AnatomyChemicals and DrugsPhenomena and ProcessesInformation Science
Adenine Nucleotide Translocator 1Mitochondrial ADP, ATP TranslocasesAdenine Nucleotide Translocator 2AtractylosideBongkrekic AcidAdenine NucleotidesAdenine Nucleotide Translocator 3Oxidative PhosphorylationMitochondriaMitochondria, LiverNucleotidyltransferasesIntracellular MembranesAdenosine DiphosphateAdenosine TriphosphateVoltage-Dependent Anion ChannelsMitochondrial Membrane Transport ProteinsMitochondrial SwellingMitochondria, HeartAdenineOxygen ConsumptionCyclophilinsMembrane Potential, MitochondrialUncoupling AgentsCell RespirationPermeabilityAryl Hydrocarbon Receptor Nuclear TranslocatorProto-Oncogene Proteins c-bcl-2Mitochondrial ProteinsNucleotidesMolecular Sequence DataApoptosisMembrane PotentialsKineticsDNA, MitochondrialAdenosine MonophosphateMyocardiumReceptors, GABAReceptors, Aryl HydrocarbonEnergy MetabolismPurine NucleotidesAmino Acid SequenceGuanine NucleotidesAdenosineBase SequenceHypoxanthines
MitochondrialTranslocaseProteinMitochondriaFragmentMutationsCytochrome2023ProteinsSubunitGenesReceptorEnzymeFunction2020AntibodiesFSHDPyruvateIncludeRangeFreeHumanContentIsoformMtDNAMitochondrial membrane potentialMediatesTransporterElectron2018Kinase202220022021SequenceFunctionTypeInterproscanLamininTranscriptionRespiratorySpecificDysfunctionActivityInhibitorRatioCases
Mitochondrial13
  • Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or mitochondrial ADP/ATP carrier, exchanges free ATP with free ADP across the inner mitochondrial membrane. (wikipedia.org)
  • Transport is fully reversible, and its directionality is governed by the concentrations of its substrates (ADP and ATP inside and outside mitochondria), the chelators of the adenine nucleotides, and the mitochondrial membrane potential. (wikipedia.org)
  • The relationship of these parameters can be expressed by an equation solving for the 'reversal potential of the ANT" (Erev_ANT), a value of the mitochondrial membrane potential at which no net transport of adenine nucleotides takes place by the ANT. (wikipedia.org)
  • Mitochondrial nucleotide transporters, defined by structural similarlities, include the adenine nucleotide translocator family (SLC25A4, SLC25A5, SLC25A6 and SLC25A31), which under conditions of aerobic metabolism, allow coupling between mitochondrial oxidative phosphorylation and cytosolic energy consumption by exchanging cytosolic ADP for mitochondrial ATP . (guidetopharmacology.org)
  • Further members of the mitochondrial nucleotide transporter subfamily convey diverse substrates including CoA, although not all members have had substrates identified. (guidetopharmacology.org)
  • This autosomal dominant disorder results from the combination of a mutation in the ANT1 ( SLC25A4 ) gene (4q35) (encoding the adenine nucleotide translocator-1) and mitochondrial DNA deletions. (arizona.edu)
  • Adenine nucleotide translocase (ANT) 3, an enzyme which exchanges ATP and ADP through mitochondrial membrane, has been identified as a novel target counter-regulated by IL-4 and IFN-gamma. (bomiprot.org)
  • Mitochondrial adenine nucleotide translocator 3 is regulated by IL-4 and IFN-gamma via STAT-dependent pathways. (bomiprot.org)
  • Mitochondrial alterations induced by the p13II protein of human T-cell leukemia virus type 1. (microbiologyresearch.org)
  • To identify determinants of mETC function, we screened a genome-wide human CRISPRi library under oxidative metabolic conditions with selective inhibition of mitochondrial Complex III and identified OCIA domain-containing protein 1 (OCIAD1) as a Complex III assembly factor. (biorxiv.org)
  • MPTP is definitely made up of at least three major parts, including the voltage-dependent anion route (VDAC), UK-427857 the adenine nucleotide translocator-1 (ANT-1) and the mitochondrial matrix proteins cyclophilin Chemical (Cyp-D) [17, 20, 21]. (technuc.com)
  • Functional studies of mitochondrial bioenergetics have focused mostly on superoxide dismutase 1 (SOD1) mutants, and showed that mutant human SOD1 impairs mitochondrial oxidative phosphorylation, calcium homeostasis, and dynamics. (peixotolab.org)
  • A class of nucleotide translocases found abundantly in mitochondria that function as integral components of the inner mitochondrial membrane. (nih.gov)
Translocase3
  • ADP/ATP translocase 1 is the major AAC in human cells and the archetypal protein of this family. (wikipedia.org)
  • ATP and ADP are the only natural nucleotides recognized by the translocase. (wikipedia.org)
  • 2.Zamora M, Granell M, Mampel T, Viñas O. Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells. (bomiprot.org)
Protein5
  • 2003). The cationic amphipathic α-helix of HIV-1 viral protein R (Vpr) binds to nucleic acids, permeabilizes membranes, and efficiently transfects cells. (tcdb.org)
  • 2006). Interaction between the HIV-1 protein Vpr and the adenine nucleotide translocator. (tcdb.org)
  • Upon cytosolic entry, it serves as a cofactor in the formation of the "apoptosome," a complex consisting of the adaptor protein Apaf-1 and procaspase-9, which in turn causes the activation of caspase-9 and downstream caspases, such as caspase-3 ( Chinnaiyan, 1999 ). (rupress.org)
  • This gene is responsible for producing a protein called adenine nucleotide translocator (ANT). (rarediseaseshealthcenter.com)
  • Mot en sadan hantering ar de nuvarande ansvarsbestammelserna inte tillrackligt effektiva, protein per ägg. (anabelcastroplaza.com)
Mitochondria1
  • The original model of the MPTP that proposed the adenine nucleotide translocator (ANT) as the inner membrane pore-forming component was challenged when mitochondria from Ant1/2 double null mouse liver still had MPTP activity. (peixotolab.org)
Fragment1
  • the shortened Eco RI fragment in FSHD is 1-10 units. (medscape.com)
Mutations1
  • Less commonly, mutations that change single nucleotides in genes found in mtDNA, such as the MT-TL1 gene, cause progressive external ophthalmoplegia. (medlineplus.gov)
Cytochrome2
  • Our data indicate that OCIAD1 is required for maintenance of normal steady state levels of Complex III and the proteolytic processing of the catalytic subunit cytochrome c 1 (CYC1). (biorxiv.org)
  • His work on Cytochrome c and Adenine nucleotide translocator as part of his general Cell biology study is frequently connected to Surface plasmon resonance, thereby bridging the divide between different branches of science. (research.com)
20231
Proteins1
  • Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. (justia.com)
Subunit4
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Calpain 1, Large Subunit (CAPN1) in samples from Tissue homogenates, cell lysates and other biological fluids. (clinical-trial-logistics.com)
  • Description: A sandwich ELISA kit for detection of Calpain 1, Large Subunit from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (clinical-trial-logistics.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Calpain 1, Large Subunit (CAPN1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (clinical-trial-logistics.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Calpain 1, Large Subunit (CAPN1) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (clinical-trial-logistics.com)
Genes1
  • It is still difficult and hazardous to assemble genes from phase 1 sequence. (uthsc.edu)
Receptor2
  • Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody [NBP2-22523] - Analysis of 25 ug of mouse thyroid (lane 1), NIH-3T3 (lane 2) and A431 (lane 3) cell lysates onto an SDS polyacrylamide gel. (novusbio.com)
  • Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection. (research.com)
Enzyme1
  • Then biochemical assays such as oxidative phosphorylation activity by respiratory chain enzymes were used to characterize enzyme disorders (eg, complex 1 or complex 3 deficiencies). (medlink.com)
Function1
  • The cardiac structure and function were restored at 1-month follow-up. (bvsalud.org)
20201
Antibodies1
  • Primary Antibodies are guaranteed for 1 year from date of receipt. (novusbio.com)
FSHD3
  • Those without FSHD have approximately 11-100 D4Z4 units, whereas patients with FSHD have 1-10 D4Z4 units. (medscape.com)
  • At least 1 copy of D4Z4 is required to develop FSHD. (medscape.com)
  • Misexpression of FRG1 (FSHD region gene 1) may lead to the development of FSHD. (medscape.com)
Pyruvate1
Include1
  • Anavar should be used for a total of 8 weeks, and the cycle should include 10 testing weeks, comprar winstrol depot en pastillas anabola steroider flashback. (anabelcastroplaza.com)
Range2
  • The size of the deleted region can range from 2,000 to 10,000 DNA building blocks (nucleotides). (medlineplus.gov)
  • I have seen version numbers reach 28, but they are usually in the 1-6 range. (uthsc.edu)
Free1
  • ANT transports the free, i.e. deprotonated, non-Magnesium, non-Calcium bound forms of ADP and ATP, in a 1:1 ratio. (wikipedia.org)
Human1
  • If one knows where to look, the progress can be monitored on genome meters like this one from the Arabidopsis genome project , (92.9% complete on July 25) slide 1 NCBI has a similar meter for the Human Genome Project slide 2. (uthsc.edu)
Content1
  • Electronic ancillary materials The online edition of this content (doi:10.1186/t13046-015-0174-1) contains supplementary materials, which is obtainable to authorized users. (technuc.com)
Isoform1
  • We have identified two heterozygous missense mutations in the nuclear gene encoding the heart/skeletal muscle isoform of the adenine nucleotide translocator (ANT1) in five families and one sporadic patient. (nih.gov)
MtDNA2
  • Less commonly, mutations that change single nucleotides in genes found in mtDNA, such as the MT-TL1 gene, cause progressive external ophthalmoplegia. (nih.gov)
  • Haplogroups and single nucleotide polymorphisms (SNP) of mitochondrial DNA (mtDNA) were associated with prognosis of many types of cancer patients. (biomed.news)
Mitochondrial membrane potential2
  • The relationship of these parameters can be expressed by an equation solving for the 'reversal potential of the ANT" (Erev_ANT), a value of the mitochondrial membrane potential at which no net transport of adenine nucleotides takes place by the ANT. (wikipedia.org)
  • This decrease indicates a change in the mitochondrial membrane potential and suggests a decline in adenine nucleotide translocator function. (medscape.com)
Mediates1
  • RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells. (utah.edu)
Transporter1
  • Most nucleotide-sugar transporter in the endoplasmic reticulum and Golgi of eukaryotic cells are members of the DMT superfamily ( Song 2013 ). (tcdb.org)
Electron2
  • Key words: adenine nucleotide translocator (ANT), electron increased 3-fold compared with that observed in control mito- microscopy, micro-compartment, mitochondrion, octameric mito- chondria. (nih.gov)
  • In the present paper, we report new data obtained by immuno- to phosphorylate ADP, thereby securing a more stable ATP electron microscopy and by quantitative analysis of MCSs in WT concentration [1,2,7]. (nih.gov)
20181
  • Arch Biochem Biophys, 2018 Jun 1. (nih.gov)
Kinase1
  • Used in conjunction with adenoviral gene transfer system containing report gene for herpes simplex virus type 1 thymidine kinase (HSV1-TK), 18F-FHBG can be phosphorylated by this enzyme, thereby accumulating in the adenoviral transfected cells. (medindex.am)
20221
  • As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. (oncotarget.com)
20024
20212
  • Anal Biochem, 2021 Oct 1. (nih.gov)
  • This work was supported by statutory activity 2021: 501/3-34-1-1. (medscape.com)
Sequence1
  • The nucleotide sequence of GLURP gene was determined by automatic sequencer (Dideoxy termination method) and analyzed by DNA Star software. (besjournal.com)
Function1
  • The primary function of Adenine nucleotide translocator (ANT) is to catalyze ADP/ATP exchange across the inner membrane. (nih.gov)
Type1
Interproscan1
Laminin1
  • Additionally, talin 1 and laminin alpha 3, which participate in signaling pathways associated with adhesion and migration, have been previously observed to be overexpressed in SCC ( 9 ). (spandidos-publications.com)
Transcription1
  • 10. TGF-beta1 induction of the adenine nucleotide translocator 1 in astrocytes occurs through Smads and Sp1 transcription factors. (nih.gov)
Respiratory1
  • It plays a very important role in the assembly and maintenance of functionally active respiratory complexes (I, III and IV and F0/F1-ATPase) in the mitochondrial membrane and in normal operation of other mitochondrial multicomponent machines such as adenine nucleotide translocator, as well as tricarboxylate, pyruvate and phosphate carriers. (cdc.gov)
Specific1
  • A defensive strategy based solely on developing new vaccines and antimicrobial and antiviral drugs, each specific for only 1 or a few agents, is unlikely to be successful in dealing with potential microbial threats and will be exceedingly expensive. (cdc.gov)
Dysfunction2
  • Ischaemia-reperfusion-induced pulmonary dysfunction is a significant clinical problem in cardiac surgery and, particularly, lung transplantation 1 . (ersjournals.com)
  • Potentially life-threatening graft dysfunction early after lung transplantation can occur in up to 20% of patients 1 . (ersjournals.com)
Activity1
  • tBid almost completely inhibited the peroxidase activity of CL/cyt c complex only at ratios exceeding 20 : 1 (versus cyt c). (cdc.gov)
Inhibitor1
  • Streit et al ( 8 ) reported that thrombospondin-1 (TSP-1) was an effective inhibitor of angiogenesis and tumor growth in carcinomas of the skin. (spandidos-publications.com)
Ratio1
  • ANT transports the free, i.e. deprotonated, non-Magnesium, non-Calcium bound forms of ADP and ATP, in a 1:1 ratio. (wikipedia.org)
Cases1
  • Legionella pneumophila serogroup 1 is the causative agent of most cases in Europe. (cdc.gov)