HLA-A1 (A1) is a human leukocyte antigen serotype within HLA-A "A" serotype group. (wikipedia.org)
Antibody3
The serotype is determined by the antibody recognition of α1 subset of HLA-A α-chains. (wikipedia.org)
A1-B58 haplotype (A1-B17 where B58 is dominant) may remain associated with anti-neutrophil cytoplasmic antibody (ANCA) With the exception of type 1 diabetes, most of the evidence for direct association of A1 with autoimmune diseases evaporated as DR3 and DQ2 genes were characterized. (wikipedia.org)
OBJECTIVES: We sought to determine vaccine antibody titres and the prevalence of hepatitis B surface antigen (HBsAg) in both HIV-positive and HIV-negative infants born to HIV-positive mothers in Botswana. (bvsalud.org)
Hepatitis1
Some diseases found associated with A1 actually link to the extended A1-B8 haplotype, viral induced hepatitis and accelerated progression of HIV are examples. (wikipedia.org)
Responses1
This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
Immune3
A1 serotype positivity is roughly linked to a large number of inflammatory diseases and conditions believed to have immune system involvement. (wikipedia.org)
Molecular docking, molecular dynamic simulation, and immune simulation were performed to ensure the binding between HLA and TLR4. (springeropen.com)
Overall primary concerns are: extrapolating human clinical studies, seeding durable effective T cell resident memory (Trm), population human leucocyte antigen (HLA) coverage, and the potential for T cell-mediated immune escape. (mdpi.com)
Minor4
Our identification of the first non-human primate-specific minor histocompatibility antigen now published at Frontiers in Immunology. (wisc.edu)
Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
CD8 + CTL clones recognizing minor H antigens were isolated from five patients studied. (aacrjournals.org)
CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)
Disease6
While it is not clear what role A1 has in infectious disease, some linkage with infection rates in HIV remain associated within the A1 region of the haplotype. (wikipedia.org)
In all instances so far, HLA-A1 has been found to be linked to disease by association, but there are few that define HLA-A1 has a predominant genetic risk relative to other gene-alleles in the vicinity of the A1 gene on the larger haplotype. (wikipedia.org)
Early in the study of HLA an association was found between HL A1,B8 in allergic disease, these are found to link to extended HLA A1-B8 region. (wikipedia.org)
Whereas A1 was found negatively associated with other disease such as coal workers pneumoconiosis and leprosy. (wikipedia.org)
Most of the disease risk conferred by A*01:01 are represented by either A1 serotype risks, or A1-B8 serotype risk (In Europe A1-B8 is almost always composed of A*01:01 and B*08:01). (wikipedia.org)
Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
Peptide4
11. Peptide-pulsed dendritic cells induce tumoricidal cytotoxic T lymphocytes from healthy donors against stably HLA-A*0201-binding peptides from the Melan-A/MART-1 self antigen. (nih.gov)
13. Identification of novel MAGE-A6- and MAGE-A12-derived HLA-A24-restricted cytotoxic T lymphocyte epitopes using an in silico peptide-docking assay. (nih.gov)
17. A novel HLA-A*0201 restricted peptide derived from cathepsin G is an effective immunotherapeutic target in acute myeloid leukemia. (nih.gov)
High cell surface expression and peptide binding affinity of HLA-DQA1*05:03, a susceptible allele of neuromyelitis optica spectrum disorders (NMOSD). (nih.gov)
Haplotype10
A1 is more common in Europe than elsewhere, it is part of a long haplotype that appears to have been frequent in the ancient peoples of Northwestern Europe. (wikipedia.org)
A1 is a frequent component of the AH8.1 haplotype. (wikipedia.org)
Because of its linkage within the AH8.1 haplotype many studies showed association with A1 or A1,B8 only later to show the association drift toward the class II region gene alleles, DR3 and DQ2.5. (wikipedia.org)
While it is not clear what role A1 has in infectious disease, some linkage with infection rates in HIV remain associated within the A1 region of the haplotype. (wikipedia.org)
In all instances so far, HLA-A1 has been found to be linked to disease by association, but there are few that define HLA-A1 has a predominant genetic risk relative to other gene-alleles in the vicinity of the A1 gene on the larger haplotype. (wikipedia.org)
A1-B58 haplotype (A1-B17 where B58 is dominant) may remain associated with anti-neutrophil cytoplasmic antibody (ANCA) With the exception of type 1 diabetes, most of the evidence for direct association of A1 with autoimmune diseases evaporated as DR3 and DQ2 genes were characterized. (wikipedia.org)
While type 1 diabetes shows an extended association on the HLA A1-B8-DR3-DQ2 haplotype, the association appears not to extend beyond the HLA-B locus. (wikipedia.org)
Some diseases found associated with A1 actually link to the extended A1-B8 haplotype, viral induced hepatitis and accelerated progression of HIV are examples. (wikipedia.org)
The A1-B8-DR3-DQ2 haplotype has a known association with Enteropathy-associated T-cell lymphoma, approximately 70% of patients are homozygotes for DQ2 with at least one copy of DR3-DQ2. (wikipedia.org)
In this report, we described clinical findings, long-term treatment outcomes, and the HLA haplotype in TINU cases. (hindawi.com)
Microglobulin1
Urinary β 2 microglobulin level and HLA typing may help in the diagnosis of TINU. (hindawi.com)
Affinity1
8. Identification of new epitopes from four different tumor-associated antigens: recognition of naturally processed epitopes correlates with HLA-A*0201-binding affinity. (nih.gov)
Genes3
A recent study of DR3-DQ2/DR4-DQ8 phenotype found that A1-cw7-B8 was actually lower than expected relative to other A-B types, indicating that risk associated genes are located between B8 and DR3. (wikipedia.org)
Antigens encoded by the genes in the group II took part in the rejection of transplanted tumors and other tissues. (slideshare.net)
The serotype is determined by the antibody recognition of α1 subset of HLA-A α-chains. (wikipedia.org)
Human4
HLA-A1 (A1) is a human leukocyte antigen serotype within HLA-A "A" serotype group. (wikipedia.org)
TINU has been reported to have an association with human leukocyte antigen (HLA), and HLA alleles have been implicated as susceptibility risk factors [ 8 , 13 - 16 ]. (hindawi.com)
14. HLA-A2-restricted cytotoxic T lymphocyte epitopes from human hepsin as novel targets for prostate cancer immunotherapy. (nih.gov)
16. Identification of human leukemia antigen A*0201-restricted epitopes derived from epidermal growth factor pathway substrate number 8. (nih.gov)
Risk3
A1 with B8 showed an increase risk of measles infection, however, the significance was not consistent. (wikipedia.org)
Most of the disease risk conferred by A*01:01 are represented by either A1 serotype risks, or A1-B8 serotype risk (In Europe A1-B8 is almost always composed of A*01:01 and B*08:01). (wikipedia.org)
Association between the HLA-DQA1 rs1391371 risk allele and chronic rhinosinusitis. (nih.gov)
Association3
Early in the study of HLA an association was found between HL A1,B8 in allergic disease, these are found to link to extended HLA A1-B8 region. (wikipedia.org)
An association between A1 and cold sores was also described. (wikipedia.org)
Association of HLA-DQ Heterodimer Residues -18β and β57 With Progression From Islet Autoimmunity to Diabetes in the Diabetes Prevention Trial-Type 1. (nih.gov)
Chain2
For A1, the alpha "A" chain are encoded by the HLA-A*01 allele group and the β-chain are encoded by B2M locus. (wikipedia.org)
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. (nih.gov)
Cell2
5. HLA-A2-restricted CTL epitopes of a novel lung cancer-associated cancer testis antigen, cell division cycle associated 1, can induce tumor-reactive CTL. (nih.gov)
10. Identification of HLA-A*0201-presented T cell epitopes derived from the oncofetal antigen-immature laminin receptor protein in patients with hematological malignancies. (nih.gov)