NO is synthesized by nitric oxide synthase from the amino acid arginine. (mysite.com)
In addition to hydroxylating aromatic amino acids, BH4 serves as the cofactor for nitric oxide synthase and glyceryl-ether mono-oxygenase. (medscape.com)
In cases of such stress, it was observed that BH4 itself, sepiapterin, folic acid, resveratrol, and a small-molecular-weight compound AVE3085 have the ability to recouple endothelial nitric oxide synthase (eNOS) and improve endothelial function. (medscape.com)
Enzyme7
Amino acid oxidoreductases are oxidoreductases, a type of enzyme, that act upon amino acids. (wikipedia.org)
The POR gene provides instructions for making the enzyme cytochrome P450 oxidoreductase. (medlineplus.gov)
An octameric enzyme belonging to the superfamily of amino acid dehydrogenases. (nih.gov)
To characterize the activity of this putative P450 enzyme, a 404 amino acid fragment of Nor1p was expressed in Escherichia coli and purified to homogeneity. (nih.gov)
The enzyme also can use glutamate and phenylalanine as amino group donors and p-hydroxy-phenylpyruvate, phenylpyruvate and alpha-ketocaproic acid as amino group acceptors. (rhea-db.org)
[ 3 ] Subsequent studies identified a defect in fatty aldehyde dehydrogenase (FALDH), a component of the fatty alcohol:NAD oxidoreductase enzyme complex. (medscape.com)
8] FALDH is a component of the fatty alcohol:NAD oxidoreductase enzyme complex that catalyzes the sequential oxidation of fatty alcohol to aldehyde and fatty acid. (medscape.com)
Oxidase5
D-Amino-Acid Oxidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
This graph shows the total number of publications written about "D-Amino-Acid Oxidase" by people in this website by year, and whether "D-Amino-Acid Oxidase" was a major or minor topic of these publications. (uchicago.edu)
Below are the most recent publications written about "D-Amino-Acid Oxidase" by people in Profiles. (uchicago.edu)
The action of L-aminoacylase and L-amino acid oxidase on the stereoisomers of 2-amino-3-methylpent-4-enoic acid was examined, to secure stereochemically pure compounds related to L-alloisoleucine. (elsevierpure.com)
The subsequent treatment of these isomers with Crotalus adamanteus L-amino acid oxidase afforded the pure (2S,3R)-isomer, related to L-alloisoleucine, in more than 99% stereochemically pure form. (elsevierpure.com)
Peptides1
The partial proteolysis of the [ 125 I]AzQ-labeled 49 kDa subunit by V8-protease and N-terminal sequencing of the resulting peptides revealed that the amino acid residue cross-linked by [ 125 I]AzQ is within the sequence region Thr25-Glu143 (118 amino acids). (elsevierpure.com)
Sequence1
Short-chain dehydrogenases/reductases (SDRs) constitute a large family of NAD(P)(H)-dependent oxidoreductases, sharing sequence motifs and displaying similar mechanisms. (researchgate.net)
A non-essential amino acid that is synthesized from GLUTAMIC ACID. (lookformedical.com)
1. Olson, J.A. and Anfinsen, C.B. The crystallization and characterization of L -glutamic acid dehydrogenase. (qmul.ac.uk)
Proteins3
Twenty alpha-amino acids are the subunits which are polymerized to form proteins. (lookformedical.com)
A potential role in disulfide bond formation in the intracellular proteins of thermophilic organisms has recently been ascribed to a new family of protein disulfide oxidoreductases (PDOs). (cnr.it)
16] Schiff-base aldehyde adducts with other amino-containing molecules, including key membrane enzymes and proteins, may also be detrimental to their function. (medscape.com)
Reductase2
Reyes, A.M. PrxQ B from Mycobacterium tuberculosis is a monomeric, thioredoxin-dependent and highly efficient fatty acid hydroperoxide reductase. (uba.ar)
Trujillo, M. 'PrxQ B from Mycobacterium tuberculosis is a monomeric, thioredoxin-dependent and highly efficient fatty acid hydroperoxide reductase' (2016) Free Radical Biology and Medicine. (uba.ar)
Quinone oxidoreductase2
G SNP, a marker of oxidative stress (NAD[P]H quinone oxidoreductase mRNA) and homeostasis model assessment of insulin resistance. (diabetesjournals.org)
quinone oxidoreductase complex (Fqo) is crucial in energy conservation in A. fulgidus during growth with lactate [ 13 ]. (hindawi.com)
Metabolism6
Because cytochrome P450 oxidoreductase helps regulate the activity of these enzymes, researchers suspect that normal variations in the POR gene may influence a person's response to particular drugs (drug metabolism). (medlineplus.gov)
SDR enzymes have critical roles in lipid, amino acid, carbohydrate, cofactor, hormone and xenobiotic metabolism as well as in redox sensor mechanisms. (researchgate.net)
Increasing amino acid supply in pea embryos reveals specific interactions of N and C metabolism, and highlights the importance of mitochondrial metabolism", PLANT JOURNAL , vol. 55, 2008, pp. 909-926. (uni-bielefeld.de)
BH4 deficiencies are grouped with phenylketonuria (PKU), which is an inborn error of protein metabolism that results from an impaired ability to metabolize the essential amino acid Phe. (medscape.com)
Two decades later, Sjögren-Larsson syndrome was shown to be an inborn error of lipid metabolism caused by deficient activity of fatty alcohol:NAD oxidoreductase. (medscape.com)
Therefore, patients with Sjögren-Larsson syndrome have deficient activity of FALDH and fatty alcohol:NAD oxidoreductase, which results in defective metabolism of both fatty aldehyde and fatty alcohol. (medscape.com)
Oxidative1
An amino acid oxidoreductase that catalyzes the oxidative hydroxylation of L-VALINE to 3-methyl-2-oxobutanoate and AMMONIA in the presence of NADP . (online-medical-dictionary.org)
Aromatic3
Carboxylic acids can be saturated, unsaturated, or aromatic. (lookformedical.com)
Tyrosine aminotransferase (TAT) catalyzes the transamination of tyrosine and other aromatic amino acids. (rhea-db.org)
The latter two are key enzymes in biogenic amine biosynthesis (ie, aromatic amino acid synthesis). (medscape.com)
NADH3
Complejo enzimático que cataliza la DESCARBOXILACIÓN oxidativa y la DESAMINACIÓN de la GLICINA en DIÓXIDO DE CARBONO, AMONÍACO, NADH y N5N10-metilenotetrahidrofolato. (bvsalud.org)
The diverse inhibitors of bovine heart mitochondrial complex I (NADH-ubiquinone oxidoreductase) are believed to share a common large binding domain with partially overlapping sites, though it remains unclear how these binding sites relate to each other. (elsevierpure.com)
NADH is produced by glycolysis, the tricarboxylic acid cycle, and other dehydrogenases. (mysite.com)
Cytochrome4
More than 50 mutations in the POR gene have been found to cause cytochrome P450 oxidoreductase deficiency. (medlineplus.gov)
Most of the mutations that cause cytochrome P450 oxidoreductase deficiency change single protein building blocks (amino acids) in cytochrome P450 oxidoreductase. (medlineplus.gov)
Reduced activity of cytochrome P450 oxidoreductase can also disrupt the production of cholesterol, which likely impairs normal bone formation in severe cases of cytochrome P450 oxidoreductase deficiency. (medlineplus.gov)
if a shortage of cytochrome P450 oxidoreductase prevents retinoic acid from being broken down, the resulting excess of that molecule can stimulate the abnormal growth and fusion of bones. (medlineplus.gov)
P4501
Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome. (medlineplus.gov)
Transcription Factors1
Both NAC and cys are important precursors to numerous oxidoreductases and transcription factors which possess thiol groups. (mysite.com)
Metabolic2
An inherited metabolic disorder that is characterized by impaired synthesis and degradation of amino acids. (mcw.edu)
Polyoxin, a peptidyl nucleoside antibiotic, consists of three building blocks including a nucleoside skeleton, polyoximic acid (POIA), and carbamoylpolyoxamic acid (CPOAA), however, little is known about the "pathway redundancy" of the metabolic networks directing the CPOAA biosynthesis in the cell factories of the polyoxin producer. (biomedcentral.com)
Deficient activity1
The genetic defect in Sjögren-Larsson syndrome results in deficient activity of FALDH, which catalyzes the oxidation of fatty aldehyde to fatty acid. (medscape.com)
Cysteine1
the N-acetylated derivative of the naturally occuring amino acid L-cysteine. (mysite.com)
Syndrome2
The definitive test for Sjögren-Larsson syndrome is measurement of FALDH or fatty alcohol:NAD oxidoreductase in cultured skin fibroblasts. (medscape.com)
12] Furthermore, patients with this disorder have low levels of certain polyunsaturated fatty acids in plasma, which can contribute to the cutaneous and neurologic disease in Sjögren-Larsson syndrome. (medscape.com)
Fragment1
Furthermore, examination of fragment patterns generated by exhaustive digestion of the [ 125 I]AzQ-labeled 49 kDa subunit by V8-protease, lysylendopeptidase, or trypsin strongly suggested that the cross-linked residue is located within the region Asp41-Arg63 (23 amino acids). (elsevierpure.com)
Nitrogen3
Leaf Amino Acid Supply Affects Photosynthetic and Plant Nitrogen Use Efficiency under Nitrogen Stress. (uni-bielefeld.de)
Upon coupling with hydroperoxyl radical (HOO*) peroxy nitric acid is produced (HOONO) which readily decomposes to hydroxyl radical (HO*) and nitrogen dioxide (*NO2). (mysite.com)
The microbiome associated with healthy individuals of the red seaweed Laurencia dendroidea can fix nitrogen and provide relevant amino acids and vitamins to the seaweed ( 3 ). (asm.org)
Activity1
NOS activity also accumpanies the action of killer cells which produce *NO as a precursor to peroxynitric acid. (mysite.com)
Mechanisms1
Update on amino acid transporter functions and on possible amino acid sensing mechanisms in plants. (uni-bielefeld.de)
Liver1
It is conjugated to GLYCINE in the liver and excreted as hippuric acid. (lookformedical.com)
Catalyze1
The recombinant mTAT is able to catalyze the transamination of tyrosine using α-ketoglutaric acid as an amino group acceptor at neutral pH. (rhea-db.org)
Class1
A class of amino acids characterized by a closed ring structure. (lookformedical.com)
Studies1
Studies suggest that a molecule called retinoic acid also plays a role in the skeletal abnormalities found in severe cases. (medlineplus.gov)
Group2
This group of compounds includes amino acids and fatty acids. (lookformedical.com)
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. (lookformedical.com)