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Alanine TransaminaseAspartate AminotransferasesAlanineLiver4-Aminobutyrate TransaminaseDrug-Induced Liver InjuryTransaminasesLiver Function TestsLiver DiseasesD-Alanine TransaminaseCarbon Tetrachloridegamma-GlutamyltransferaseProtective AgentsBilirubinPlant ExtractsAcetaminophenGalactosamineLiver CirrhosisAlkaline PhosphataseLiver Cirrhosis, ExperimentalPhytotherapyFatty LiverAlanine RacemaseBiological MarkersHepatitis B, ChronicL-Lactate DehydrogenaseReperfusion InjuryAnalgesics, Non-NarcoticRats, WistarLipid PeroxidationThiobarbituric Acid Reactive SubstancesHepatitis C, ChronicTyrosine TransaminaseAntioxidantsNecrosisRats, Sprague-DawleyAntiviral AgentsHepatitis CDisease Models, AnimalInterferon-alphaTreatment OutcomeTime FactorsAlanine DehydrogenaseHepacivirusOrnithine-Oxo-Acid TransaminaseAminooxyacetic AcidVigabatrinPredictive Value of Testsbeta-Alanine-Pyruvate TransaminaseRetrospective StudiesAmino AcidsMice, Inbred C57BLPyridoxal PhosphateTumor Necrosis Factor-alphaAspartate Aminotransferase, CytoplasmicIsoleucineProspective StudiesKetoglutaric AcidsAmino Acid SequenceMolecular Sequence DataAminobutyratesClinical Enzyme TestsPyridoxineGlutamine-Fructose-6-Phosphate Transaminase (Isomerizing)Aspartate Aminotransferase, MitochondrialMutagenesis, Site-DirectedKineticsGlycine TransaminaseGlutamineKeto AcidsAspartic AcidGlutamatesPyruvatesMutationHepatitisSuccinyldiaminopimelate TransaminasePyridoxamineValeratesLyasesLeucineValineEscherichia coliKynurenineAminationSuccinate-Semialdehyde DehydrogenaseAmino Acid SubstitutionOxaloacetic AcidAminocaproatesSerineBlood Chemical AnalysisRecombinant ProteinsSubstrate SpecificityAminoethylphosphonic Acid

Normal alanine transaminaseAminotransferaseAspartate transaminaseElevationsSerumPyruvateEnzymeLiver diseaseLevelProteinBloodActivityIncreaseGreater

Normal alanine transaminase3

• Approximately 20-30% of patients chronically infected with hepatitis C virus (HCV) have persistently normal alanine transaminase (PNALT) levels. (medscape.com)
• Controversies about the histological features of chronic HCV patients with persistently normal alanine transaminase levels: what can be done about the present definition? (pasteur.fr)
• Improved Performance of Serum Alpha-Fetoprotein for Hepatocellular Carcinoma Diagnosis in HCV Cirrhosis with Normal Alanine Transaminase. (nih.gov)

Aminotransferase5

• It is also called alanine aminotransferase (ALT or ALAT) and was formerly called serum glutamate-pyruvate transaminase or serum glutamic-pyruvic transaminase (SGPT) and was first characterized in the mid-1950s by Arthur Karmen and colleagues. (wikipedia.org)
• In 2000, the American Association for Clinical Chemistry determined that the appropriate terminology for AST and ALT are aspartate aminotransferase and alanine aminotransferase. (wikipedia.org)
• Serum triglyceride (TG), total-cholesterol (T-cho), glucose (Glu), alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), geranylgeranyltransferase (GGT) and albumin (Alb) levels were measured. (spandidos-publications.com)
• First, look at liver enzymes: alanine transaminase (ALT) or aspartate aminotransferase (AST). (nih.gov)
• Plasma alanine aminotransferase levels, hepatic expression of tumor necrosis factor-α, interleukin-6, fatty acid synthesis-related genes, oxidative stress biomarker 8-hydroxydeoxyguanosine (8-OHdG), and apoptosis marker terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL)-positive cells in the liver were decreased in the HW and PGZ groups. (researchgate.net)

Aspartate transaminase3

• Serum ALT level, serum AST (aspartate transaminase) level, and their ratio (AST/ALT ratio) are commonly measured clinically as biomarkers for liver health. (wikipedia.org)
• Aspartate transaminase Liver function tests Karmen A, Wroblewski F, Ladue JS (January 1955). (wikipedia.org)
• For example, elevated alanine transaminase and aspartate transaminase disproportional to bilirubin and alkaline phosphatase levels often indicates liver disease. (healthline.com)

Elevations1

• Hepatotoxicity: Monitor liver laboratory tests every 2 weeks during the first 3 months of treatment, then once a month and as clinically indicated, with more frequent testing in patients who develop transaminase and bilirubin elevations. (nih.gov)

Serum1

• Is Serum Alanine Transaminase Level a Reliable Marker of Histological Disease in Chronic Hepatitis C Infection? (medscape.com)

Pyruvate2

• ALT catalyzes the transfer of an amino group from L-alanine to α-ketoglutarate, the products of this reversible transamination reaction being pyruvate and L-glutamate. (wikipedia.org)
• citation needed] L-alanine + α-ketoglutarate ⇌ pyruvate + L-glutamate ALT (and all aminotransferases) require the coenzyme pyridoxal phosphate, which is converted into pyridoxamine in the first phase of the reaction, when an amino acid is converted into a keto acid. (wikipedia.org)

Enzyme2

• Alanine transaminase (ALT) is a transaminase enzyme (EC 2.6.1.2). (wikipedia.org)
• The alanine transaminase (ALT) blood test measures the level of the enzyme ALT in the blood. (medlineplus.gov)

Liver disease1

• The term transaminase is outdated and no longer used in liver disease. (wikipedia.org)

Level3

• Alanine Transaminase Level: Reliable Marker of HCV Histological Disease? (medscape.com)
• An elevated alanine transaminase (ALT) level is indicative of hepatocellular necrosis and has been used as a surrogate marker of liver injury. (medscape.com)
• Liver function tests showed a depressed level of alanine transaminase and an abnormal HDL: LDL. (open.ac.uk)

Protein1

• Alanine transaminase (ALT) is used by your body to metabolize protein. (healthline.com)

Blood1

• Their blood was used to measure alanine transaminase (ALT), asparagine transaminase (AST), cholesterol, creatinine and glycosylated haemoglobin (HbA 1 C). (aaem.pl)

Activity1

• We conducted Western blotting, real-time polymerase chain reaction (PCR), 3-(4,5-dimethylthiazol-2-yl)-2,5-triphenyl tetrazolium bromide (MTT) assays, liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) analysis, alanine transaminase (ALT) activity, histopathological analysis, and rotarod test. (nih.gov)

Increase1

• This study determined whether 12 weeks of treatment with acetaminophen at half the maximum recommended daily dose causes an increase in alanine transaminase (ALT) in healthy adults participating in a clinical trial of the effect of acetaminophen on asthma control and severity. (nih.gov)

Greater1

• This research is being done to determine if men with rising PSA after initial therapy for localized prostate cancer who display the Alanine/Alanine SOD2 genotype of MnSOD and supplement their diet with MPX have greater decrease in PSA slope following treatment compared to men that do not supplement with MPX. (dana-farber.org)