Aminorex. Medical search. Frequent questions

Aminorex associated with possible idiopathic pulmonary hypertension in a cocaine user. (styleglassitalia.com)

PAH can be associated with exposure to certain drugs or toxins, particularly appetite suppressants, such as aminorex, fenfluramine derivatives and benfluorex. (janssenmedicalcloud.be)
Subgroup 3 - Drug- and toxin-induced PAH (Aminorex, fenfluramine derivatives, and toxic rapeseed oil have been identified as definite risk factors for PAH. (medscape.com)

Pharmacological characterization of the aminorex analogs 4-MAR, 4,4'-D. (erowid.org)
4F-MAR (4-Fluoro-4-methylaminorex, 4F-4-MAR) is a new stimulant drug of the 2-amino-5-aryloxazoline class, a kind of aminorex analogs. (rawpowdereu.com)

4-Methylaminorex Clominorex Cyclazodone Fenozolone Fluminorex Pemoline Thozalinone List of aminorex analogues Anvisa (2023-03-31). (wikipedia.org)

The synthesis was first reported in a structure-activity relationship study of 2-amino-5-aryl-2-oxazolines, where aminorex was found to be approximately 2.5 times more potent than D-amphetamine sulfate in inducing anorexia in rats, and was also reported to have CNS stimulant effects. (wikipedia.org)
This article provides information on 4,4′-DMAR, a new psychoactive substance that is a derivative of aminorex, an amphetamine-like appetite suppressant. (safrole.com)
The results were then compared with those of d-amphetamine, aminorex, and (±)-cis-4-MAR. All substances were found to exhibit potent releasing activity at DAT, with considerable potency at NET. (safrole.com)

Aminorex has been shown to have locomotor stimulant effects, lying midway between dextroamphetamine and methamphetamine. (wikipedia.org)

4,4'-DMAR is a psychostimulant and entactogen similar to aminorex, 4-methylamino-rex, and pemoline. (researchems.net)

Aminorex was a widely-prescribed appetite suppressant before it was pulled for causing lung damage. (naturalhealthwatchers.com)
The interest in the topic was raised in previous years due to a sudden increase in the number of PH patients in Switzerland, Germany and Austria, which was associated with the intake of the appetite-reducing drug aminorex. (ersjournals.com)

It is a derivative of aminorex and 4-methylaminorex (4-MAR), two synthetic stimulants that are strictly controlled under the 1971 United Nations Convention on Psychotropic Substances, with 4-MAR listed in Schedule I and aminorex listed in Schedule IV. (safrole.com)

Aminorex, in the 2-amino-5-aryl oxazoline class, was developed by McNeil Laboratories in 1962. (wikipedia.org)
141:180-184 1964 J Clinical Pharmacology 7:296-302 1967 Science 218(457) 487-490 1982 Annual Review of Med Chem 51-58 1965, 44-47 1966 52 Federal Registry (FR) 30174 52 FR 38225 The stuff is called 4-methyl aminorex or 4-methyl-5-phenyl-2-amino-oxazoline. (works.org)

4B-4-MAR (4-Bromo-4-methylaminorex) is a stimulating drug, a new analogue of 4-methylaminorex, aminorex and has a similar effect on the body. (researchchemsupplier.com)
Examples of substances that show up on these schedules include: ecstasy, aminorex (a now-withdrawn weight loss drug), hydrocodone, pentobarbital (a barbiturate used as a sedative and anesthetic), and clonazepam. (karimilawoffice.com)

Aminorex Isotretinoin (AT) AT is a synthetic estrogens that is made via a process that involves the synthesis of a fatty acid called a tripeptide. (aelart.com)

This graph shows the total number of publications written about "Aminorex" by people in this website by year, and whether "Aminorex" was a major or minor topic of these publications. (childrensmercy.org)
Below are the most recent publications written about "Aminorex" by people in Profiles. (childrensmercy.org)
At 1986 Rainbow Gathering in Pennsylvania some people combined 4-methyl aminorex with LSD (stoopid! (works.org)

Aminorex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)

Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. (drugbank.com)
Our data show that drugs known or suspected to increase the risk of PPH (eg, aminorex, fenfluramine, and chlorphentermine) are 5-HT transporter substrates, whereas drugs that have not been shown to increase the risk of PPH are less potent in this regard. (drugbank.com)
Epidemiological studies have established that fenfluramine, D-fenfluramine, and aminorex, but not other appetite suppressants, increase the risk of primary pulmonary hypertension (PH). (nih.gov)
It is no longer used due mainly to safety concerns, as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex which were found to cause pulmonary hypertension and cardiac fibrosis following prolonged use. (wikidoc.org)
PAH can be associated with exposure to certain drugs or toxins, particularly appetite suppressants, such as aminorex, fenfluramine derivatives and benfluorex. (janssenmedicalcloud.com)

Aminorex was associated with an increased prevalence of primary pulmonary hypertension (PPH), fenfluramines with an increased prevalence of PPH and valvulopathy, and phenylpropanolamine with an increased risk of haemorrhagic stroke. (nih.gov)
The serotonin hypothesis of pulmonary arterial hypertension (PAH) arose after an outbreak of PAH in patients taking the anorexigenic drugs aminorex and dexfenfluramine. (gla.ac.uk)

Safety concerns have led to the withdrawal of aminorex, followed by the fenfluramines in 1997, and phenylpropanolamine (norephedrine) in 2000. (nih.gov)

however, in the screening of levamisole positive racehorse urine and plasma samples, aminorex could only be detected in trace amounts or not at all. (bvsalud.org)
In forensic laboratories, hydroxy levamisole and its phase II conjugates make it easier to confirm levamisole misuse and to differentiate between the abuse of levamisole and aminorex. (bvsalud.org)
But it is known that one of the metabolites of levamisole is a compound called aminorex, which has amphetamine-like stimulation properties. (alternativefreepress.com)

Aminorex has been shown to have locomotor stimulant effects, lying midway between dextroamphetamine and methamphetamine. (wikipedia.org)
Aminorex effects have been attributed to the release of catecholamines. (wikipedia.org)

Once aminorex was removed from the market, the incidence of PPH went down to normal levels. (savvyhealth.com)

4,4'-DMAR is a psychostimulant and entactogen similar to aminorex, 4-methylamino-rex, and pemoline. (researchems.net)