Amplification neuroblastoma. Medical search. Frequent questions

Patients whose tumors have MYCN amplification tend to have rapid tumor progression and poor prognosis, even in the setting of other favorable factors such as low-stage disease or 4S disease. (medscape.com)
Cytogenetically, the presence of double-minute chromatin bodies and homogeneously staining regions correlates with MYCN gene amplification. (medscape.com)
A relationship between 1p loss of heterozygosity (LOH) and MYCN amplification has been described. (medscape.com)
Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma. (bvsalud.org)
Amplification of the MYCN oncogene is a molecular hallmark of aggressive neuroblastoma (NB), a childhood cancer of the sympathetic nervous system . (bvsalud.org)
The global gene expression and DNA copy number alterations have been shown to have profound differences in tumors of low or high stage and those with or without MYCN amplification. (biomedcentral.com)
In this study, we used exon array profiling to investigate global alternative splicing pattern of 47 neuroblastoma samples in stage 1 and stage 4 with normal or amplified MYCN copy number (stage 1-, 4- and 4+). (biomedcentral.com)
Our results demonstrated a significant role of alternative splicing in high stage neuroblastoma, and suggested a MYCN -associated splicing regulation pathway in stage 4+ tumors. (biomedcentral.com)
MYCN is the most important biologic marker for neuroblastoma. (biomedcentral.com)
Age 12-18 months (365-547 days) with any of the following 3 unfavorable biologic features (MYCN amplification, unfavorable pathology and/or DNA index = 1) or iii. (archildrens.org)
3. Subjects must not have had prior systemic therapy except for localized emergency radiation to sites of life-threatening or function-threatening disease and/or no more than 1 cycle of chemotherapy per a low or intermediate risk neuroblastoma regimen (as per P9641, A3961, ANBL0531, or similar) prior to determination of MYCN amplification status and histology. (archildrens.org)
Ploidy and MYCN amplification have been used as genetic markers for risk stratification and therapeutic decision making, and, more recently, gene expression profiling and genome-wide DNA copy number analysis have come into the picture as sensitive and specific tools for assessing prognosis. (biomedcentral.com)
Eighty-eight percent had stage IV disease and 38.2% had MYCN amplification. (oncologynurseadvisor.com)
Invited discussant for this abstract Dominique Valteau-Couanet, MD, PhD, head of the pediatric and adolescent oncology department at Institut Gustave Roussy in France, questioned which patients actually benefit from tandem autologous HCT: patients with localized disease and MYCN amplification? (oncologynurseadvisor.com)
Excellent outcome with reduced treatment for infants with disseminated neuroblastoma without MYCN gene amplification. (gv.at)
While past research has pointed to a role for circularized, extrachromosomal MYCN oncogene sequences in neuroblastoma, the team explained, the full suite and the frequency of somatic mutations involving small or large stretches of circularized extrachromosomal DNA amplifications had not been fully explored. (genomeweb.com)
Even so, the team's follow-up analyses - including RNA sequencing experiments - indicated that rearrangements stemming from extrachromosomal circular DNA from MYCN and other genes may be a recurrent and ongoing source of new mutations through a multi-hit model in neuroblastoma. (genomeweb.com)
Essentially all patients who have tumors with many copies (or amplification) of the MYCN oncogene also have high-risk disease, even if they do not have evidence of the tumor having spread. (acco.org)
My lab currently focuses on defining the cancer pathways that support neuroblastoma development, particularly those that interact with the MYCN gene, and in developing novel therapeutics that might target this disease. (chop.edu)
First, we are studying how MYC genes regulate polyamines, and how amplification of the MYCN gene (which is found in about 25 percent of tumors and is associated with a very aggressive tumor) causes a tumor to be dependent on polyamines. (chop.edu)
MYCN gene amplification occurs in 20% of cases, but other recurrent somatic mutations are rare. (oncotarget.com)
Our network-based approach identified vulnerable therapeutically targetable nodes that function as critical regulators or effectors of MYCN in neuroblastoma. (oncotarget.com)
19 ] selected 43 candidate markers from the methylome data of 5-aza-2′-deoxycytidine (DAC) treatment and MBD-seq analysis, and found a relationship between DNA methylation and risk factors such as age, stage, and MYCN amplification. (biomedcentral.com)
these biological variables will be analyzed for independent clinical significance compared to MYCN amplification, International Neuroblastoma Staging System (INSS) stage, age, ploidy, and histologic variables in predicting either response to treatment or outcome. (uchicagomedicine.org)
I. To prospectively analyze the concordance between detection of MYCN amplification in tumor samples and quantitative detection of MYCN DNA in serum, and to analyze the prognostic significance of MYCN amplification as detected in serum samples. (uchicagomedicine.org)
Some markers (eg, MYCN oncogene amplification, DNA index, segmental chromosomal aberrations, histopathology) correlate with progression and prognosis. (msdmanuals.com)
MYCN amplification occurs in about 20% of neuroblastoma cases and is associated with advanced disease and unfavorable biology. (msdmanuals.com)
There was sensitivity reaching 100% in predicting RFS in patients who had neither CSV + CTCs nor MycN amplification. (psu.edu)
development of high-risk neuroblastoma missing MYCN amplification [19]. (techuniq.com)
When Lafutidine the MYCN amplified and lowly GLI1 expressing SK-N-BE(2) neuroblastoma cell line was used S6K1 knockdown did not change GLI1 expression in the absence of TNF-α. (techuniq.com)
Introduction of miR-193b mimics into nine neuroblastoma cell lines with distinct genetic characteristics significantly reduces cell growth in vitro independent of risk factors such as p53 functionality or MYCN amplification. (oncotarget.com)
Functionally, miR-193b induces a G1 cell cycle arrest and cell death in neuroblastoma cell lines by reducing the expression of MYCN , Cyclin D1 and MCL-1 , three important oncogenes in neuroblastoma of which inhibition has shown promising results in preclinical testing. (oncotarget.com)
MYCN-amplification in high-grade Neuroblastoma (NB) tumors correlates with increased vascularization and therapy resistance. (caninebiologics.com)
CT-based morphologic and radiomics features for the classification of MYCN gene amplification status in pediatric neuroblastoma. (cdc.gov)

Neuroblastoma (NB) tumors are well known for their pronounced clinical and molecular heterogeneity. (biomedcentral.com)
The identification of differentially spliced genes and pathways in neuroblastoma tumors of different stages and molecular subtypes may be important to the understanding of cancer biology and the discovery of diagnostic markers or therapeutic targets in neuroblastoma. (biomedcentral.com)
Neuroblastoma is one of the most common solid tumors of childhood, arising from immature sympathetic nervous system cells. (biomedcentral.com)
The clinical heterogeneity of neuroblastoma mirrors the biological and genetic heterogeneity of these tumors. (biomedcentral.com)
The applica tion of new genetic tools also led to the discovery of an important familial neuroblastoma cancer gene, ALK , which is mutated in approximately 8% of sporadic tumors, and genome-wide association studies have unveiled loci with risk alleles for neuroblastoma development. (biomedcentral.com)
The differential diagnosis of a malignant effusion is accordingly broad, especially for the small round blue cell tumors that includes not only mesenchymal tumors, but also non-mesenchymal tumors, such as neuroblastoma and Wilms tumor. (cytojournal.com)
Other rare non-epithelial malignancies that may be encountered in effusion cytology include neuroblastoma, Wilms tumor, and metastatic brain tumors. (cytojournal.com)
That finding prompted the team to take a closer look at these sequences using a modified version of circle sequencing (Circle-seq) in 21 of the neuroblastoma tumors, making it possible to enrich for circularized DNA. (genomeweb.com)
Hormones made by the body that may also be made by neuroblastoma tumors. (neuroblastoma-info.com)
The results of this study are exciting for patients with high-risk neuroblastoma whose tumors have a genetic alteration in the ALK gene and who have lacked effective targeted treatment options for this often lethal cancer," said senior study author Yael P. Mossé, MD , Professor of Pediatrics in the Cancer Center at Children's Hospital of Philadelphia (CHOP). (emory.edu)
The clinical behavior of neuroblastoma is highly variable, with some tumors being easily treatable, but the majority being very aggressive. (acco.org)
On the clinical side, I have developed expertise in the management of patients with neuroblastoma, germ cell tumors, and histiocytic diseases (such as Langerhans cell histiocytosis and hemophagocytic lymphohistiocytosis, or LCH and HLH). (chop.edu)
We've discovered that numerous medications that interfere with steps in the pathway of making polyamines can disrupt neuroblastomas -- either blocking them before they form, or making tumors regress or respond more fully to standard therapies. (chop.edu)
V. To serve as a Registry for neuroblastoma patients whose tumors demonstrate clinical and genetic features defined as ?Low Risk? (uchicagomedicine.org)
Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas while the N-Myc gene has been found amplified in neuroblastomas. (ihcworld.com)
Neuroblastomas are immature, undifferentiated, malignant tumors. (msdmanuals.com)
Neuroblastoma is one of the small, blue, round cell tumors of childhood. (medscape.com)

A nomogram of clinical and biologic factors to predict survival in children newly diagnosed with high-risk neuroblastoma: An International Neuroblastoma Risk Group project. (uni-koeln.de)
Metastatic Neuroblastoma Confined to Distant Lymph Nodes (stage 4N) Predicts Outcome in Patients With Stage 4 Disease: A Study From the International Neuroblastoma Risk Group Database. (uni-koeln.de)
Prognostic significance of pattern and burden of metastatic disease in patients with stage 4 neuroblastoma: A study from the International Neuroblastoma Risk Group database. (uni-koeln.de)
This involves leadership roles within the Children's Oncology Group (COG), the International Neuroblastoma Risk Group (INRG), and the International Histiocyte Society. (chop.edu)

The main clinical problem in treating NB is metastasis, specifically metastatic stages III and IV according to the International Neuroblastoma Staging System ( 1 , 2 ), because metastatic lesions are often resistant to current therapies. (iiarjournals.org)

The group hypothesized that the HSR region was due to amplification of the DHFR gene. (wikipedia.org)
The notion that gene amplification could result in an increase of protein product was initially not accepted. (wikipedia.org)
At least 16 mutations in the ALK gene have been identified in some people with neuroblastoma, a type of cancerous tumor composed of immature nerve cells (neuroblasts). (medlineplus.gov)
Somatic mutations in the ALK gene occur during the development of some cases of sporadic neuroblastoma, and inherited mutations in the ALK gene increase the risk of developing familial neuroblastoma. (medlineplus.gov)
Arg1275Gln has been found in both familial and sporadic neuroblastoma and is the only common ALK gene mutation that has been found in both types of the condition. (medlineplus.gov)
Occasionally, extra copies of the ALK gene are found in people with neuroblastoma. (medlineplus.gov)
This phenomenon, known as gene amplification, results in overexpression of ALK receptor tyrosine kinase. (medlineplus.gov)
Neuroblastoma is sometimes caused by a gene mutation (change) passed from the parent to the child. (wustl.edu)
Gene mutations that increase the risk of neuroblastoma are sometimes inherited (passed from the parent to the child). (wustl.edu)
In children with a gene mutation, neuroblastoma usually occurs at a younger age and more than one tumor may form in the adrenal glands or in the nerve tissue in the neck, chest, abdomen, or pelvis. (wustl.edu)
A notoriously challenging disease to cure, neuroblastoma is characterized by a variety of types and subtypes caused by separate and interacting gene mutations, which only adds to the complexity in devising rational and effective therapies. (emory.edu)
In 2008, Dr. Mossé and colleagues discovered that the anaplastic lymphoma kinase (ALK) gene causes most cases of rare, inherited neuroblastoma. (emory.edu)
Since then, she and colleagues from around the world have investigated how mutations in the ALK gene lead to different types of nonhereditary neuroblastoma. (emory.edu)
Based on Dr. Mossé's discovery, in 2009 COG launched a clinical trial for children with neuroblastoma that repurposed crizotinib, an ALK inhibitor that was already approved by the FDA to treat adults with a subtype of lung cancer caused by abnormalities in the ALK gene. (emory.edu)
Chromosomal rearrangments (most common), mutations, and amplifications in this gene are associated with numerous tumours including: anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. (2bscientific.com)

For the study, researchers enrolled 355 children (median age, approximately 3 years) who were newly diagnosed with high-risk neuroblastoma. (oncologynurseadvisor.com)
Based on the CCG data, a child diagnosed with high-risk neuroblastoma when treated with the above approaches, can expect an estimated 40% probability of disease- free survival four years from diagnosis. (acco.org)

Patients with low-risk and intermediate-risk neuroblastoma have excellent prognosis and outcome. (medscape.com)
Deletion of the short arm of chromosome 1 is the most common chromosomal abnormality present in neuroblastoma and confers a poor prognosis. (medscape.com)
Although the outcome for children with cancer has improved considerably during the past decades, the prognosis of children with aggressive neuroblastoma remains dismal. (biomedcentral.com)
Being able to induce this differentiation by not leaving it to chance would be a therapeutic challage and could categorically change the prognosis of neuroblastomas. (lupinepublishers.com)

Neuroblastoma and other cancers occur when a buildup of genetic mutations in critical genes-those that control cell proliferation or differentiation-allows cells to grow and divide uncontrollably to form a tumor. (medlineplus.gov)
This study is the culmination of decades of work that began at CHOP with our initial discovery of ALK mutations in neuroblastoma in 2008. (emory.edu)
These fusion proteins, as well as other mutations and amplifications, likely confer hightened (possibly consititutive) kinase activity and thus promote cell growth and anti-apoptotic pathways such as the Akt MAPK pathways. (2bscientific.com)

Genetic Clinical Markers of Human Neuroblastoma with Special Reference to N- myc Oncogene: Amplified or Not Amplified? (karger.com)
The clinical course of patients with neuroblastoma is highly variable, ranging from spontaneous regression to widespread metastatic disease. (biomedcentral.com)
In clinical studies of patients with high-risk neuroblastoma, Grade 3 peripheral sensory neuropathy occurred in 2% to 9% of patients. (nih.gov)
The findings, published today in Nature Medicine , have led to a major amendment in a phase 3 Children's Oncology Group (COG) clinical trial, which has incorporated lorlatinib for newly diagnosed ALK-driven high-risk neuroblastoma, as well as a planned amendment to the European phase 3 trial in collaboration with the International Society of Paediatric Oncology European Neuroblastoma (SIOPEN). (emory.edu)
This trial will truly change the paradigm of clinical care and improve outcomes for our neuroblastoma patients. (emory.edu)
During the last part of the 20th century, clinical trials have shown that the basis for treating high-risk neuroblastoma should consist of induction chemotherapy, consolidation with high dose chemotherapy + stem cell transplant. (acco.org)
Thus, it is reasonable to expect the potential for a higher disease- free survival for high-risk neuroblastoma in ongoing and future clinical trials. (acco.org)
I help coordinate the care of children with these diseases at Children's Hospital, and have roles in the international community in developing clinical and translational programs for neuroblastoma and histiocytic diseases. (chop.edu)
We anticipate that drugs in both of these classes will soon be tested in clinical trials to see if they improve the outcome of children with advanced neuroblastoma. (chop.edu)

is an oncogene that is overexpressed in approximately one quarter of cases of neuroblastoma via the amplification of the distal arm of chromosome 2. (medscape.com)
The American Cancer Society estimated that 710 new cases of neuroblastoma (including gangioneuroblastoma) would be diagnosed in the United States in 2014. (medscape.com)

Close collaborating between COG (Children's Oncology Group) and SIOPEN (International Society of Paediatric Oncology Europe Neuroblastoma) will allow for the design of complementary studies to define the most effective risk-tailored intensified strategies. (oncologynurseadvisor.com)
Holmes K. et al (2020): Influence of Surgical Excision on the Survival of Patients With Stage 4 High-Risk Neuroblastoma: A Report From the HR-NBL1/SIOPEN Study. (gv.at)
International Society of Paediatric Oncology Europe Neuroblastoma Group (SIOPEN). (gv.at)
SIOP Europe Neuroblastoma Group (SIOPEN). (gv.at)
Ladenstein R. et al (2017): Validation of the mIBG skeletal SIOPEN scoring method in two independent high-risk neuroblastoma populations: the SIOPEN/HR-NBL1 and COG-A3973 trials. (gv.at)
Neuroblastoma: A Report From the HR-NBL1/SIOPEN Study. (cancercentrum.se)

Neuroblastoma (NB) is the most common extra-cranial solid tumor of childhood. (biomedcentral.com)
Neuroblastoma (NB) is the most common and deadly extracranial solid tumor of childhood as it accounts for 6-8% of all childhood cases of cancer ( 1 ). (iiarjournals.org)
Neuroblastoma is a solid tumor of childhood that arises in the nervous system, outside of the brain. (acco.org)
Neuroblastoma is the most common intra-abdominal malignancy of infancy, the most common cancer in infancy, and the most common extracranial solid tumor of childhood, with an incidence of over 700 cases in the United States every year. (medscape.com)

The specificity of our case is the benign evolution of an osteomedullary stage 4 neuroblastoma and its maturation into a ganglioneuroma 6 years after the end of chemotherapy. (lupinepublishers.com)
We report the case of a female patient aged 21 months at the time of diagnosis, who was followed and treated for stage 4-neuroblastoma. (lupinepublishers.com)
The diagnosis was stage 4 neuroblastoma. (lupinepublishers.com)

Signs and symptoms of neuroblastoma vary with the site of presentation. (medscape.com)
Signs and symptoms of neuroblastoma include a lump in the abdomen, neck, or chest or bone pain. (wustl.edu)

The aim was to describe neurologic outcome in children with neuroblastoma and opsoclonus-myoclonus. (nih.gov)
In conclusion, persistent neurologic deficits are characteristic for children with neuroblastoma and opsoclonus-myoclonus. (nih.gov)

Various karyotypic abnormalities occur, but a deletion of the short arm of chromosome 1 is found in 70-80% of all patients with neuroblastomas. (medscape.com)

a) Subjects with newly diagnosed neuroblastoma with INSS Stage 4 are eligible with the following: i. (archildrens.org)

For some of the genomic regions that are deleted in some neuroblastomas, on 1p, 3p and 11q, candidate tumor suppressor genes have been identified. (biomedcentral.com)
Outcomes Although knockdown of either S6K1 or GLI1 decreases the mobile proliferation of neuroblastoma cells there is certainly little aftereffect Mouse monoclonal to eNOS of S6K1 over the appearance of GLI1 mRNA and proteins and on the capability of GLI1 to activate focus on genes. (techuniq.com)
It should be also noted that a recent kinome-wide siRNA screen in a non-small cell lung cancer cell line revealed that S6K1 silencing does not alter the expression of GLI1 protein and GLI1 regulated genes [29] in line with our observations in neuroblastoma. (techuniq.com)

Treatment for neuroblastoma consisted of surgery alone in 19/29 (18 stage A, 1 stage C in thorax), and surgery plus chemotherapy in 10/ 29. (nih.gov)
Chemotherapy used after surgery for children with low-risk or intermediate-risk neuroblastoma. (neuroblastoma-info.com)
Occurs after the induction chemotherapy/surgery phase of high-risk neuroblastoma treatment. (neuroblastoma-info.com)
We also are studying the process by which neuroblastoma cells become resistant to the body's protective mechanisms to prevent them from becoming cancerous, and ultimately how these cells become resistant to the chemotherapy and radiation therapy used to kill them. (chop.edu)

In order to develop a relevant xenogenic animal model of neuroblastoma (NB), we compared the tumorigenicity and metastatic potential of SK-N-SH and SK-N-DZ NB cell lines in nude mice and NOD/SCID Il2rg null (NSG) mice. (iiarjournals.org)

BACKGROUND: Despite intensive treatment protocols and recent advances, neuroblastomas still account for approximately 15% of all childhood cancer deaths. (uu.nl)
Here we focus on MYCN's role in neuroblastoma, the most common extracranial childhood cancer. (oncotarget.com)
Neuroblastoma (NB) is a deadly childhood disease that carries a 50% chance of relapse for anyone in remission and similar level of 5-year survival. (psu.edu)
Neuroblastoma is the most common diagnosed tumor in infants and the second most common extracranial tumor of childhood. (oncotarget.com)

This partially randomized phase III trial studies iobenguane I-131 or crizotinib and standard therapy in treating younger patients with newly-diagnosed high-risk neuroblastoma or ganglioneuroblastoma. (tuftsmedicalcenter.org)
Giving iobenguane I-131 or crizotinib and standard therapy may work better in treating younger patients with neuroblastoma or ganglioneuroblastoma. (tuftsmedicalcenter.org)

Neuroblastoma is a disease in which malignant (cancer) cells form in neuroblasts (immature nerve tissue) in the adrenal glands, neck, chest, or spinal cord. (wustl.edu)
The sternal puncture showed a very poor marrow with the presence of rarely isolated malignant cells often grouped in rosettes evoking an invasion by a neuroblastoma. (lupinepublishers.com)
In 1927, Cushing and Wolbach further characterized neuroblastoma by describing the transformation of malignant neuroblastoma into its benign counterpart, ganglioneuroma . (medscape.com)
Neuroblastoma is a malignant neural tumor that typically affects very young children. (medscape.com)

Neuroblastoma is a tumor of neural crest origin that arises in tissue of sympathetic nervous system and occurs in young children," said lead investigator Julie R. Park, MD, professor of medicine at Seattle Children's Hospital and the University of Washington. (oncologynurseadvisor.com)
NEW YORK - New research suggests circularized DNA falling outside of linear chromosomes may serve as a recurrent source of somatic rearrangements in neuroblastoma, a pediatric cancer affecting immature cells in the sympathetic nervous system. (genomeweb.com)
Neuroblastoma is a relatively common pediatric pathology of the sympathetic nervous system. (lupinepublishers.com)

CONCLUSION: We conclude that p53 and pRb pathway aberrations cannot be used as predictive biomarkers for neuroblastoma sensitivity to MDM2 and/or CDK4/6 inhibitors. (uu.nl)

The differences in outcome for patients with neuroblastoma are striking. (medscape.com)

The duration of opsoclonus-myoclonus symptoms prior to the diagnosis of neuroblastoma ranged from 6 days to 17 months (median duration, 6 weeks). (nih.gov)
To maintain a reference bank containing clinically and genetically characterized frozen tumor tissue, tumor DNA and ribonucleic acid (RNA), histology slides and paraffin blocks, neuroblastoma-derived cell lines, patient serum and paired normal DNA obtained at the time of diagnosis, at the time of second-look surgery and at the time of relapse for future research studies. (uchicagomedicine.org)

Moreover, we advise to be cautious with combining these inhibitors in neuroblastomas. (uu.nl)
Furthermore inhibitors of PI3K/mTOR and GLI signaling decreased Lafutidine neuroblastoma cell development but no extra development inhibitory effects had been detected when both classes of medications were combined. (techuniq.com)
Additionally the combination of small molecule inhibitors of GLI and PI3K/mTOR signaling revealed no additive or synergistic effects on the suppression of neuroblastoma cell growth. (techuniq.com)

In the literature, many cases of spontaneous regression of neuroblastoma have been reported, but the mechanisms for which they are responsible remain ambiguous. (lupinepublishers.com)
In addition, the evolution of neuroblastoma is unlikely: the tumor can be aggressive and evolves rapidly into a metastatic disease, as it can be "nice" and undergoes regression or maturation (spontaneous or probably induced) into a benign tumor: the ganglioneuroma. (lupinepublishers.com)
Spontaneous regression of neuroblastoma is rare, occurring in 1 to 2% of cases. (lupinepublishers.com)
The incidence of spontaneous regression in neuroblastoma is estimated to be between 10 and 100 times greater than that of any other human cancer [3]. (lupinepublishers.com)
Spontaneous regression of microscopic clusters of neuroblastoma cells, called neuroblastoma in situ, was noted to occur quite commonly. (medscape.com)
According to Beckwith and Perrin in 1963, regression occurs nearly 40 times more often than clinically apparent neuroblastoma. (medscape.com)

Neuroblastoma is the most common extracranial solid tumor of infancy. (medscape.com)

It is amplified in approximately 25% of de novo neuroblastoma cases and is more common in patients with advanced-stage disease. (biomedcentral.com)

Simultaneous disturbance of these pathways can occur via co-amplification of MDM2 and CDK4 or homozygous deletion of CDKN2A, which encodes both p14ARF and p16INK4a. (uu.nl)

One was a solid or isolated growth of oval primitive cells with Schwannian stroma, representative of a neuroblastoma (Figure 1 C). The second was a diffuse growth of large polygonal cells with ganglion cell differentiation and prominent Schwannian stroma, which was regarded as a ganglioneuroma. (springeropen.com)

Less than 50% of children with high-risk neuroblastoma will survive following current multi-agent, aggressive therapy. (oncologynurseadvisor.com)
However, the regimen we use for high-risk neuroblastoma is also the most aggressive and toxic regimen we give to children with cancer. (oncologynurseadvisor.com)
Neuroblastoma is an aggressive pediatric cancer that develops from early nerve cells, often appearing as a solid tumor in the chest or abdomen. (emory.edu)

We demonstrate that the majority of genomic rearrangements in neuroblastoma involve circular DNA, challenging our current understanding about cancer genome remodeling," the authors wrote. (genomeweb.com)

Constitutive activation of ALK receptor tyrosine kinase may increase the proliferation of immature nerve cells, leading to neuroblastoma. (medlineplus.gov)

In stage 4 disease, the neuroblastoma tumor cells have already spread (or metastasized) to other sites in the body, such as the bone or bone marrow. (acco.org)

Histologic subtypes of neuroblastoma are shown in the image below. (medscape.com)
Histologic subtypes of neuroblastoma. (medscape.com)

A prospective open label, multicenter study to evaluate the feasibility and side effects of using molecularly guided therapy in combination with standard therapy followed by a Randomized Controlled Trial of standard immunotherapy with or without DFMO followed by DFMO maintenance for Subjects with Newly Diagnosed High-Risk Neuroblastoma. (archildrens.org)
Unituxin is a GD2-binding monoclonal antibody indicated, in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2 (IL-2), and 13-cis-retinoic acid (RA), for the treatment of pediatric patients with high-risk neuroblastoma who achieve at least a partial response to prior first-line multiagent, multimodality therapy. (nih.gov)
A differentiating agent given with antibody therapy to help neuroblastoma cells transform into mature nerve cells. (neuroblastoma-info.com)
In a significant step for the treatment of neuroblastoma, an international group of researchers led by Children's Hospital of Philadelphia (CHOP), Winship Cancer Institute of Emory University and the New Approaches to Neuroblastoma Therapy (NANT) Consortium has shown that the targeted therapy lorlatinib is safe and effective in treating high-risk neuroblastoma. (emory.edu)
These established principles apply to "up-front" therapy of high-risk neuroblastoma. (acco.org)
This article will only address therapy of high-risk neuroblastoma. (acco.org)
Given the aggressiveness of the tumor type, it is accepted practice to treat high-risk neuroblastoma patients with intensive therapy, to increase the probability of cure. (acco.org)
Therefore, we suggest that miR-193b may represent a new candidate for miRNA-based anticancer therapy in neuroblastoma. (oncotarget.com)

Over the last 2 decades, many chromosomal and molecular abnormalities have been identified in patients with neuroblastoma. (medscape.com)
In addition, Biedler made important contributions to an understanding of the molecular mechanisms of neuroblastoma development, particularly of the role of the N-myc oncogene in the genesis of neuroblastoma Biedler was born June 24, 1925, in New York City. (wikipedia.org)

Both types of mutation occur in neuroblastoma. (medlineplus.gov)
The most common mutation in neuroblastoma replaces the amino acid arginine with the amino acid glutamine at position 1275 (written as Arg1275Gln or R1275Q). (medlineplus.gov)
To determine if this mutation may have eluded standard detection methods pretreatment, blocker displacement amplification was used to detect rare variants on multiple regions of the pretreatment tumor. (aacrjournals.org)
In contrast with adult cancers, p53 pathway inactivation in neuroblastomas is rarely caused by p53 mutation but rather by altered MDM2 or p14ARF expression. (uu.nl)

Anatomy10

Organisms1

Diseases13

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes37

Disciplines and Occupations1

Information Science4

Named Groups1

Health Care2

MYCN34

Tumors17

International Neuroblastoma Risk Group4

Staging System1

Gene15

Diagnosed with high-risk neuroblastoma2

Prognosis4

Mutations3

Clinical9

Cases of neuroblastoma2

SIOPEN6

Solid tumor of childhood4

Stage 4 neuroblastoma3

Symptoms of neuroblastoma2

Children with neuroblastoma2

Patients with neuroblastomas1

INSS1

Genes3

Chemotherapy4

Compared the tumorigenicity1

Childhood4

Ganglioneuroblastoma2

Malignant4

Sympathetic nervou3

Biomarkers1

Outcome1

Diagnosis2

Inhibitors3

Regression6

Common extracranial1

Advanced-stage1

Pathways1

Ganglioneuroma1

Aggressive3

Genomic1

Immature1

Bone marrow1

Subtypes2

Therapy8

Molecular2

Mutation4