• Enables hydrolase activity, acting on ester bonds and zinc ion binding activity. (nih.gov)
  • Extending this work, immobilised lipases have novel capabilities in the synthesis of sugar esters. (researchgate.net)
  • In this animated object, learners examine the formation of ester bonds in the synthesis of lipids using triglyceride biosynthesis as an example. (wisc-online.com)
  • Ester bond formation is described as a dehydration synthesis reaction. (wisc-online.com)
  • Harringtonine (HT), produced from Cephalotaxus species, is known to exhibit potent antiproliferative activity against myeloid leukemia cells by inhibiting protein synthesis. (elsevierpure.com)
  • These advantages motivated the research team to develop an efficient synthesis route for the synthesis of sulfinate esters via direct oxidation of thioesters. (sciencedaily.com)
  • Compared to conventional preparation methods of sulfinate esters from other sulfur surrogates, the superior accessibility of aryl iodides from a wide variety of aromatic compounds will enable the synthesis of highly functionalized sulfinate esters, " remarks Dr. Yoshida. (sciencedaily.com)
  • For example, sulfinate esters are used in the synthesis of sulfonamide-containing compounds, which have antimicrobial, anti-inflammatory, and enzyme inhibitory activities. (sciencedaily.com)
  • Further studies towards finding applications for the preparation of bioactive organosulfur derivatives, as well as the synthesis of bis-sulfinate esters, are underway in our laboratory. (sciencedaily.com)
  • This is a list of androgen esters, including esters (as well as ethers) of natural androgens like testosterone and dihydrotestosterone (DHT) and synthetic anabolic-androgenic steroids (AAS) like nandrolone (19-nortestosterone). (wikipedia.org)
  • BACKGROUND: Per- and polyfluoroalkyl substances ( PFAS ), organophosphate esters (OPEs), and polybrominated diphenyl ethers (PBDEs) are hormone-disrupting chemicals that migrate from building materials into air and dust. (cdc.gov)
  • Organophosphate ester flame retardants: are they a regrettable substitution for polybrominated diphenyl ethers? (crossref.org)
  • Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol. (planteome.org)
  • Most importantly, it carries the potential to produce various sulfinate esters from easily available starting materials, including carboxylic acids, anilines, and a wide variety of aryl iodides. (sciencedaily.com)
  • The compounds with the highest potencies as well as SI-values are esters of 1 with various carboxylic acids. (lu.se)
  • Link to all annotated objects annotated to fatty-acyl-ethyl-ester synthase activity. (planteome.org)
  • Link to all direct and indirect annotations to fatty-acyl-ethyl-ester synthase activity. (planteome.org)
  • The mechanism of activation of the transient receptor potential vanilloid 4 (TRPV4) channel by 4α-phorbol esters was investigated by combining information from chemical modification of 4α-phorbol-didecanoate (4α-PDD, 2a ), site-directed mutagenesis, Ca 2+ imaging, and electrophysiology. (acs.org)
  • Binding of 4α-phorbol esters occurs in a loop in the TM3−TM4 domain of TRPV4 that is analogous to the capsaicin binding site of TRPV1, and the ester decoration of ring C and the A,B ring junction are critical for activity. (acs.org)
  • ProTGF-alpha cleavage is activated in response to tumor-promoting phorbol ester or to calcium ionophore. (nih.gov)
  • The enzyme activity was about 5-6-fold increased by exposure of the cells with phorbol ester or with calcium ionophore. (nih.gov)
  • The enzyme was partially purified from membranes of phorbol ester-treated CHO cells. (nih.gov)
  • These findings suggest that the enzyme is a processing protease involved in the cleavage of proTGF-alpha and that induction of proTGF-alpha conversion by phorbol ester or by calcium ionophore can be attributed to activation of the processing protease. (nih.gov)
  • In the cell-free reconstitution system, the membrane-bound Suc-Ala-Ala-Ala-MCA-hydrolyzing enzyme from CHO cells was also activated by phorbol ester in the presence of the soluble fraction, ATP, and vanadate. (nih.gov)
  • Down-regulation of mannose receptor activity in macrophages after treatment with lipopolysaccharide and phorbol esters. (aai.org)
  • Generally, most phosphate esters are poorly soluble in water and adsorb strongly to soils. (cdc.gov)
  • Phosphate esters are subject to biodegradation in aquatic and terrestrial environments. (cdc.gov)
  • Breathing contaminated outdoor air: Hydraulic fluid is the primary source of phosphate esters in outdoor air. (cdc.gov)
  • Fire tests shall be performed which measure and describe the properties of the phosphate esters in response to heat and flame under controlled laboratory conditions and should not be considered or used for the description or appraisal of the fire hazard of the fluids under actual fire conditions. (astm.org)
  • HepG2 cells and medium were assayed for cholesteryl ester hydrolase (CEH) activity in the presence and absence of sodium cholate. (psu.edu)
  • The early-onset form was known as Wolman disease, and the later-onset form was known as cholesteryl ester storage disease. (medlineplus.gov)
  • The lysosomal acid lipase enzyme breaks down lipids such as cholesteryl esters and triglycerides. (medlineplus.gov)
  • Decreased lysosomal acid lipase activity results in the accumulation of cholesteryl esters, triglycerides, and other lipids within lysosomes, causing fat buildup in multiple tissues. (medlineplus.gov)
  • disorders that result in accumulation of cholesteryl esters and triglycerides, mainly in lysosomes of histiocytes, resulting in foam cells in the liver, spleen, lymph nodes, and other tissues. (msdmanuals.com)
  • Dive into the research topics where Ester Barinaga is active. (lu.se)
  • Ester Barinaga is professor in social entrepreneurship and wishes that teachers and entrepreneurs might see - and teach - alternatives to the current economic system. (lu.se)
  • Long-range transport, trophic transfer, and ecological risks of organophosphate esters in remote areas. (crossref.org)
  • In a recent study published in Organic and Biomolecular Chemistry on 11 August 2023, a research team from Japan has come up with a new approach to synthesize sulfinate esters, a subclass of organosulfur compounds, using thioesters. (sciencedaily.com)
  • The optimised conditions for sugar fatty acid ester syntheses are 48 h at 2:1 of molar ratio of lactose sugar to capric acid at 55 °C. Furthermore, a high operational stability with half-lives of over 13 and 10 runs was achieved for NER-CRL and Amino-CRL, respectively, indicating the efficiency of the immobilisation process. (researchgate.net)
  • The Committee evaluated a group of 25 flavouring agents consisting of alicyclic ketones, secondary alcohols and related esters (see Table 1). (inchem.org)
  • The total annual volume of production of the 25 alicyclic ketones, secondary alcohols and related esters in this group is approximately 520 kg in Europe (International Organization of the Flavor Industry, 1995) and 310 kg in the USA (Lucas et al. (inchem.org)
  • In order to investigate the effect of hydrocarbon chains at C-5′ on the resultant activity, the C-5′ methyl group was replaced with various straight- and branched-chain hydrocarbons using the corresponding alcohols, and their antiproliferative activity against HL-60 and HeLa cells was investigated. (elsevierpure.com)
  • Biological applications with a focus on permeability enhancing, antimicrobial activity, and antibiofilm properties of 6′-lactose-based esters are also reported. (researchgate.net)
  • In this study, the changes caused by variation of altitude to the essential oils (EOs), fatty acid methyl esters (FAMEs), and antimicrobial activities of Primula vulgaris Huds. (erdogan.edu.tr)
  • The antimicrobial activity of the EOs of Pvv and Pvs were tested against nine bacterial species, which showed activity against Mycobacterium smegmatis with minimum inhibitory concentrations (MIC) varying from 8.5 to 59.2 mu g/mL in all samples, respectively, depending on the altitude at which the oils were obtained. (erdogan.edu.tr)
  • The clinical manifestations of LCAT deficiency are likely due to a defect in LCAT-mediated cholesterol ester formation and, therefore, accumulation of unesterified (free) cholesterol in certain tissues, such as the cornea, kidneys, and erythrocytes. (medscape.com)
  • Here, we use two animal models and several techniques (two-photon imaging of CBF and neuronal calcium dynamics, intracellular and extracellular recordings, local pharmacology) to analyze the relationship between neuronal activity and local CBF during odor stimulation in the rodent olfactory bulb. (jneurosci.org)
  • Ascorbyl palmitate is a fat-soluble form of ascorbic acid that exerts the antioxidant activity characteristic of vitamin C on lipids throughout the body. (vitanetonline.com)
  • Sulfinate esters, a type of organosulfur compounds, are typically synthesized using thiols. (sciencedaily.com)
  • Moreover, sulfinate esters can help synthesize functional polymers and agrochemicals and serve as reagents in analytical chemistry techniques to detect the presence of specific compounds or functional groups. (sciencedaily.com)
  • We consider dialkyl esters of 5-aminosulfonylisophthanoate-based compounds in our efforts to determine factors involved in determining the overall inhibitory activity against estrone sulfatase (ES). (ingentaconnect.com)
  • All 27 compounds, including the two natural products 1 and 5a, were subsequently assayed in vitro for antiparasitic activity against Trypanozoma cruzi, Leishmania brasiliensis and Leishmania amazoniensis. (lu.se)
  • 5-(and-6)-Carboxyfluorescein diacetate N -succinimidyl ester (CFSE) is a fluorescent dye, which is membrane permeable. (sigmaaldrich.com)
  • 5(6)-Carboxyfluorescein diacetate N -succinimidyl ester (CFSE) is an amine reactive fluorescent probe used to stain cells, especially immune cells, for analysis in applications such as flow cytometry. (sigmaaldrich.com)
  • 5(6)-Carboxyfluorescein diacetate N -succinimidyl ester is used as an indicator for esterase activity. (sigmaaldrich.com)
  • Diphosphate ester salt of phenytoin acts as water-soluble prodrug of phenytoin. (medscape.com)
  • As it is not understood which molecular features of 1 are important for the antiparasitic activity, several analogues were synthesized and assayed. (lu.se)
  • Carbonochloridic acid, 2-methyl-2-propenyl ester can be analyzed by this reverse phase (RP) HPLC method with simple conditions. (sielc.com)
  • Benzoic acid, 4-butyl-, 4'-propyl[1,1'-biphenyl]-4-yl ester can be analyzed by this reverse phase (RP) HPLC method with simple conditions. (sielc.com)
  • Phosphate ester flame retardants can change chemical composition in the environment. (cdc.gov)
  • Biochemical assays indicated that SVEVs are functionally active, showing high metalloproteinase and fibrinogenolytic activity besides being cytotoxic against HUVEC cells. (nature.com)
  • Laboratory studies should be done to ascertain that the lipid levels are consistently abnormal before instituting therapy with omega-3-acid ethyl esters capsules. (nih.gov)
  • Some of these 6′-lactose esters were synthesized employing green solvents such as acetone [8, 9] . (researchgate.net)
  • These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. (guidetopharmacology.org)
  • Do most proteins show cross-species activity? (medchemexpress.com)
  • Other proteins may have a lower specific activity when used in the opposite species. (medchemexpress.com)
  • Bromoperoxidase Activity from a 94 Species of Marine Algae," C.M. Moore and R.K. Okuda, Journal of Natural Toxins, 1996 , 5, 295-305. (sjsu.edu)
  • Pulchrol (1) is a natural benzochromene isolated from the roots of Bourreria pulchra, shown to possess potent antiparasitic activity towards both Leishmania and Trypanozoma species. (lu.se)
  • A specific overview regarding synthetic methodologies and properties of 6′-lactose-based surfactants is presented herein, particularly all the synthetic approaches to this class of lactose esters, such as enzymatic and traditional organic syntheses. (researchgate.net)
  • Ester Partegàs will be partcipating in MATERIA PRIMA , a new exhibition at Centre d'Art Contemporari in Barcelona, Spain. (parsons.edu)
  • This Public Health Statement is the summary chapter from the Toxicological Profile for Phosphate Ester Flame Retardants . (cdc.gov)
  • This public health statement tells you about phosphate ester flame retardants and the effects of exposure to them. (cdc.gov)
  • This profile discusses the following phosphate ester flame retardants: tris(2-chloroethyl) phosphate (TCEP), tributyl phosphate (TnBP), tris(2-butoxyethyl) phosphate (TBEP), tris(1,3-dichloro-2-propyl) phosphate (TDCP), triphenyl phosphate (TPP), tris(2-chloroisopropyl) phosphate (TCPP), triisobutyl phosphate (TiBP), and tricresyl phosphate (TCP). (cdc.gov)
  • Phosphate ester flame retardants have been found in at least 8 of the 1,699 current or former NPL sites. (cdc.gov)
  • Although the total number of NPL sites evaluated for these substances is not known, the possibility exists that the number of sites at which phosphate ester flame retardants are found may increase in the future as more sites are evaluated. (cdc.gov)
  • If you are exposed to phosphate ester flame retardants, many factors will determine whether you will be harmed. (cdc.gov)
  • Phosphate ester flame retardants are human-made chemicals added to consumer and industrial products for the purpose of reducing flammability. (cdc.gov)
  • Phosphate ester flame retardants are composed of a group of chemicals with similar properties but slightly different structures. (cdc.gov)
  • What happens to phosphate ester flame retardants when they enter the environment? (cdc.gov)
  • Phosphate ester flame retardants are released to the environment from industrial sources and disposal of consumer products containing flame retardants. (cdc.gov)
  • How might I be exposed to phosphate ester flame retardants? (cdc.gov)
  • Ingesting contaminated food: Most foods have been found to contain trace amounts of phosphate ester flame retardants due to their wide use in plastics and presence in the environment. (cdc.gov)
  • These highlights do not include all the information needed to use OMEGA-3-ACID ETHYL ESTERS CAPSULES safely and effectively. (nih.gov)
  • See full prescribing information for OMEGA-3-ACID ETHYL ESTERS CAPSULES. (nih.gov)
  • Omega-3-acid ethyl esters capsules are a combination of ethyl esters of omega 3 fatty acids, principally eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), indicated as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe (≥500 mg/dL) hypertriglyceridemia. (nih.gov)
  • The effect of omega-3-acid ethyl esters capsules on the risk for pancreatitis has not been determined. (nih.gov)
  • The daily dose of omega-3-acid ethyl esters capsules is 4 grams per day taken as a single 4-gram dose (4 capsules) or as two 2-gram doses (2 capsules given twice daily). (nih.gov)
  • Patients should be advised to swallow omega-3-acid ethyl esters capsules whole. (nih.gov)
  • Do not break open, crush, dissolve, or chew omega-3-acid ethyl esters capsules. (nih.gov)
  • Omega-3-acid ethyl esters capsules are contraindicated in patients with known hypersensitivity (e.g., anaphylactic reaction) to omega-3-acid ethyl esters or any of its components. (nih.gov)
  • Omega-3-acid ethyl esters capsules are indicated as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe (greater than or equal to 500 mg/dL) hypertriglyceridemia. (nih.gov)
  • Patients should be placed on an appropriate lipid-lowering diet before receiving omega-3-acid ethyl esters capsules and should continue this diet during treatment with omega-3-acid ethyl esters capsules. (nih.gov)
  • As a result, 4′-n-heptyl-4′-demethylharringtonine (1f, n-heptyl derivative) showed the most potent cytotoxicity among the HT ester derivatives produced, with IC 50 values of 9.4 nM and 0.4 μM for HL-60 and HeLa cells, respectively. (elsevierpure.com)
  • Phenytoin in turn stabilizes neuronal membranes and decreases seizure activity. (medscape.com)
  • Latanoprost is administered in the isopropyl ester form shown here, which is then hydrolysed in vivo in to active metabolite lanoprost free acid. (guidetopharmacology.org)
  • Methyl palmitoleate ((Z)-Methyl hexadec-9-enoate), a fatty acid methyl ester, is an analogue of Palmitoleate with cytoprotective and growth-promoting properties. (medchemexpress.com)
  • They are also used to produce drugs with sulfoxide groups, which can have various biological activities, including anti-clotting and anti-acid effects. (sciencedaily.com)
  • Omega-3-acid ethyl esters may increase levels of low-density lipoprotein (LDL). (nih.gov)
  • There is a possible association between omega-3-acid ethyl esters and more frequent recurrences of symptomatic atrial fibrillation or flutter in patients with paroxysmal or persistent atrial fibrillation, particularly within the first months of initiating therapy. (nih.gov)
  • Patients taking omega-3-acid ethyl esters and an anticoagulant or other drug affecting coagulation (e.g., anti-platelet agents) should be monitored periodically. (nih.gov)
  • Individuals with the early-onset form of lysosomal acid lipase deficiency have no normal enzyme activity. (medlineplus.gov)
  • Prenatal diagnosis is based on the absence of acid lipase activity in cultured chorionic villi. (msdmanuals.com)
  • To contribute to the development of antibacterial products from propolis produced by native Brazilian bees, twenty-nine samples of propolis collected from hives in the state of Minas Gerais, Brazil, were screened for in vitro activity against Aeromonas hydrophila, Bacillus subtilis, Pseudomonas aeruginosa, and Staphylococcus aureus. (scielo.br)
  • Toxins with hemorrhagic and myonecrotic activity are generally found in the venoms of the Viperidae family due to synergic action of proteolytic enzymes, such as metalloproteinases and serine proteinases 4 . (nature.com)
  • Those with the later-onset form are thought to have some enzyme activity remaining, and the amount generally determines the severity of signs and symptoms. (medlineplus.gov)
  • OBJECTIVES: We aimed to quantify the hormonal activities of 46 dust samples and identify chemicals driving the observed activities. (cdc.gov)
  • It is the first study involving the use of a $p$-cresol probe for the determination of the HOBr scavenging activity of biothiols. (tubitak.gov.tr)
  • Afterwards, the thioester was directly oxidized in the presence of N -bromosuccinimide, which created an intricate reaction pathway culminating with the formation of a sulfinate ester. (sciencedaily.com)
  • Enzyme immobilisation technology is an effective means to improve sugar ester production through the employment of biocatalysts. (researchgate.net)
  • Inhibitor profile of the enzyme, including inhibition by serine protease inhibitors and no inhibition by elastatinal, coincides with that previously reported for proTGF-alpha cleavage activity on CHO cells. (nih.gov)
  • These results provide evidence for the secretion of a bile salt-dependent CEH activity, from both a hepatic cell line and the intact liver, that has similar properties to the enzyme previously isolated from rat liver homogenates and rat pancreas. (psu.edu)
  • METHODS: We evaluated associations between hormonal activities of extracted dust in five cell-based luciferase reporter assays and dust concentrations of 42 measured PFAS , OPEs, and PBDEs, transformed as either raw or potency-weighted concentrations based on Tox21 high-throughput screening data. (cdc.gov)
  • The effect of these agents on receptor activity was not reversible, and activity continued to decline after the agents were removed. (aai.org)
  • Serine protease inhibitors did not block the reduction in receptor activity, suggesting that proteolysis is not involved in receptor down-regulation. (aai.org)
  • Binding of 125I-mannose-BSA to intact macrophages showed a 70% decrease in surface receptor activity after treatment with LPS/PMA. (aai.org)
  • We show that RBC flow and local neuronal activity uncouple with repetitive stimulation and local blockade of glutamatergic synaptic transmission. (jneurosci.org)
  • Steel HC, Theron AJ, Cockeran R, Anderson R, Feldman C: Pathogen- and host-directed anti-inflammatory activities of macrolide antibiotics. (karger.com)
  • The evaluation of chemicals in food by the Committee is an ongoing activity. (who.int)
  • In ascertaining the erectogenic and antidiabetic properties of the extracts, the effects of the extracts on activities of some enzymes relevant to erectile dysfunction (arginase and phosphodiesterase-5) and type-2 diabetes (α-amylase and α-glucosidase) were determined. (degruyter.com)
  • to investigate the glomerular specificity and the role of postsynaptic activity in neurovascular coupling. (jneurosci.org)
  • Professor Titular de Química Orgànica en 1987. (uji.es)
  • Familial LCAT deficiency (FLD), first reported in 1967 in a Norwegian family, is characterized by the absence of LCAT activity towards HDL and LDL. (medscape.com)
  • Fish eye disease, initially described in two families of Swedish origin, is characterized by the absence of LCAT activity towards HDL only. (medscape.com)