations of Mycobacterium leprae total cell wall antigen (MLCWA), Trat and MDP-BE using flow cytometric analysis. (bvsalud.org)
Unlike immunoglobulins, the alpha-beta T-cell receptors recognize antigens only when presented in association with major histocompatibility (MHC) molecules. (uams.edu)
TCR's recognize antigen peptides bound to MHC molecules forming the basis of antigen specific response by T cells (3, 4). (ancell.com)
The antigenic phenotype of OCs and foreign body giant cells (FBGCs) was investigated for the presence of several integrin molecules and other largely platelet-associated antigens involved in cell adhesion reactions. (ox.ac.uk)
Both OCs and FBGCs expressed the alpha-chains of the vitronectin receptor (CD51) and of the VLA-2 (CDw49b) and VLA-4 (CDw49d) molecules as well as their respective beta-chains, gpIIIa (CD61) and CD29. (ox.ac.uk)
These molecules can recognize the cancer cells expressing tumor-associated antigens with high affinity and selectivity triggering anticancer effects TH-302 [12 13 such as complement dependent cytotoxicity antibody-dependent cellular cytotoxicity inhibition of angiogenesis and induction of apoptosis. (researchatlanta.org)

Cross-linked R73 mAb induces T-cell activation and differentiation. (bdbiosciences.com)
Consistent with this, the ability of dendritic cells to produce the cytokine IL-6, required for in vivo Tfh differentiation, and antibody affinity maturation are both reduced in absence of type I interferon signaling. (nih.gov)
Cluster of Differentiation 79 (CD79) is a transmembrane protein found exclusively in B cells that is the transducer component of B-cell receptor (BCR), generating a signal following recognition of antigen by the BCR. (nationaljewish.org)
Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. (thermofisher.com)
The alpha and beta subunits of Ti bear no precursor-product relationship to one another and are encoded by separate germline V, D, J and C segments which rearrange during intrathymic differentiation to form an active gene set. (ox.ac.uk)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)

Allergic (including atopic) and other hypersensitivity disorders are inappropriate or exaggerated immune reactions to foreign antigens. (msdmanuals.com)

The tumor antigens are often proteins or other macromolecules (e.g., carbohydrates). (wikipedia.org)
Treatment vaccines: also known as therapeutic cancer vaccines, help the immune system learn to recognize and react to mutant proteins specific to the tumor and destroy cancer cells containing them. (wikipedia.org)
HLA-DR is expressed primarily by B cells and dendritic cells (DC), in which it binds peptides derived from internalized and processed antigenic proteins. (rndsystems.com)
Prime candidates are the streptococcal superantigens (SAgs), a family of highly mitogenic proteins secreted individually or in certain combinations by many Streptococcus pyogenes strains ( 7 - 10 ), although other virulence factors, such as Streptolysin O and various cell wall antigens can also cause toxic shock ( 11 ). (cdc.gov)
The Toll-like receptor (TLR) family in mammals comprises a set of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain, and in the IL-1 receptor motif in the cytoplasmic domain. (novusbio.com)
CD79A and CD79B, also known as Ig alpha and Ig beta, respectively, are transmembrane immunoglobulin superfamily proteins with one cytoplasmic immunoreceptor tyrosine-based activation motif (ITAM). (bio-techne.com)
Osteoclasts (OCs) and other cells of the mononuclear phagocyte system possess receptors for adhesive proteins present in the extracellular matrix. (ox.ac.uk)
The data suggest that cell-cell and cell-matrix interactions involving adhesive proteins may be important in OC and FBGC function. (ox.ac.uk)
Cancer cells proliferate abnormally compared to normal cells often expressing proteins (tumor-associated antigens) that cannot be seen in normal developmental stages [6]. (researchatlanta.org)
Moreover in recent years these antigen receptor proteins have attracted attention in the field of cancer immunotherapy to elevate the patient's immune response against tumor cells with few side-effects [10 11 In cellular immunotherapy T cells recognizing tumor-associated antigens can be administrated back to patients after ex vivo culture and processing for immune response enhancement. (researchatlanta.org)
Some authors propose a role for an antibody-mediated pathogenesis supported by: (1) reports that up to 30% of patients have antibodies against myelin proteins, (2) reports that there is deposition of immunoglobulin and complement in sural nerve biopsies, and (3) therapeutic response to intravenous immunoglobulins and plasma exchange. (medlink.com)
The important components of this system are various cell membrane-associated proteins such as complement receptor 1 (CR1), complement receptor 2 (CR2), and decay accelerating factor (DAF). (medscape.com)

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. (bdbiosciences.com)
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. (biolegend.com)
Further experiments will involve the characterization of the effectiveness of Curly 14 for modulating immune disease, understanding Curly 14 binding affinity, determination of the antibody binding site and the ability to destabilize and/or desensitize B cells in huSCID and human CD79 knockin mouse models. (nationaljewish.org)
The modified spike-trimer's binding affinity to the human angiotensin-converting enzyme-2 (ACE-2) receptor and other kinetic properties were determined using biolayer interferometry assays. (news-medical.net)
previously designated IL-13 R alpha or NR4) with low affinity, then recruits the IL-4 R alpha chain to form a high affinity receptor, causing downstream STAT6 activation. (reliatech.de)
Central tolerance occurs during lymphocyte development in the primary lymphoid organs (i.e. thymus and bone marrow), where T or B cell clones that recognize autoantigens with high-affinity are deleted. (frontiersin.org)

Cell types that can be used in this way are natural killer (NK) cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. (wikipedia.org)
Type I interferon signaling in dendritic cells and in nonhematopoietic cells selectively stimulates Tfh cell development in response to antigen in conjunction with Toll-like receptor (TLR)3 or TLR4 agonists. (nih.gov)
32-34 kDa) is expressed as alpha/beta heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as alpha/alpha homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. (exbio.cz)
CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. (thermofisher.com)
CD206 is a 175-kDa, type 1 integral membrane glycoprotein receptor that is present in macrophages, some dendritic cells, as well as liver and lymphoid endothelial cells. (fishersci.com)
The surface protein gp120 is a ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses. (antikoerper-online.de)
SIV subverts the migration properties of dendritic cells to gain access to CD4+ T-cells in lymph nodes. (antikoerper-online.de)

A human CD4 clone (Mx9/9) using the V beta 8 receptor was used as antigen to generate autologous clones (termed anti-Mx9/9 clones) which proliferate in response to this clone, but not other autologous clones. (ox.ac.uk)
Here, we derived a T-cell clone from a leprosy lesion that expressed TCR BV6 and the conserved CDR3 sequence L-S-G. This T-cell clone produced a T helper type 1 cytokine pattern, directly lysed M. leprae-pulsed antigen-presenting cells by the granule exocytosis pathway, and expressed the antimicrobial protein granulysin. (bvsalud.org)
PE conjugated Mouse anti Human CD25 antibody, clone MEM-181 ( MCA2127PE ) used for the identification of human Tregs by flow cytometry. (bio-rad-antibodies.com)
The iReceptor Turnkey Repository is a fully AIRR v1.4 compliant, searchable repository, supporting the loading and querying of rearrangement, clone, single cell/GEX, and genotype data. (ireceptor-plus.com)

He was one of the first to introduce immunotherapy with bispecific antibodies in children with relapsed/refractory acute lymphoblastic leukemia (R/R ALL), and is also involved in clinical trials using anti-CD19 and anti-CD19/22 chimeric antigen receptors in pediatric R/R ALL. (globalleukemiaacademy.com)
Second, T cell therapies using Tregs (either polyclonal, antigen-specific, or genetically engineered to express chimeric antigen receptors) to establish active dominant immune tolerance or T cells (engineered to express chimeric antigen receptors) to delete pathogenic immune cells. (frontiersin.org)

Hünig T, Wallny HJ, Hartley JK, Lawetzky A, Tiefenthaler G: A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. (exbio.cz)
Anti-CD79 antibody induces B cell anergy that protects against autoimmunity. (nationaljewish.org)
Triggering of the T3-Ti receptor complex induces a rapid increase in free cytoplasmic Ca2+ and gives rise to specific antigen-induced proliferation through an autocrine pathway involving endogenous interleukin-2 production, release and subsequent binding to interleukin-2 receptors. (ox.ac.uk)

Heterodimers of CD79A and CD79B associate with a membrane bound immunoglobulin on the B cell surface to form the B cell antigen receptor complex (BCR). (bio-techne.com)
History Immunoglobulin (IG or antibody) as well as the T-cell receptor TH-302 (TR) are pivotal protein in the disease fighting capability of higher microorganisms. (researchatlanta.org)
The classical pathway is triggered by interaction of the Fc portion of an antibody (immunoglobulin [Ig] M, IgG1, IgG2, IgG3) or C-reactive protein with C1q. (medscape.com)

The R73 monoclonal antibody specifically recognizes the αβ T-cell Receptor (TCR) found on most peripheral T lymphocytes, intestinal intraepithelial lymphocytes, and thymocytes. (bdbiosciences.com)
Human peripheral blood lymphocytes were stained with (A) Mouse Anti-Human HLA-DR Alexa Fluor® 700-conjugated Monoclonal Antibody (Catalog # FAB4869N) or (B) isotype control antibody (Catalog # IC002N ) Mouse anti-Human CD19 PE-conjugated Monoclonal Antibody (Catalog # FAB4867P ). (rndsystems.com)
In addition, this modality does not eliminate all B lineage cells and thus may not be appropriate for all pathologic conditions involving B lymphocytes. (nationaljewish.org)
The antibody MEM-31 recognizes a conformationally-dependent extracellular epitope of CD8, a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. (exbio.cz)
Distribution of lymphocytes of the alpha(E)beta(7) phenotype and E-cadherin in normal human urothelium and bladder carcinomas. (ox.ac.uk)
The primary aim of this work was to survey normal urothelium and transitional cell carcinoma (TCC) for the presence of T lymphocytes expressing the intraepithelial, CD103(+) phenotype. (ox.ac.uk)
In cancer studies monitoring the immune status of patients is thus very important for diagnosis as expression of an autoantibody [7] and the activation of cytotoxic T lymphocytes (CTLs) [8] specific to tumor-associated antigens are observed. (researchatlanta.org)
FSX P3D] RF Scenery Building - Catania LICC Hack Tool 2016 [Activation Code] Â·Role of the lymphocyte complement receptor in the function of T lymphocytes. (praxisbenefits.net)
their biopsies demonstrate T lymphocytes to be the predominant cells in early inflammatory lesions [ 5 ]. (escholarship.org)
Whether neutrophils or lymphocytes are first at the lesion site, evidence suggests that both immune cells are involved in the immunopathophysiology of acne. (escholarship.org)
Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)

In cell-mediated therapies like CAR-T cell therapy, immune cells are extracted from the patient, genetically engineered to recognize tumor-specific antigens, and returned to the patient. (wikipedia.org)
Finally, specific antibodies can be developed that recognize cancer cells and target them for destruction by the immune system. (wikipedia.org)
Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo- galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. (antikoerper-online.de)
Polyclonal anti-receptor antibodies directed against the gamma C3H/Cr1 cell receptor inhibit erythrocyte rosette formation and suppress the ability of the T lymphocyte to recognize lymphokine-activated killer cells. (praxisbenefits.net)

Shao H, Sun SL, Kaplan HJ, Sun D: Characterization of rat CD8+ uveitogenic T cells specific for interphotoreceptor retinal-binding protein 1177-1191: J Immunol. (exbio.cz)
M protein is a filamentous protein anchored to the cell membrane, which has antiphagocyte properties. (medscape.com)
The World Health Organization (WHO) has classified the SARS-CoV-2 Alpha, Beta, Gamma, Delta, and Omicron variants as variants of concern because they carry mutations in their spike protein that increase their transmissibility and ability to evade vaccine-induced immunity, as compared to the ancestral Wuhan strain. (news-medical.net)
Full length human recombinant protein of human CD3E(NP_000724) produced in HEK293T cell. (origene.com)
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. (origene.com)
Purified antibody is conjugated with activated Peridinin-Chlorophyll Protein (PerCP) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography. (exbio.cz)
Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. (genetex.com)
CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T-cell development and activation of mature T cells. (thermofisher.com)
Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. (thermofisher.com)
In our previous study, the defective T cell function in LL patients was restored to a proliferating state with the release of TH1 type cytokines using mycobacterial antigen(s) with two immunomodulators (Murabutide (MDP-BE) and T cell epitope of Trat protein of Escherichia coli) by presenting the antigen in particulate form in vitro to PBMC derived from leprosy patients. (bvsalud.org)
A soluble form of CD206 is generated by cleavage of the full-length protein, and it can be detected in in vitro macrophage cell culture supernatants and in mouse serum. (fishersci.com)
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of IL-13R a2 extracellular domain. (reliatech.de)
The key targets in the Bone Marrow Transplant Rejection pipeline drugs market are Tyrosine Protein Kinase JAK1, Tyrosine Protein Kinase JAK2, Tyrosine Protein Kinase BTK, Interleukin 2 Receptor, Programmed Cell Death Protein 1, Alpha 1 Antitrypsin, Cells Expressing B Lymphocyte Antigen CD20, Interleukin 2 Receptor Subunit Beta, Macrophage Colony Stimulating Factor 1 Receptor, and Tyrosine Protein Kinase ITK/TSK among others. (globaldata.com)
The key mechanisms of action in the Bone Marrow Transplant Rejection pipeline drugs market are Tyrosine Protein Kinase JAK1 Inhibitor, Tyrosine Protein Kinase JAK2 Inhibitor, Tyrosine Protein Kinase BTK Inhibitor, Interleukin 2 Receptor Agonist, Alpha 1 Antitrypsin Replacement, Cytotoxic To Cells Expressing B Lymphocyte Antigen CD20 , Interleukin 2 Receptor Subunit Beta Antagonist, Programmed Cell Death Protein 1 Agonist, Tyrosine Protein Kinase ITK/TSK Inhibitor, and CD40 Ligand Inhibitor among others. (globaldata.com)
CD97 is a G-protein-coupled seven-span transmembrane adhesive receptor that is constitutively expressed on granulocytes and monocytes and rapidly upregulated on T and B cells upon activation. (thermofisher.cn)
the latter are ligands for several of the above matrix protein receptors. (ox.ac.uk)
The surface protein gp120 (SU) attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. (antikoerper-online.de)
Surface protein gp120 (SU) may target the virus to gut- associated lymphoid tissue (GALT) by binding host ITGA4/ITGB7 (alpha-4/beta-7 integrins), a complex that mediates T-cell migration to the GALT. (antikoerper-online.de)
Each one of these protein includes two string types known as light and weighty stores for IG (you can find two similar light chains and two identical heavy chains in an IG) and alpha and beta chains or gamma and delta chains for TR. (researchatlanta.org)

Mouse splenocytes either (A) stimulated to induce Th1 cells or (B) unstimulated were stained with Rat Anti-Mouse IFN-gamma Alexa Fluor® 700-conjugated Monoclonal Antibody (Catalog # IC485N) and Rat Anti-Mouse CD4 PE-conjugated Monoclonal Antibody (Catalog # FAB554P ). (rndsystems.com)
Quadrant markers were set based on control antibody staining (Catalog # IC006N ). (rndsystems.com)
To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (Catalog # FC004 ) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005 ). (rndsystems.com)
Mouse splenocytes either (A) stimulated for 4 hours with Cell Activation Cocktail 500x ( 5476 ) or (B) unstimulated were stained with Rat Anti-Mouse IFN-gamma Alexa Fluor® 700-conjugated Monoclonal Antibody (Catalog # IC485N) and Rat Anti-Mouse CD4 PE-conjugated Monoclonal Antibody ( FAB554P ). (rndsystems.com)
The following product was used in this experiment: CD8a Monoclonal Antibody (RPA-T8), eFluor™ 450, eBioscience™ from Thermo Fisher Scientific, catalog # 48-0088-42, RRID AB_1272062. (thermofisher.com)
The following product was used in this experiment: CD97 Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA5-80320, RRID AB_2787649. (thermofisher.cn)
The following product was used in this experiment: CaV1.2 (CACNA1C) Polyclonal Antibody from Thermo Fisher Scientific, catalog # ACC-003-GP200UL. (thermofisher.com)

An isotype control should be used at the same concentration as the antibody of interest. (bdbiosciences.com)
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml. (reliatech.de)

Current pathophysiology studies are focused on the origin of the antibody response, the nature of the antigenic complex and pathologic epitopes, the mechanisms of interindividual differences in platelet activation, and the functions of monocytes and endothelial cells. (immune-source.com)

Quadrant markers were set based on control antibody staining ( IC006N ). (rndsystems.com)

RON is a receptor tyrosine kinase that is translated as a single polypeptide and then proteolytically cleaved to yield a mature heterodimer consisting of an extracellular 35 kDa α chain disulfide-linked to a membrane-spanning 150 kDa beta chain. (affbiotech.com)
In trans infection, bound virions remain infectious over days and it is proposed that they are not degraded, but protected in non-lysosomal acidic organelles within the DCs close to the cell membrane thus contributing to the viral infectious potential during DCs' migration from the periphery to the lymphoid tissues. (antikoerper-online.de)
Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. (thermofisher.com)
Normal neuromuscular junction showing a presynaptic terminal with a motor nerve ending in an enlargement (bouton terminale): Synaptic cleft and postsynaptic membrane with multiple folds and embedded with several acetylcholine receptors. (medscape.com)

Carlson BC, Jansson AM, Larsson A, Bucht A, Lorentzen JC: The endogenous adjuvant squalene can induce a chronic T-cell-mediated arthritis in rats. (exbio.cz)
RON antibody detects endogenous levels of total RON. (affbiotech.com)
Autoimmune Disorders In autoimmune disorders, the immune system produces antibodies to an endogenous antigen (autoantigen). (msdmanuals.com)

This binding results in the activation of a large proportion of antigen-presenting cells and T cells, with subsequent release of high systemic levels of cytokines ( 12 - 15 ). (cdc.gov)
The major cytokines released from antigen-presenting cells and T cells after activation by SAgs are tumor necrosis factor alpha (TNF-α), tumor necrosis factor beta (TNF-β), interleukin (IL)-1, and IL-2 ( 11 - 14 ). (cdc.gov)
Antigen binds to IgE that is bound to tissue mast cells and blood basophils, triggering release of preformed mediators (eg, histamine, proteases, chemotactic factors) and synthesis of other mediators (eg, prostaglandins, leukotrienes, platelet-activating factor, cytokines). (msdmanuals.com)

Müller N, van den Brandt J, Odoardi F, Tischner D, Herath J, Flügel A, Reichardt HM: A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats. (exbio.cz)
B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation. (nationaljewish.org)
this interaction does not cause activation of STAT6, but does induce TGF-beta production. (reliatech.de)
Significantly, PF4As inhibited ULC formation at all PF4 : Hep ratios tested, and both antagonists prevented cellular activation by ULC and HIT antibodies. (immune-source.com)
Progress in therapy is usually hampered by the difficulties of inadequate positive predictive value of antibody detection and clinical scores in suspected HIT, very limited availability of practical platelet activation assays, and the paucity of new agents in human clinical trials. (immune-source.com)
HIT pathophysiology has an initiation phase, immunization to produce pathologic antibodies, then platelet activation by IgGCPF4CHep immune complexes. (immune-source.com)
Interaction of CD97 on leukocytes and CD55 on vessel cells probably facilitate leukocyte activation and migration into the tissues, similarly, CD97 seems to play a role in tumour migration and invasiveness. (thermofisher.cn)
D) Mean (+SEM) percentage suppression of effector cell proliferation following activation with CD3/28 beads at 2:1 (closed boxes) and 0.2:1 (open boxes) bead: cell ratios. (bio-rad-antibodies.com)
CD79A and CD79B are required for BCR-mediated signaling and consequently for the development and activation of B lineage cells. (bio-techne.com)
Virion capture also seems to lead to MHC-II-restricted viral antigen presentation, and probably to the activation of SIV-specific CD4+ cells (By similarity). (antikoerper-online.de)
Loss of immune tolerance to autoantigens associated with a specific organ results in the activation of organ-specific T and B cells that in turn cause organ-specific inflammation and the development of autoimmune diseases such as multiple sclerosis (MS) ( 5 ), rheumatoid arthritis (RA) ( 6 ), psoriasis ( 7 ), and type 1 diabetes (T1D) ( 8 ). (frontiersin.org)

During the live virus neutralization experiments, plaque reduction neutralization assays were used to measure the macaque serum samples, while cytopathic effect neutralization assays were used to determine the neutralizing antibody titers in hamster serum samples. (news-medical.net)
Vaccination resulted in generation of neutralizing antibody titers in most recipients, but neutralization titers waned over time, necessitating frequent booster doses. (cdc.gov)

It presents these peptides on the cell surface for recognition by the T cell receptor on CD4 + T cells. (rndsystems.com)
This antibody was developed against a mixture of synthetic peptides containing amino acids 180-196, 353-370, and 473-489 of human TLR2 (NP_003255). (novusbio.com)

HLA-DR is a transmembrane human major histocompatibility complex 2 (MHC II) family member and consists of a 34 kDa (alpha) subunit and one of several 28 kDa (beta) subunits. (rndsystems.com)
Dr. Cambier and his laboratory discovered that in certain circumstances, subunits of the B cell antigen receptor (BCR) become dissociated rendering the receptor incompetent to transduce activating signals. (nationaljewish.org)
Integrin alpha 2 is one of twelve integrin family alpha subunits that share the beta 1 subunit (1‑3). (novusbio.com)
Integrin alpha 2 beta 1 is the non-covalent heterodimer of 160 kDa alpha 2 (CD49b) and 130 kDa beta 1 (CD29) type I transmembrane glycoprotein subunits and is one of six very late antigens on activated T cells, designated VLA2 (3). (novusbio.com)
IFN-gamma dimers bind to IFN-gamma RI (alpha subunits) which then interact with IFN-gamma RII (beta subunits) to form the functional receptor complex of two alpha and two beta subunits. (rndsystems.com)
The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. (thermofisher.com)

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis . (biolegend.com)
The fluorochrome-labeled 359-81-11 antibody is useful for intracellular immunofluorescent staining and flow cytometric analysis to identify LT-α -producing cells within mixed cell populations. (biolegend.com)
Applications Reported: This RPA-T8 antibody has been reported for use in flow cytometric analysis. (thermofisher.com)
Applications Tested: This RPA-T8 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
Applications Reported: This MR6F3 antibody has been reported for use in flow cytometric analysis, and intracellular staining followed by flow cytometric analysis. (fishersci.com)
Applications Tested: This MR6F3 antibody has been tested by intracellular staining and flow cytometric analysis of mouse resident peritoneal exudate cells using the Intracellular Fixation & Permeabilization Buffer Set (cat. (fishersci.com)

Estefanía E, Flores R, Gómez-Lozano N, Aguilar H, López-Botet M, Vilches C: Human KIR2DL5 is an inhibitory receptor expressed on the surface of NK and T lymphocyte subsets. (exbio.cz)
Cells in the lymphocyte gate were used for analysis. (thermofisher.com)
The ontogeny, structure and function of the human T lymphocyte receptor for antigen and major histocompatibility complex. (ox.ac.uk)
This paper reports the study of the influence of antibodies against the receptor for C3 on a number of lymphocyte function tests. (praxisbenefits.net)
D-Mixture of antibodies against the alpha and beta receptors completely inhibits all lymphocyte functions tested. (praxisbenefits.net)
The suppression of the C3H/Cr1 lymphocyte receptor by antibodies does not appear to be due to lysis of the cells but rather by interference with interleukin-2 production. (praxisbenefits.net)
These results demonstrate that the function of the lymphocyte C3 receptor is not only involved in the binding of C3b to cells via the alpha C3H/Cr1 receptor but also in the production of interleukin-2. (praxisbenefits.net)

Here, we demonstrate that lymph-node-resident CXCR5(+) Tfh cells and gut-homing integrin alpha(4)beta(7)-expressing T helper cells are generated as separate subsets in the gut-draining mesenteric lymph nodes. (nih.gov)
Detects human Integrin alpha 2/CD49b. (novusbio.com)
This antigen defines the alpha(E)beta(7)-integrin. (ox.ac.uk)

Novel gene editing systems were deployed in NK cells to disrupt CD38 - a cell surface immune modulator that can be targeted in the development of cancer immunotherapy - and to integrate a CAR construct that led to robust CAR-directed cellular cytotoxicity. (businesswire.com)
Antibodies against alpha and beta C3H/Cr1 are more potent in inhibiting both rosette formation and cell-mediated cytotoxicity. (praxisbenefits.net)

Eady and Cove have suggested that increased permeability of the follicular wall secondary to the release of the proinflammatory and cell-differentiating cytokine interleukin 1 alpha (IL-1α) may be all that is necessary to initiate the intradermal inflammatory process that characterizes inflammatory lesions [ 4 ]. (escholarship.org)

The I domain-containing beta 1 integrins ( alpha 1 beta 1, alpha 2 beta 1, alpha 10 beta 1 and alpha 11 beta 1) all bind collagens, with alpha 2 beta 1 preferring collagens I‑III (4, 5). (novusbio.com)

The development of CAR T therapies and other genetically engineered cell therapies in recent years has resulted in significant benefits for patients, yet there remains a large unmet need for gene editing systems that can be used to develop novel immunotherapy approaches to treat blood cancers," said Brian C. Thomas, PhD, CEO and Co-Founder of Metagenomi. (businesswire.com)

The mouse monoclonal R73 recognizes an extracellular epitope TCR alpha/beta, the dominant subtype of T cell receptor expressed in peripheral blood. (exbio.cz)
One such subset, germline-encoded, mycolyl lipid-reactive (GEM) T cells, recognizes mycobacterial cell wall lipids and expresses a conserved TCR-É chain that is shared among genetically unrelated individuals. (bvsalud.org)
Description: This MR6F3 antibody recognizes mouse CD206 also known as Macrophage Mannose Receptor (MMR) or Mannose Receptor C, Type 1 (MRC1). (fishersci.com)

CD14+ monocytes expressed the highest level of TLR2 followed by CD15+ granulocytes, and CD19+ B-cells, CD3+ T-cells, and CD56+ NK cells did not express TLR2. (novusbio.com)

The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta subunit. (exbio.cz)
Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. (exbio.cz)
The N501Y mutation in the receptor binding domain (RBD), which is reported to increase transmissibility by 40-70%, is shared by the Alpha, Beta, Gamma, and Omicron variants. (news-medical.net)
Additionally, the Beta, Gamma, and Omicron variants also carry substitution mutations in the E484 and K417 positions, while the D614G mutation is present in all five variants of concern. (news-medical.net)
Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. (genetex.com)
In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. (genetex.com)
If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. (genetex.com)
In Western blots, this antibody does not cross-react with recombinant human IFN‑ gamma, recombinant rat IFN‑ gamma, recombinant porcine IFN‑ gamma, recombinant rhesus macaque IFN‑ gamma, recombinant feline IFN‑ gamma, or recombinant canine IFN‑ gamma. (rndsystems.com)
IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells. (rndsystems.com)
Human T cell receptor (TCR) is a T cell surface expressed heterodimer of alpha/beta or gamma/delta chains. (ancell.com)

Furthermore, peripheral blood mononuclear cells (PBMCs) or splenocytes harvested from the vaccinated animals 14 days after the second vaccine dose and analyzed through flow cytometry were used for intracellular cytokine staining assay and enzyme-linked immunospot (ELISPOT) assay to examine the immune responses elicited by the vaccines. (news-medical.net)
Staining of normal human peripheral blood cells with Anti-Human CD3 APC (Product # 17-0038-42) and 0.25 µg of Mouse IgG1 K Isotype Control eFluor® 450 (Product # 48-4714-82) (left) or Anti-Human CD8a eFluor® 450 (right). (thermofisher.com)
Circulating tumor cells (CTCs) can be detected in the peripheral blood and peritoneal liquid in most of the ovarian cancer patients in the different stages of the disease. (uni-hamburg.de)
Peripheral blood mononuclear cells from this cohort of individuals were used to map out the viral epitopes targeted by T cells in humans. (cdc.gov)

This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. (origene.com)
In leprosy, cell-mediated immunity (CMI) is more significant than humoral response to eliminate intracellular pathogen. (bvsalud.org)
It has been demonstrated that only a small fraction of CD206 is present at the cell surface, therefore, intracellular staining is recommended. (fishersci.com)

Active cellular therapies aim to destroy cancer cells by recognition of distinct markers known as antigens. (wikipedia.org)
Kraus E, Lambracht D, Wonigeit K, Hünig T: Negative regulation of rat natural killer cell activity by major histocompatibility complex class I recognition. (exbio.cz)
Recombination of many different V segments with several J segments provides a wide range of antigen recognition. (genetex.com)
Each chain contains at its N-terminal end a variable (V) domain name which participates in antigen recognition. (researchatlanta.org)

Two members of the type 5 subfamily of type I cytokine receptors can serve as receptors for IL-13. (reliatech.de)
IL-13 R alpha 1 and IL-13 R alpha 2 each have three extracellular fibronectin type III domains, two cytokine receptor homology modules and a WSXWS motif typical of the class I cytokine receptor family, but IL-13 R alpha 2 has a much shorter cytoplasmic tail. (reliatech.de)

Linnebacher M, Wienck A, Boeck I, Klar E: Identification of an MSI-H tumor-specific cytotoxic T cell epitope generated by the (-1) frame of U79260(FTO). (exbio.cz)
Recent advances on the iReceptor Science Gateway include the ability to link sequence searches to binding characteristics of the immune receptors, through external databases such as the Immune Epitope Database ( IEDB ). (ireceptor-plus.com)

The animals were intramuscularly administered different vaccine doses, and the control and enzyme-linked immunosorbent assays (ELISA) and pseudovirus neutralization assays were used to determine the serum antibody titers. (news-medical.net)
Blood was taken just prior to vaccination and 3 weeks after and serum antibody levels (IgG) were assayed using inactivated antigen from the mycoplasma vaccine culture. (octagon-services.co.uk)

As a consequence CD79 is an ideal candidate molecule for B cell-targeted therapy. (nationaljewish.org)
Description: The RPA-T8 monoclonal antibody reacts with the human CD8a molecule, an approximately 32-34 kDa cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). (thermofisher.com)

The alpha 2 extracellular domain (ECD) contains an I (inserted) domain which includes the ligand binding site (2, 3). (novusbio.com)
The 1102 amino acid (aa) human alpha 2 extracellular domain (ECD) shares 83‑89% aa sequence identity with mouse, rat, canine, bovine and equine alpha 2. (novusbio.com)
Extracellular matrix receptor and platelet antigens on osteoclasts and foreign body giant cells. (ox.ac.uk)

RON (MST1R): macrophage stimulating 1 receptor (c-met-related tyrosine kinase). (affbiotech.com)

CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel. (thermofisher.com)
The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. (thermofisher.com)

Moreover, no antibodies to the nuclease were detected in serum from 50 healthy human donors, while between one third and half of the same serum samples contained antibodies that bind to spCas9, which is derived from a Streptococcus bacteria that commonly infects humans. (businesswire.com)

Receptor desensitization and therapeutic efficacy has been demonstrated in vitro and in vivo. (nationaljewish.org)
In later experiments they developed a proprietary monoclonal antibody against human CD79 (Curly 14) that has the capacity to desensitize the BCR in vitro. (nationaljewish.org)
An increased surface expression of CD80, CD86 and CD28 but decreased CD152 expression was observed when PBMC of normal, BT/TT (tuberculoid) and BL/LL (lepromatous) patients were stimulated in vitro with MLCWA+MDP-BE+Trat peptide using liposomal mode of antigen delivery, while opposite results were obtained with the antigen alone. (bvsalud.org)
Subsequent in vitro studies have demonstrated that antigens from P. acnes can stimulate the development of subclasses of T cells [ 6 ]. (escholarship.org)
Although other irritants in the smoke may have contributed to the incident, there is supporting evidence that stable strontium can stimulate the release of histamine from mast cells in vitro (ATSDR 2001e). (cdc.gov)

Normal antibodies bind to external pathogens, but the modified immunotherapy antibodies bind to the tumor antigens marking and identifying the cancer cells for the immune system to inhibit or kill. (wikipedia.org)
Furthermore they established that anti-CD79a/b antibodies (intact, or mutants incompetent to bind IgG receptors and activate the complement cascade) block the development of disease and ameliorate ongoing target organ injury in MRL/LPR mouse model of Rheumatoid Arthritis, NOD mice for Type 1 Diabetes and EAE mouse model for MS. (nationaljewish.org)

T-cell transfer therapy: a treatment that takes T-cells from the tumor and selects or changes them in the lab to better attack cancer cells, then reintroduces them into the patient. (wikipedia.org)
Active immunotherapy specifically targets tumor cells via the immune system. (wikipedia.org)
In contrast, passive immunotherapy does not directly target tumor cells, but enhances the ability of the immune system to attack cancer cells. (wikipedia.org)
Lymphotoxin-α (LT-α), also known as tumor necrosis factor-beta (TNF-β), is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells. (biolegend.com)
Metastatic outgrowth of disseminated tumor cells is thought to be fueled by clonal cooperation of tumor clones from early and late stages of cancer evolution. (uni-hamburg.de)
This study will elucidate the metastatic cascade of ovarian cancer by investigating the natural cancer evolution through the analysis of single tumor cells on genomic, transcriptomic, proteomic, and methylomic (multi‐omic) level. (uni-hamburg.de)
The entries in Group I are especially crucial for tumor immunotherapy offering supportive info for genetic executive of book antibody medications tumor-specific TR and peptide vaccines. (researchatlanta.org)
In hematological tumors such as leukemia or lymphoma IG and TR themselves are the subject of investigation because the encoding genes are often mutated by translocation in tumor B or T cells [9]. (researchatlanta.org)
The cancer diagnostics market is on the verge of explosion, as the researchers approach major technological breakthroughs in tumor diagnosis and therapy, discover new specific antigens, and unlock the mystery of the genetic basis of the disease. (aarkstore.com)
However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)
GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)

CD97 is produced in alternatively spliced forms and its cellular ligand is CD55 (DAF), which protects various cell types from complement-mediated damage. (thermofisher.cn)
Lectins activate the lectin pathway in a manner similar to the antibody interaction with complement in the classical pathway. (medscape.com)

Research continued in the 20th century under Maria O'Connor Hornung at Tulane Medical School There are several types of immunotherapy used to treat cancer: Immune checkpoint inhibitors: drugs that block immune system checkpoints to allow immune cells to respond more strongly to the cancer. (wikipedia.org)

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase. (thermofisher.com)

Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 10 6 cells in a suspension. (exbio.cz)
Further, these results reveal the feasibility of developing a simple, field deployable molecular diagnostic based on mycobacterial lipid antigen-specific TCR sequences that are readily detectable in human tissues and blood independent of genetic background. (bvsalud.org)
Cryostat sections of normal bladder and TCC were treated with antibodies specific for human CD103, CD3, CD8 and E-cadherin. (ox.ac.uk)
Novel CRISPR-Associated Gene Editing Systems Discovered in Metagenomic Samples Enable Efficient and Specific Genomic Engineering for Cell Therapy Development," three novel gene editing systems were used to make reproducible and efficient edits to human immune cells, demonstrating utility for the next generation of cell therapy development for blood cancers. (businesswire.com)
In summary, these novel systems were shown to result in highly efficient and specific gene edits in human immune cells and display the potential for use in cell therapy development. (businesswire.com)
He has implemented in Italy the first-in-human academic studies on children with CD19+ lymphoid malignancies using second-generation retroviral chimeric antigen receptor (CAR) T cells and on children with GD2+ neuroblastoma. (globalleukemiaacademy.com)
In transfected human TLR2 cell lysate, a 90 kDa band is observed. (novusbio.com)
TLR2 is differentially expressed in human cells. (novusbio.com)
Antibody JOVI-3 is specific for the human V beta 3 TCR gene product and reacts with 1-10 of T cells in normal human blood (1, 5). (ancell.com)
The implications of these findings for understanding of human T cell growth and its regulation in disease states are discussed. (ox.ac.uk)
These include hepatitis C virus, human immunodeficiency virus (HIV), and human T-cell lymphotrophic virus (HTLV). (medscape.com)
In general the source of antibody medicines is the human or mouse: (i) fully murine (ii) chimeric with V domains from the mouse and constant regions from the human and (iii) humanized or human antibodies have been developed [12]. (researchatlanta.org)
For instance trastuzumab (trade name Herceptin) a humanized antibody that targets the human epidermal growth factor receptor. (researchatlanta.org)
These data provide tools for assessing human RVFV-specific T cell responses and are thus a valuable resource for future human RVFV vaccine efforts. (cdc.gov)

DCs are professional antigen presenting cells, critical for host immunity by inducing specific immune responses against a broad variety of pathogens. (antikoerper-online.de)
fundamental substances for humoral immunity and cell-mediated immunity respectively [1]. (researchatlanta.org)
Recent progress in the study of innate immunity identifies two key factors relevant to acne: β defensins and toll-like receptors (TLRs). (escholarship.org)

RVFV-specific CD8 T cells were expanded and of a cytotoxic and proliferating phenotype in the liver following infection. (cdc.gov)

This has also been reported to work well in bronchial epithelial cells (UBH16E) and THP-1 cells. (novusbio.com)
Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. (antikoerper-online.de)
This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity). (antikoerper-online.de)

For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 10 6 cells in 100 µl volume. (biolegend.com)

This was used as an experimental model to explore the specific interactions between autologous T cells. (ox.ac.uk)
Most patients with primary Sjogren syndrome have two specific antibodies: against Ro (SS-A) and La (SSB) antigens. (medscape.com)
In this study, we sought to define the specific type(s) of CD4 T cells that mediate protection from RVFV encephalitis. (cdc.gov)
RVFV-specific CD4 T cells were identified in the liver and spleen following infection and phenotyped as largely Th1 or Tfh subtypes. (cdc.gov)
Virus-specific antibody responses correlated with protection from encephalitis in all mouse strains, suggesting that Tfh-B cell interactions modulate clinical outcome in this model. (cdc.gov)
In this study we develop reagents to detect RVFV-specific T cells and provide evidence for Tfh cells and CD40/CD40L interactions as critical mediators of this protection. (cdc.gov)
RVFV-specific T cell responses were detectable up to 24 years post vaccination. (cdc.gov)

Anatomy17

Organisms6

Chemicals and Drugs71

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes24

Disciplines and Occupations1

Information Science3

Health Care1

Monoclonal antibodies9

Specificity6

Molecules14

Differentiation7

Foreign antigens1

Proteins12

Affinity6

Dendritic cells7

Clone4

Chimeric antigen receptors2

Induces3

Immunoglobulin3

Lymphocytes11

Recognize4

Protein19

Catalog7

Concentration2

Endothelial cells1

Control antibody1

Membrane4

Endogenous3

Cytokines3

Activation11

Neutralizing antibody titers2

Peptides2

Subunits6

Flow cytometric analysis6

Lymphocyte7

Integrin3

Cytotoxicity2

Interleukin1

Integrins1

Genetically engineered1

Recognizes3

Monocytes1

Gamma10

Peripheral blood4

Intracellular3

Recognition4

Cytokine2

Epitope2

Serum antibody2

Molecule2

Extracellular3

Tyrosine kinase1

Subunit2

Humans1

Vitro5

Bind2

Tumor12

Complement2

Immunotherapy1

Invitrogen1

Human14

Immunity3

Cytotoxic1

Epithelial cells3

Cytometric1

Specific7