Urinary angiotensinogenHepatic angiotensinogenRenin-angiotHypertensionTransgenic ratsMRNAInactive angiotensinogenRenalPolymorphismGeneExpressionSiRNAEnzymeGenotypeDiseaseProteinLevelsBloodBrainRenin and angiotensinogenSerpin A8Angiotensin converHypertensionAlpha-2-globulinAGTR1AntibodyCleavesSubstrateLiverSynthesisKidneyRegulationEffectRelease
Urinary angiotensinogen12
- To examine this system in human neonates, we measured urinary angiotensinogen levels in preterm and full-term neonates, and examined the relationship between urinary angiotensinogen levels and gestational age. (tokushima-u.ac.jp)
- However, the urinary angiotensinogen-to-creatinine ratio was significantly higher in preterm neonates compared to that in full-term neonates (P = 0.0011). (tokushima-u.ac.jp)
- Importantly, the urinary angiotensinogen-to-creatinine ratio dropped significantly with increasing gestational age (P = 0.0010), whereas the plasma angiotensinogen concentration was not correlated with gestational age (P = 0.7814). (tokushima-u.ac.jp)
- These results suggest that urinary angiotensinogen levels may indicate the involvement of intrarenal RAS activation in prenatal renal development. (tokushima-u.ac.jp)
- We have shown that compared to control adult offspring whose mothers were fed a 20% protein diet, programmed adults whose mothers were fed a 6% protein diet during the last half of pregnancy have an increase in renal sympathetic nerve activity and urinary angiotensinogen/creatinine levels. (elsevierpure.com)
- We hypothesized that the increase in urinary angiotensinogen was mediated by renal sympathetic nerve activity in programmed rats. (elsevierpure.com)
- We confirm that the intrarenal renin-angiotensin system assessed by urinary angiotensinogen/creatinine is upregulated in offspring of rats fed a 6% protein diet rats compared to 20% controls. (elsevierpure.com)
- To determine if sympathetic nerve activity was mediating the increase in urinary angiotensinogen in programmed rats, we compared denervated to sham-operated control and programmed rats. (elsevierpure.com)
- Renal denervation had no effect on urinary angiotensinogen/creatinine ratio in the 20% group and no effect on the increased urinary angiotensinogen/creatinine ratio found in programmed rats. (elsevierpure.com)
- This study demonstrates that the increase in urinary angiotensinogen in programmed rats is not mediated by renal sympathetic nerve activity. (elsevierpure.com)
- Urinary Angiotensinogen in addition to Imaging Classification in the Prediction of Renal Outcome in Autosomal Dominant Polycystic Kidney Disease. (bvsalud.org)
- Urinary angiotensinogen to creatinine ratio (AGT/Cr) was suggested as a novel biomarker to reflect intrarenal RAS activity. (bvsalud.org)
Hepatic angiotensinogen3
- We evaluated whether siRNA targeting maternal hepatic angiotensinogen (Agt) could ameliorate symptoms of preeclampsia without adverse placental or fetal effects in 2 rodent models. (jci.org)
- Furthermore, antisense oligonucleotides or small interfering ribonucleic acids suppress hepatic angiotensinogen for weeks to months after 1 injection and thus could potentially overcome adherence issues. (nih.gov)
- In a multi-part, multicenter study funded by Alnylam Pharmaceuticals, researchers from the US and UK aimed to assess the safety, study the pharmacokinetic and pharmacodynamic characteristics, and examine the antihypertensive efficacy of zilebesiran, an investigation RNAi agent designed to bind to and reduce the levels of hepatic angiotensinogen mRNA. (genomeweb.com)
Renin-angiot2
- This review discusses novel insights (including the data of recent clinical trials) with regard to interference with the renin-angiotensin system, focusing on the enzymes aminopeptidase A and angiotensin-converting enzyme 2 (ACE2) in the brain, as well as the substrate of renin- angiotensinogen-in the liver. (nih.gov)
- Angiotensinogen is an essential component of the renin-angiotensin system. (ox.ac.uk)
Hypertension8
- The T235 angiotensinogen allele was more common in Japanese than in Caucasians, and was a predisposing factor for hypertension. (lww.com)
- The human renin-angiotensinogen double transgenic rat (dTGR) is a model of hypertension. (go.jp)
- Analysis of the angiotensinogen gene in the MRC British genetics of Hypertension study. (ox.ac.uk)
- Background Novel angiotensinogen (AGT) inhibitors are in early clinical development for treatment of hypertension. (ox.ac.uk)
- Experimental Approach To address this, TGR (mRen2)27 rats (angiotensin II-dependent hypertension model) were made diabetic with streptozotocin over 18 weeks and treated with either vehicle, angiotensinogen siRNA, the AT(1) antagonist valsartan, the ACE inhibitor captopril, valsartan + siRNA or valsartan + captopril for the final 3 weeks. (eur.nl)
- Although some single polymorphism analyses of the angiotensinogen (AGT) gene have been found to be associated with hypertension, the results are still inconsistent. (tmu.edu.tw)
- Angiotensinogen is the rate limiting factor in the production of angiotensinII, and evidence links angiotensinogen and angiotensin II to hypertension: the greater the copy number of angiotensin heme, the higher the blood pressure. (standardofcare.com)
- An RNA interference therapy for hypertension may decrease serum angiotensinogen and blood pressure levels, findings from a Phase I study suggest. (genomeweb.com)
Transgenic rats1
- In double transgenic rats (dTGR) harboring the human angiotensinogen (hAOGEN) and human renin (hREN) genes, we studied cardiac transcript levels of hypertrophy-related, Ca2+ regulatory, and {beta}-adrenoceptor-associated proteins. (mdc-berlin.de)
MRNA1
- Angiotensinogen siRNA did not affect renal angiotensinogen mRNA expression, confirming its liver-specificity. (eur.nl)
Inactive angiotensinogen3
- Conventional RAS involves the conversion of inactive angiotensinogen into angiotensin I (Ang I) in the presence of renin which is released from the kidney in response to low blood volume. (hindawi.com)
- The liver secretes inactive angiotensinogen, which is converted by renally secreted renin to angiotensin I. (standardofcare.com)
- Renin catalyzes inactive angiotensinogen to angiotensin I. (standardofcare.com)
Renal1
- Conclusion and Implications Angiotensinogen siRNA exerts renoprotection in diabetic TGR (mRen2)27 rats and this relies, at least in part, on the suppression of renal angiotensin II formation from liver-derived angiotensinogen. (eur.nl)
Polymorphism3
- Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or beta-blockers. (ox.ac.uk)
- To investigate whether the association between use of ACE-inhibitors or beta-blockers and the risk of myocardial infarction (MI) or stroke is modified by the T-allele of the angiotensinogen M235T polymorphism. (ox.ac.uk)
- C angiotensinogen polymorphism. (cdc.gov)
Gene2
- Effect of the angiotensinogen gene Met235$Thr variant on blo. (lww.com)
- Angiotensinogen is encoded by the gene AGT, and is a glycoprotein secreted by hepatocytes that is cleaved by renin to yield angiotensin I which is further cleave to generate angiotensin II. (standardofcare.com)
Expression1
- CONCLUSIONS: Combination of the -6:A and -20:C substitutions in the B-haplotype may promote the development of cSVD by enhancing cerebral angiotensinogen expression. (ox.ac.uk)
SiRNA1
- Background and Purpose Small interfering RNA (siRNA) targeting liver angiotensinogen lowers blood pressure, but its effects in hypertensive diabetes are unknown. (eur.nl)
Enzyme3
- Angiotensinogen levels were measured using enzyme-linked immunosorbent assay. (tokushima-u.ac.jp)
- Intrinsic brain RAS is an enzyme-neuropeptide system having functional components (angiotensinogen, peptidases, angiotensin, and specific receptor proteins) with important biological and neurobiological activities in the brain. (hindawi.com)
- Renin cleaves angiotensinogen to angiotensin I, which is in turn converted by angiotensin-converting enzyme (ACE) to angiotensin II. (standardofcare.com)
Genotype1
Disease1
- Angiotensinogen promoter B-haplotype associated with cerebral small vessel disease enhances basal transcriptional activity. (ox.ac.uk)
Protein3
- The stimulus tells us that angiotensinogen is a protein in human blood. (testmaxprep.com)
- A key regulatory protein that regulates blood pressure, angiotensinogen, is damaged or oxidized by free radicals. (selfgrowth.com)
- Renin then enters the blood where it catalyzes a protein called angiotensinogen to angiotensin I. (standardofcare.com)
Levels2
- Typically, the higher a person's angiotensinogen levels are, the. (testmaxprep.com)
- As the researchers report in the New England Journal of Medicine , patients receiving zilebesiran experienced declines in serum angiotensinogen levels as well as in blood pressure, and only reported mild injection site reactions. (genomeweb.com)
Blood2
- The higher a person's angiotensinogen, the higher their blood pressure. (testmaxprep.com)
- The doctor infers that since increased angiotensinogen is correlated with elevated blood pressure that an increase in angiotensinogen causes an increase in BP, which means X causes an increase in BP. (testmaxprep.com)
Brain1
- The brain has shown the presence of various components of brain RAS such as angiotensinogen (AGT), converting enzymes, angiotensin (Ang), and specific receptors (ATR). (hindawi.com)
Renin and angiotensinogen2
- The in vivo generation of angiotensin appears to be dependent on both plasma renin and angiotensinogen concentrations. (duke.edu)
- Given the presence of the blood-brain barrier, angiotensin generation in the brain, if occurring, should depend on local synthesis of renin and angiotensinogen. (portlandpress.com)
Serpin A81
- Serpin A8/Angiotensinogen " has 9 results in Products. (rndsystems.com)
Angiotensin conver2
- Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I . Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II , an extremely powerful vasoconstrictor. (bvsalud.org)
- In such a situation, the kidneys release renin which cleaves the liver derived angiotensinogen into Angiotensin I. Angiotensin I is then converted to angiotensin II via the angiotensin-converting-enzyme (ACE) in the pulmonary circulation. (wikidoc.org)
Hypertension2
- Analysis of the angiotensinogen gene in the MRC British genetics of Hypertension study. (ox.ac.uk)
- Une recherche documentaire a été effectuée dans PubMed de 1980 à 2021 en utilisant diverses combinaisons de termes MeSH comme tabac, diabète, hypertension, dyslipidémie, trouble dépressif majeur, trouble bipolaire, schizophrénie. (bvsalud.org)
Alpha-2-globulin1
- The renal juxtaglomerular apparatus generates renin, an enzyme that converts angiotensinogen to angiotensin I. Angiotensinogen, derived from the liver, is an alpha-2-globulin. (loinc.org)
AGTR11
- Polymorphisms in the Delta-aminolevulinic acid dehydratase (ALAD), hemochromatosis (HFE), heme oxygenase-1 (HMOX1), vitamin D receptor (VDR), glutathione S-transferase (GST) supergene family (GSTP1, GSTT1, GSTM1), apolipoprotein E (APOE),angiotensin II receptor-1 (AGTR1) and angiotensinogen (AGT) genes, are believed to alter toxicokinetics and/ or toxicodynamics of lead. (cdc.gov)
Antibody2
- However, infusion of angiotensin I (with simultaneous suppression of plasma renin by antirenin antibody infusion and angiotensin II production by captopril administration) had no effect on the angiotensinogen release rate. (duke.edu)
- Indeed, when conditions were such that the renin-angiotensin system was completely suppressed, such as binephrectomy and antirenin antibody infusion, angiotensinogen release rate was markedly stimulated. (duke.edu)
Cleaves1
- It is an aspartyl protease that cleaves angiotensinogen to form angiotensin I. In mouse, there are two genes that code for Renin. (rndsystems.com)
Substrate2
- Renin is a secreted endopeptidase that plays a crucial role in the regulation of blood pressure and salt balance through the cleavage of angiotensinogen, which is the only known physiological substrate of Renin. (rndsystems.com)
- When renin is released into the blood, it acts upon a circulating substrate, angiotensinogen that undergoes proteolytic cleavage to form the decapeptide angiotensin I. (southtees.nhs.uk)
Liver1
- In this study, we examined the feedback regulation of angiotensinogen synthesis and release by various components of the renin-angiotensin system, using an in vitro rat liver slice system. (duke.edu)
Synthesis1
Kidney1
- Urinary Angiotensinogen in addition to Imaging Classification in the Prediction of Renal Outcome in Autosomal Dominant Polycystic Kidney Disease. (bvsalud.org)
Regulation1
- Scholars@Duke publication: The feedback regulation of angiotensinogen production by components of the renin-angiotensin system. (duke.edu)
Effect1
- Angiotensin I has no effect on angiotensinogen release rate. (duke.edu)
Release5
- Infusion of angiotensin II has been reported to increase angiotensinogen release rate. (duke.edu)
- Direct infusion of renin in rats treated with captopril resulted in further suppression of the angiotensinogen release rate, compared with those given captopril alone. (duke.edu)
- We postulate that renin (or des-angiotensin I-angiotensinogen) inhibits the angiotensinogen release rate, whereas angiotensin II stimulates it. (duke.edu)
- When angiotensin II production was prevented by captopril treatment, angiotensinogen release rate declined. (duke.edu)
- Thus, angiotensinogen release rate is subject to a complex feedback control by other components of the renin-angiotensin system. (duke.edu)