Activation gene expression regulation developmental. Medical search. Frequent questions

Cardiac differentiation involves a cascade of coordinated gene expression that regulates cell proliferation and matrix protein formation in a defined temporal-spatial manner. (anthropogeny.org)
To understand the development of adiposity, it is crucial to identify the genes which expression is associated with adipogenic differentiation. (biomedcentral.com)
Proliferation cluster comprised 1028 genes up-regulated from days 3 to 8 of culture meanwhile the differentiation cluster was characterized by 2140 induced genes from days 15 to 21. (biomedcentral.com)
On the other hand, the terminal differentiation phase was enriched with genes involved in energy production, lipid and carbohydrate metabolism. (biomedcentral.com)
Overall, our study demonstrates the coordinated expression of functionally related genes during proliferation and differentiation of rainbow trout adipocyte cells. (biomedcentral.com)
MiR-29, on the other hand, is more abundant in adult CD8+ T cells and regulates the expression of transcription factors involved in effector and memory cell differentiation. (cornell.edu)
In summary, the macronucleus is a vital organelle within Paramecium cells that controls gene expression, cellular functions, reproduction, cellular differentiation, and environmental adaptation. (philosophynews.com)
Several genes involved in different aspects of stem cell activation are being studied, including some that transduce initial signals, and others that regulate self-renewal and differentiation. (chicagobiomedicalconsortium.org)
We focus our research on the post-transcriptional regulation of embryonic myogenesis and adult muscle differentiation by RNA-binding proteins.We use zebrafish as a model, which is most suitable for in vivo and in vitro analyses using cell and molecular biology, genetics, and living imaging approaches. (sorbonne-universite.fr)
In particular, we focus our research on the role of RNA-binding proteins in the post-transcriptional regulation of muscle differentiation and regeneration. (sorbonne-universite.fr)
Homeobox (HOX) genes encode evolutionarily conserved transcription factors that are essential for embryonic morphogenesis and differentiation [5]. (cancerhugs.com)
HOX genes exert pleiotropic functions in many cell types and may control cell proliferation, differentiation, adhesion, and migration [7]. (cancerhugs.com)
Latest research claim that HOX genes might play essential jobs in ovarian cancer differentiation [9-11]. (cancerhugs.com)
They pointed towards activation of Wnt signaling as a candidate pathway leading to a redirection of differentiation away from neuroepithelial cells towards neural crest. (fu-berlin.de)

This analysis indicates that each Otx class is characterized by highly specific and conserved expression features in the presumptive RPE, where Otx1 and Otx2, but not Otx5, are transcribed at optic vesicle stages, in the differentiating neural retina, where Otx2 and Otx5 show a conserved dynamic expression pattern, and in the forming ciliary process, a major site of Otx1 expression. (ox.ac.uk)
Northern blot analysis shows that ZNF322 is expressed in every human tissue examined at adult stage and during embryonic developmental stages from 80 days to 24 weeks. (anthropogeny.org)
While previous studies in chickens, cattle, and pigs have identified lncRNAs in developmental stages or differentially expressed under specific conditions in a limited number of tissues, more comprehensive identification of lncRNAs in these species is needed. (usda.gov)
Furthermore, the information generated will allow future investigations of specific genes involved in particular stages of fish adipogenesis. (biomedcentral.com)
Our findings highlight fundamental and conserved differences in regulatory logic at distinct developmental stages, characterized by simpler promoter-centric regulation in embryonic cells and combinatorial enhancer-driven control in adult cells. (keystonesymposia.org)
Therefore, the expres sion of each gene was measured by RT PCR during dif ferent stages of S. flexneri growth in Luria Bertani at pH 7. (gp120-inhibitors.com)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism. (jefferson.edu)
Our findings indicated that SEC facilitates the coordinated and controlled induction of genes that are active during the early developmental stages," says Ali Shilatifard, Ph.D., investigator and the study's senior author. (stowers.org)
Here we generated a high-resolution map of enhancer three-dimensional contacts during Drosophila embryogenesis, covering two developmental stages and tissue contexts, at unprecedented resolution. (ens-lyon.fr)

Under normal circumstances, these enzymes transfer methyl groups on and off histones to regulate genes via epigenetic pathways. (wikipedia.org)
Activation of host translational control pathways by a viral developmental switch. (ucsb.edu)
ZNF322, a novel human C2H2 Kruppel-like zinc-finger protein, regulates transcriptional activation in MAPK signaling pathways. (anthropogeny.org)
Together, these results suggest that ZNF322 is a member of the zinc-finger transcription factor family and may act as a positive regulator in gene transcription mediated by the MAPK signaling pathways. (anthropogeny.org)
Metabolism underpins development and physiology, but little is known about how metabolic genes and pathways are regulated, especially in multicellular organisms. (biorxiv.org)
Moreover, during this phase an enrichment in genes involved in the formation of the lipid droplets was evidenced as well as the activation of the thyroid-receptor/retinoic X receptor (TR/RXR) and the peroxisome proliferator activated receptors (PPARs) signalling pathways. (biomedcentral.com)
Major immune response pathways control the expression of hundreds of genes that represent potential effectors of the immune response. (cnrs.fr)
A single RNA polymerase in bacteria and archaea-and only three different polymerases in eukaryotes-program an amazing variety of developmental pathways. (nih.gov)
Recent studies have revealed that AXL contributes to leukaemic phenotypes through activation of oncogenic signalling pathways that lead to increased cell migration and proliferation. (cancerindex.org)

To direct signals to specific target genes, Ets proteins interact with (other) transcription factors that promote the binding of Ets proteins to composite Ras-responsive elements. (embl.de)
Expression and estrogen sensitivity of target genes and nuclear receptor coregulators were altered at mRNA and protein levels in adult uterus, prostate and brain. (researchgate.net)
At the beta-globin locus, enhancer-promoter interactions appear dynamic and cell-type specific, whereas atthe HoxD locus they are stable and ubiquitous, being present in tissues where the target genes are not expressed. (ens-lyon.fr)

We will also review various screens that have detected differentially expressed pituitary lncRNAs associated with changes in reproductive state and those whose expression is found to play a role in gonadotrope-derived nonfunctioning pituitary adenomas. (endocrine.org)

Expression patterns were examined in the developing eye of a chondrichthyan, the dogfish, and an amniote, the chick, and compared with the capacity of paralogous proteins to induce a pigmented phenotype in cultured retina cells in cooperation with the bHLH-leucine zipper protein Mitf. (ox.ac.uk)
It is widely believed that in mammalian cells the cellular transcription factor (DRTF1/E2F integrates cell-cycle events with the transcription apparatus by interacting with important regulators of the cell cycle, such as the retinoblastoma gene product (pRb) and related proteins, cyclins, and cyclin-dependent kinases. (ox.ac.uk)
Both DP-1 and DP-2 synergistically interact with members of the E2F family of proteins, E2F-1, E2F-2, and E2F-3, to generate DNA binding complexes that specifically recognize the E2F site and functionally interact with E2F-1 in E2F site-dependent transcriptional activation of cellular genes. (ox.ac.uk)
Within the macronuclear DNA, specific genes are amplified and transcribed to produce functional RNA molecules, which are then translated into proteins. (philosophynews.com)
Polycomb Group (PcG) of proteins compact chromatin keeping genes in a repressed state. (chicagobiomedicalconsortium.org)
The post-transcriptional regulation of gene expression orchestrated by RNA-binding proteins is involved in a wide variety of physiological and pathological processes. (sorbonne-universite.fr)
Current research goals are to investigate the mechanisms by which interactions of cis -regulatory sequences with sequence-specific trans-acting proteins in situ in chromatin effect the chromatin remodeling and the transcriptional regulation of Adh . (rochester.edu)

The MZT marks the transfer of control of development from the mother to the zygote as maternal mRNAs are degraded, transcription from the zygotic genome begins, and embryonic development becomes dependent on zygotic gene products ( Tadros and Lipshitz, 2009 ). (elifesciences.org)
The gradual conversion from endosymbiont to organelle during the course of evolution has clearly been accompanied by a dramatic reduction in genome size as the chloroplasts lost most of their genes to the nucleus. (frontiersin.org)
Enrichment of modifications in each metabolic domain, relative to all the genes in the genome, revealed both shared and diverse patterns. (biorxiv.org)
While genome assemblies and the identification of coding genes greatly enhanced our ability to connect DNA sequence (genotype) to traits of interest (phenotype), it becoming clear that genomes need to be more comprehensively annotated, especially with respect to regulatory elements. (usda.gov)
CRISPR/Cas9 mediated genome editing in selected loci demonstrated distal enhancers are required for gene expression in EryD but not in EryP. (keystonesymposia.org)
The beads were then washed repeatedly with RIPA buffer supplemented with increasing levels of NaCl and bound DNA then released and de-crosslinked by proteinase K digestion at 65?C for 4-15?h. accessibility, which may serve as the underlying basis of clonal maintenance at this locus, as well as other instances of monoallelic expression throughout the genome. (estme.org)
The Genome Regulation Group is a mixed group of experimental and computational biologists that uses genomic tools to study developmental and stem cell biology with a particular interest in the role of epigenetic regulation. (mpg.de)
Their work utilizes early mouse development as well as various mouse and human stem cell paradigms to dissect basic molecular mechanisms including the role of DNA methylation and other epigenetic modifications in gene and genome regulation. (mpg.de)

Sarah E. Millar, PhD is Director of the Black Family Stem Cell Institute, and Lillian and Henry M. Stratton Professorial Chair in the Departments of Cell, Developmental and Regenerative Biology and Dermatology at the Icahn School of Medicine at Mount Sinai. (mountsinai.org)
The resulting information helps define how genes can be regulated and should enable better predictive biology for farm animals. (usda.gov)

When the genes that encode these enzymes are mutated, epigenetic activation of certain developmental genes is impaired and developmental abnormalities occur, leading to the characteristics of Kabuki syndrome patients. (wikipedia.org)

The PEP enzyme recognizes the -10 and -35 cis -elements, similar to those found in bacterial promoters whereas the NEP enzyme recognizes the YRTA-motif, which can also be found upstream of several genes with PEP promoters indicating that these genes can be transcribed by both polymerases ( Pfannschmidt and Liere, 2005 ). (frontiersin.org)
The plasmid containing a fragment from the dksA promoters to the beginning of the gluQ rs gene, with the first five amino acids of GluQ RS, named pVCPDT, represents the full length dksA gene with its native promoters. (gp120-inhibitors.com)
In particular, we have investigated the activation of phage T4 promoters during T4 infection and the regulation of promoters that express virulence gene products in the pathogens Bordetella pertussis and Vibrio cholerae . (nih.gov)
Adh is transcribed from 2 tandem promoters ~700 bp apart, each has distinct developmental- and tissue-specific patterns, and each is regulated by a distinct enhancer. (rochester.edu)
Each enhancer contacts multiple enhancers, and promoters with similar expression, suggesting a role in their co-regulation. (ens-lyon.fr)

Drosophila has been a powerful system for deciphering the conserved mechanisms that regulate hormone signaling, sugar and lipid homeostasis, and the molecular mechanisms underlying the nutritional regulation of development. (sdbonline.org)
In this submission, the chicken, cattle, and pig genomes were surveyed for what is known as long non-coding RNAs, which help to regulate gene expression. (usda.gov)
The Goodell Lab focuses on the basic mechanisms that regulate hematopoietic stem (HSC) cells, and how their mis-regulation leads to leukemia development. (chicagobiomedicalconsortium.org)
However, the function of SEC in our cells is not to give us leukemia, but rather to regulate transcription of developmentally regulated genes, and therefore, we tried to learn more about the normal biological function of SEC. (stowers.org)
Enhancer clusters overlapping disease-associated mutations in Pierre Robin sequence (PRS) patients regulate SOX9 expression at genomic distances over 1.25 megabases. (4dnucleome.org)
Dr. Benyajati is interested in studying the molecular mechanisms that regulate differential gene expression during development using the Drosophila alcohol dehydrogenase ( Adh ) gene as the model system. (rochester.edu)
Introduction regulate choices of expressed genes as part of the macrophage/ neutrophil lineage. (lu.se)

Our work on T4 promoter activation established a new paradigm for transcriptional activation, called sigma appropriation. (nih.gov)
Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity-independent manner (By similarity). (affbiotech.cn)

Mice contain at least four, and perhaps five, genes with the same TEA DNA binding domain (mTEAD genes). (embl-heidelberg.de)

The prin2.2 and csp41b-2 single mutants displayed pale phenotypes, abnormal chloroplasts with reduced transcript levels of photosynthesis genes and defects in embryo development. (frontiersin.org)
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)

Since microRNAs (miRNAs) are developmentally regulated and required for CD8+ T cell function, we hypothesized that defective CD8+ T cell memory formation in early life may be due to differences in miRNA expression patterns between neonatal and adult CD8+ T cells. (cornell.edu)
Surprisingly, our results indicated that differences in miRNA expression profiles were most pronounced prior to immunological challenge, suggesting that developmentally-regulated miRNAs do not operate by altering the fate of effector cells at the peak of the response. (cornell.edu)
PCR2 targets genes that are developmentally regulated and catalyzes di- and histone tri-methylation, resulting in chromatin compaction and gene repression. (chicagobiomedicalconsortium.org)
The accidental activation of developmentally regulated genes could explain how leukemia arises as a result of MLL translocations," explains Lin. (stowers.org)

An analysis of lncRNA conservation across species identified a set of conserved lncRNA with potential functions associated with chromatin structure and gene regulation. (usda.gov)

Here we demonstrate that, during brain maturation, the potential of the intrinsic apoptotic pathway is progressively reduced and that such repression is associated with downregulation of apoptotic protease-activating factor-1 (Apaf-1) and caspase-3 gene expression. (jneurosci.org)
Eldadah and Faden, 2000 ), we hypothesized that suppression of apoptotic capability during maturation of mammalian brain results from repression of genes involved in the caspase-3 activation pathway, and that injury-induced neuronal apoptosis in the mature brain results from reactivation of these genes. (jneurosci.org)
Surprisingly, specialized metabolic genes, often involved in defense, were predominantly regulated by two modifications that have opposite effects on gene expression, H3K27me3 (repression) and H3K18ac (activation). (biorxiv.org)
Interestingly, group IV included two modifications that have opposite effects on expression: H3K18ac, an activation mark, and H3K27me3, a repression mark. (biorxiv.org)
In contrast, metabolic genes involved in specialized and hormone metabolic domains, which are generally involved in interactions with biotic and abiotic environmental stimuli, showed distinct patterns with the enrichment of a repression mark H3K27me3 and an activation mark H3K18ac ( Fig. 1B ). (biorxiv.org)
Chromatin-mediated repression is established after formation of a 2-cell embryo, concurrent with the developmental acquisition of enhancer function. (embl-heidelberg.de)
Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (affbiotech.cn)
During the activation phase, promotes the accumulation of ubiquitinated ARNTL/BMAL1 at the E-boxes and during the repression phase, blocks FBXL3-mediated CRY1/2 ubiquitination and promotes the interaction of CRY1 and ARNTL/BMAL1 (By similarity). (affbiotech.cn)

In the third mode, reguland regulation, the regulated entity is the target of a regulatory shift, which is often irreversible or requires action of another regulator to return to original state. (researchsquare.com)
A major goal of this grant is to identify the key gene regulatory networks that underlie cell-intrinsic differences between neonatal and adult CD8+ T cells. (cornell.edu)
Rearrangement of immune receptor loci in B and T lymphocytes takes place in an ordered developmental manner using transcription factors and regulatory elements to open up and turn on the rearrangement process at each individual cluster during its specific stage of differentiation1,2,3,4,5. (estme.org)
While over half the genes are estimated to be regulated at the transcriptional level, few regulatory motifs and transcription regulators have been found. (biomedcentral.com)
The study seeks to identify putative regulatory motifs in the upstream regions of 13 functional groups of genes expressed in the intraerythrocytic developmental cycle of Pf . (biomedcentral.com)
Rather than studying 40 different genes to search for a relevant use of a regulatory mechanism you can often look at the Hox clusters and uncover relevant examples. (stowers.org)
Resistance to antimicrobial drugs of convenience, the examples will be taken mainly from in bacteria can result from mutations in housekeeping the work carried out in the author's laboratory, although structural or regulatory genes. (cdc.gov)
which remain susceptible to most antimicrobial drugs ing structural or regulatory genes or from acquiring foreign even though they can acquire plasmids from both entero- genetic information. (cdc.gov)

Most of these mutations are in the KMT2D gene and involve a change in amino acid sequence that creates a shortened and nonfunctional chromatin-modifying enzyme. (wikipedia.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)

The molecular mechanisms of ecdysone-regulated metamorphosis and developmental timing have been studied extensively in Drosophila. (sdbonline.org)
Our overall goal is to elucidate how the process of transcription initiation and activation is regulated at a molecular level. (nih.gov)
Our goal is to understand this activation process at a molecular level. (nih.gov)
In all of our systems, we combine classic protein and nucleic acids biochemistry with state-of-the-art structural and molecular modeling techniques to understand the protein-protein and protein-DNA contacts that are needed for regulation. (nih.gov)
Understanding the underlying molecular circuitry in terms of how it governs both a primed state and, at the other extreme, a committed state is of relevance not only to hematopoiesis but also to developmental systems in general. (lu.se)

Specifically, these genes code for a histone methyltransferase (KMT2D) and a histone demethylase (KDM6A), and play a part in the regulation of gene expression. (wikipedia.org)
Here, we show that Shh regulates sustained activation of histone deacetylases (HDACs) and that this activity is required for continued proliferation of CGP cells. (nih.gov)
Calebin-A induced death of malignant peripheral nerve sheath tumor cells by activation of histone acetyltransferase. (cancerindex.org)
The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. (affbiotech.cn)

In Xenopus, zebrafish, and Drosophila the major activation of zygotic transcription occurs as the cell cycle lengthens and gastrulation begins, a developmental period referred to as the midblastula transition. (elifesciences.org)
1990 . Alternative DNA-protein interactions in variable-length internucleosomal regions associated with Drosophila Adh distal promoter expression. (rochester.edu)

Most cell types have relatively stable CpG dinucleotide methylation patterns and our understanding of which CpGs participate in genomic regulation is still relatively limited. (mpg.de)

In contrast to EryP-specific genes, which exhibit promoter-centric regulation through Gata1, EryD-specific genes employ distal enhancers for long-range regulation through enhancer-promoter looping, confirmed by Gata1 HiChIP. (keystonesymposia.org)
By modulating the expression of specific genes, the macronucleus allows Paramecium to adjust its metabolism, behavior, and morphology in response to environmental cues. (philosophynews.com)

They are about 6-8 nucleotides (nt) in length and occur upstream of the gene transcription start site (TSS). (biomedcentral.com)
The latter pair inherits the state of its upstream master genes and further reinforces the decision due to several feedback loops, thereby leading to irreversible commitment. (lu.se)

Therefore, it is all the more surprising pathogenic for humans have evolved toward antimi- that genes commonly found on plasmids in the latter bac- crobial drug resistance. (cdc.gov)

Most cases of Kabuki syndrome occur de novo, that is, the parents are unaffected and the gene was mutated early in embryological development. (wikipedia.org)
Here, the concept of poikilosis allowed development of a model for biological regulation applicable to all types of regulated systems. (researchsquare.com)
Aberrant activation of Shh signaling during this time has been associated with hyperplasia of CGP cells and eventually may lead to the development of medulloblastoma. (nih.gov)
These results suggest that differential expression of Apaf-1 and caspase-3 genes may underlie regulation of apoptotic susceptibility during brain development, as well as after acute injury to mature brain, through the intrinsic pathway of caspase activation. (jneurosci.org)
In silico analysis of available array data showed that a large number of genes traditionally classified as PEP dependent genes are transcribed during early embryo development from the pre-globular stage to the mature-green-stage. (frontiersin.org)
The C(2)H(2) zinc finger-containing transcription factors have been implicated as critical regulators of multiple cardiac-expressed genes and are important for human heart development and diseases. (anthropogeny.org)
Adipogenesis has been described as a two-step developmental process consisting on the commitment of undifferentiated MSCs into preadipocytes and the further development of these cells into fully functional mature adipocytes [ 4 ]. (biomedcentral.com)
Controlling the process of transcription is fundamental to gene expression, gene regulation, and development. (nih.gov)
GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
The research interests include important aspects of post-transcriptional regulations of gene expression during early development. (sorbonne-universite.fr)
Transcriptional derepression and post-translational regulation of gene expression play important roles in tumorigenesis, but their implication in early development remains elusive. (sorbonne-universite.fr)
Regulation of gene expression at the beginning of mammalian development and the TEAD family of transcription factors. (embl-heidelberg.de)
Published in the July 15, 2011, issue of Genes and Development , their study not only assigns a new role to the SEC, but also emphasizes the importance of transcription elongation control for the rapid induction of genes in response to developmental and environmental cues. (stowers.org)
Expressed early during development, Hox genes are key regulators of an organism's basic body plan. (stowers.org)
In light of the functional links between MLL and SEC emerging from Shilatifard's lab it made sense to study the induction of Hox genes in murine embryonic stem cells, as model system to learn more about SEC and its role during early development," recalls Krumlauf. (stowers.org)
Hox genes are not only rapidly turned on in differentiating ES cells but because precise regulation of their gene expression is so important to coordinating normal development, they seem to use every known mechanism in the book," says Krumlauf. (stowers.org)
Accueil / Publications avant IGFL / Y. GHAVI-HELM - Developmental epigenomics / Enhancer loops appear stable during development and are associated with paused polymerase. (ens-lyon.fr)
Notably, most interactions appear unchanged between tissue context and across development, arising before gene activation, and are frequently associated with paused RNA polymerase. (ens-lyon.fr)

Isolation of the murine Nbr1 gene adjacent to the murine Brca1 gene. (nih.gov)
The gene, and its paralogues, have become a well-studied model for the family, and hence much of what is known about the T-box family is derived from the murine Brachyury gene. (embl-heidelberg.de)

Heterogeneity is generated both passively, e.g. by differential gene expression in cells of a tissue, and actively, such as the generation of the immense variation for immunological recognition molecules. (researchsquare.com)
Instead, these miRNAs appear to set the activation threshold prior to infection, causing neonatal CD8+ T cells to differentiate more rapidly into effector cells and biasing them away from a memory precursor fate. (cornell.edu)
MiR-130 is preferentially expressed in neonatal CD8+ T cells and targets a number of genes involved in negative regulation of T cell proliferation or apoptosis. (cornell.edu)
We propose that the miR-29/miR-130 axis acts as a developmental rheostat for adjusting the activation threshold of CD8+ T cells, controlling the balance between rapid effector cells (neonates) and long-lived memory cells (adults). (cornell.edu)
Animal cells undergo fundamental shifts in gene expression when there are changes in the oxygen levels around them. (nobelprize.org)
Homozygous mutation of this gene results in a 70% reduction in the mixed lymphocyte response in LPS- and dextran sulfate-stimulated B cells. (jax.org)
However, the part of HOX genes in developing granulosa cells isn't well known. (cancerhugs.com)
However, prior to commitment, it has been cells, it is evident that GATA-1 and PU.1 are able to specify observed that many genes are expressed at intermediate or basal erythroid and myeloid cell fates (see [16] and references therein). (lu.se)

Substantial portion of molecules in an organism is involved in regulation of a wide spectrum of biological processes. (researchsquare.com)
Although the processes are very different, the principles of the regulation are the same in all these systems. (researchsquare.com)
However, compared to developmental processes, knowledge about the epigenetic regulation of metabolism is limited in multicellular organisms. (biorxiv.org)
Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
This unique structure allows for rapid gene expression and facilitates the macronucleus' role in regulating various cellular processes. (philosophynews.com)
Background Ovarian follicular maturation represents one of the most complex and clinically important developmental processes during the reproductive life of women. (cancerhugs.com)

We are interested in elucidating the details of gene regulation by the B. pertussis global response regulator, BvgA, which regulates all the known pertussis virulence genes. (nih.gov)

As such, it exemplifies a cell whose function is defined through changes in developmental and temporal patterns of gene expression, including those that are hormonally induced. (endocrine.org)
She is an Editorial Board member for Developmental Cell and Experimental Dermatology, and Deputy Editor for the Journal of Investigative Dermatology. (mountsinai.org)
The tissue-specific expression of DP family members suggests that the combination of DP/E2F heterodimers that constitute DRTF1/E2F is influenced by the phenotype of the cell. (ox.ac.uk)
The gene and cell approaches are more likely to be curative, but they are still under investigation. (medscape.com)
How overall principles of cell-type-specific gene regulation (the "logic") may change during ontogeny is largely unexplored. (keystonesymposia.org)
The macronucleus is closely associated with this process and determines the developmental fate of the cell. (philosophynews.com)
Originally, it was thought that at the time of rearrangement the two alleles in each cell are equal substrates for activation, with the choice being made in a stochastic manner10,11. (estme.org)
Further insight into the regulation of Renshaw cell activity. (nature.com)
These changes in gene expression alter cell metabolism, tissue re-modeling, and even organismal responses such as increases in heart rate and ventilation. (nobelprize.org)
William Kaelin, Jr. was in 1995 engaged in the study of the von Hippel-Lindau tumor suppressor gene, and after isolation of the first full-length clone of the gene showed that it could suppress tumor growth in VHL mutant tumorigenic cell lines. (nobelprize.org)
Through the combined work of these three laureates it was thus demonstrated that the response by gene expression to changes in oxygen is directly coupled to oxygen levels in the animal cell, allowing immediate cellular responses to occur to oxygenation through the action of the HIF transcription factor. (nobelprize.org)
The transcriptome of the Pf asexual intraerythrocytic developmental cycle (IDC) has been analysed and transcriptional regulation has been shown to orchestrate a continuous cascade of gene expression, with genes being induced once per cycle, in a "just-in-time" manner, only when the gene product is required by the cell [ 3 ]. (biomedcentral.com)
This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. (cancerindex.org)
Conclusions Our present study reveals a novel mechanistic role for HOXA7 in modulating granulosa cell proliferation via the regulation of EGFR. (cancerhugs.com)
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. (affbiotech.cn)
Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress. (affbiotech.cn)
From forced expression studies in both cell lines and primary turned ON/OFF. (lu.se)
We characterize the activation kinetics of these reagents in vitro and demonstrate their efficacy in zebrafish embryos that express NfsB either ubiquitously or in defined cell populations. (cdc.gov)
In combination with transgenic organisms, such enzyme-actuated antisense tools will enable gene silencing in specific cell types, including tissues that are not amenable to optical targeting. (cdc.gov)
11 , 12 Light-dependent gene silencing can be achieved through whole-organism irradiation or the targeted illumination of specific cell populations. (cdc.gov)

The specific developmental genes that are affected by the impaired epigenetic mechanisms in Kabuki syndrome are not yet fully known. (wikipedia.org)
Our results also revealed the presence of tail-length-independent mechanisms that maintained translation despite tail-length shortening during oocyte maturation, and prevented essentially all translation of bicoid and several other mRNAs before egg activation. (elifesciences.org)
My lab focuses on elucidating these mechanisms of transcription initiation and regulation. (nih.gov)

Thus, the onset of zygotic gene expression (ZGE) is regulated at the level of both transcription and translation. (embl-heidelberg.de)

Our work has revealed a unique architecture for the interaction of the Bordetella pertussis response regulator (BvgA) with a particular virulence gene promoter. (nih.gov)

We searched the crop and wild Prunus germplasm from the Armeniaca and Amygdalus taxonomic sections for allelic variants in the eIF4E and eIFiso4E genes, to identify alleles potentially linked to resistance to Plum pox virus (PPV). (bvsalud.org)
We identified new alleles for both genes differing from haplotypes associated with PPV susceptible accessions. (bvsalud.org)

Recent studies highlighted the importance of IMD pathway regulation as it is tightly controlled by numbers of negative regulators at multiple levels. (cnrs.fr)

Various levels of regulation, including epigenetic modifications and transcription factors, play important roles in coordinating the expression of genes. (biorxiv.org)
To see if there are any interactions between epigenetic modifications across metabolic genes, we computed pairwise Pearson's correlation coefficients between the 16 epigenetic modifications based on their relative abundance at each metabolic gene region. (biorxiv.org)
Groups I and II included mainly the epigenetic modifications that activate gene expression. (biorxiv.org)
The enrichment patterns of epigenetic modifications were consistent with expression levels of genes involved in each domain under healthy conditions (Fig. S1A). (biorxiv.org)

The production of viable offspring requires three key developmental events: oocyte maturation, the oocyte-to-embryo transition (OET), and the maternal-to-zygotic transition (MZT) ( Figure 1A ). (elifesciences.org)
Here we have identified and characterized a novel zinc-finger gene named ZNF322 using degenerated primers from a human embryo heart cDNA library. (anthropogeny.org)

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. (cancerindex.org)

It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. (affbiotech.cn)

In the adult however, the expression of DP-1 and DP-2 is tissue restricted. (ox.ac.uk)
Figure 1: Altered KCC2 expression in lumbar motoneurons after thoracic SCI in adult rats. (nature.com)

Transient patterns of gene regulation were identified from model predictions. (fu-berlin.de)

Regulation of gene expression in Plasmodium falciparum (Pf) remains poorly understood. (biomedcentral.com)

Due to their importance in the temporal and spatial control of gene expression, a growing number of human diseases are associated with RNAs and RBPs. (sorbonne-universite.fr)
Phosphorodiamidate morpholino oligonucleotides are widely used to interrogate gene function in whole organisms, and light-activatable derivatives can reveal spatial and temporal differences in gene activity. (cdc.gov)

Tissue-specific lncRNA were identified, and genes nearby tissue-specific lncRNAs were enriched for GO terms associated with those tissues. (usda.gov)
Deficiency in its expression level could be the cause of congenital disorders, such as cardiomyopathy, myopathy or blindness, which affect the normal function of related tissues where crucial roles of this gene have been demonstrated in different animal models. (sorbonne-universite.fr)

A. Correlation analysis reveals four groups of epigenetic marks, activating (red) and repressing (blue), based on their relative abundance on metabolic genes. (biorxiv.org)

This gene is regarded as a potential tumor suppressor gene. (affbiotech.cn)

HOX genes perform essential jobs in organogenesis and in the introduction of the human being reproductive program during embryogenesis and during organic redesigning in adults [8]. (cancerhugs.com)

These transcripts match previously known patterns of lncRNA, such as generally lower expression levels than protein-coding genes and higher tissue specificity. (usda.gov)
We and others have synthesized light-activatable cMOs that allow spatiotemporal control of RNA splicing or translation, complementing the use of conditional knockouts to study stage- and tissue-specific differences in gene function. (cdc.gov)
18 , 19 We surmised that cyclic cMOs containing an NfsB-cleavable linker could be used with analogous lines to knock down gene function in a tissue-specific manner (Figure 1 a). (cdc.gov)

The methylation of cytosine, usually at CpGs, is a common feature of epigenetic regulation of gene expression. (mpg.de)

Injury-induced cytochrome c -specific cleavage of caspase-9 followed by activation of caspase-3 in mature brain correlated with marked increases in Apaf-1 and caspase-3 mRNA and protein expression. (jneurosci.org)

For example, lncRNAs specific to spleen were nearby genes enriched in immune system related GO terms such as leukocyte activation. (usda.gov)
These findings highlight a new level of Shikimic acid (Shikimate) immune system regulation that optimizes gene diversity. (estme.org)

Therefore, modification of one of those eukaryotic translation initiation factors or changes in their gene expression may result in resistance. (bvsalud.org)
Because transcription initiation proceeds through multiple steps, this process provides multiple points for regulation. (nih.gov)
Early work suggested that the process and regulation of transcription initiation fundamentally differed between bacterial polymerase and higher organisms. (nih.gov)

Silencing of Velo led to constitutive expression of the IMD pathway dependent antimicrobial peptides (AMPs), and Escherichia coli stimulation further enhanced the AMP expression. (cnrs.fr)

However, for most of the 20th century, it was not clear how adaptations to oxygen flux were regulated at the fundamental level of gene expression. (nobelprize.org)
Developmental enhancers initiate transcription and are fundamental to our understanding of developmental networks, evolution and disease. (ens-lyon.fr)

Here, a new model and explanation is provided for biological regulation, applicable at any level of regulation, system and organism. (researchsquare.com)
Conventional MOs are typically used to constitutively disrupt targeted genes in an organism-wide manner. (cdc.gov)

Furthermore, this analyses confirmed the positive roles of CDK9 and Yorkie in regulating Mad-dependent gene expression in vivo. (sdbonline.org)
Here, we will present an overview of the different kinds of lncRNAs that alter gene expression, and what is known about their roles in regulating some of the key gonadotrope genes. (endocrine.org)

For example, genes associated with energy metabolism showed higher expression levels compared to those involved in specialized metabolism (Fig. S1B). (biorxiv.org)
This technique, for example, was used successfully to study the have to protect themselves from the products of their own extent of variations in penicillinase genes that generate secondary metabolism. (cdc.gov)

A similar decline in apoptotic susceptibility associated with downregulation of Apaf-1 expression as a function of developmental age was also found in cultured primary rat cortical neurons. (jneurosci.org)

In the nucleus, some are chromatin-associated, transcribed from transcriptional enhancers (eRNAs) and/or direct changes in the epigenetic landscape with profound effects on gene expression. (endocrine.org)
The macronucleus is a prominent feature of Paramecium, serving as the primary nucleus responsible for controlling gene expression and cellular functions. (philosophynews.com)

Catechol-o-methyltransferase enzyme activity and protein expression in human prefrontal cortex across the postnatal lifespan. (ox.ac.uk)
Conclusions In this work we have shown that the expression of gluQ rs, a gene codifying an enzyme involved in the formation of GluQ present on the tRNAAsp, is under the control of http://www.selleckchem.com/products/mek162.html the dksA promoter. (gp120-inhibitors.com)
We also anticipated that our cyclic cMO strategy could be adapted to accommodate enzyme-mediated activation. (cdc.gov)

Anatomy10

Organisms6

Diseases2

Chemicals and Drugs33

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes66

Disciplines and Occupations3

Information Science6

Health Care2

Differentiation14

Stages9

Pathways9

Target genes3

Detected differentially expressed1

Proteins7

Genome8

Biology2

Encode1

Promoters5

Regulate7

Transcriptional Activation2

Mice1

Phenotypes2

Developmentally regulated4

Chromatin structure1

Repression8

Regulatory8

Mutations2

Molecular5

Histone4

Drosophila2

Genomic1

Specific genes2

Upstream2

Humans1

Development18

Murine2

Cells8

Processes6

Regulates1

Cell20

Mechanisms3

Zygotic gene1

Regulator1

Alleles2

Regulators1

Epigenetic modifications4

Embryo2

Protein encoded by this gene1

Transcription Factor1

Adult2

Patterns of gene1

Poorly understood1

Temporal2

Tissues2

Metabolic1

Tumor supp1

Reproductive1

Tissue3

Methylation1

MRNA and protein1

Immune system2

Initiation3

Pathway1

Fundamental2

Organism2

Roles2

Metabolism2

Susceptibility1

Nucleus2

Enzyme3