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NeurogenesisAlzheimer DiseaseDentate GyrusNeuronsNeural Stem CellsAmyloid beta-PeptidesBromodeoxyuridineHippocampusBrainAmyloid beta-Protein PrecursorStem Cellstau ProteinsNerve Tissue ProteinsNeurofibrillary TanglesCell DifferentiationPlaque, AmyloidAdult Stem CellsCell ProliferationLateral VentriclesNervous SystemGene Expression Regulation, DevelopmentalMice, TransgenicBasic Helix-Loop-Helix Transcription FactorsOlfactory BulbPresenilin-1NestinAgingCell CountApolipoprotein E4Cerebral CortexCognition DisordersCerebral VentriclesNeurofibrilsAmyloid Precursor Protein SecretasesNeuropeptidesImmunohistochemistryDementiaMice, Inbred C57BLMicrotubule-Associated ProteinsMaze LearningTelencephalonReceptors, NotchNeurogliaAmyloidNeuroepithelial CellsAtrophyDisease Models, AnimalNeuropsychological TestsMemoryDementia, VascularCognitionIn Situ HybridizationSignal TransductionIntermediate Filament ProteinsAntimetabolitesMemory DisordersCentral Nervous SystemProsencephalonMice, KnockoutAstrocytesGlial Fibrillary Acidic ProteinCells, CulturedPeptide FragmentsNerve DegenerationApolipoproteins EMild Cognitive ImpairmentAnimals, NewbornZebrafishNeuronal PlasticityNeocortexBrain-Derived Neurotrophic FactorCell SurvivalHomeodomain ProteinsSOXB1 Transcription FactorsBehavior, AnimalOlfactory MucosaPresenilin-2PresenilinsTime FactorsNeurodegenerative DiseasesRats, Sprague-DawleyCell LineageEmbryo, MammalianBiological MarkersTranscription FactorsBrain ChemistryEmbryo, NonmammalianCell MovementMagnetic Resonance ImagingFluoxetineStem Cell NicheMutationMicrogliaNerve RegenerationMental Status ScheduleMolecular Sequence DataLewy Body DiseaseOrganogenesisAspartic Acid EndopeptidasesPhosphopyruvate Hydratase

NeuronsHippocampal neurogenesisHippocampusCognitionStimulates neurogenesisAlzheimer's DiseaseStimulateNeuronSynapticMiceSubventricular zoneDifferentiationPostnatalDiseaseAdultsStimuliContributesEpigeneticPathwayPromotesPromotingMemoryPromoteResearchersDepressionNeuralProcessReseaRCHBrain cellsPotentialLevelsRoleTime

Neurons13

• Targeted augmentation of neurogenesis in FAD mice restored the number of new neurons in the engram, the dendritic spine density, and the transcription signature of both immature and mature neurons, ultimately leading to the rescue of memory. (altmetric.com)
• Chemogenetic inactivation of immature neurons following enhanced neurogenesis in AD, reversed mouse performance, and diminished memory. (altmetric.com)
• Epigenetic regulation of neurogenesis is the role that epigenetics (hertitable characteristics that do not involve changes in DNA sequence) plays in the regulation of neurogenesis (the production of neurons from neural stem cells). (wikipedia.org)
• The percentage of neurons in the neuron glia co-culture was increased without affecting the total number of cells, indicating an enhancement of neurogenesis. (frontiersin.org)
• In the monkey ( Macaca mulatta ) hippocampus, proliferation of neurons in the subgranular zone was found in early postnatal life, but this diminished during juvenile development as neurogenesis decreased. (nature.com)
• We conclude that recruitment of young neurons to the primate hippocampus decreases rapidly during the first years of life, and that neurogenesis in the dentate gyrus does not continue, or is extremely rare, in adult humans. (nature.com)
• One of the major cellular processes the authors highlighted was adult hippocampal neurogenesis , the birth of new neurons in the hippocampus - vital for learning and memory - that continues to occur throughout life. (iflscience.com)
• The question of whether adults can form new neurons, called neurogenesis, has long been a source of controversy. (newscientist.com)
• Neurogenesis is the mechanism whereby neurons are developed within the nervous system. (news-medical.net)
• Therefore, neurogenesis is used to counteract this problem, by generating new neurons to replace older ones. (news-medical.net)
• It is the process of generating new neurons through neurogenesis, NSCs have been recognised as a potential treatment for Alzheimer's. (express.co.uk)
• Dr. Belluscio, who studies the olfactory system, teamed up with Heather Cameron, Ph.D., a neurogenesis researcher at the NIH's National Institute of Mental Health, to better understand how the continuous addition of new neurons influences the circuit organization of the olfactory bulb. (nih.gov)
• Annie Eng, CEO of HP Ingredients Corp. commented, "Typically, a 30-minute aerobic exercise, such as running, has positive effects on brain structure and function, for example, the generation of neurons (neurogenesis) in the hippocampus, a brain structure important in learning. (nutraceuticalsworld.com)

Hippocampal neurogenesis7

• Hippocampal neurogenesis is impaired in Alzheimer's disease (AD) patients and familial Alzheimer's disease (FAD) mouse models. (altmetric.com)
• The early decline in hippocampal neurogenesis raises questions about how the function of the dentate gyrus differs between humans and other species in which adult hippocampal neurogenesis is preserved. (nature.com)
• Altman, J. & Das, G. D. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. (nature.com)
• Yan XB, Hou HL, Wu LM, Liu J, Zhou JN (2007) Lithium regulates hippocampal neurogenesis by ERK pathway and facilitates recovery of spatial learning and memory in rats after transient global cerebral ischemia. (springer.com)
• Lactate also promotes hippocampal neurogenesis (the birth of new brain cells) to ward off Alzheimer's. (lesmills.com)
• Hippocampal neurogenesis continues to occur well into old age, and in those with Alzheimer's disease. (neurosciencenews.com)
• Overall, conclude the researchers, the results suggest that an interaction between APOE4 and cadmium exposure "leads to accelerated cognitive impairment and that impaired adult hippocampal neurogenesis may be one of the underlying mechanisms. (medicalnewstoday.com)

Hippocampus7

• Kornack, D. R. & Rakic, P. Continuation of neurogenesis in the hippocampus of the adult macaque monkey. (nature.com)
• Functional neurogenesis in the adult hippocampus. (nature.com)
• Adult neurogenesis regulates plasticity and function in the hippocampus, which is critical for memory and vulnerable to Alzheimer's disease (AD). (cornell.edu)
• The hippocampus, which has been linked with adult neurogenesis, is vulnerable to Alzheimer's disease and other neurodegenerative conditions. (newscientist.com)
• Promoting neuroplasticity and neurogenesis via the 5HT2A-R in regions such as the hippocampus could theoretically help protect this and other brain structures and may, therefore, hold potential for treating AD. (frontiersin.org)
• Researchers report irisin, a hormone released during physical exercise, may promote neurogenesis in the hippocampus. (neurosciencenews.com)
• In 2015 alone, Inestrosa and Hancke had published a total of three research papers about Andrographolide and Alzheimers.The latest research titled "Andrographolide Stimulates Neurogenesis in the Adult Hippocampus" was published on Neural Plasticity in December 2015. (nutraceuticalsworld.com)

Cognition2

• Neurogenesis in Alzheimer's disease (AD) is impaired, and thus promoting neurogenesis is a promising strategy for treating AD-related cognition impairment. (cabi.org)
• We can now target platelets to promote neurogenesis, enhance cognition, and counteract age-related cognitive decline. (scitechdaily.com)

Stimulates neurogenesis2

• CAD-31 potently stimulates neurogenesis in human cells in culture and in mice, and prevents nerve cell death in cell culture models of toxicities associated with old age and AD. (ca.gov)
• In doing so, Andrographolide induces post-synaptic proteins and synaptic function, improves memory and spatial learning in APP Alzheimer model mice, and stimulates neurogenesis. (nutraceuticalsworld.com)

Alzheimer's Disease5

• 20 S -protopanaxatriol improves cognitive function of Alzheimer's disease by promoting endogenous neurogenesis. (cabi.org)
• Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease. (cornell.edu)
• Techniques to stimulate neurogenesis may help in the treatment of stroke patients and people with Alzheimer's disease and other neurodegenerative disorders. (oxfordreference.com)
• While neurogenesis continues to occur in those with Alzheimer's disease, it is significantly reduced compared to those who have normal cognitive function. (neurosciencenews.com)
• The effect of Alzheimer's disease on cognitive decline after an ischemic stroke and the role of neurogenesis. (vub.be)

Stimulate3

• The renaissance in psychedelic research in recent years, in particular studies involving psilocybin and lysergic acid diethylamide (LSD), coupled with anecdotal reports of cognitive benefits from micro-dosing, suggests that they may have a therapeutic role in a range of psychiatric and neurological conditions due to their potential to stimulate neurogenesis, provoke neuroplastic changes and reduce neuroinflammation. (frontiersin.org)
• NeuroActin was found to prevent and reverse neuropathology and stimulate neurogenesis. (nutraceuticalsworld.com)
• The patent, 'Treatment of Alzheimer's and Cognitive Impairment with Andrographolides,' describes how Andrographolide (ANDRO), a labdane diterpene and a major component of Andrographis paniculata (NeuroActin) was found to prevent and reverse neuropathology and stimulate neurogenesis. (nutraceuticalsworld.com)

Neuron1

• Neurogenesis is the mechanism for neuron proliferation and differentiation. (wikipedia.org)

Synaptic2

• Since neurotrophic factors are the primary architects of neurogenesis, synaptic plasticity, learning, and memory, the findings from preclinical and clinical studies that assess changes in neurogenesis and neurotrophic factors and their relationship to cognitive performance in schizophrenia, and how these mechanisms might be impacted by APD treatment, may provide valuable clues in developing therapies to combat cognitive deficit in schizophrenia. (benthamscience.com)
• In addition, Wnts participate in adult neurogenesis and protect excitatory synaptic terminals from amyloid-beta oligomer toxicity. (nih.gov)

Mice1

• While researchers have discovered adult neurogenesis in mice and macaques , any evidence of this ability in humans is less clear. (newscientist.com)

Subventricular zone2

• In the postnatal forebrain, DNMT3a is expressed in the subventricular zone (SVZ) and the hippocampal dentate gyrus, the primary locations for adult neurogenesis. (wikipedia.org)
• In a process known as neurogenesis, adult-born neuroprogenitor cells are generated in the subventricular zone deep in the brain and migrate to the olfactory bulb where they assume their final positions. (nih.gov)

Differentiation2

• but upregulation of genes involved in astroglial and oligodendroglial differentiation, indicating a role in the cell-fate switch from neurogenesis to gliogenesis. (wikipedia.org)
• Conclusion: BDNF in CSF contributes to post-ICH neurogenesis, including NSC proliferation and differentiation toward neuroblasts in a rat model and patients with ICH. (bvsalud.org)

Postnatal1

• DNMT3a silencing did not cause embryonic lethality, but did result in a severe detriment in postnatal neurogenesis. (wikipedia.org)

Disease4

• Alzheimer disease), genetic mutations (e.g. (intechopen.com)
• Mendes CT, Mury FB, de Sa-Moreira E, Alberto FL et al (2009) Lithium reduces Gsk3b mRNA levels: implications for Alzheimer disease. (springer.com)
• It was then put into an AD mouse model where it stimulated neurogenesis, prevented behavioral deficits and some of the disease pathology. (ca.gov)
• Alzheimer y esclerosis disease, a narrative review of original articles in both national and international scientific journals, in English and Spanish múltiple languages with no greater obsolescence than five years. (bvsalud.org)

Adults2

• In recent years, several studies identified various stimuli capable of enhancing neurogenesis in adults, a process, which is dysfunctional in the senescent brain as well as in neurodegenerative and neuropsychiatric diseases. (frontiersin.org)
• Why is neurogenesis required in adults? (news-medical.net)

Stimuli2

• In recent years, various stimuli were identified capable of enhancing neurogenesis, a process which is dysfunctional in the senescent brain and in neurodegenerative and certain neuropsychiatric diseases. (frontiersin.org)
• Once the nervous system is fully formed, neurogenesis only occurs due to stimuli. (news-medical.net)

Contributes1

• Collectively, these observations suggest that defective neurogenesis contributes to memory failure in AD. (altmetric.com)

Epigenetic1

• There are also epigenetic factors which are utilized in the control of neurogenesis, as well as cytokines, morphogens, neurotransmitters and growth factors. (news-medical.net)

Pathway1

• When the Wnt pathway is blocked, this reduces healthy neurogenesis and impairs learning and memory function. (nutraceuticalsworld.com)

Promotes1

• She explained that allopregnanolone is a pleiotropic neuro-steroid that promotes neurogenesis, oligogenesis, and synaptogenesis, as well as mitochondrial function and has anti-inflammatory effects. (medscape.com)

Promoting2

• Promoting neurogenesis may improve hippocampal function in AD brains. (cornell.edu)
• In patients with ICH, the BDNF concentration in CSF and the neurogenesis-promoting capacity of post-ICH CSF correlated positively with ICH volume. (bvsalud.org)

Memory1

• This is because the formation and retention of memory are directly impacted by neurogenesis. (express.co.uk)

Promote2

• Animal studies demonstrate that decreasing high glucocorticoid levels can promote neurogenesis. (usbiotek.com)
• The study, lead by Dr Jordi Riba, investigated the potential of ayahuasca to promote neurogenesis - which is the development of new brain cells. (beckleyfoundation.org)

Researchers2

• One of the researchers involved in this work, María Llorens-Martín at the Autonomous University of Madrid, believes neurogenesis might hold the key to figuring out what causes Alzheimer's and how to diagnose it early. (beingpatient.com)
• Researchers found evidence of neurogenesis in people up to the age of 99. (neurosciencenews.com)

Depression1

• Alterations have also been attributed to several diseases, such as depression and epilepsy, highlighting the importance of a highly controlled balance between neurogenesis and neurodegeneration. (news-medical.net)

Neural1

• MicroRNAs are a small form of non-coding RNA (ncRNA) which often act as "fine-tuning" mechanisms for gene expression by repressing or inducing messenger RNA (mRNA) in neural cells but can also act directly with transcription factors to guide neurogenesis. (wikipedia.org)

Process1

• But in the 1960s and 1970s, scientists discovered dividing cells in the brain through a process called neurogenesis. (beingpatient.com)

ReseaRCH1

• There is reseaRCH THAT INTTRANASAL STEM CELLTHERAPY CAN ACCELERATE NEUROGENESIS;however, the ir no accelerated effort to make this available to a patient. (beingpatient.com)

Brain cells1

• Wu and Prentice have been developing GCSF as a therapeutic method to replenish new brain cells because of its ability to preserve the central nervous system, suppress cell death and at the same time elicit neurogenesis as well as angiogenesis. (sciencedaily.com)

Potential1

• We are thrilledto learn of the potential of Andrographolide in stimulating neurogenesis. (nutraceuticalsworld.com)

Levels1

• Neurogenesis is tightly controlled, to ensure correct levels of activation. (news-medical.net)

Role1

• We investigated the role of brain-derived neurotrophic factor (BDNF) in post-ICH neurogenesis in a rodent model and in patients with ICH using cerebrospinal fluid (CSF). (bvsalud.org)

Time1

• DNA demethylation, as well as methylation, of certain genes allows for neurogenesis to proceed in a time dependent manner. (wikipedia.org)