SpirometryInflammationObstructiveResistanceImpulse oscillometryObstructionLungsBarometricMethacholineHyperresponsivenessAsthmaComputed tomographyInduceDilutionResidual volumeBrachycephalic dogsUpperPulmonary function testsLower airwaysConductanceEosinophilsFunctionAssessmentInspiratoryAllergicHeliumPharyngealSevereMeasurementsEpithelialMouthpiecesEmphysemaInflammatoryNasalPatientsInvasiveOpensEfficacyExerciseMethodsMeasuresSmallChestDiseasesTreatmentsVentilation
Spirometry14
- Assessments include pulmonary function measurements (spirometry, impulse oscillometry and plethysmography), chest computed tomography, biomarker measurement (in blood, sputum, urine and exhaled breath condensate), health outcomes, body impedance, resting oxygen saturation and 6-min walking distance. (ersjournals.com)
- Lung function assessment included plethysmography and spirometry. (bmj.com)
- Characterization of the patients is crucial and includes symptoms (questionnaires), lung function tests (spirometry, body plethysmography, diffusion capacity, and impulse oscillometry), imaging (Chest X-ray and computer tomography), 6 minute walk test, echocardiography and blood chemistry. (ki.se)
- Children performed arterial blood oxygen measurement, nitrogen MBW, 3 , 4 body plethysmography and spirometry. (bmj.com)
- In addition, all participants performed pulmonary function tests including spirometry, body plethysmography, diffusion capacity for carbon monoxide, and the forced oscillation technique. (rcjournal.com)
- In this context, we review the advantages and limitations of routine physiological measurements of respiratory function including spirometry, body plethysmography and diffusing capacity and discuss less widely used methods such as forced oscillometry, inert gas washout and the multiple inert gas elimination technique. (ox.ac.uk)
- Q-Box is a variable-pressure body plethysmograph that includes all the hardware and software required for Lung Volumes, Airways Resistance, Spirometry and Respiratory Mechanics (MIP/MEP, PO.1) tests. (chsltd.com)
- Researchers employed both spirometry and body plethysmography testing methods. (wildfiretoday.com)
- Most previous studies in PD based their diagnoses of restriction on spirometry alone, rather than whole body plethysmography (1). (mdsabstracts.org)
- spirometry, flow volume loops, lung volume assessment by whole body plethysmography and respiratory muscle strength testing. (mdsabstracts.org)
- Of 64 non-smoking people with no known pre-existing lung disease, 28% had obstructive spirometry and up to 61% had at least one indicator of upper airway obstruction. (mdsabstracts.org)
- The increased prevalence of obstructive spirometry, upper airway obstruction and inspiratory muscle weakness observed could lead to increased morbidity and mortality. (mdsabstracts.org)
- Spirometry is used before and after inhalation of a breathing spray (e.g., methacholine) to assess the sensitivity of the airways in the lungs. (ucsd.edu)
- We tested lung function (spirometry, body plethysmography, as well as diffusion potential) and also 6MWD. (mdm2signals.com)
Inflammation17
- Asthma is a heterogeneous disease characterized by airway chronic inflammation together with airway hyperresponsiveness 1 . (nature.com)
- COPD is a multicomponent disease, comprising emphysema in the lung parenchyma, large central airway inflammation and mucociliary dysfunction, bronchiolitis and small airway structural changes 3 . (ersjournals.com)
- The evidence showing inflammation and remodelling in distal airways, and their possible involvement in asthma control and natural history, was reviewed. (ersjournals.com)
- Inflammation in distal airways appeared more intense in severe and uncontrolled asthma. (ersjournals.com)
- In a cohort of 40 COPD-patients, 40 smokers with normal lung function and 40 neversmokers (Karolinska COSMIC study) we have made significant attempts, by performing bronchoscopy, to characterize inflammation and structural changes in various levels in the airways as well as in the systemic circulation. (ki.se)
- Exhaled nitric oxide (FeNO) has proved to be a marker of inflammation in the airways and has become a substantial part of clinic. (biomedcentral.com)
- Exhaled nitric oxide has been proposed as a noninvasive marker of eosinophilic airway inflammation in lower airways. (biomedcentral.com)
- In addition to narrowed airways, inflammation of the bronchi or bronchioles (bronchitis, bronchiolitis) is also present. (mediservice.ch)
- We conclude that multiple exposures to endotoxin-containing swine barn air induce AHR, increase in mucus-containing airway epithelial cells and lung inflammation. (biomedcentral.com)
- Further confirmative data in the allergic asthma model demonstrated that CRAC played a central role in the airway inflammation and late asthmatic response (LAR). (docsbay.net)
- Asthma is characterised by airway inflammation, cough, bronchial hyperresponsiveness, and variable airflow obstruction (e.g. (docsbay.net)
- Patients with severe asthma may have neutrophilic airway inflammation and skew towards a more Th1 type response [6] characterised by the production of cytokines such as IFNγ and IL-2. (docsbay.net)
- Methods: We used a well-characterized mouse model of allergic airway inflammation. (utmb.edu)
- Results: CLN did not increase IgE/IgG1 levels or induce cutaneous hypersensitivity reaction, airway inflammation and mucin production. (utmb.edu)
- The fractional exhaled nitric oxide test is used to show airway inflammation. (forteco.pl)
- Often, this obstruction occurs when your inflammation and swelling narrow your airways. (healthline.com)
- Further, it has been reported that liraglutide attenuated bleomycin-induced pulmonary fibrosis and OVA-induced chronic airway inflammation. (justia.com)
Obstructive12
- The spectrum of sleep disordered breathing ranges from habitual snoring, to upper airway resistance syndrome, to obstructive sleep apnea, and to obstructive apnea/hypoventilation syndrome. (medscape.com)
- Chronic Obstructive Pulmonary Disease (COPD) Chronic obstructive pulmonary disease is persistent narrowing (blocking, or obstruction) of the airways occurring with emphysema, chronic obstructive bronchitis, or both disorders. (msdmanuals.com)
- Her research focused on brachycephalic obstructive airway syndrome (BOAS) has led to groundbreaking advancements in the objective assessment of airway function and the development of effective surgical strategies to improve the health and well-being of these unique canine companions. (fecava.org)
- Validation of exercise testing and laryngeal auscultation for grading brachycephalic obstructive airway syndrome in pugs, French bulldogs, and English bulldogs by using whole-body barometric plethysmography. (fecava.org)
- Objective effectiveness of and indications for laser-assisted turbinectomy in brachycephalic obstructive airway syndrome. (fecava.org)
- Conformational risk factors of brachycephalic obstructive airway syndrome (BOAS) in pugs, French bulldogs, and bulldogs. (fecava.org)
- Outcomes and prognostic factors of surgical treatments for brachycephalic obstructive airway syndrome in 3 breeds. (fecava.org)
- Comparison between computed tomographic characteristics of middle ear in nonbrachycephalic and brachycephalic dogs with obstructive airway syndrome. (fecava.org)
- COPD includes chronic bronchitis and chronic obstructive airways disease. (mse.nhs.uk)
- The aim of this study is to demonstrate the effectiveness of upper airway surgery in brachycephalic obstructive airway syndrome (BOAS) based on objective data using whole body barometric plethysmography (WBBP). (cam.ac.uk)
- Asthma is a condition that causes the airways to your lungs to become inflamed and swollen, making it difficult to breathe - and because it makes it more difficult for you to exhale, it's known as an obstructive lung disease. (healthline.com)
- An obstruction or blockage in your airways causes obstructive lung diseases. (healthline.com)
Resistance8
- Although these airways contribute little to airflow obstruction in normal airways, studies have revealed that distal airways accounted for up to 50-90% of total airflow resistance in asthmatics [ 1 ], implying that distal airways were the main site of airflow obstruction in asthmatics. (ersjournals.com)
- The Q-Box is the standalone body-box from COSMED for Gold Standard measurement of Static Lung Volumes (TLC, RV, TGV) and Airway Resistance and Conductance (RAW, GAW) through the body plethysmography technique. (cosmed.com)
- Background: Functional respiratory imaging (FRI) uses high-resolution computed tomography (HRCT) scans to assess changes in airway volume and resistance. (uantwerpen.be)
- The measurement of Static Lung Volumes (TLC, RV, ITGV) and Airway Resistance and Conductance (RAW, GAW) with the body plethysmography technique guarantees highly accurate results and has become a necessity for any high-level respiratory pathophysiology laboratory. (chsltd.com)
- Parameters for respiratory rate, minute volume, thoracic gas volume, expiratory/inspiratory time ratio, thoracic gas volume, inspiratory and expiratory flow, and expiratory airway resistance were not significantly different from the time 0 control reading. (lsu.edu)
- These interactions may be the cause of the increased level of bronchomotor tone and resulting increased airway resistance observed in horses after administration of 3MI. (lsu.edu)
- Warmed, humidified air minimizes airway constriction and the resultant increased airway resistance. (frontiersin.org)
- Despite this, the respiratory resistance devices available in the market only use mouthpieces (oral airway). (frontiersin.org)
Impulse oscillometry1
- Can impulse oscillometry and body plethysmography differentiate response to two salbutamol doses? (ers-education.org)
Obstruction11
- It was concluded that both proximal and distal airways were involved in asthma and that distal airways were the major determinant of airflow obstruction. (ersjournals.com)
- The study will, in particular, gain knowledge on predisposing factors for developing of airway obstruction in smokers. (ki.se)
- There are a number of other risk factors besides smoking for development of chronic airway obstruction. (ki.se)
- The study will explore one explanation to chronic airway obstruction not caused by tobacco smoke. (ki.se)
- Recently, it has become evident that chronic airway obstruction in never-smokers is more prevalent than previously known. (ki.se)
- In this national multicenter study we will identify factors associated with chronic airway obstruction in never-smokers and to determine the molecular mechanisms of this disease in order to find potential targets for intervention. (ki.se)
- In this group, we have identified persons with chronic airway obstruction who have never smoked. (ki.se)
- These results suggest that improvement of LCI after antibiotic treatment in this patient group can be explained by: less secretion and obstruction (better ventilation of conductive airways=lower Scond), better ventilated lung units (net increase of expired tracer gas=FRC MBW ) and less hyperinflation (lower RV). (bmj.com)
- 11. Harding R, Buttress JA, Caddy DJ, Wood GA. Respiratory and upper airway responses to nasal obstruction in awake lambs and ewes. (phypha.ir)
- Upper airway obstruction during sleep in normal subjects after selective topical oropharyngeal anesthesia. (phypha.ir)
- Therefore, finding alternative therapies should help alleviate obstruction in the upper airway and improve compliance. (frontiersin.org)
Lungs8
- Your airways are the parts of your body that carry air to your lungs, including your nose, throat, trachea (windpipe), and bronchial tubes that connect your windpipe to each lung. (medlineplus.gov)
- Often, the tests are repeated after a person takes a drug that opens the airways of the lungs (bronchodilator). (msdmanuals.com)
- The term "lung volume" usually refers to the volume of gas within the lungs, as measured by body plethysmography, gas dilution or washout. (ersjournals.com)
- As well as narrowed airways, patients suffer from hyperinflated lungs (pulmonary emphysema). (mediservice.ch)
- Lungs from the exposed groups were inflamed as indicated by recruitment of neutrophils in all three exposed groups and eosinophils and an increase in numbers of airway epithelial goblet cells in 5- and 20-day exposure groups. (biomedcentral.com)
- An analysis of health data from 218 officers revealed that the small airways in their lungs underwent structural changes after they were deployed, potentially increasing their risk for respiratory diseases in the future. (wildfiretoday.com)
- Sputum induction for microbiological analysis: Helps create extra moisture in the airways in the lungs so patients can cough up secretions more easily. (ucsd.edu)
- The inventors found that GLP-1R agonists inhibited IL-33 expression and release from the lungs of mice in response to an airway challenge the allergen extract of the aeroallergen Alternaria alternata , an aeroallergen which has protease activity and which is associated with severe asthma exacerbations. (justia.com)
Barometric1
- Evaluation of barometric whole-body plethysmography for therapy monitoring in cats with feline lower airway disease. (uni-muenchen.de)
Methacholine5
- Airway hyperreactivity following chemical exposure was evaluated by methacholine challenge using whole body plethysmography. (cdc.gov)
- Following dermal exposure 5 days a week for 28 days, 2 of 5 animals exposed to 25% AMT demonstrated elevated levels of total serum IgE and an increase in airway hyperreactivity upon methacholine challenge. (cdc.gov)
- After the exposure periods, airway hyper-responsiveness (AHR) to methacholine (Mch) was measured and rats were euthanized to collect bronchoalveolar lavage fluid (BALF), blood and lung tissues. (biomedcentral.com)
- Changes in IgE/IgG1 and mucin levels, airway eosinophilia and hyperreactivity to methacholine were determined by ELISA, differential cell counting and whole-body plethysmography, respectively. (utmb.edu)
- The methacholine challenge test is done by providing an irritant for the patient to breath in that causes a bronchospasm to show if the airway is hyperactive. (forteco.pl)
Hyperresponsiveness2
- Vitamin A supplement after neonatal S. pneumoniae pneumonia significantly promoted Foxp3 + Treg and Th1 productions, decreased Th2 and Th17 cells expressions, alleviated airway hyperresponsiveness (AHR) and inflammatory cells infiltration during AAD. (nature.com)
- On day 10, they received an intranasal dose of TDI (0.1%) mation, and nonspecific airway hyperresponsiveness in or vehicle. (cdc.gov)
Asthma9
- Asthma Asthma is a condition in which the airways narrow-usually reversibly-in response to certain stimuli. (msdmanuals.com)
- The present review is the summary of an expert workshop that took place in Vence (France) in 2007 on the role of distal airways in asthma. (ersjournals.com)
- Finally, the available data studying the benefit of treatment better targeting distal airways in asthma was examined. (ersjournals.com)
- Distal airways were poorly attained by conventional aerosol of asthma medications owing to their granulometry, being composed of 3-5 μm particles. (ersjournals.com)
- Thus, it is not surprising that the roles of distal airways in the natural history of asthma have long been neglected. (ersjournals.com)
- Chronic airways diseases, including asthma, COPD and cystic fibrosis, cause significant morbidity and mortality and are associated with high healthcare expenditure, in the UK and worldwide. (ox.ac.uk)
- Risk of severe asthma episodes predicted from fluctuation analysis of airway function. (phypha.ir)
- For instance, asthma attacks occur when your airways become inflamed and filled with mucus. (healthline.com)
- This obstructs your airways, making it difficult to breathe and leading to the symptoms of an asthma attack. (healthline.com)
Computed tomography1
- Endotracheal tube placement during computed tomography of brachycephalic dogs alters upper airway dimensional measurements. (fecava.org)
Induce2
- Four weeks after pneumonia, mice were sensitized and challenged with OVA to induce allergic airway disease (AAD). (nature.com)
- These studies indicate that DE498 does not induce sensitization following dermal exposure, however AMT was identified as a sensitizer and has the potential to induce airway hyperreactivity. (cdc.gov)
Dilution2
- These include the following: body plethysmography (using various methodologies), nitrogen washout, gas dilution, and radiographic imaging methods. (ersjournals.com)
- Determination of the residual volume can be done by radiographic planemetry, body plethysmography , closed circuit dilution and nitrogen washout. (wikidoc.org)
Residual volume1
- Improvement of LCI (Δ LCI before minus after treatment) and change of functional residual capacity from nitrogen multiple-breath washout (FRC MBW ) minus residual volume (RV) from body plethysmography after 19 antibiotic courses in children with cystic fibrosis. (bmj.com)
Brachycephalic dogs1
- Background: We are conducting a prospective study to objectively evaluate the respiratory function of brachycephalic dogs pre and post airway surgery. (cam.ac.uk)
Upper7
- [ 14 ] and upper airway function. (medscape.com)
- In addition, it improves upper airway mucociliary function, which augments the elimination of secretions. (frontiersin.org)
- Breathing route influences upper airway muscle activity in awake normal adults. (phypha.ir)
- Understanding the pattern of any respiratory dysfunction in PD is of importance in breathlessness, exercise limitation, upper airway dysfunction and impaired airway protection with consequent lower respiratory tract infections and pneumonia, acute and chronic respiratory failure, sleep disordered breathing, daytime somnolence, speech and swallowing. (mdsabstracts.org)
- The secondary aims were to evaluate the effects of the exercises on rehabilitation of neurological function, sleeping, and morphology change of upper airway. (frontiersin.org)
- It also included upper airway magnetic resonance imaging (MRI) measurements. (frontiersin.org)
- Recent studies have demonstrated that training the upper airway muscles can ameliorate moderate OSAS ( 14 , 15 ). (frontiersin.org)
Pulmonary function tests1
- The usefulness and limitations of various techniques used for assessing distal airways were also evaluated, including pulmonary function tests and imaging. (ersjournals.com)
Lower airways1
- The lower airways are permanently constricted (obstructed). (mediservice.ch)
Conductance2
Eosinophils1
- Synta 66 also repressed OVA induced airway cellular recruitment showing a reduction in neutrophils and eosinophils. (docsbay.net)
Function5
- Lung function tests also help check the health of your airways. (medlineplus.gov)
- This lung function test determines the FEV1 value (one-second capacity measurement of the lung, in which you exhale as quickly as possible), which indicates the extent to which the airways are narrowed. (mediservice.ch)
- This requires not only better understanding of airway pathophysiology but also an enhanced ability to make physiological measurements of disease activity and lung function and, if we are to impact on the natural history of these diseases, reliable measures in early disease. (ox.ac.uk)
- A study on the health of Royal Canadian Mounted Police (RCMP) officers who were deployed in Alberta, Canada in 2016 to the Horse River Fire at Fort McMurray found that their airway function was compromised in the first three months after deployment. (wildfiretoday.com)
- Small airways are potentially more vulnerable and there is no way that a spirometer (a device commonly used to measure lung function) can detect the progression of their damage over time," said Subhabrata Moitra, first author on the study and a post-doctoral fellow in the U of A's Division of Pulmonary Medicine. (wildfiretoday.com)
Assessment2
- Discover the future of metabolic testing with the ground-breaking Q-NRG Max, an innovative metabolic system designed by COSMED, a worldwide leader in the development of Research grade and Clinical devices for metabolic and body composition assessment. (cosmed.com)
- These emerging techniques have the potential to enhance existing measures in the assessment of airways diseases, may be particularly valuable in early disease, and should facilitate the efforts to deliver precision respiratory medicine. (ox.ac.uk)
Inspiratory1
- Static hyperinflation (inspiratory-to-total respiratory capacity ratio [IC/TLC], well-designed recurring capacity, as well as residual size) confirmed more robust links with cardiovascular chamber Severe malaria infection dimensions compared to airway obstructions as well as diffusion ability. (mdm2signals.com)
Allergic1
- Specific pathogen may play a critical role in the allergic airway diseases (AAD) pathogenesis by affecting the immune system 5 . (nature.com)
Helium1
- examinations, such as rapid chest compression, single breath occlusion, plethysmography and helium dilution6. (bvsalud.org)
Pharyngeal1
- The anatomic structural remodeling of the pharyngeal airway was measured using MRI, including the lager retropalatal distance ( P = 0.018) and shorter length of soft palate ( P = 0.044) compared with the baseline. (frontiersin.org)
Severe1
Measurements1
- The Q-Box is the new generation body-box from COSMED for Gold Standard thoracic gas volume measurements. (chsltd.com)
Epithelial1
- Subsequently, coordinated branching morphogenesis and vascular development result in a tree-like structure of epithelial tubules with differentiated airways and saccules. (biomedcentral.com)
Mouthpieces1
- Accurate measurement of pulmonary ventilation or breathing often requires the use of devices such as masks or mouthpieces coupled to the airway opening. (wikipedia.org)
Emphysema1
- In addition, patients with similar FEV 1 may show very different underlying pathologies, e.g. predominantly airspace disease ( i.e. emphysema) or disease of the airways, as manifested by increased airway wall thickness 8 . (ersjournals.com)
Inflammatory2
- Exhaled nitric oxide (eNO) has been suggested as a marker of airway inflammatory diseases. (biomedcentral.com)
- The best effect on large and small airways was achieved with combined anti-inflammatory therapy. (nih.gov)
Nasal1
- The nasal airway a common route for normal breathing. (phypha.ir)
Patients2
- Early use of continuous positive airway pressure (CPAP) appears to accelerate neurological recovery and delay cardiovascular events in patients with ischemic stroke ( 6 ). (frontiersin.org)
- Multiple imaging modalities have been used to study the airway passage and have demonstrated anatomical differences between patients with and without OSAS for physiologic dysfunction of muscles ( 10 , 11 ). (frontiersin.org)
Invasive1
- Respiratory and pulmonary functions were measured by whole-body and invasive plethysmography. (biomedcentral.com)
Opens1
- You may be given medicine to inhale (breath in) that opens your airways. (medlineplus.gov)
Efficacy1
- The efficacy of BOD POD has been confirmed by more than 2.000 peer reviewed research studies describing a wide range of subjects in both clinical and non-clinical environments. (cosmed.com)
Exercise3
- Forty subjects (19-65 years) underwent body plethysmography, ergometry, cardiopulmonary exercise test and a 4-h wearing period without a mask, with a surgical mask (SM), a community mask (CM), and an FFP2 respirator (FFP2). (researchgate.net)
- Aetna considers the FDA-cleared weight reduction device, Plenity (Gelesis, Inc.), as medically necessary to aid in weight management in overweight and obese adults with a Body Mass Index (BMI) of 25-40 kg/m 2 , when used in conjunction with diet and exercise. (aetna.com)
- This can help you and your physician understand why you become short of breath, how much exercise you can handle if you should oxygen when exercising, and how your body responds to physical activity. (ucsd.edu)
Methods1
Measures1
- Dual band respiratory inductance plethysmography can be used to describe various measures of complex respiratory patterns. (wikipedia.org)
Small2
- Studies of distal airways have proved difficult, owing to their small size and their peripheral location. (ersjournals.com)
- Sampling of biological material from the lung is performed by bronchoscopy where tissues and cells from the large and from the small airways are harvested. (ki.se)
Chest2
- Respiratory inductance plethysmography (RIP) is a method of evaluating pulmonary ventilation by measuring the movement of the chest and abdominal wall. (wikipedia.org)
- It was submitted for review and approval to the governing bodies of the American Thoracic Society, the European Respiratory Society, and the American College of Chest Physicians. (atsjournals.org)
Diseases1
- In this article, we outline some of the key challenges faced by the respiratory community in the management of airways diseases, including early diagnosis, disease stratification and monitoring of therapeutic response. (ox.ac.uk)
Treatments1
- In this context, the identification and targeting of 'treatable traits' is an important priority in airways disease, both to ensure the appropriate use of existing treatments and to facilitate the development of new disease-modifying therapy. (ox.ac.uk)
Ventilation2
- As an alternative RIP devices that sense respiratory excursions at the body surface can be used to measure pulmonary ventilation. (wikipedia.org)
- In multivariable regression analysis, change of FRC MBW -RV and ventilation homogeneity of conductive airways (Scond) explained 58% variability of delta LCI (R 2 , see online supplementary table S2). (bmj.com)