MesnexChemotherapyCyclophosphamideAmifostine and mesnaInfusionsSulfonateDoxorubicinIntravenousChemotherapeutic agentsCysteine2023DrugsMucolytic agentCytotoxic agentsNitrogen MustardReduce the incidenceToxicityInjectionDoseCompoundsMetabolitesProphylaxisPregnancyHemorrhagicCystitisGlutathioneMyelosuppressionPreparationsTumorPaclitaxelBiologic agentsAntineoplastic AgentUptakeAlkylatingCombinationSevereMechanismsTherapeutic agentsMedicineCancerAntioxidantAlterationsTreatment
Mesnex3
- Mesna, sold under the brand name Mesnex among others, is a medication used in those taking cyclophosphamide or ifosfamide to decrease the risk of bleeding from the bladder. (wikipedia.org)
- min w/ concurrent Mesna [Mesnex] therap + extensive hydration. (freezingblue.com)
- Patients sometimes also receive a medication called mesna (Mesnex) to avoid cystitis, a severe irritation of the bladder that can occur with cyclophosphamide therapy. (heartlandinfusion.com)
Chemotherapy9
- Mesna is used therapeutically to reduce the incidence of haemorrhagic cystitis and haematuria when a patient receives ifosfamide or cyclophosphamide for cancer chemotherapy. (wikipedia.org)
- Mesna reduces the toxicity of urotoxic compounds that may form after chemotherapy administration. (wikipedia.org)
- Mesna concentrates in the bladder where acrolein accumulates after administration of chemotherapy and through a Michael addition, forms a conjugate with acrolein and other urotoxic metabolites. (wikipedia.org)
- Systemic Chemotherapy plus Single-Agent Intrathecal Chemotherapy. (knowcancer.com)
- 4-Drug Combination Systemic Chemotherapy plus Single-Agent Intrathecal Chemotherapy. (knowcancer.com)
- IFEX is indicated for use in combination with certain other approved antineoplastic agents for third-line chemotherapy of germ cell testicular cancer. (guidelinecentral.com)
- continued to use CP either alone or in combination with other agents in cancer chemotherapy due to its efficacy. (researchwap.com)
- [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
- After chemotherapy is given, normal cells often would receive various degrees of damage from the cytotoxic agents. (vin.com)
Cyclophosphamide10
- The IV mesna infusions would be given with IV ifosfamide, while oral mesna would be given with oral cyclophosphamide. (wikipedia.org)
- Mesna is a water-soluble compound with antioxidant properties, and is given concomitantly with the chemotherapeutic agents cyclophosphamide and ifosfamide. (wikipedia.org)
- A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE. (rush.edu)
- Cyclophosphamide (CP) is one of the most potent and widely used alkylating anticancer agents. (researchwap.com)
- Cyclophosphamide, [2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxzaphosphorine-2- oxide] is one of the most effective and widely used cytotoxic antitumor agents. (researchwap.com)
- Cyclophosphamide is a antineoplastic , immunosuppressive agent that is FDA approved for the treatment of malignant diseases , minimal change nephrotic syndrome in pediatric patients. (wikidoc.org)
- Single agent: oral cyclophosphamide is usually administered at dosages in the range of 1 to 5 mg/kg/day for both initial and maintenance dosing. (wikidoc.org)
- Cytoxan (cyclophosphamide) is an alkylating agent, which inhibits DNA replication (NCI Drug Dictionary). (jax.org)
- Cyclophosphamide (Cytoxan) is a cytotoxic agent that suppresses both red and white blood cells in the bone marrow. (heartlandinfusion.com)
- An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. (lookformedical.com)
Amifostine and mesna1
- The Pediatric Oncology Group study for metastatic Ewing's sarcoma used amifostine and mesna with the alkylating agents. (uaeu.ac.ae)
Infusions2
- The oral preparation allows patients to leave the hospital sooner, instead of staying four to five days for all the IV mesna infusions. (wikipedia.org)
- WR-1065 and mesna appeared in the cells by the end of the drug infusions, although WR-1065 uptake was more efficient than mesna. (uaeu.ac.ae)
Sulfonate2
- Sodium -2-macarptoethane sulfonate (MESNA) was used as a positive control. (researchwap.com)
- Sodium-2-mecarptoethane sulfonate (MESNA), a sulfhydryl-containing agent has long been used in detoxifying and ameliorating specifically the urotoxic effects of CP and other oxazaphosphorines. (researchwap.com)
Doxorubicin1
- Neoadjuvant Interdigitated Chemoradiotherapy Using Mesna, Doxorubicin, and Ifosfamide for Large, High-grade, Soft Tissue Sarcomas of the Extremity: Improved Efficacy and Reduced Toxicity. (rush.edu)
Intravenous2
- The oral doses must be double the intravenous (IV) mesna dose due to bioavailability issues. (wikipedia.org)
- I the same agents may significantly improve recovery in hematologic disorders ~~i i definitions of disease progression while a skin rash or a nonstimulantheg, guanfacine, atomoxetine add an arb is not possible, however, to date, and day as needed for pain management should include administration o intravenous access should be tested and screened very closely. (easternpropane.com)
Chemotherapeutic agents2
- Most chemotherapeutic agents will unselectively cause damage to the rapidly growing/dividing cells such as cells in the bone marrow, the gastrointestinal epithelial cells and hair follicle cells, whereas cells with slower turnover (e.g., spinal cord, muscle and more) are generally very resistant to most chemotherapeutic drugs. (vin.com)
- A neutrophil nadir in dogs is most commonly seen 5-10 days (14 days for carboplatin) after the administration of most chemotherapeutic agents. (vin.com)
Cysteine2
- Mesna also increases urinary excretion of cysteine. (wikipedia.org)
- Both agents increased blood cysteine and decreased total reducible cysteine. (uaeu.ac.ae)
20231
- 2023. https://www.drugguide.com/ddo/view/Davis-Drug-Guide/51480/all/mesna. (drugguide.com)
Drugs1
- Over the next five years, Dr. Chawla's medical research will continue its focus on development of cancer gene therapy, vaccines, immunotherapies (treatments that use the body's own defenses to combat cancer) and anti-angiogenic agents (drugs to block development of blood vessels and starve the tumor) to treat soft-tissue sarcomas. (sarcomaoncology.com)
Mucolytic agent1
- Mesna used as a mucolytic agent (e.g. administered by a nebuliser) is classified here. (whocc.no)
Cytotoxic agents1
- Many alkylating cytotoxic agents, which cyclophoshpamide (CP) is a member, have been well documented to be effective in management of many human malignancies in order to improve quality of life and extend patients life span (Philip et al. (researchwap.com)
Nitrogen Mustard1
- What drug is the safest nitrogen mustard (alk agent)? (freezingblue.com)
Reduce the incidence1
- Mesna should be used to reduce the incidence of hemorrhagic cystitis. (guidelinecentral.com)
Toxicity2
- These agents also form covalent cross-links in DNA, more typically at the 0-6 position of guanine as the most important DNA adduct site, and have the primary adverse effects of myelosuppression and GI toxicity. (vin.com)
- Mesna in i.v. formulations used for the prophylaxis of urothelial toxicity is classified in V03AF. (whocc.no)
Injection1
- Many therapeutic agents cannot be delivered effectively to treat cancerous cells by conventional means such as ingestion, injection, inhalation, and topical application because many of these agents are subject to rapid degradation. (justia.com)
Dose4
- What is it, and how dose it vary among these agents? (freezingblue.com)
- Give a dose of mesna equal to 20% of the ifosfamide dose at the same time as ifosfamide and 4 and 8 hr after. (drugguide.com)
- then give PO mesna equal to 40% of the ifosfamide dose 2 and 6 hr after ifosfamide (total mesna dose is 100% of ifosfamide dose). (drugguide.com)
- If PO mesna is vomited within 2 hr of administration, repeat dose or use IV mesna. (drugguide.com)
Compounds1
- Mesna assists to detoxify these metabolites by reaction of its sulfhydryl group with α,β-unsaturated carbonyl containing compounds such as acrolein. (wikipedia.org)
Metabolites2
- These two anticancer agents, in vivo, may be converted to urotoxic metabolites, such as acrolein. (wikipedia.org)
- Rapidly converted to mesna disulfide, then back to mesna in the kidneys, where it binds to toxic metabolites of ifosfamide (18-26% excreted as free mesna in urine after IV and PO dosing). (drugguide.com)
Prophylaxis1
- It should be used in combination with mesna for prophylaxis of hemorrhagic cystitis. (guidelinecentral.com)
Pregnancy1
- Obtain a negative pregnancy test before starting when mesna is given with ifosfamide. (drugguide.com)
Hemorrhagic2
- Hemorrhagic cystitis can be severe and can be reduced by the prophylactic use of mesna. (guidelinecentral.com)
- Mesna is used to reduce the risk of hemorrhagic cystitis (a condition that causes inflammation of the bladder and can result in serious bleeding) in people who receive ifosfamide (a medication used for the treatment of cancer). (pharmika.co.in)
Cystitis1
- The antiviral agents acyclovir and valacyclovir are administered for the treatment of cystitis caused by herpes simplex virus-1 (HSV-1) or HSV-2. (medscape.com)
Glutathione2
- WR-1065 and mesna prevented glutathione depletion by 4-hydroperoxycyclophosphamide. (uaeu.ac.ae)
- Mesna alone and mesna plus amifostine prevented cellular glutathione depletion. (uaeu.ac.ae)
Myelosuppression1
- There are 3 agents that cause very little myelosuppression, making them good candidates for combo therapy. (freezingblue.com)
Preparations2
- Cold preparations with therapeutic levels of analgesics/anti-inflammatory agents should be classified in the respective N02/M01 groups. (whocc.no)
- The invention also provides nanosphere particle preparations that are useful for selectively delivering therapeutic, diagnostic, and/or other agents to cancer cells of subjects without eliciting a serotype-specific immunogenic response in the subjects. (justia.com)
Tumor1
- Hormone therapy can work by stopping the production of a certain hormone, blocking hormone receptors, or substituting chemically similar agents for the active hormone, which cannot be used by the tumor cell. (chemocare.com)
Paclitaxel1
- The use of the newer agents in the taxane class (paclitaxel and docetaxel) is being explored in veterinary medicine as these agents are highly effective in human medicine. (vin.com)
Biologic agents1
- Rituximab (Rituxan) and biosimilar rituximab-abbs (Truxima) are biologic agents that deplete B cells (cells that produce antibodies) by binding to CD20+, a protein on the surface of certain B cells. (heartlandinfusion.com)
Antineoplastic Agent1
- An antimetabolite antineoplastic agent with immunosuppressant properties. (lookformedical.com)
Uptake1
- Incubation of a volunteer's blood with mesna, WR-1065, or both revealed that cellular uptake of total reducible drug was ∼10% of plasma level for mesna but ∼60% for WR-1065. (uaeu.ac.ae)
Alkylating2
- and the non-classical alkylating agents such as procarbazine and hexamethylmelamine. (vin.com)
- Adequate dosing of either drug is necessary for protecting the cells from toxic effects of alkylating agents. (uaeu.ac.ae)
Combination1
- Pyrazinamide is used only in combination with other effective antituberculous agents. (medscape.com)
Severe1
Mechanisms1
- Agents that suppress immune function by one of several mechanisms of action. (lookformedical.com)
Therapeutic agents1
- Talati C, Pinilla-Ibarz J. Resistance in chronic myeloid leukemia: definitions and novel therapeutic agents. (celljournal.org)
Medicine2
- The newest agent in this class to be used in veterinary medicine is the fluorinated cytidine analog gemcitabine. (vin.com)
- Anti Neoplastic Agents Sub Medicine. (medicscientist.com)
Cancer3
- For example, those agents that target actively dividing cells are not able to discriminate between actively dividing cancer cells and actively dividing healthy cells. (justia.com)
- METHODS: In this retrospective analysis, we compared the time to treatment failure (TTF) for molecular-targeted agents as first-line therapy, or nivolumab therapy as sequential therapy between ccRCC and nccRCC using the data of Japanese metastatic RCC patients registered in the Michinoku Japan Urological Cancer Study Group database. (bvsalud.org)
- Sorafenib is an antineoplastic (cancer) agent. (pharmika.co.in)
Antioxidant1
- These results provide opportunities to develop Cr-SPs as natural antioxidant and antibacterial agents. (brjnmims.org)
Alterations1
- Coadministration with isoniazid or pyrazinamide may result in a higher rate of hepatotoxicity than with either agent alone (discontinue 1 or both agents if alterations in liver function test results occur). (medscape.com)
Treatment4
- We also conducted analogous measurements on two patients who received mesna alone and a volunteer's blood following in vitro treatment. (uaeu.ac.ae)
- Our research showed that AMP-WF3 could be developed as a novel treatment agent with minimum side effects for ALL patients. (celljournal.org)
- Side effects of treatment included amenorrhea (3 patients), microscopic hematuria (3) which cleared with co-administration of mesna, vomiting (1), weight gain (10), gastritis (1), and cataract (2). (cdlib.org)
- Belimumab (Benlysta) is the first biologic agent specifically for the treatment of lupus. (heartlandinfusion.com)