• The population frequency of the indel (rs66698963) is remarkably different among human populations with the insertion being far more frequent in South Asians, Africans and some East Asian populations, and far less common in European and other East Asian populations. (fatsoflife.com)
  • We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. (ox.ac.uk)
  • In order to determine a new subject's genetic ancestry, Parabon Snapshot analyzes tens of thousands of SNPs from a DNA sample to determine a person's percent membership in each of these global populations. (parabon-nanolabs.com)
  • Most other forensic ancestry systems use only a small number of SNPs and thus are limited to very coarse populations and cannot detect admixture between populations. (parabon-nanolabs.com)
  • Parabon's scientists have collected data from many published scientific articles, totalling more than 9,000 individuals with clearly defined ancestry from more than 150 populations around the world, as shown in the map below. (parabon-nanolabs.com)
  • Academic research using hundreds of thousands of SNPs from across the genome has shown that human groups generally divide into seven continental populations, which have been established over the past 50,000 years during the migration out of Africa. (parabon-nanolabs.com)
  • The 150 populations collected as the ancestry background can thus be divided into these seven continental groups according to their origin. (parabon-nanolabs.com)
  • Snapshot takes a similar approach to identifying within-continental (regional) ancestry, although the local populations were identified through empirical analysis performed by our bioinformatics team. (parabon-nanolabs.com)
  • In an ancestry analysis, Snapshot will determine an individual's precise genetic origins, as well as whether there is any evidence of admixture (contribution from multiple populations). (parabon-nanolabs.com)
  • Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. (ox.ac.uk)
  • Interethnic analyses of blood pressure loci in populations of East Asian and European descent. (ox.ac.uk)
  • TMB-high was significantly associated with improved outcomes only in European ancestries and merits validation in non-European ancestry populations. (bvsalud.org)
  • For example, the incidence rate of liver cancer has been shown with substantial disparity between Hispanic, Asian and non-Hispanic white populations. (omicsdi.org)
  • RESULTS:In this study we designed an unique AIM panel that infers 3-way genetic admixture from three distinct and selective continental populations (African (AFR), European (EUR), and East Asian (EAS)) within evolutionarily conserved exonic regions. (omicsdi.org)
  • Because of extensive admixture among these various groups, the Brazilian population shows great variability in terms of Populations on different continents vary considerably in their skin pigmentation, phenotypic features, and genomic structure [2]. (cdc.gov)
  • Compared with whites, other racial and ethnic groups were on average younger and had a higher median score on the National Institutes of Health Stroke Scale. (elsevierpure.com)
  • To evaluate the possibility that such differences are accompanied by differences in brain structure, we conducted a large comparative study on cognitively matched young and old adults from two cultural/ethnic groups - Chinese Singaporeans and non-Asian Americans - that involved a total of 140 persons. (illinois.edu)
  • it cannot be assumed that treatments shown to work for Caucasians will be efficacious for those from minority ethnic groups. (ox.ac.uk)
  • OBJECTIVE: HbA(1c) levels are higher in most ethnic groups compared with white Europeans (WEs) independent of glycemic control. (ox.ac.uk)
  • At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. (ox.ac.uk)
  • Subjects identified themselves as belonging to one of four major racial/ethnic groups (white, African American, East Asian, and Hispanic) and were recruited from 15 different geographic locales within the United States and Taiwan. (blogspot.com)
  • From ∼ 1000 individuals of a founder population in Quebec, we reveal a substantial impact of the environment on the transcriptome and clinical endophenotypes, overpowering that of genetic ancestry. (nature.com)
  • Air pollution impacts gene expression and pathways affecting cardio-metabolic and respiratory traits, when controlling for genetic ancestry. (nature.com)
  • The EuroDNA(TM) 2.0 test is by far the most advanced genetic ancestry test yet to be offered to the public. (thegeneticgenealogist.com)
  • Using two clinical cohorts, we investigated the interplay between genetic ancestry, TMB, and tumor-only versus tumor-normal paired sequencing in solid tumors. (bvsalud.org)
  • BACKGROUND:Europeans and American Indians were major genetic ancestry of Hispanics in the U.S. These ancestral groups have markedly different incidence rates and outcomes in many types of cancers. (omicsdi.org)
  • Worldwide, its incidence has increased progressively over the last a result of genetic ancestry. (cdc.gov)
  • Whites had higher 30-day unadjusted mortality than other groups (white versus black versus Hispanic versus Asian=15.0% versus 9.9% versus 11.9% versus 11.1%, respectively). (elsevierpure.com)
  • This lack of association was not influenced by adjustment for sex, diastolic blood pressure, history of coronary disease, or ethnicity (Asian or non-Asian). (ox.ac.uk)
  • Independent effect of ethnicity on glycemia in South Asians and white Europeans. (ox.ac.uk)
  • We analyzed the independent effect of ethnicity on HbA(1c) and fasting and 2-h plasma glucose (FPG and 2 hrPG, respectively) between these groups. (ox.ac.uk)
  • In June 2002, ADC joined the American-Civil Liberties Union (ACLU) in filing lawsuits against American Airlines, United Airlines, and Continental Airlines alleging that the airlines engaged in the unlawful removals of Arab, Arab-American, Muslim, or South Asian passengers based on their perceived religion, ethnicity, or national origin. (adc.org)
  • On the other hand, we detected only modest genetic differentiation between different current geographic locales within each race/ethnicity group. (blogspot.com)
  • Thus, ancient geographic ancestry, which is highly correlated with self-identified race/ethnicity-as opposed to current residence-is the major determinant of genetic structure in the U.S. population. (blogspot.com)
  • The old descriptor ANIMALS will be changed to ANIMAL POPULATION GROUPS. (bvsalud.org)
  • The NHANES II sample was selected so that certain population groups thought to be at high risk of malnutrition (persons with low incomes, preschool children and the elderly) were oversampled. (cdc.gov)
  • We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals. (ox.ac.uk)
  • Currently, ancestry informative marker (AIM) panels have been widely utilized with up to a few hundred ancestry-informative single nucleotide polymorphisms (SNPs) to infer ancestry admixture. (omicsdi.org)
  • Heart failure among South Asians: a narrative review of risk, nature, outcomes and management. (ox.ac.uk)
  • These papers also implied that outcomes for South Asians with HF were similar or even better than for Caucasians. (ox.ac.uk)
  • Our data suggest that survival of Korean-American gastric cancer patients are comparable with outcomes from East Asian hospitals and may be independent of surgical technique. (houstonmethodist.org)
  • 3060 non-Hispanic Asian Americans, 1.5%) from 926 US centers participating in the Get With The Guidelines-Stroke program from April 2003 through December 2008. (elsevierpure.com)
  • After risk adjustment, Asian American patients with AIS had lower 30-day and 1-year mortality than white, black, and Hispanic patients. (elsevierpure.com)
  • Results: Among the 70,221 included patients, 91.3% were white, 3.8% were black, 3.4% were Hispanic, and 1.5% were of Asian/Native American/Pacific Islander race. (elsevierpure.com)
  • An ancestry informative marker panel design for individual ancestry estimation of Hispanic population using whole exome sequencing data. (omicsdi.org)
  • Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (ox.ac.uk)
  • We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. (ox.ac.uk)
  • This effect was consistent across a variety of targeted outgroups (Mainland Chinese, Arabs, Russians, Blacks, Asian Americans, and homosexuals), regardless of whether multicultural experience was measured or manipulated, and across samples (Hong Kongers, Jewish Israelis, and U.S.-born Americans). (iucc.ac.il)
  • Intriguingly, we found differences in the antiproliferative response between gastric cancer cells tested derived from Brazilian patients as compared to those from Asian patients, the latter being largely resistant to BET inhibition. (ox.ac.uk)
  • Where EuroDNA 1.0 used just 320 SNPs to delineate people of European ancestry into four groups â€" Northern European, Southeastern European, Middle Eastern, and South Asian â€" EuroDNA 2.0 uses 1,349 SNPs. (thegeneticgenealogist.com)
  • 2007 paper, looking for the SNPs that provided most of the European Ancestry Information. (thegeneticgenealogist.com)
  • Snapshot uses tens of thousands of SNPs across the genome to obtain very precise estimates of ancestry, even for admixed individuals. (parabon-nanolabs.com)
  • After attributing a regional and/or continental ancestry to each individual using genome-wide polymorphism data, we are able to capture the effect of different environmental exposures on gene expression and health-related traits, while simultaneously controlling for genetic relatedness and migration. (nature.com)
  • The polymorphism was present as an insertion in cells derived from a group of Japanese individuals, but was completely absent (a deletion) in others, albeit with a lower frequency (hence called the minor allele). (fatsoflife.com)
  • The population frequency of the allele corresponding to the rs66698963 insertion (allele named I) or deletion (allele named D) was determined from genomic DNA extracted from human samples (blood, breast milk, and placenta) obtained from several participating institutions in the US and Canada (n=211, nearly all from Kansas City), as well as from a group of Asian Indians (n=76). (fatsoflife.com)
  • Here, we present Summix, a method to efficiently deconvolute ancestry and provide ancestry-adjusted allele frequencies (AFs) from summary data. (omicsdi.org)
  • The relationship between treatment response and genotype was assessed separately for Caucasians and Asians. (york.ac.uk)
  • Therefore, a literature review relating to the nature, outcome and treatment of HF in South Asian patients compared to Caucasians was conducted. (ox.ac.uk)
  • DNAPrint(R)'s EuroDNA(TM) 2.0 clarifies European sub-ancestry by using 1,349 European Ancestry Informative Markers (AIMs). (thegeneticgenealogist.com)
  • Ethnic ancestry is one of the most informative traits that can be predicted from DNA. (parabon-nanolabs.com)
  • Model-based clustering and ancestry informative markers analyses suggested that this is due to taurine introgression. (biomedcentral.com)
  • Latino ancestry is a mixture of European and Native American ancestry, so these groups are shown as well. (parabon-nanolabs.com)
  • Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP. (ox.ac.uk)
  • We report a fixed-effect, inverse-weighted-variance meta-analysis from 10,074 PCOS cases and 103,164 controls of European ancestry and characterisation of PCOS related traits. (ox.ac.uk)
  • Data were technically validated using published algorithms to evaluate donor relatedness, ancestry, imputed HLA, and T1D genetic risk score. (nature.com)
  • Individuals of South Asian descent have a high prevalence of comorbidities that are risk factors for the development of heart failure (HF), including diabetes mellitus and metabolic syndrome. (ox.ac.uk)
  • After risk-adjustment, there was no difference in the rates of in-hospital mortality, myocardial infarction, stroke, major bleeding, vascular complications, or new pacemaker requirements among the 4 racial groups. (elsevierpure.com)
  • However, group differences were evident when high-performing old were compared. (illinois.edu)
  • It was anticipated that collating existing studies in this manner would be useful for guiding professionals in managing HF within this ethnic group, given that to achieve optimal care, regimens need to take into account cultural differences that may impact on adherence. (ox.ac.uk)
  • These findings offer the first insights into ancestry-specific differences in the prostate cancer AR cistrome. (bvsalud.org)
  • We apply Summix to gnomAD v.2.1 exome and genome groups and subgroups, finding heterogeneous continental ancestry for several groups, including African/African American (∼84% AFR, ∼14% EUR) and American/Latinx (∼4% AFR, ∼5% EAS, ∼43% EUR, ∼46% IAM). (omicsdi.org)
  • Using continental reference ancestry, African (AFR), non-Finnish European (EUR), East Asian (EAS), Indigenous American (IAM), South Asian (SAS), we obtain accurate and precise estimates (within 0.1%) for all simulation scenarios. (omicsdi.org)
  • Drawing from this founding population of individuals with largely French ancestry, we selected 1007 individuals to determine mechanisms by which genomes, the environment, and their interactions contribute to phenotypic variation. (nature.com)
  • TMB estimates from tumor-only panels substantially overclassified individuals into the clinically important TMB-high group due to germline contamination, and this bias was particularly pronounced in patients with Asian/African ancestry. (bvsalud.org)
  • This analysis is robust to admixture, such that each piece of continental ancestry can be precisely localized within that continent. (parabon-nanolabs.com)
  • Some of the ancestry-specific association signals are also influenced by a selective sweep. (ox.ac.uk)
  • Although a large part of South American zebu cattle also descend from taurine cows, we did not detect significant levels of taurine ancestry in these breeds, probably because of systematic backcrossing with zebu bulls. (biomedcentral.com)
  • Reviewed literature showed that South Asians with HF were more likely to be younger and have diabetes and hypertension. (ox.ac.uk)
  • There is an emergent literature suggesting that East Asians and Westerners differ in cognitive processes because of cultural biases to process information holistically (East Asians) or analytically (Westerners). (illinois.edu)
  • These findings, derived from an east Asian population, provide new perspectives on the etiology of T2D. (ox.ac.uk)
  • Global ancestry map showing mostly East Asian and Native/South American ancestry, with some European ancestry as well. (parabon-nanolabs.com)
  • For example, the admixed East Asian and Latino example from the global map above was determined to have specifically Japanese, Central American, and Southwest European ancestry, as shown in the map below. (parabon-nanolabs.com)
  • Each piece of continental ancestry is partitioned according to its regional ancestry (e.g., if an individual is 50% European and 50% East Asian, the precise origin of each of those pieces will be determined). (parabon-nanolabs.com)
  • Below is an example plot for an individual who was determined to be 50% East Asian and 50% Latino. (parabon-nanolabs.com)
  • The researchers found that during the Kofun period, people with East Asian ancestry, most likely Han Chinese, migrated to Japan and added their genes to those of the Jomon and Yayoi. (archaeology.org)
  • Most Indo-Guyanese trace their ancestry to the mid-1800s, when (East) Indian indentured servants were brought to Guyana, an English-speaking, continental West Indian country formerly known as British Guiana (1). (cdc.gov)
  • Compared to the unadjusted gnomAD AFs, Summix's ancestry-adjusted AFs more closely match respective African and Latinx reference samples. (omicsdi.org)
  • Methods: We retrospectively collected 15818 raw digital mammograms from 3772 Asian women aged 35-80 years who underwent screening or diagnostic mammography between Jan 2012 and Dec 2014 at our center. (um.edu.my)
  • Although several methods exist to estimate ancestry in individual-level data, methods to estimate ancestry proportions in summary data are lacking. (omicsdi.org)
  • A very important new article by a group of Greek and Chinese researchers provides the first quantitative assessment of mental processing in two groups of students, aged 8 to 14, belonging to the Caucasoid and Mongoloid races. (blogspot.com)
  • We grouped patients according to examined LN number (1-15 and 16+) and compared characteristics. (houstonmethodist.org)
  • Ancestry-aware tumor-only TMB calibration and ancestry-diverse biomarker studies are critical to ensure that existing disparities are not exacerbated in precision medicine. (bvsalud.org)
  • Recent genetic research indicates that the degree of genetic heterogeneity within groups and homogeneity across groups make race per se a less compelling predictor. (bvsalud.org)
  • While United maintained that no passenger was ever removed from a flight or denied boarding under unlawful circumstances, the investigation revealed that United unlawfully removed passengers from flights or denied boarding to passengers based on their race, color, national origin, religion or ancestry. (adc.org)