Animal models adenoviruses human. Medical search. Frequent questions

Adenovirus vectors are widely used in gene therapy and vaccine development due to their ability to efficiently deliver genes and antigens to target cells. (inventiv.org)
The use of adenovirus vectors for multiple vaccinations is particularly attractive because they can be engineered to express multiple antigens, which can provide protection against multiple diseases. (inventiv.org)
The global market for adenovirus vectors is expected to grow at a compound annual growth rate (CAGR) of 9.9% from 2020 to 2027. (inventiv.org)
Several companies are actively engaged in the development of adenovirus vectors for multiple vaccinations. (inventiv.org)
The market for adenovirus vectors for multiple vaccinations is also witnessing significant investments from governments and private organizations. (inventiv.org)
Methods to generate immune responses using the adenovirus Vectors are provided that allow multiple vaccinations with one adenovirus virus vector, and vaccinations of individuals with preexisting immunity. (inventiv.org)
The invention concerns methods of generating immune responses using Adenovirus vectors that allow multiple vaccination regimens. (inventiv.org)
The greatest problem with adenovirus-based vectors is their inability to maintain long-term transgene expression. (inventiv.org)
Adenovirus vectors, however, can't cause these infections because they can't complete their replication cycle. (mayo.edu)
E1-deleted (including E1a-deleted) adenoviruses are replication defective and are commonly used as viral vectors to carry therapeutic genes for gene therapy. (hindawi.com)
Replication defective adenovirus vectors with low sero-prevalence and low T-cell reactivity in the relevant human populations. (nih.gov)

Adipocyte commitment of 3T3-L1 cells is required to support human adenovirus 36 productive replication concurrent with altered lipid and glucose metabolism. (leibniz-liv.de)
Evidence that the Adenovirus Single-Stranded DNA Binding Protein Mediates the Assembly of Biomolecular Condensates to Form Viral Replication Compartments. (leibniz-liv.de)
To overcome this obstacle, conditional oncolytic viruses (such as conditional replication adenovirus (CRAD)) are developed to specifically target prostate without (or with minimal) systemic toxicity due to viral self-replication. (hindawi.com)
The adenovirus early region 1 (E1) gene, which comprises E1a and E1b, encodes the viral early proteins that are necessary for adenoviral replication and the consequent oncolysis of permissive host cells. (hindawi.com)
The idea behind this study is to place the Ad5 E1 region in cis complementation (i.e., use E1 as a transgene) back into an E1-deleted, replication-defective adenovirus under the control of a prostate-specific promoter (PSP). (hindawi.com)
Antisense therapies, in which oligonucleotides inhibit viral replication, have shown promising results in non-human primates following post-exposure treatment. (biomedcentral.com)
There are no good animal models of rhinovirus replication," Moore says. (futurity.org)
We tested the possibility of altering the course of retinal degeneration in the rd mouse through subretinal injection of a recombinant replication-defective adenovirus that contains the murine cDNA for wild-type (beta PDE, Ad.CMV beta PDE. (nih.gov)
To combat such an unprecedented global public-health crisis before these experimental agents are available, alternative available interventions that can target different steps in the replication cycle of the EBOV should be explored in the management of the human EBOV infection as contingency preparation for the international dissemination of the EBOV outbreak in West Africa. (biomedcentral.com)

Brincidofovir (CMX001) was the subject of widespread social media campaigning in 2014, which was then picked up by national news sources about a boy with an adenovirus infection following a bone marrow transplant. (wikipedia.org)
As induced pluripotent stem (iPS) cells maintain the genetic information of the donor, they can be used to model individual differences in SARS-CoV-2 infection in vitro. (onenucleus.com)
He and his colleagues demonstrated that transduction of mice with an adenovirus expressing the human receptor for MERS-CoV, DPP4, rendered them sensitive to infection, providing the first rodent model useful for studying MERS. (hstalks.com)
Human Adenovirus Type 5 Infection Leads to Nuclear Envelope Destabilization and Membrane Permeability Independently of Adenovirus Death Protein. (leibniz-liv.de)
Humans get infection accidentally by exposure to infected animals tissues, urine etc (Prabhu et al. (biocoreopen.org)
Prevention of leptospiral infections among animals and humans are considered as long-term strategies that adopt the importance of rodent control, a major source of infection followed by individual's and environmental hygiene (Srivatsava, 2006). (biocoreopen.org)
Technically, the urgent requirement of the newer and effective vaccines may help to control the infection in animals in husbandry, pet animals and cattles to control the spread of infections to humans. (biocoreopen.org)
Some studies highlighted the usage of bivalent vaccine leads to the protection of animals form the infection and reduction in shedding of leptospires in the urine. (biocoreopen.org)
In rat models, neither coxsackievirus infection nor histological indications of myocarditis occur when CAR is wiped out. (ontariohomeopath.ca)
The recent outbreak of the human Zaire ebolavirus (EBOV) infection starting in West African countries has resulted in 15,351 infected patients, as of 18th of November 2014. (biomedcentral.com)
Apart from supportive care, neither a licensed vaccine nor a specific therapy is available for the treatment of the human EBOV infection [ 2 ]. (biomedcentral.com)
Persistent human hepatitis B virus infection in cynomolgus monkeys: A novel animal model in the search for a cure? (snprc.org)
Establishment of a neonatal rhesus macaque model to study Mycobacterium tuberculosis infection. (snprc.org)
A novel adenovirus species associated with an acute respiratory outbreak in a baboon colony and evidence of coincident human infection. (snprc.org)
Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infection. (snprc.org)
Unlike the laboratory mouse, which either lacks or has defective Mx genes that are of great importance in the host response to infection, the cotton rat has fully functional Mx genes that appear to respond to infection in the same manner as human Mx genes. (sigmovir.com)

Adenovirus serotype 11 causes less long-term intraperitoneal inflammation than serotype 5: implications for ovarian cancer therapy. (ox.ac.uk)
A combination of DNA vaccination and a recombinant adenovirus serotype 5 boost resulted in cross-protective immunity in non-human primates. (biomedcentral.com)

other viruses such as respiratory syncytial virus, parainfluenza virus, and adenoviruses can cause them too. (futurity.org)
Over the ensuing decades the cotton rat has been shown to be a preferred model of an impressive list of human pathogens: RSV, influenza (A and B serotypes), adenoviruses (several serotypes), parainfluenza virus (type 3), measles, herpes simplex (types 1 and 2), human metapneumovirus, Staphylococcus species, Streptococcus species, and Mycobacterium tuberculosis. (sigmovir.com)

His laboratory has developed several novel animal models useful for studying pathogenesis and evaluating vaccines and anti-viral therapies. (hstalks.com)
With the development of more effective and safe adenovirus vector-based vaccines, the market is expected to witness further growth in the coming years. (inventiv.org)
Preexisting or inducible immunity to vaccines against adenovirus (Ad), limits the use of First Generation vector vaccines. (inventiv.org)
Several vaccines have now been approved for human use, including mRNA vaccines (BioNTech/Pfizer, Moderna), adenovirus-vector-based vaccines (AstraZeneca, Johnson & Johnson, CanSino Biologics, Gamaleya), and inactivated virus vaccines (Sinovac Biotech and Sinopharm). (frontiersin.org)
In addition, the reported adverse cases of thrombosis with the adenovirus vaccines ( 13 ) and myocarditis with the mRNA vaccines particularly in young individuals ( 14 ) indicate that a deeper understanding of the mechanisms of action of the vaccines should be undertaken. (frontiersin.org)
Around the world, researchers have been testing 48 vaccines in clinical trials on humans, with another 140 or so preclinical vaccines under active investigation in animals according to World Health Organisation. (scottishpharmacist.co.uk)
Some COVID-19 vaccines use messenger RNA to trick human cells into making proteins from the SARS-CoV-2 spike. (mayo.edu)
During that period, mRNA vaccines have been investigated in animal models of other infectious diseases and cancer. (mayo.edu)
Although no licensed Ebolavirus vaccines are currently available, vaccine research in non-human primates, the 'gold standard' animal model for Ebolavirus, has produced several promising candidates. (biomedcentral.com)
2016), Scenario of leptospiral vaccines for humans and animals. (biocoreopen.org)
More number of leptosprial vaccines have been identified and evaluated among risk group of animals where the usage of inactivated leptospiral serovars is quite common (Wang et al. (biocoreopen.org)
To overcome this issue, multiserovar vaccines have been introduced and successfully tested on experimental animals. (biocoreopen.org)
2014). In some instances, shedding of leptospries in the urine of the animals observed even multi-valent vaccines provides high MAT titre leads to the observation of non efficiency of this type of vaccines (Vallee et al. (biocoreopen.org)
In addition, peptides for cancer vaccines that target examples of overexpressed proteins are summarized, including human epidermal growth factor receptor 2 (HER-2), mucin 1 (MUC1), folate receptor, and others. (bvsalud.org)
However, the vaccines were not tested for their ability to stop animals from getting sick. (futurity.org)
What is the status of COVID-19 vaccines in human clinical trials? (miamilivingmagazine.com)
Although several promising therapeutic agents and vaccines against EBOV are undergoing the Phase I human trial, the current epidemic might be outpacing the speed at which drugs and vaccines can be produced. (biomedcentral.com)
These achievements place the RSV cotton rat model as the "gold standard" for testing vaccines, antivirals and anti-inflammatory therapies against RSV. (sigmovir.com)

In the studies conducted in humans, it was not possible to determine whether G-CSF was successfully expressed in the brains of the patients, which could explain the discrepancy in results in humans versus mice. (neurosciencenews.com)
The dramatic reduction in brain atrophy in mice, if verified in humans, could lead to highly effective emergency treatments for stroke and other diseases that often cause brain damage such as heart attack. (neurosciencenews.com)
Ad11 triggered short-term cytokine and cellular responses equal to Ad5 in both human CD46-positive and -negative mice. (ox.ac.uk)
Both mice model with xenograft prostate tumor model and canine model were used. (hindawi.com)
Mutations in the beta subunit of the cGMP phosphodiesterase gene (beta PDE) can cause a recessively inherited retinal degeneration in several species, including mice, dogs and humans. (nih.gov)
Consequently, the genome editing contract services market was established and has grown to become an indispensable segment of the modern healthcare industry, offering a range of services, such as gRNA design and construction, cell line development (involving gene knockout, gene knockin, tagging and others) and transgenic animal model generation (such as knockout mice). (rootsanalysis.com)
The intracellular machinery of cotton rats differs markedly from that of laboratory mice, as evidenced by the fact that human immunodeficiency virus (HIV-1) productively infects cotton rat cells, yet is blocked by post-entry mechanisms in mouse cells. (sigmovir.com)
Furthermore, we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX) mice, in which a normal level of estrogen (E2) was maintained by exogenous supplementation. (nature.com)
Animal models of human BTK mutations are confined to mice at this time. (medscape.com)
However, murine models, including knockout and transgenic mice, have been useful in understanding the mechanisms of B lymphopoiesis, B-cell differentiation, and antibody formation. (medscape.com)
Murine gene mutations in human counterparts may be associated with a clinical illness different from the illness seen in mice. (medscape.com)

Cell-Surface Integrins and CAR Are Both Essential for Adenovirus Type 5 Transduction of Canine Cells of Lymphocytic Origin. (auburn.edu)

The volume of distribution of the drug is 1230 L. Because smallpox is eradicated, the effectiveness of brincidofovir was studied in animals infected with viruses that are closely related to the variola virus. (wikipedia.org)
One group of viruses commonly used for this purpose are adenoviruses. (mayo.edu)
In addition to adenoviruses, other viruses have been adapted for use in experimental therapies from infectious disease to cancer and even gene therapy. (mayo.edu)
The coxsackie and adenovirus receptor, a shared transmembrane receptor, coxsackie B viruses, and some adenoviruses show tropism towards cardiomyocytes. (ontariohomeopath.ca)

Brincidofovir is under investigation for the treatment of cytomegalovirus, adenovirus, poxvirus, and ebolavirus infections. (wikipedia.org)
Côte d'Ivoire ebolavirus (CIEBOV) was discovered during an epizootic (animal epidemic) in chimpanzees in the Taï National Park in Côte d'Ivoire in 1994, in the first confirmed introduction of an EBOV into a great ape population [ 13 ]. (biomedcentral.com)
The recent outbreak of the human Zaire ebolavirus (EBOV) epidemic is spiraling out of control in West Africa. (biomedcentral.com)

As of 2014[update], brincidofovir is in Phase III clinical trials for use in humans against cytomegalovirus and adenovirus. (wikipedia.org)
Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. (lu.se)

The CiRA team headed by Dr Takayama report on results demonstrating that human iPS cells expressing the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) (ACE2-iPS cells) can be infected with SARS-CoV-2. (onenucleus.com)
A crosslinking study revealed that recombinant human (rh) BMP-9 bound to ALK1, ALK2, bone morphogenetic protein receptor (BMPR)2, ACVR2A/B and endoglin on primary HSVSMCs. (gla.ac.uk)

KIR3DS1 directs NK cell-mediated protection against human adenovirus infections. (leibniz-liv.de)
Some studies highlighted the increase in leptospiral infections in animals and humans in various parts of India. (biocoreopen.org)
These coronaviruses that cause severe respiratory infections are zoonotic pathogens, which begin in infected animals and are transmitted from animals to people. (msdmanuals.com)

The animals in the community should be targeted for vaccination economically and effective management. (biocoreopen.org)
Studies in animal models of COVID-19 provide convincing evidence that vaccination with the spike glycoprotein will protect from COVID-19. (miamilivingmagazine.com)

17 , 19 - 24 BMP-2, −4, and −7 have been shown to stimulate de novo, in vitro, and in vivo bone formation in various animal models. (allenpress.com)
The observation of in vivo SMC phenotype switching in pre-implantation SVGs prompted development and generation of a ligand-independent contractile differentiation protocol for primary HSVSMCs and primary human coronary artery (HCA) SMCs. (gla.ac.uk)
Lead polymers have efficacy comparable to adenovirus for gene delivery in vitro and, with cytotoxic DNA payloads, can induce tumor regression in vivo. (johnshopkins.edu)

There is evidence to suggest that increasing vaccine doses can induce desired cell-mediated immune (CMI), responses in Ad-immune animal models (Barouch et al. (inventiv.org)

A recombinant vesicular stomatitis vaccine vector protected non-human primates in pre- and post-exposure challenge studies. (biomedcentral.com)

Here an adenovirus found in chimpanzees shuttles the instructions for manufacturing the spike glycoprotein into cells. (miamilivingmagazine.com)

Protective antibodies act by preventing the spike glycoprotein from attaching the virus to human cells, thereby neutralizing the SARS-CoV-2 virus that causes COVID-19. (miamilivingmagazine.com)
In studies in hamsters an adenovirus viral vector - the approach used by Oxford/AstraZeneca, for example - was used to immunize with the Spike glycoprotein. (miamilivingmagazine.com)
The natural binding of coronaviruses' spike (S) glycoprotein occurs with various receptors - ACE2, APN, DPP4, CEACAM, Sia, and O-acSia of human cells. (openaccesspub.org)
ZMapp), anti-sense phosphorodiamidate morpholino oligomers (PMO AVI-6002), lipid nanoparticle small interfering RNA (LNP-siRNA: TKM-Ebola), and an EBOV glycoprotein-based vaccine using live-attenuated recombinant vesicular stomatitis virus (rVSV-EBOGP) or a chimpanzee adenovirus (rChAd-EBOGP)-based vector. (biomedcentral.com)
Inhibited by human adenovirus e3-19k glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. (lu.se)

Conserved E1B-55K SUMOylation in different human adenovirus species is a potent regulator of intracellular localization. (leibniz-liv.de)

Preclinical research in primates by the VRC and Okairos, a biotechnology company acquired last year by GSK, indicate that the vaccine provides protection in non-human primates exposed to Ebola without significant side effects. (genengnews.com)
Lead lipidoids can provide for effective siRNA delivery in a number of cell types and animal models, including non-human primates. (johnshopkins.edu)
normal cardiac anatomy and function in subhuman primates compared to humans. (snprc.org)

Susceptibility loci for lupus: a guiding light from murine models? (jci.org)

Drawing upon a huge and comprehensive biorepository, AMSBIO is widely recognised as a leading provider of high-quality tissue specimens (including custom procurement) from both human and animal tissues. (onenucleus.com)
The spontaneously hypertensive rat (SHR) is the most widely studied animal model of essential hypertension. (jci.org)
Direct intratumoural (IT) administration of adenovirus is widely used, however little is known about the resulting distribution of virus particles. (ox.ac.uk)

Gene therapy using a recombinant adenovirus (Ad) encoding secretory human endostatin (Ad-Endo) has been demonstrated to be a promising antiangiogenesis and antitumor strategy of in animal models and clinical trials. (biomedcentral.com)
The primary intent of this BAA solicitation is to provide support to multifunctional teams for advanced development and manufacture of HIV vaccine candidates that have demonstrated success in NHP challenge studies, equivalent preclinical animal models or early human clinical trials, and have demonstrated manufacturing feasibility. (nih.gov)

It consists of an adenovirus that was modified to prevent multiplication in humans, and which produces a single attachment protein of Ebola virus. (genengnews.com)
Immune responses directed against the protein have been shown to be highly protective in animal model challenge studies carried out under the highest level of physical containment - a response that researchers hope will be protective in humans as well. (genengnews.com)
A number of PSPs have been defined over the years that include, but not limited to, promoters of prostate-specific antigen (PSA), probasin (PB), mouse mammary tumor virus (MMTV LTR), prostate-specific membrane antigen (PSMA), human glandular kallikrein 2 (hK2), and prostatic steroid-binding protein C3. (hindawi.com)
Expression of TAP1 is down-regulated by human Epstein-Barr virus vil-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. (lu.se)

The disease is general in domestic animals including cattle, buffalo, sheep, goat, dogs and equines and causes fever and its related illnesses, jaundice, acute to chronic renal failures, reproductive disorders and increasing mortality (Kamath and Dikken, 2003). (biocoreopen.org)
Modern developments in PCR technology have made it possible to discover enteroviruses, adenoviruses, parvovirus B19, and human herpesvirus 6 in patients with acute myocarditis, despite the fact that the pathophysiology is poorly understood in humans. (ontariohomeopath.ca)

An insightful 2X2 representation, highlighting the competitiveness of various CRISPR-based genome editing service providers captured in our database (segregated across various peer groups based on company size), taking into consideration the supplier power and the specific genome editing capabilities (which include gRNA service(s), endonuclease service(s), cell line engineering service(s), animal model generation service(s) and availability of CRISPR library(s)) of different companies. (rootsanalysis.com)
We provide custom mouse and rat models , including transgenics, knockouts and knockins, CRISPR/Cas9 and TALEN genome editing, as well as custom virus packaging, stem cells, and cell culture reagents. (cyagen.com)

STEM-CELLBANKER® is a chemically defined, animal-free GMP-grade cryopreservation media, optimized for ES/iPS cells. (onenucleus.com)
The G-CSF was delivered by inserting the G-CSF gene into an adenovirus that is safe in humans and known to infect brain cells efficiently. (neurosciencenews.com)
The efficacy and specificity of CRAD on prostate cancer cells were examined in cell culture and animal models. (hindawi.com)
In this paper, antibodies generated in response to the vaccine were tested for their ability to prevent the virus from infecting human cells in culture. (futurity.org)
The human body is made up of about 220 different kinds of specialized cells such as nerve cells, muscle cells, fat cells and skin cells. (benthamscience.com)
Embryonic stem cells (ESCs) can grow infinitely and give rise to all types of cells in human body, thus of tremendous therapeutic potentials for a variety of diseases, such as Parkinson's disease, spinal cord injury, and diabetes. (benthamscience.com)
Animal models of viral myocarditis predict a post-viral immune-mediated immunological response that is maladaptive and eventually results in reduced contractility and dysfunction of myocardial cells. (ontariohomeopath.ca)
Once these instructions are inside the cells, the mRNA is read by the human cell machinery and made into many spike proteins so that the immune system can respond and begin producing antibodies against this coronavirus. (miamilivingmagazine.com)
Animals that produced antibody that prevented virus attachment to human cells were most likely to be protected. (miamilivingmagazine.com)
In cultured human aortic smooth muscle cells, pharmacologic or genetic activation of AMPK inhibited the signal transducer and activator of transcription-1 (STAT1), while inhibition of AMPK had opposite effects. (diabetesjournals.org)
Stem cells, and in particular human embryonic stem (ES) cells, have earned a reputation for being labour intensive and difficult to grow and control in culture. (ddw-online.com)
F urther complicating matters, human ES cells are typically co-cultured with feeder layers of mouse fibroblast cells. (ddw-online.com)
The use of mouse feeder layers and animal serum are particularly problematic in the culturing of stem cells for possible therapeutic applications. (ddw-online.com)
Several growth factors have been identified that promote growth of human ES cells in culture, most notably basic fibroblast growth factor (bFGF). (ddw-online.com)
However, the use of bFGF for human ES cell culture, particularly at the high levels used by some for 'feeder-free' culture, must be considered carefully, as bFGF may drive ES cells towards differentiation. (ddw-online.com)
Xeno-free media that do not rely upon high levels of bFGF have been developed that contain only humanised or synthetic components and are engineered to support the undifferentiated growth and expansion of human ES cells. (ddw-online.com)
Use of progenitor cell lines can eliminate the need to culture challenging human ES cells. (ddw-online.com)
For example, neural progenitor cells derived from a human ES cell line are easily propagated and require less handling than human ES cells. (ddw-online.com)
Mechanistic analysis of cycling genes using destabilized luciferase reporters, cultured cells, and animal models demonstrated that these 12-hour rhythms are cell-autonomous, are independent of circadian rhythms, and can be entrained by external cues such as feeding and metabolic stress. (cyagen.com)

The best PSP was selected to construct a prostate-specific oncolytic adenovirus (CRAD) by controlling the adenoviral E1 region. (hindawi.com)

This review also provides an overview of model peptide epitopes used to stimulate non-specific immune responses, and of self-adjuvanting peptides, as well as the influence of other adjuvants on peptide formulations. (bvsalud.org)

The WHO published a report on the ethics of using unregistered interventions to treat Ebola, where they concluded that "In the particular context of the current Ebola outbreak in West Africa, it is ethically acceptable to offer unproven interventions that have shown promising results in the laboratory and in animal models but have not yet been evaluated for safety and efficacy in humans as potential treatment or prevention. (wikipedia.org)
One of these 3 trials, designated RV144, has shown modest efficacy in humans and this result coupled with promising results from nonhuman primate (NHP) studies has now stimulated the field to continue to test more advanced vaccine candidates in humans. (nih.gov)
The World Health Organization (WHO) has considered that it is ethically acceptable to offer unproven interventions that have shown promising results in laboratory and animal models, but have not yet been evaluated for safety and efficacy in humans as potential sources of treatment or prevention [ 3 ]. (biomedcentral.com)

In the nude mouse xenograft model, the combined treatment with dl 1520 and Ad-Endo significantly inhibited tumor angiogenesis and the growth of GC xenografts through the increased endostatin expression and oncolytic effects. (biomedcentral.com)
However, we had found that i.p. group B, in contrast to group C adenoviruses, did not cause adhesions in nude BALB/c ovarian cancer models, prompting further investigation. (ox.ac.uk)

In addition, his laboratory is characterizing a liver specific knockout mouse model of human Niemann Pick disease type C. (auburn.edu)

The combination of simple delivery and non-invasive monitoring has the potential to contribute to improved studies of experimental gene therapy in animal models of stroke, Alzheimer's dementia, Parkinson's disorder, and ALS. (neurosciencenews.com)
Cyagen Biosciences can help you harness the experimental power of animal models in your own research. (cyagen.com)

The cotton rat is considered the model of choice for Respiratory Syncytial Virus (RSV) studies because it recapitulates several characteristic features in the human disease. (sigmovir.com)

This article discusses the alloimmune-dependent and -independent risk factors for bronchiolitis obliterans, the current understanding of the pathogenesis of bronchiolitis obliterans based on results of animal and human studies, the clinical staging of the complication, strategies that may contribute to the prevention and/or early detection of bronchiolitis obliterans, and suggestions for future research. (ersjournals.com)

Genomic and phylogenetic analysis of two guinea pig adenovirus strains recovered from archival lung tissue. (leibniz-liv.de)

At this virtual meeting - Dr. Kazuo Takayama from the renowned Center for iPS Cell Research and application (CiRA) at Kyoto University will be giving a unique insight into his recent pioneering research that has successfully modelled the SARS-CoV-2 life cycle in undifferentiated iPSCs, which were previously uninfectable. (onenucleus.com)
This new, rapid, non-invasive administration and evaluation of gene therapy has the potential to be successfully translated to humans," says Richard Conroy, Ph.D., Director of the NIBIB Division of Applied Science and Technology. (neurosciencenews.com)
The overall aim is to successfully demonstrate a system in animals that can be translated to humans. (neurosciencenews.com)

Evidence for the involvement of sFlt1 in the occurrence of PE was initially provided by an animal model in which gravid rats were infected with a recombinant adenovirus encoding sFlt1 and compared to animals infected with the empty control adenovirus. (hindawi.com)

The next step would be human challenge models with volunteers, which are feasible because the virus is not very pathogenic. (futurity.org)
Many microorganisms that are pathogenic to humans and animals enter ambient waters after import from various point and diffuse sources. (nationalacademies.org)

For instance, Vaxart Inc. is developing an oral adenovirus vector-based vaccine for COVID-19 that can provide long-lasting immunity against the virus. (inventiv.org)
Preexisting immunity can interfere with the effectiveness of adenovirus vector vaccinations. (inventiv.org)
2007). The generation of serovar specific immunity is the major drawback observed where the animals become carriers for leptospirosis (Brunnet and Meyer, 1950). (biocoreopen.org)

EBOV was discovered in humans during two concurrent outbreaks in 1976. (biomedcentral.com)

Extracellular vesicle DNA from human melanoma tissues contains cancer-specific mutations. (gu.se)

ARID1A, encoding a subunit of the SWI/SNF complex, is the most frequently mutated epigenetic regulator in human cancers and is mutated in more than 50% of ovarian clear cell carcinomas (OCCC), a disease that currently has no effective therapy. (aacrjournals.org)

However, scarcity and cost of these animals had severely limited their utility as a model for vaccine development. (sigmovir.com)

Effectiveness was determined by measuring animals' survival at the end of the studies. (wikipedia.org)
The FDA approved brincidofovir under the agency's Animal Rule, which allows findings from adequate and well-controlled animal efficacy studies to serve as the basis of an approval when it is not feasible or ethical to conduct efficacy trials in humans. (wikipedia.org)
The clinical trial in Mali follows two months of work by an international consortium dedicated to advancing the vaccine into human clinical studies in West Africa. (genengnews.com)
In past studies in a number of animal models of brain disorders including stroke, Alzheimer's, and Parkinson's, G-CSF held promise as a potential treatment. (neurosciencenews.com)
Studies in small and large animal models have shown that TGF-b1 is up-regulated following vein grafting. (gla.ac.uk)
All activities must be performed in strict adherence to FDA regulations and guidance, including requirements for manufacturing of the vaccine candidate under CGMP (21 CFR 11, 210, 211, 600-680, and 820) and the conduct of animal studies and assays under GLP (21 CFR 58). (nih.gov)
What have the early Phase 1 and 2 studies in humans shown? (miamilivingmagazine.com)
We have reviewed currently available therapeutic agents that have been shown to be effective in suppressing the proliferation of the EBOV in cell cultures or animal studies. (biomedcentral.com)
Given the significant breadth of the areas under study, and the limited human and financial resources of the Organization to carry out the full studies, the Secretariat sought external support. (who.int)

Differential Regulation of Cellular FAM111B by Human Adenovirus C Type 5 E1 Oncogenes. (leibniz-liv.de)
Wild-type animals had completely normal cardiac electrophysiology. (jci.org)

Tumor Suppressor Gene p16/INK4A/CDKN2A: Regulation Into and Out of the Cell Cycle in a Spontaneous Canine Model of Breast Cancer. (auburn.edu)
Broughton R, Mullington J. Circasemidian sleep propensity and the phase-amplitude maintenance model of human sleep/wake regulation. (cyagen.com)

Méthodologie: Entre septembre 2021 et février 2022, des écouvillonnages oropharyngés et/ou nasopharyngés de travailleurs symptomatiques COVID-19 et apparemment en bonne santé sélectionnés consécutivement du site minier de Wahgnion dans le sud-ouest du Burkina Faso qui ont consenti à l'étude ont été prélevés selon les deux programme de quart de semaines et testé pour le SRAS-CoV-2 à l'aide d'un test RT-PCR. (bvsalud.org)

Altogether, this new study suggests that the 12-hour clock is a prominent and important feature of animal biology. (cyagen.com)

First, they showed that mutations to one of the six genes, PDGDRB, could be traced along different layers within samples of human aneurysms. (riken.jp)
RNA from RSV-infected cotton rat lungs reacts with double (about 600) the number of genes on a human gene chip as on a mouse chip (about 300). (sigmovir.com)

Although this approach eliminates the need for feeder layers, the system still contains undefined animal proteins, as well as possible contaminants. (ddw-online.com)

Brincidofovir is indicated for the treatment of human smallpox disease caused by variola virus. (wikipedia.org)
Ordinarily, CVD said, it takes between six to 11 months to advance a vaccine from animal-model research to to a clinical trial in a developing country where subjects are at risk of the natural disease. (genengnews.com)
Another company, GenVec Inc., is developing an adenovirus vector-based vaccine for the prevention of Ebola virus disease. (inventiv.org)
Worldwide leptospirosis is a widespread disease of livestock, domestic pet and animals caused by sprirochete bacteria Leptospira interrogans. (biocoreopen.org)
Moreover, the combination of gene modification and directed differentiation of ESCs provides perfect tool for disease modelling and drug discovery. (benthamscience.com)
The understanding of the underlying mechanisms is complicated by the heterogeneity of cases within a particular retinopathy and by the interplay of multiple cellular signaling involved in each disease model. (molvis.org)
With evolutionary origins likely extending as far back as circatidal clocks in invertebrates, human 12-hour cycles have important implications for health and disease, and much more still needs to be learned. (cyagen.com)
Baboons as a model to study genetics and epigenetics of human disease. (snprc.org)
Mouse models have milder disease than humans. (medscape.com)

In conclusion, the market for methods, compositions, and methods for creating an adenovirus virus vector for multiple vaccinations is witnessing significant growth due to the increasing prevalence of infectious diseases, the growing demand for gene therapy, and the rising investments in research and development activities. (inventiv.org)
Animal Models in Human Adenovirus Research. (leibniz-liv.de)
An adenovirus-vector vaccine approach is being examined for a COVID-19 vaccine, building on research that has been underway for five decades . (mayo.edu)
Future research will aim at identifying specific inhibitors and/or inducers of UPR regulatory markers as well as expand the list of UPR-related animal models. (molvis.org)
Dr. Sandey was awarded a Junior Research Fellowship to pursue Master of Veterinary Science (M.V.Sc) in Animal Biotechnology from the Indian Veterinary Research Institute, Izzatnagar (in India) in 2005. (auburn.edu)
Additional research will be required to demonstrate that this kind of drug treatment is effective for human patients. (riken.jp)

Anatomy30

Organisms50

Diseases19

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Psychiatry and Psychology1

Phenomena and Processes55

Disciplines and Occupations2

Information Science4

Health Care2

Vectors11

Replication9

Infection16

Serotype2

Parainfluenza virus2

Vaccines18

Mice11

Transduction1

Viruses4

Ebolavirus3

Cytomegalovirus2

Receptor2

Infections3

Vaccination2

Vivo3

Cell-mediated1

Protected non-human pr1

Chimpanzees1

Glycoprotein5

Species1

Primates3

Murine models1

Widely3

Clinical trials2

Protein4

Acute2

CRISPR2

Cells19

Adenoviral1

Peptide1

Efficacy in humans3

Nude2

Knockout1

Experimental2

Respiratory1

Pathogenesis1

Tissue1

Successfully3

Evidence1

Pathogenic2

Immunity3

Concurrent1

Tissues1

Regulator1

Vaccine development1

Studies9

Type2

Regulation2

20221

Biology1

Genes2

Proteins1

Disease9

Research6