• Given these results, the authors discuss the difficulty in diagnosing differentiation from a primary or metastatic neoplasm of the scalp, with the resources currently available, until the conclusion that it was a primary carcinoma of the sweat gland. (bvsalud.org)
  • Rarely, other malignancies such as sebaceous carcinoma, microcystic adnexal carcinoma, and melanoma may complicate NS. (aad.org)
  • In contrast to squamous cell carcinoma and basal cell carcinoma, molecular changes in adnexal neoplasia have been poorly characterized, and there are few published reviews on the current state of knowledge. (ejmjih.com)
  • A rare adnexal carcinoma that is histopathologically identical to homologous lesions in the salivary gland and breast. (nih.gov)
  • Secretory Carcinoma of the Eyelid Arising in an Adnexal Gland. (nih.gov)
  • Differential diagnosis initially included basosquamous carcinoma, acanthoytic squamous cell carcinoma, and adnexal tumor. (cdlib.org)
  • Primary mucinous carcinoma (PMC) of the skin is a rare malignant neoplasm deriving from sweat glands [ 1 ]. (cdlib.org)
  • Syringomatous carcinoma (SC) is a rare, slow-growing, heterogenous tumor of sweat gland origin. (appliedradiationoncology.com)
  • 3 Histologically, the absence of keratinizing cysts and squamous differentiation (ie, islands with parakeratotic keratinization) distinguish SC from other sclerosing adnexal tumors such as microcystic adnexal carcinoma (MAC) and squamoid eccrine ductal carcinoma (SEDC), respectively. (appliedradiationoncology.com)
  • Even though immunohistochemical comparisons of microcystic adnexal carcinoma vs infiltrative basal cell carcinoma and desmoplastic trichoepithelioma exist, they are mostly restricted to the use of a single stain. (dadospdf.com)
  • We found that the majority of microcystic adnexal carcinoma (92%) and desmoplastic trichoepithelioma (100%) cases expressed CK15 while the infiltrative basal cell carcinoma and squamous cell carcinoma cases were all negative. (dadospdf.com)
  • while only two microcystic adnexal carcinoma cases (15%) and one squamous cell carcinoma with ductal differentiation (12%) expressed CK7 in the remaining three tumor categories. (dadospdf.com)
  • While the neoplastic cells were negative, luminal staining of ductal structures was noted for CK7, CD15 and CEA in some of the microcystic adnexal carcinoma, desmoplastic trichoepithelioma and squamous cell carcinoma with ductal differentiation cases. (dadospdf.com)
  • Sixty percent of infiltrative basal cell carcinoma, 31% of microcystic adnexal carcinoma, and 25% of squamous cell carcinoma express CD10. (dadospdf.com)
  • BerEP4 expression was noted in 38% of microcystic adnexal carcinoma, 57% of desmoplastic trichoepithelioma, 100% of infiltrative basal cell carcinoma, and 38% of squamous cell carcinoma. (dadospdf.com)
  • In conclusion, we found CK15 to be a useful marker in distinguishing microcystic adnexal carcinoma from infiltrative basal cell carcinoma and squamous cell carcinoma with ductal differentiation. (dadospdf.com)
  • First reported in 1982 by Goldstein et al,1 microcystic adnexal carcinoma has been referred to by a variety of names-all of which allude to the clinical behavior and histopathologic features of this lesion. (dadospdf.com)
  • published online 7 December 2007 histopathologic perspective, the main differential diagnosis for microcystic adnexal carcinoma, a stratified, infiltrating neoplasm characterized by a superficial component of keratinous cysts and a deeper component of smaller nests and strands of cells embedded in a markedly hyalinized stroma, is sclerosing/infiltrative basal cell carcinoma and desmoplastic trichoepithelioma. (dadospdf.com)
  • In addition, we noticed misdiagnosis of a few cases of microcystic adnexal carcinoma as squamous cell carcinoma at our institution-most likely a consequence of the biopsy technique (superficial shave). (dadospdf.com)
  • The differentiation of microcystic adnexal carcinoma from any of these other entities is not merely semantic but extremely relevant to clinical management. (dadospdf.com)
  • Microcystic adnexal carcinoma MP Hoang et al 179 believed to account for its high recurrence rate. (dadospdf.com)
  • While local recurrence is reported in 50% of cases of microcystic adnexal carcinoma with positive margins, 40-60% of patients experience one or more local recurrences anywhere from 6 months to 30 years after standard wide local excision.4,6,7,9-11 Thus, while the standard of care for microcystic adnexal carcinoma is wide local excision, no further management is mandated for a desmoplastic trichoepithelioma. (dadospdf.com)
  • We report 23 cases of tumors of the salivary gland comprising 18 cases of carcinoma ex pleomorphic adenoma, four cases of carcinosarcoma of the parotid and one case of benign metastasizing pleomorphic adenoma. (ijpmonline.org)
  • Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms . (lookformedical.com)
  • It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (lookformedical.com)
  • Intraepidermal Eccrine Adenocarcinomas (IEA) are rare malignant tumors derived from the eccrine sweat glands of the skin. (faoj.org)
  • Secondary neoplasms - mostly benign and occasionally malignant - can develop within NS, usually in adulthood. (aad.org)
  • Malignant Sweat Gland Tumors. (nih.gov)
  • Hidradenoma refers to a benign adnexal tumor of the apical sweat gland. (wikipedia.org)
  • Folliculoma, also known as trichofolliculoma , is a type of benign cutaneous adnexal tumor. (medscape.com)
  • Trichofolliculomas represent a hamartomatous, adnexal tumor originating from the hair follicle. (medscape.com)
  • 1 First described in 1956, poroma was originally identified as a tumor originating from the eccrine sweat gland. (clinicaladvisor.com)
  • Acrospiroma is a cutaneous ailment that appears mainly in women and is a kind of benign adnexal neoplasm linked to poromo, a benign skin tumor. (wordinfo.info)
  • Adnexal tumors often present as solitary sporadic lesions, but can herald the presence of an inherited tumor syndrome such as Muir-Torre Syndrome, Cowden Syndrome, or CYLD Cutaneous Syndrome. (ejmjih.com)
  • Ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms are gynecologic malignancies for which tumor markers are in clinical use. (medscape.com)
  • Alsaad KO, Obaidat NA, Ghazarian D. Skin adnexal neoplasms--part 1: an approach to tumours of the pilosebaceous unit. (medscape.com)
  • Malignancy arising in mixed tumors of the salivary gland is a distinct entity that can occur sporadically or in association with a background of pleomorphic adenoma. (ijpmonline.org)
  • Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. (lookformedical.com)
  • Hidradenomas are often sub-classified based on subtle histologic differences, for example: Eccrine acrospiroma Clear-cell hidradenoma or acrospiroma Nodular hidradenoma or acrospiroma Solid-cystic hidradenoma Discussion of sweat gland tumors can be difficult and confusing due to the complex classification and redundant terminology used to describe the same tumors. (wikipedia.org)
  • There has also been a change in understanding about how tumors that were previously believed to strictly derive from specific sweat gland types may, in fact, derive from both eccrine or apocrine glands. (wikipedia.org)
  • 2 With time, it became evident that poromas of an eccrine lineage also exist, but the historic view of poromas as neoplasms of eccrine lineage has persisted such that many poromas are assumed to be eccrine poromas. (clinicaladvisor.com)
  • Spiroma List of cutaneous conditions List of cutaneous neoplasms associated with systemic syndromes Laws RA, English JC, Elston DM (November 1996). (wikipedia.org)
  • In summary, molecular alterations in cutaneous neoplasms of the head and neck are often related to UV exposure. (ejmjih.com)
  • Poroma is a benign adnexal neoplasm of the intraepidermal portion of the sweat gland duct, called the acrosyringium . (clinicaladvisor.com)
  • Ameloblastoma is a benign epithelial odontogenic neoplasm which is common amongst the Yoruba ethinc group. (bvsalud.org)
  • With the emergence of many immunomarkers, immunohistochemistry has become a vital ancillary diagnostic tool in dermatopathology and an essential adjunct for the correct identification of skin neoplasms. (edu.au)
  • The complexity of some skin neoplasms makes it imperative that the role of immunohistochemistry in subtyping these conditions is clearly understood. (edu.au)
  • Background: Adnexal skin tumors share many features in common and differentiate along one line. (bvsalud.org)
  • were the first to describe tumors exhibiting features of the epidermal sweat duct. (faoj.org)
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
  • Overproduction of prolactin by the pituitary gland can cause galactorrhea (excessive or abnormal lactation) and amenorrhea (absence of menstruation). (rnpedia.com)
  • Additional benign neoplasms such as trichoepithelioma (8), tubular apocrine adenomas (9), sebaceomas (1), and others have been reported within NS. (aad.org)
  • For example, acrospiroma and hidradenoma are synonymous, and sometimes the term acrospiroma is used to generally describe benign sweat gland tumors. (wikipedia.org)
  • Diffuse gliomas in adults encompass a heterogenous group of central nervous system neoplasms. (cn1699.cn)
  • The incidence of secondary neoplasms was statistically related to age and anatomic site (P (aad.org)
  • It has a non-debatable contribution to the diagnosis of hematolymphoid neoplasm as well as in minimal residual disease. (ijpmonline.org)
  • Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. (lookformedical.com)
  • Paediatric cutaneous adnexal tumours: a study of 559 cases. (medscape.com)
  • The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. (lookformedical.com)
  • Endometrioid neoplasms with clear cells: a report of 21 cases in which the alteration is not of typical secretory type. (nih.gov)
  • The authors concluded: "Our study confirms that most of the secondary neoplasms arising in association with nevus sebaceus are benign. (aad.org)
  • The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause. (lookformedical.com)
  • An area of ongoing controversy revolves around the risk of secondary neoplasms within a NS. (aad.org)
  • Development of a closely related neoplasm, MAC, however, has been linked to patients who previously received radiation treatment. (appliedradiationoncology.com)
  • Sweat Gland Tumors Arising on Acral Sites: A Molecular Survey. (nih.gov)