• The amendment was sponsored by Senator J. James Exon and Representative James J. Florio. (wikipedia.org)
  • In February of 1995, Senator James Exon (D-NE) introduced the Communications Decency Act (CDA) in an attempt to regulate obscenity and indecency online. (eff.org)
  • Don previously served as legal counsel and legislative assistant to U.S. Senator J. James Exon (D-NE), a senior member of the Senate Commerce Committee and Chairman of its Surface Transportation Subcommittee. (blankromegr.com)
  • Back in 1995, Senator Jim Exon (D-NE) stepped into the void and introduced the Communications Decency Act or the CDA, which makes it a felony to send "indecent" or "patently offensive" material over the Internet or other online service if the material will be viewed by children. (llrx.com)
  • The censorship drive began in February, 1995, with the introduction of "The Computer Decency Act of 1995" (S.314) , by Senator Jim Exon (D-NE). (well.com)
  • METHODS In this double-blind, phase 3 trial, we randomly assigned 556 patients with previously untreated, EGFR mutation-positive (exon 19 deletion or L858R) advanced NSCLC in a 1:1 ratio to receive either osimertinib (at a dose of 80 mg once daily) or a standard EGFR-TKI (gefitinib at a dose of 250 mg once daily or erlotinib at a dose of 150 mg once daily). (ncku.edu.tw)
  • The amendment was passed into law under the Omnibus Trade and Competitiveness Act of 1988 and amended Section 721 of Defense Production Act of 1950. (wikipedia.org)
  • The 1988 Exon-Florio amendment to the Defense Production Act authorizes the Pres. (dianepublishing.net)
  • EGFR mutation must have been identified as determined by Food and Drug Administration (FDA) approved or other validated test of either circulating tumor deoxyribonucleic acid (ctDNA) or tumor tissue in a clinical laboratory improvement amendments (CLIA) certified laboratory (sites in the United states [US]) or an accredited local laboratory (sites outside of the US). (stanford.edu)
  • Worried about the future of free speech online and responding directly to Stratton Oakmont , Representatives Chris Cox (R-CA) and Ron Wyden (D-OR) introduced an amendment to the Communications Decency Act that would end up becoming Section 230. (eff.org)
  • The Exon-Florio Amendment 50 U.S.C. app 2170 is a law that was enacted by the United States Congress in 1988 to review foreign investment within the United States. (wikipedia.org)
  • The 2007 amendments now require that CFIUS (1) publish guidance in the Federal Register on the types of transactions that it has reviewed and that have presented national security considerations and (2) notify Congress after each review and investigation. (heritage.org)
  • In the Fall, the time has arrived when the Congress must choose between competing amendments and enact some form of the proposed legislation. (well.com)
  • He was also a cosponsor of the Exon-Florio Amendment, which created the Treasury Department's Committee on Foreign Investment in the United States to remove Congress from the approval process on foreign takeovers of US industrial concerns. (rutgers.edu)
  • Don is particularly skilled in navigating and implementing numerous legislative language and line-item amendments in Congress, as well as working with federal agencies on interpretive issues that avoid the need for congressional action. (blankromegr.com)
  • In each of these areas, I examine the role of social science,both in fuelling the porn panic and in potentially informing the policydebate, and I address the broad First Amendment implications of(inappropriately) applying broadcast regulation standards to onlinecommunication. (bigskillz.com)
  • The Department of the Treasury also released amendments to CFIUS's regulations effective October 11, 2018 to implement the immediately effective portions of FIRRMA. (clearymawatch.com)
  • As Chairman of the House subcommittee with jurisdiction over environmental matters, Florio wrote and steered passage of an amendment to the National Parks and Recreation Act of 1978 creating the Pinelands National Reserve within portions of seven counties in the southern part of the state. (rutgers.edu)
  • Elementary and secondary schools are eligible for up to 90% discounts on Internet connections according to the Passage of the Snowe-Rockefeller-Exon-Kerry Amendment Universal Service section of the Telecommunications Act of 1996. (leskobooks.com)
  • Section 230, the amendment that promoted free speech, survived. (eff.org)
  • Section 1727(c) of FIRRMA authorizes CFIUS to conduct one or more pilot programs to implement any authority provided pursuant to any provision of, or amendment made by, FIRRMA that did not take effect immediately upon enactment. (clearymawatch.com)
  • Implementing Exon-Florio can pose a significant challenge because of the need to weigh security concerns against U.S. open investment policy -- which requires equal treatment of foreign & domestic investors. (dianepublishing.net)
  • At present, this net is the epitome of the first amendment: free speech. (benjaminbarber.org)
  • NIOSH announced a change in priority order and projected dates for publication of proposed rule amendments (modules) or respiratory devices used to protect workers in hazardous environments. (cdc.gov)
  • It is especially ironic that the Exon amendment, which would chill the development of online services and communities and 'dumb down' the content of the Net's public spaces to a grade-school level, has been attached to a bill deregulating communications infrastructure. (ua.edu)
  • In response to public comments received from its May 16, 1996, request (61 FR 24740), NIOSH announced the intended priority order for the development of the next proposed rule amendments (modules) to the current NIOSH procedures for certifying respiratory devices used to protect workers in hazardous environments. (cdc.gov)
  • The amendment specifically made sure that "providers of an interactive computer service" would not be treated as publishers of third-party content. (eff.org)
  • Enacted before the New Jersey legislature passed Governor Brendan Byrne's Pinelands proposal, the federal amendment helped protect approximately 1.1 million acres by restricting incompatible federal actions and establishing a planning process to preserve the region's natural resources. (rutgers.edu)
  • Approximately 10% to 12% of EGFR mutations and about 2% to 4 % of HER2 mutations in NSCLC are present in exon 20. (asiaone.com)
  • Importantly, 90% of HER2 mutations in NSCLC are exon 20 mutations. (asiaone.com)
  • We screened 178 non-small cell lung cancer specimens for mutations in exons 18 to 21 of EGFR using a DNA endonuclease, SURVEYOR, which cleaves mismatched heteroduplexed DNA. (aacrjournals.org)
  • The FDA has granted approval for an investigational new drug protocol amendment for ABT-101, a mutant selective tyrosine kinase inhibitor which has shown superior selectivity against HER2 exon 20 mutations in NSCLC in preclinical studies. (targetedonc.com)
  • Also includes mutations in the protein-coding region that neither alter the amino acid sequence nor are predicted to significantly affect exon splicing, and base pair alterations in non-coding portions of the gene that have been demonstrated to have no deleterious effect on the length or stability of the mRNA transcript. (cdc.gov)
  • One of the most common causes of NDM is the active mutations of the gene ABCC8 located in the 11p15.1 region, which has a length of 84kb with 39 exons [14]. (biomedres.us)
  • An advisory committee had voted against poziotinib to treat patients with non-small cell lung cancer with HER2 exon 20 insertion mutations. (formularywatch.com)
  • With the mission in mind, we want to make impact to transform the treatment for patients with non-small cell lung cancer harboring exon 20 insertions (e20i) in HER2,' said John Tsu-An Hsu , Ph.D, Founder and Chief Executive Officer of Anbogen Therapeutics. (asiaone.com)
  • ABT-101 demonstrates excellent therapeutic potential and superior safety profile compared to competitors that are under clinical development, and it meets challenges of unmet medical needs for cancer drugs targeting exon 20 insertions (e20i) in HER2. (asiaone.com)
  • It is estimated that the global annual patient population is greater than 56,000 who harbor HER2 exon insertion mutation. (asiaone.com)
  • Single gene testing was performed on each patient in a Clinical Laboratory Improvement Amendment (CLIA) certified laboratory. (nih.gov)
  • DNA was isolated, and all exons in the gene of interest were analyzed along with 20 base pairs of flanking intronic sequence. (nih.gov)
  • The Johnston motion to table failed 41-58, and the amendment then passed by a voice vote. (lcv.org)
  • We are pleased to receive approval from the FDA on the protocol amendment, and continue to drive ABT-101 clinical development program forward. (asiaone.com)
  • In a stunning ruling issued on July 15, 2014, the U.S. Court of Appeals for the D.C. Circuit held that review by the Committee on Foreign Investment in the United States ("CFIUS") and the subsequent unwinding of the investment deprived the foreign investor of due process under the 5th Amendment to the U.S. Constitution. (governmentcontractslawblog.com)
  • As implemented, Exon-Florio establishes a process for the "voluntary" submission of information relating to "covered transactions" and a three-step review process that is administered principally by the Committee on Foreign Investment in the United States ("CFIUS"), an interagency organization created by Executive Order in 1975. (corporatesecuritieslawblog.com)
  • Recognizing § 230's more stable constitutional provenance explains why courts traditionally adopted a broad reading of the law, demonstrates the law's substantive importance, and helps predict what might occur should detractors succeed in achieving amendment by Congress. (harvardlawreview.org)
  • 6. Public opinion survey conducted by Cambridge Survey Research on the voter initiative constitutional amendment. (google.com.pe)
  • The CDA's "indecent transmission'' and "patently offensive display'' provisions abridge "the freedom of speech'' protected by the First Amendment . (cornell.edu)
  • First Amendment: Speech Note 131 Harv. (harvardlawreview.org)
  • In its decision to reject the federal law, the judges unanimously agreed to protect the First Amendment right to free speech in the landmark case of ACLU vs. Janet Reno, declaring the Internet the most participatory form of mass speech the world has yet seen. (cnet.com)
  • Obscene speech can be prohibited or otherwise regulated without violating the prohibitions of the First Amendment to the U.S. Constitution. (vlex.com)
  • The Exon-Florio Amendment 50 U.S.C. app 2170 is a law that was enacted by the United States Congress in 1988 to review foreign investment within the United States. (wikipedia.org)
  • The Government appealed to this Court under the Act's special review provisions, arguing that the District Court erred in holding that the CDA violated both the First Amendment because it is overbroad and the Fifth Amendment because it is vague. (cornell.edu)
  • According to the administration, this emphasis on improved communication between regulators and applicants can be traced to previous amendments to the Prescription Drug User Fee Act (PDUFA V), in which a new review model dubbed "the Program" was introduced and carried through the current PDUFA VI. (hcplive.com)
  • According to the amendment, the president may block the investment when "there is credible evidence that leads the President to believe that the foreign interest exercising control might take action that threatens to impair the national security. (wikipedia.org)
  • During the same debate, the Senate voted on an amendment proposed by Sen. Bill Bradley (D-NJ) to follow President Clinton's recommendation and terminate another unwise Department of Energy nuclear project: the Modular High-Temperature Gas-Cooled Reactor (MHTGR). (lcv.org)
  • Implementing Exon-Florio can pose a significant challenge because of the need to weigh security concerns against U.S. open investment policy -- which requires equal treatment of foreign & domestic investors. (dianepublishing.net)
  • Against this current, this Note provides the first thorough argument that the First Amendment requires § 230's bar on holding websites liable for the defamation of their users. (harvardlawreview.org)
  • Obscenity has been determined to be outside the realm of first amendment protection. (berghel.net)
  • a) Although the CDA's vagueness is relevant to the First Amendment overbreadth inquiry, the judgment should be affirmed without reaching the Fifth Amendment issue. (cornell.edu)
  • Under the Supreme Court's First Amendment case law on defamation, the private censorship produced by defamation liability for internet intermediaries cannot be justified by a government interest in defamation law. (harvardlawreview.org)
  • VYONDYS 53: Participants amenable to exon 53 skipping will receive SRP-4053 IV infusions, weekly, at 30 mg/kg for up to 96 weeks in the double-blinded period. (who.int)
  • AMONDYS 45: Participants amenable to exon 45 skipping will receive SRP-4045 IV infusions, weekly, at 30 mg/kg for up to 96 weeks in the double-blinded period. (who.int)
  • Control Intervention1: Placebo Comparator: Placebo followed by SRP-4045 or SRP-4053: Participants amenable to exon 45 or 53 skipping will receive SRP-4045 or SRP-4053 placebo-matching IV infusions, weekly, at 30 mg/kg for up to 96 weeks in the double-blinded period. (who.int)
  • CFIUS labored in relative obscurity until Exon-Florio infused it with a critical oversight role regarding trillions of dollars of inbound foreign investment. (corporatesecuritieslawblog.com)
  • Forwarded message ---------- FORWARDED FROM: /mail/cr/croth(#4131) From:croth(Chris Roth) THE FIRST AMENDMENT TEACH-IN MISSION STATEMENT The First Amendment Teach-In is a free crash course in freedom of expression and separation of state and church. (exploit-db.com)
  • This argument is profoundly repugnant to First Amendment principles. (cnet.com)
  • Third, by mailing printed comments to: The First Amendment Teach-In Attn: Letters to the Editor PO Box 17121 Milwaukee WI 53217-0121 USA ACCESS INFORMATION You may want to leave your terminal now to locate a pen and paper to record the following instructions. (exploit-db.com)