TransplantationRejectionAssociated with chronic lung allograft dysfunctionDetection of allograft dysfunctionBoneDysfunctionRecipientsFibrosisChronicDermalSterileResectionTissue BankDonorMembraneReconstructionSurvivalTransplantBeneficialPatientsHumanTreatmentTechniqueWoundSuccessfullyYearsRepairExpressionFreshEffective
Transplantation11
- Nerve regeneration, is described for the first time in 1795 and in 1885 the first nerve allograft transplantation was reported. (wikipedia.org)
- Meniscal allograft transplantation is surgery in which a meniscus -- a c-shaped cartilage in the knee -- is placed into your knee. (medlineplus.gov)
- reported that arterial lesions of donor kidneys had significant effects on the renal allograft function 2 years after transplantation, and correlations between donor age and arterial lesions were significant in this regard. (hindawi.com)
- The notion of allografts is explored in specialty areas ranging from orthopedics and thoracic surgery to kidney and liver transplantation, in an effort to identify certain common themes having to do with the immunological response to the allograft and the various methods to avoid rejection. (novapublishers.com)
- Chapters in this book present current challenges in the use of bone allografts in complex orthopedic procedures, in addition to dealing in depth with the use of hepatic and renal allografts in liver and kidney transplantation. (novapublishers.com)
- Renal allograft compartment syndrome (RACS) is an underreported and poorly described surgical complication of renal transplantation. (bepress.com)
- Mesh Hood Fascial Closure in Renal Allograft Compartment Syndrome" Transplantation Proceedings Vol. 35 Iss. (bepress.com)
- Role of pulmonary function in the detection of allograft dysfunction after heart-lung transplantation. (bmj.com)
- Living-related conjunctival limbal allograft (lr-CLAL) is a type of ocular stem cell transplantation (OSST) that treats limbal stem cell deficiency (LSCD). (aao.org)
- Kenyon and Rapoza described the first lr-CLAL procedure in 1995, which they termed limbal allograft transplantation. (aao.org)
- Although aimed at protecting the host from infection, in the context of transplantation, this injury leads to allograft rejection. (medscape.com)
Rejection10
- An immune response against an allograft or xenograft is called transplant rejection. (wikipedia.org)
- Complex issues, such as the role of the immune system trying to deal with allograft acceptance or rejection on the one hand, and the presence of hepatitis B or C infection on the other hand, with the addition of the possibility of coexisting hepatocellular malignancy, are at the core of this book. (novapublishers.com)
- Whether the alternated microbiota in the gut contribute to the risk of allograft rejection (AR) and pulmonary infection (PI) in the setting of lung transplant recipients (LTRs) remains unexplored. (nature.com)
- In conclusion, a disruptive gut microbiota showed a significant association with allograft rejection and infection and with systemic cytokines and metabolites in LTRs. (nature.com)
- Severe allograft rejection (AR) and pulmonary infection (PI) are the most common complications within 1 year after the transplant. (nature.com)
- Beyond GWAS—Could Genetic Differentiation within the Allograft Rejection Pathway Shape Natural Immunity to COVID-19? (mdpi.com)
- Thus, the mycophenolate mofetil dose or mycophenolic acid plasma concentration are not a primary factor related to organ rejection, but chronic lung allograft dysfunction may be influenced by other components of immunosuppression or other factors. (smw.ch)
- Diagnostic accuracy of donor-derived cell-free DNA in renal-allograft rejection: a meta-analysis. (physiciansweekly.com)
- Without further manipulation or selection, the resultant population delayed skin allograft rejection mediated by polyclonal CD4(+) effectors or donor-reactive CD8(+) T cell receptor transgenic T cells and inhibited both effector cell proliferation and T cell priming for interferon-γ production. (lu.se)
- The recipient had a fever 8 days after receiving the renal allograft, and a biopsy of it showed acute rejection. (cdc.gov)
Associated with chronic lung allograft dysfunction2
- 4 These diseases are not only the major causes of death but are also associated with chronic lung allograft dysfunction (CLAD). (nature.com)
- CONCLUSION: Mycophenolate mofetil dosage and mycophenolic acid were not associated with chronic lung allograft dysfunction development. (smw.ch)
Detection of allograft dysfunction1
- The sensitivity, specificity, and positive/negative predictive values (PPV and NPV) of lung function for the detection of allograft dysfunction in these patients were measured. (bmj.com)
Bone17
- The technique used with the Dovetail Meniscal Transplant Set creates a trapezoidal bone block allograft for a bone-to-bone interlock, requiring no additional bone graft fixation. (arthrex.com)
- Massive Bone Allograft Reconstruction in High-Grade Osteosar. (lww.com)
- From 1986 to 1994, 112 bone allograft reconstructions were performed in patients with high-grade osteosarcoma in whom neoadjuvant chemotherapy was administered. (lww.com)
- Clinical use of massive bone allografts was reported by Lexter 14 in 1908 using fresh allografts retrieved from amputated limbs. (lww.com)
- In the authors' institute, massive frozen allografts have been used as a means of reconstruction after segmental resection for bone tumors since 1984. (lww.com)
- LifeNet Health introduced PliaFX® Strip allograft, comprising 100% cortical bone fibers, to be available in 1H18. (orthoworld.com)
- Objectives: To investigate the potential role of a commercially available preparation of micronized Amniotic Membrane Allograft (AMA) (Amniofix, MiMedx, USA) in the biological augmentation of an in vitro model of rotator cuff repair with respect to cellular pro- liferation, collagen content and mechanical properties of the bone- tendon interface. (researchgate.net)
- The specific areas covered in this report are the products and markets for bone allografts and bone graft substitutes, which include allograft bone substitutes, ceramic-based, polymer-based, factor-based (recombinant growth factors) and hyaluronic acid synovial fluid substitutes. (kaloramainformation.com)
- Decalcified freeze-dried bone allograft (DFDBA), believed to serve as a matrix for new bone growth and to contain various bone-inducing growth factors, is currently used to regenerate periodontal defects and to restore and maintain dental alveolar ridges. (allenpress.com)
- Recipient(s) will receive an email with a link to 'Enhancement of Osteoblast Proliferation In Vitro by Selective Enrichment of Demineralized Freeze-dried Bone Allograft With Specific Growth Factors' and will not need an account to access the content. (allenpress.com)
- The aim of the study was to compare fresh-frozen bone (FFB) allograft and autograft in the treatment of forearm aseptic non-union. (qxmd.com)
- The study reported a good reliability of FFB allograft for large non-union bone defects. (qxmd.com)
- Iliac Crest Fresh-Frozen Allografts Versus Autografts in Oral Pre-Prosthetic Bone Reconstructive Surgery: Histologic and Histomorphometric Study. (bvsalud.org)
- ABSTRACT Objective: the objective of this paper is to provide a descriptive histological analysis of the use of a buried, static and permanent magnetic field in lyophilized bone allografts in a dentoalveolar area associated with surgical defects in rat mandibles. (bvsalud.org)
- This surgical defect allowed the use of magnetized (test group) and non-magnetized (control group) metal devices associated with molar apices and distal stump of the lower incisor, where the lyophilized bone allograft was performed. (bvsalud.org)
- In the test and control groups, there was gradual integration of the lyophilized bone allograft, maintenance of pulp vitality of the molars and proximal stump of the lower incisor, in addition to continuous eruption of the lower incisor. (bvsalud.org)
- Lyophilized bone allograft. (bvsalud.org)
Dysfunction10
- Despite continued improvement in short-term graft survival, late allograft dysfunction remains a significant problem in the clinic, especially in kidney transplant patients. (hindawi.com)
- It is our hope that, by understanding the fundamental immune mechanisms in late allograft dysfunction, new and much improved strategies could be developed to further enhance transplant outcomes. (hindawi.com)
- conversely, the low NPV indicates that a stable pulmonary function does not rule out allograft dysfunction. (bmj.com)
- INTRODUCTION: Development of chronic lung allograft dysfunction is a limiting factor for post-lung transplant survival. (smw.ch)
- We evaluated whether the dose of the immunosuppressant mycophenolate mofetil or plasma concentrations of the active metabolite mycophenolic acid affect the development of chronic lung allograft dysfunction. (smw.ch)
- An event-time-analytical Cox proportional-hazards regression model with time-varying-covariates (18,431 measurements for MPA, mycophenolate mofetil dosage, lymphocytes) was used to predict chronic lung allograft dysfunction, with adjustment for sociodemographic factors and lung function at baseline. (smw.ch)
- RESULTS: 37 patients did not develop chronic lung allograft dysfunction (age 41.3 ± 15.6 years, baseline FEV1 95.5 ± 19.1% predicted) and 34 patients developed chronic lung allograft dysfunction (age 50.9 ± 13.3 years, baseline FEV1 102.2 ± 25.4% predicted). (smw.ch)
- 0.001), but only the traditional risk factor age predicted chronic lung allograft dysfunction. (smw.ch)
- Continuously measured mycophenolic acid did not predict chronic lung allograft dysfunction (hazard ratio 0.98, 95% confidence interval 0.90-1.06, p = 0.64 over a period of 382.97 patient-years). (smw.ch)
- Chronic lung allograft dysfunction: Definition, diagnostic criteria, and approaches to treatment-A consensus report from the Pulmonary Council of the ISHLT. (smw.ch)
Recipients3
- Lung transplants were performed using Lewis donors and Sprague-Dawley recipients (allografts) or the same strain (isografts). (nih.gov)
- Forty-three renal transplant recipients with well-functioning allografts were immunized with H. influenzae type b vaccine in order to investigate the immune response. (scienceopen.com)
- H. influenzae type b vaccination is safe and effective in patients with well-functioning renal allografts and should be recommended to renal transplant recipients who may have the risk of invasive disease on the basis of the immunosuppressive state. (scienceopen.com)
Fibrosis4
- In lung allografts, progressive terminal airway fibrosis leads to an irreversible decline in lung function termed bronchiolitis obliterans syndrome (BOS). (jci.org)
- Here, we have identified an autocrine pathway linking nuclear factor of activated T cells 2 (NFAT1), autotaxin (ATX), lysophosphatidic acid (LPA), and β-catenin that contributes to progression of fibrosis in lung allografts. (jci.org)
- In an in vivo mouse orthotopic lung transplant model of BOS, antagonism of the LPA receptor (LPA1) or ATX inhibition decreased allograft fibrosis and was associated with lower active β-catenin and dephosphorylated NFAT1 expression. (jci.org)
- These results suggest that pirfenidone inhibits local arginase activity possibly through suppression of endogenous TGF-beta, hence, limiting the development of fibrosis in lung allografts. (nih.gov)
Chronic2
- EpiFix allografts provide a semi-permeable protective barrier that supports the healing cascade and protects the wound bed to aid in the development of granulation tissue in acute and chronic wounds. (medgadget.com)
- No clinical evidence of hyperlipidemia as a risk factor for chronic renal allograft failure. (bvsalud.org)
Dermal3
Sterile2
- This means the nerve allograft only consists of extracellular matrix (ECM), which is sterile and decullularized. (wikipedia.org)
- Sharper than a scalpel, but ergonomically safer, this innovative approach to allograft tissue processing enables a sterile cleaning technique, thereby saving processing time, increasing yield, and reducing workplace injuries. (hydrocision.com)
Resection2
- Tracheal replacement with aortic allografts enables resection of extensive tumors with a curative intent. (nih.gov)
- From August 1986 to December 1994, 112 patients with high-grade osteosarcoma underwent preoperative chemotherapy, limb-sparing resection, reconstruction with a massive allograft, and postoperative chemotherapy. (lww.com)
Tissue Bank2
- LifeLink Tissue Bank will provide allografts to treat sports, orthopaedic and spine injuries to HCT Regenerative for distribution in Taiwan. (orthoworld.com)
- Musculoskeletal Transplant Foundation and Rocky Mountain Tissue Bank currently use the AlloJet Allograft debridement system. (hydrocision.com)
Donor3
- On the mechanistic side, while C4d remains a marker of a humoral response, recent evidence indicates that, in renal allografts, microvascular injury in the presence of donor antibodies is indicative of antibody mediated graft injury. (hindawi.com)
- The AlloJet Allograft debridement system uses a powerful, 500 mph, high-velocity fluidjet to safely and effectively remove soft tissue from donor bones. (hydrocision.com)
- Although rare, pulmonary embolism, infections, or neoplasms in the allograft may be diagnosed in this manner, which would affect the decision to use the donor lung. (medscape.com)
Membrane1
- EpiFix is a dehydrated human amnion-chorion membrane (dHACM) allograft derived from placental tissues and has broad reimbursement coverage. (medgadget.com)
Reconstruction4
- A nerve allograft is used for the reconstruction of peripheral nerve discontinuities in order to support the axonal regeneration across a nerve gap caused by any injury. (wikipedia.org)
- The allograft reconstruction was used in arthrodesis in 44 cases (41 knees, three ankles), as an intercalary graft in 39 (28 femurs, 11 tibias), as an osteoarticular graft in 22 (three proximal and/or distal humeri, six distal femurs, 13 proximal tibias), and as an allograft and prosthesis composite in seven (two proximal humeri, one proximal femurs, four proximal tibias). (lww.com)
- Parrish 19 in 1966 and Mankin et al 15 in 1976 reported good results in 80% of allograft reconstruction performed primarily for tumor resections. (lww.com)
- Debate continues 6,9,11,12,22,23 relative to the effectiveness of massive allograft reconstruction compared with other techniques (endoprostheses), particularly for patients receiving intensive chemotherapy. (lww.com)
Survival1
- Blood transfusions and renal allograft survival. (bmj.com)
Transplant1
- The transplant is called an allograft, allogeneic transplant, or homograft. (wikipedia.org)
Beneficial1
- An allograft contains many of the beneficial characteristics of nerve autograft, such as three-dimensional microstructural scaffolding and protein components inherent to nerve tissue. (wikipedia.org)
Patients6
- It has been shown that in allograft surgeries, post-operative neuropathic pain was present in some patients, but only if they had this condition pre-operatively. (wikipedia.org)
- We performed tracheal and carinal replacements with aortic allografts in 6 patients with extensive mucoepidermoid (n = 1) or adenoid cystic (n = 5) carcinomas. (nih.gov)
- The allograft consisted of an aortic segment, either fresh (in the first 2 patients) or cryopreserved (in the last 4). (nih.gov)
- In 20 patients an autologous vascularized fibula was used to augment the allograft. (lww.com)
- Ottolenghi 17,18 and Volkov, 21 reported successful results in approximately 75% of patients using anatomic specimen frozen allografts. (lww.com)
- The sample size was divided in two groups: patients treated with FFB allograft (Allograft Group) and patients treated with iliac crest autograft (Autograft Group). (qxmd.com)
Human1
- Nerve allografts are prepared from donated human nerve tissue. (wikipedia.org)
Treatment3
- MiMedx , a medtech company based in Georgia, has developed EpiFix , an off-the-shelf allograft system for the treatment of diabetic foot ulcers. (medgadget.com)
- Pirfenidone treatment decreased PawP and collagen content in lung allografts. (nih.gov)
- Allograft versus autograft in forearm aseptic non-union treatment. (qxmd.com)
Technique1
- We describe the surgical technique and peroperative management of tracheal and carinal replacement with aortic allografts for large salivary gland-type carcinoma and report the results with a mean 34 months' follow-up. (nih.gov)
Wound2
- EpiFix is a durable allograft with natural barrier properties that, when applied to a wound, provides a protective environment to help promote wound closure. (medgadget.com)
- Skin allografts or amnion grafts are effective burn-wound dressings and are within the reach of low- or medium-income countries. (who.int)
Successfully1
- Processed nerve allografts have now been used successfully to restore nerve continuity for over two decades. (wikipedia.org)
Years1
- The mean patient age was 33.58±16.72 (18-75) years old in Allograft Group and 33.28±17.24 (18-75) in Autograft Group. (qxmd.com)
Repair1
- I would probably bill it all under 27299, but make sure the comparable code, description, and the fee accurately reflect the repair with allograft. (aapc.com)
Expression1
- Mesenchymal cells (MCs) derived from fibrotic lung allografts (BOS MCs) demonstrated constitutive nuclear β-catenin expression that was dependent on autocrine ATX secretion and LPA signaling. (jci.org)
Fresh1
- Unlike keratolimbal allografts (KLAL), lr-CLAL provides fresh conjunctiva in addition to limbal tissue. (aao.org)
Effective1
- Purion is a unique patented processing method for placental-based allografts that is in accordance with the American Association of Tissue Banks (AATB) standards and FDA regulations and guidance, and specifically designed to deliver a clinically effective and minimally manipulated allograft tissue. (medgadget.com)