Adrenergic alpha antagonists. Medical search. Frequent questions

Naloxone is a potent antagonist at the mu opioid receptors and produces opioid withdrawal signs and symptoms in individuals physically dependent on full opioid agonists when administered parenterally. (medscape.com)
Another source names recurring urinary retention, recurring urinary infections, uncontrolled macrohematuria, bladder stones, hydronephrosis, combination with other α1-antagonists or dopamine agonists, and severe renal or hepatic impairment as contraindications. (wikipedia.org)
Centrally-acting sympatholytic agent/agents (alpha2 adrenergic receptor agonists). (pharmacology2000.com)
It is unclear whether this is caused by structural changes in the arterial wall or by hyperresponsiveness of vascular smooth muscle to endogenous alpha adrenergic agonists. (ox.ac.uk)
This indicates that small doses of prazosin (1-2 mg) cause significant in vivo shifts in the dose-response relationship of alpha adrenergic agonists. (ox.ac.uk)
Now a team of investigators [ 1 ] from the University of Adelaide, Australia, has undertaken a systematic review of 27 studies involving 3048 participants to assess the effects of buprenorphine versus tapered doses of methadone , alpha-2-adrenergic agonists, symptomatic medications or placebo, or different buprenorphine regimens for managing opioid withdrawal. (medscape.com)

In previous studies we investigated the role of beta- and alpha 2-adrenergic receptors through local microinjections of various drugs into the dorsal pontine tegmentum (DPT) of the cat. (nih.gov)
In this study we examined the role of alpha 1-adrenergic receptors. (nih.gov)
The H2 antagonists are highly selective, do not affect the H1 receptors, and are not anticholinergic agents. (medscape.com)
Looking at pharmacologic and pathophysiologic principles, two paths are responsible for IFIS: (1) The direct effect of alpha-blockers on iris receptors reduces the power of dilating agents and (2) ultrastructural changes lead to irreversible functional loss in the smooth muscle tissue of the iris and to chronic loss of muscular tension, with or without the presence of dilating drugs. (crstodayeurope.com)
In the human prostate, tamsulosin hydrochloride, a selective alpha 1A-adrenoceptor blocking drug, shows selectivity for alpha 1A-receptors. (yashodahospitals.com)
Nanoparticle inhalation modulates arteriolar sympathetic constriction: role of nitric oxide, prostanoids, and alpha-adrenergic receptors. (cdc.gov)
These results show no evidence for a generalized change in alpha adrenergic responsiveness in hypertension and support the concept that increased blood pressure responses to alpha adrenergic stimulation in hypertensives are due to structural and geometric changes in the arterial wall rather than to an increased responsiveness of postsynaptic alpha adrenergic receptors. (ox.ac.uk)
The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. (citizendium.org)
Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. (citizendium.org)

These data indicate that low doses of the alpha-2 receptor antagonist piperoxane and rauwolscine act centrally to increase SND. (erowid.org)
It acts as an alpha-1 adrenergic receptor antagonist. (wikipedia.org)
Alpha-receptor antagonist medications potentially interfere with iris muscle dilation, resulting in difficult lens removal and possibly increasing complications. (urotoday.com)
RAPAFLO, an alpha-1 adrenergic receptor antagonist, is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH). (globalrph.com)
A serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively. (drugbank.com)
A 5HT-3 receptor antagonist used as an antiemetic in the treatment of chemotherapy-induced nausea and vomiting. (drugbank.com)

RAPAFLO is the brand name for silodosin, a selective antagonist of alpha-1 adrenoreceptors. (globalrph.com)
Silodosin is a selective antagonist of post-synaptic alpha-1 adrenoreceptors, which are located in the human prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra. (globalrph.com)
One week later, animals were spinally pretreated with receptor antagonists selective for opioid, serotonin or alpha-adrenoceptors, and the ability of these agents to alter spinal morphine-induced antinociception was assessed. (omeka.net)
A non selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients. (drugbank.com)

The alpha 1-agonist methoxamine and the alpha 1-antagonist prazosin were injected into the DPT of freely moving, unanaesthetized cats. (nih.gov)
Effects of 10 mg/kg 4-CMC alone or in combination with the alpha-adrenergic antagonist prazosin (Praz, 0.3 mg/kg, n = 5), the dopamine D1 antagonist SCH23390 [SCH, 0.1 mg/kg, n = 5 (except for SCH + 4CMC, n = 4)] and the ganglionic blocker chlorisondamine (chloro 1.0 mg/kg, n = 5) on BP, HR, and activity. (aspetjournals.org)
Alpha adrenergic blockade during prazosin therapy. (ox.ac.uk)
The phenylephrine studies were repeated in seven hypertensive patients during treatment with prazosin, an alpha 1 adrenergic antagonist. (ox.ac.uk)

Blockade of these alpha-1 adrenoreceptors can cause smooth muscle in these tissues to relax, resulting in an improvement in urine flow and a reduction in BPH symptoms. (globalrph.com)
The enhanced sensitivity to alpha-adrenergic receptor blockade following TiO2 exposure suggests an augmented responsiveness to tonic sympathetic activity. (cdc.gov)

Nonsteroidal anti-inflammatory drugs (NSAIDs) and alpha blockers help with symptom relief. (medscape.com)
Alpha blockers may also help to decrease recurrences, by diminishing urinary obstruction. (medscape.com)
Researchers tested the capacity of adrenergic antagonists, drugs such as alpha and beta blockers, to disrupt the receptor's sensing ability. (sciencedaily.com)
The "intra-operative floppy iris syndrome" cataract surgery complication has been reported in men using alpha-blockers. (urotoday.com)
The risk of complicated cataract surgery was 14.9% in patients using alpha-blockers, approximately 50% higher than those not receiving this medication (9.5%) (p=0.003). (urotoday.com)
Four drug classes were evaluated in the trials: thiazides (21 trials), beta-adrenergic blockers (5), calcium-channel blockers (4) and angiotensin-converting-enzyme (ACE) inhibitors (1). (cmaj.ca)
RAPAFLO should not be used in combination with other alpha-blockers. (globalrph.com)
Alpha-blockers: Interactions involving concomitant use have not been determined. (globalrph.com)
Concomitant use of PDE5 inhibitors with alpha-blockers including Rapaflo can potentially cause symptomatic hypotension. (globalrph.com)
The cause of IFIS has been identified as the intake of systemic alpha-adrenoceptor antagonists (alpha-blockers), drugs prescribed in men for lower urinary tract syndromes such as benign prostatic hyperplasia. (crstodayeurope.com)
Include alpha-blockers in preoperative medical history. (crstodayeurope.com)
When general practitioners (GPs) conduct preoperative work-ups in patients taking alpha-blockers, in most cases their interest focuses on cardiovascular risks and patients' use of anticoagulants, as the connection between the intake of alpha-blockers and intraoperative cataract surgery complications is largely unknown to primary-care physicians. (crstodayeurope.com)
Although atropine is no longer in common use in ophthalmology because of its long duration of action, some surgeons prescribe topical use of this cycloplegic agent for 2 to 3 days prior to surgery for patients with known intake of alpha-blockers. (crstodayeurope.com)

The mechanism of its therapeutic actions is not clear, but it can act as an alpha-adrenergic antagonist and a dopamine agonist. (umassmed.edu)

Using the dorsal hand vein compliance technique we compared the changes in diameter of superficial veins in response to phenylephrine, an alpha 1 adrenergic receptor agonist, and to nitroglycerin, a venorelaxant, in patients with essential hypertension and in normotensive subjects. (ox.ac.uk)
The dorsal hand vein compliance technique is useful in detecting systemic effects of alpha adrenergic antagonists. (ox.ac.uk)
Modulation of vestibulospinal reflexes through microinjection of an alpha 1-adrenergic antagonist in the dorsal pontine tegmentum of decerebrate cats. (architalbiol.org)

Caution is advised when alpha-adrenergic-antagonist-containing products, including JALYN®, are coadministered with PDE-5 inhibitors. (jalyn.com)
Alpha-adrenergic antagonists and PDE-5 inhibitors are both vasodilators that can lower blood pressure. (jalyn.com)

In a study made available online this week and in an upcoming issue of the Proceedings of the National Academy of Sciences, researchers describe how they used phentolamine, an alpha blocker drug used to treat hypertension, to successfully impede signaling to the receptor. (sciencedaily.com)
Phentolamine, an alpha-adrenergic antagonist (1 microM), reduced sympathetic constriction in controls, but abolished this response in TiO2 exposed rats (max % change -22.3+/-3.1 control, -9.7+/-2.9 TiO2). (cdc.gov)

An in vitro study examining binding affinity of silodosin to the three subtypes of the alpha-1 adrenoreceptors (alpha-1A, alpha-1B, and alpha-1D) was conducted. (globalrph.com)

In vitro binding experiments indicated that piperoxane and rauwolscine bound selectively to the alpha-2 adrenergic receptor and had little affinity for alpha-1 receptor sites. (erowid.org)
Silodosin has high affinity for the α1A adrenergic receptor in the prostate, the bladder, and the prostatic urethra. (wikipedia.org)
The results of the study demonstrated that silodosin binds with high affinity to the alpha-1A subtype. (globalrph.com)

These agents stimulate alpha-adrenoreceptors in brain stem, activating an inhibitory neuron, which in turn results in reduced sympathetic outflow. (medscape.com)

Alpha-blocker medications are the first line of therapy for men with these urinary symptoms. (urotoday.com)
Urimax is an antagonist prescribed for treating prostatic hyperplasia (benign) as it helps relieve symptoms, such as urinary incontinence. (yashodahospitals.com)

The effect of alpha-2 adrenergic receptor antagonists on sympathetic nerve discharge (SND) recorded from the external carotid and splanchnic nerves were studied in baroreceptor-denervated cats.Low i.v. doses of piperoxane end rauwolscine dramatically increased SND and produced a concomitant rise in mean arterial pressure and heart rate. (erowid.org)

citation needed] Alpha-1 adrenergic receptor antagonists are being investigated as a means to male birth control due to their ability to inhibit ejaculation but not orgasm. (wikipedia.org)
Alternatively, one can admit that CEC is able to inhibit alpha-2 autoreceptors, which causes an increase of the transmitter release, and to activate a nonadrenergic inhibitory receptor thus causing a reduction of the transmitter release. (unesp.br)

No, Urimax is an alpha-adrenergic antagonist used to treat benign prostatic hyperplasia. (yashodahospitals.com)
Fual extended-release tablet, USP is an alpha adrenergic antagonist, indicated for the treatment of signs and symptoms of benign prostatic hyperplasia. (sdrugs.com)

Tamsulosin-containing products, including JALYN®, should not be coadministered with other alpha-adrenergic antagonists because of the increased risk of symptomatic hypotension. (jalyn.com)

Preliminary reports suggest improved executive function in patients with lobar dementia after treatment with single doses of the alpha 2 adrenoceptor antagonist, idazoxan. (ox.ac.uk)

Intra operative floppy iris syndrome occurs in some people taking alpha adrenoreceptor antagonists and may lead to complications during cataract surgery. (wikipedia.org)

To assess the frequency of cataract surgery complications arising from alpha-blocker therapy in a large patient population. (urotoday.com)
The purpose of this study was to assess the impact of alpha-blocker therapy on complications during cataract surgery in a large patient population. (urotoday.com)
This lack of information among GPs has been identified as the most salient risk factor for complications related to alpha-blocker intake, and, as a result, the number of published studies in urology, general, and family medicine journals describing IFIS outside the ophthalmic community has increased in recent years. (crstodayeurope.com)

If possible, alpha blocker medications should be discontinued prior to eye surgery in older patients. (urotoday.com)
As alpha-blocker medications are the first line of therapy for men with LUTS, these reports of IFIS led the Food and Drug Administration, American Urological Association, American Academy of Ophthalmology, and American Society of Cataract and Refractive Surgery to issue statements alerting physicians and patients to potential difficulties during cataract surgery in patients using alpha-1 blocker therapy [7,8,9]. (urotoday.com)

The direction of the effect of any dose of agonist or antagonist may depend critically upon the age and pathology of the experimental subjects and the relationship between performance, noradrenergic drive and task difficulty. (ox.ac.uk)

Buprenorphine is a semisynthetic narcotic mixed agonist-antagonist analgesic. (medscape.com)

Injections of a beta-adrenergic antagonist in pontine reticular structures modify the gain of vestibulospinal reflexes in decerebrate cats. (architalbiol.org)
Injections of beta-adrenergic substances in the locus coeruleus affect the gain of vestibulospinal reflexes in decerebrate cats. (architalbiol.org)

These side effects are similar to those of other α1 antagonists. (wikipedia.org)

This knowledge opens the door to further understanding of the signaling processes between microbes and humans and to the development of novel treatments of bacterial infections with antagonists to these signals, Dr. Sperandio said. (sciencedaily.com)

These results highlight the urgent need for prospective trials testing whether prophylactic use of α1-AR antagonists ameliorates diseases associated with cytokine storm syndrome, such as COVID-19. (stanford.edu)

The FDA considers the risk for IFIS to be a class effect for alpha-1 adrenergic receptor antagonists [8,9]. (urotoday.com)

Silodosin, is an alpha-adrenoreceptor antagonist. (wikipedia.org)

As with other alpha-adrenergic antagonists, orthostatic hypotension (postural hypotension, dizziness, and vertigo) may occur in patients treated with tamsulosin-containing products, including JALYN®, and can result in syncope. (jalyn.com)

although combination with other α1-antagonists is not well studied. (wikipedia.org)

We previously demonstrated that alpha-1 adrenergic receptor (α1-AR) antagonists can prevent cytokine storm syndrome in mice. (stanford.edu)

Federated across two ARD cohorts, our main result shows that patients using α1-AR antagonists, as compared to nonusers, had a 40% relative risk reduction for ventilation and dying (p=0.014). (stanford.edu)

Organisms1

Diseases1

Chemicals and Drugs28

Phenomena and Processes1

Agonists6

Receptors9

Receptor antagonist6

Selective4

Prazosin4

Blockade2

Blockers13

Dopamine1

Dorsal3

Inhibitors2

Phentolamine2

Subtypes1

Affinity3

Adrenoreceptors1

Urinary2

Sympathetic1

Inhibit2

Benign2

Symptomatic hypotension1

Doses1

Iris1

Complications3

Medications2

Dose1

Buprenorphine1

Beta2

Effects1

Humans1

Trials1

IFIS1

Silodosin1

Tamsulosin1

Combination1

Syndrome1

Reduction1