Acidosis. Medical search. Frequent questions

Metabolic acidosis may result from either increased production of metabolic acids, such as lactic acid, or disturbances in the ability to excrete acid via the kidneys, such as either renal tubular acidosis or the acidosis of kidney failure, which is associated with an accumulation of urea and creatinine as well as metabolic acid residues of protein catabolism. (wikipedia.org)
Lactic acidosis is a medical condition driven by heightened levels of lactic acid in the bloodstream caused by an inadequate supply of oxygen to the body tissue or an altered metabolism mediated by drugs or toxins. (healthnews.com)
Lactic acidosis can occur due to the liver and kidneys' inability to filter lactic acid from the blood and break it down into glucose, the body's main energy source. (healthnews.com)
Lactic acidosis is caused by elevated levels of lactic acid in the blood due to several factors used to characterize the two types of lactic acidosis: type A and type B. Lactic acidosis type A is a common type resulting from an inadequate supply of oxygen to the blood tissue. (healthnews.com)
Lactic acidosis refers to lactic acid build up in the bloodstream. (mountsinai.org)
Metabolic acidosis is diagnosed through laboratory tests like arterial blood gas, blood ketones, basic metabolic panel, lactic acid test, urine pH, and urine ketones. (nursetogether.com)
Lactic acidosis typically occurs when lactic acid production exceeds clearance, often in the setting of impaired tissue oxygenation and defective mitochondrial oxygenation. (logicalimages.com)
D-lactic acidosis - Occurs in patients with short gut syndrome or malabsorption due to bacterial fermentation of large amounts of glucose and starch to organic acids, including D-lactic acid. (logicalimages.com)
Because of slow metabolism of D-lactic acid, systemic absorption leads to elevated plasma D-lactic acid levels and metabolic acidosis. (logicalimages.com)
This OnePager reviews the physiology of why/how we produce lactic acid and breaks lactic acidosis into two categories: Impaired O2 Delivery (Type A Lactic Acidosis) and Impaired O2 clearance/utilization (Type B Lactic Acidosis). (tactuum.com)
It is a form of metabolic acidosis, in which excessive acid accumulates due to a problem with the body's metabolism of lactic acid. (diabetestalk.net)

ADV7103 is being evaluated in a Phase III trial in Europe in children and adults with distal renal tubulopathy acidosis. (pharmtech.com)
Biopharmaceutical company, Advicenne, announced that the European Union has granted orphan drug designation to its lead candidate ADV7103 for the treatment of distal renal tubulopathy acidosis (dRTA). (pharmtech.com)
The term renal tubular acidosis (RTA) describes a group of disorders of acid-base homeostasis, in which the primary impairment is the excretion of fixed acid (distal RTA) or the reabsorption of filtered bicarbonate (proximal RTA). (bmj.com)
Mutations to the V-ATPase 'a4' or 'B1' isoforms result in distal renal tubular acidosis, a condition that leads to metabolic acidosis, in some cases with sensorineural deafness . (iiab.me)
Alternatively, distal renal tubular acidosis (type 1) can cause acidosis due to decreased hydrogen ion excretion in the collecting duct, even if GFR is preserved. (openanesthesia.org)

However, Hif1a deletion in all CCD cells prevented acidosis-induced IC subtype distribution, resulting in more severe acidosis. (jci.org)
Background Therapeutic hypothermia improves outcomes for asphyxiated infants, however not all infants born with severe acidosis are assessed as eligible for cooling and few data describe short-term clinical outcomes for the whole cohort of babies with severe perinatal acidosis. (bmj.com)
Results 69 infants were admitted with severe acidosis. (bmj.com)
However, both mechanisms can be overwhelmed if the body continues to produce too much acid, leading to severe acidosis and eventually heart problems and coma. (msdmanuals.com)

Type B lactic acidosis - Due to drug- or toxin-induced impairment of cellular metabolism, ischemia, nutritional deficient state, or rarely malignancy. (logicalimages.com)
Type B lactic acidosis is an underrecognized clinical entity that must be distinguished from type A (hypoxic) lactic acidosis. (northwestern.edu)
We briefly review type A versus type B lactic acidosis in this case report. (northwestern.edu)
Shah, S & Wald, E 2015, ' Type B lactic acidosis secondary to thiamine deficiency in a child with malignancy ', Pediatrics , vol. 135, no. 1, pp. e221-e224. (northwestern.edu)

If you are on any of these medications and have any symptoms of lactic acidosis, get medical help immediately. (webmd.com)
If you start to feel the symptoms of lactic acidosis while exercising, begin warming down right away. (webmd.com)
If you feel burning and other symptoms of lactic acidosis while exercising, this is your body's way of saying stop. (webmd.com)

The development of lactic acidosis depends on the magnitude of hyperlactatemia, the buffering capacity of the body, and the coexistence of other conditions that produce tachypnea and alkalosis (eg, liver disease, sepsis). (medscape.com)
Although comorbidities such as liver, kidney, and heart diseases are strongly associated with lactic acidosis, trauma or adverse reaction to medication can also contribute to the development of lactic acidosis. (healthnews.com)

X-rays of his chest showed fluid in the lungs (pulmonary edema), and bloodwork revealed an acid-base disorder (respiratory and metabolic acidosis). (cdc.gov)

The Metabolic Acidosis market report provides current treatment practices, emerging drugs, Metabolic Acidosis market share of the individual therapies, current and forecasted Metabolic Acidosis market Size from 2019 to 2032 segmented by seven major markets. (marketresearch.com)
The Metabolic Acidosis market outlook of the report helps to build the detailed comprehension of the historic, current, and forecasted Metabolic Acidosis market trends by analyzing the impact of current therapies on the market, unmet needs, drivers and barriers and demand of better technology. (marketresearch.com)

Nervous system involvement may be seen with acidosis and occurs more often with respiratory acidosis than with metabolic acidosis. (wikipedia.org)
Respiratory acidosis is a condition that occurs when your lungs can't remove all of the carbon dioxide produced by your body. (medlineplus.gov)
Chronic respiratory acidosis occurs over a long time. (medlineplus.gov)
Acute respiratory acidosis occurs when carbon dioxide builds up very quickly, before the kidneys can return the body to a state of balance. (medlineplus.gov)
It also occurs as a result on markedly increased transient metabolic demand (eg, postseizure lactic acidosis). (medscape.com)
Metabolic acidosis occurs when there is an accumulation of acid in the body. (nursetogether.com)
Respiratory acidosis typically occurs due to failure of ventilation and accumulation of carbon dioxide. (statpearls.com)
In chronic respiratory acidosis, renal compensation occurs gradually over the course of days. (statpearls.com)
Respiratory acidosis occurs when breathing difficulties allow carbon dioxide to build up in the body. (nucleusmedicalmedia.com)
Metabolic acidosis occurs when metabolic disorders allow certain acids to build up or cause the loss of basic buffers such as bicarbonate. (nucleusmedicalmedia.com)
Increased generation of acid occurs in processes such as lactic acidosis, ketoacidosis, and exposure to certain drugs/toxins. (openanesthesia.org)

4 mmol/L. It is the most common cause of metabolic acidosis and can be associated with an anion gap metabolic acidosis or mixed acid-base disorder. (logicalimages.com)
The mnemonic MUDPILES can be used to remember many of the common causes of anion gap metabolic acidosis: Methanol, Uremia, DKA, Propylene glycol, Iron or INH, Lactic acidosis, Ethylene glycol, and Salicylates. (roshreview.com)

Increasing the proportion of barley silage in a barley grain-based diet with distillers grains may reduce the incidence of subacute ruminal acidosis, but feed conversion efficiency also is reduced, Koenig et al. (feedstuffs.com)
These swings, in turn, can lead to subacute ruminal acidosis (SARA), a prevalent metabolic disorder found in high producing dairy herds. (hoards.com)

An increase in the production of other acids may also produce metabolic acidosis. (wikipedia.org)
Acid consumption from poisoning such as methanol ingestion, elevated levels of iron in the blood, and chronically decreased production of bicarbonate may also produce metabolic acidosis. (iiab.me)

Some people with chronic respiratory acidosis get acute respiratory acidosis when a serious illness worsens their condition and disrupts their body's acid-base balance. (medlineplus.gov)
On the contrary, chronic respiratory acidosis may be caused by COPD where there is a decreased responsiveness of the reflexes to states of hypoxia and hypercapnia. (statpearls.com)
Other individuals who develop chronic respiratory acidosis may have fatigue of the diaphragm resulting from a muscular disorder. (statpearls.com)
Chronic respiratory acidosis can also be seen in obesity hypoventilation syndrome, also known as Pickwickian syndrome, amyotrophic lateral sclerosis, and in patients with severe thoracic skeletal defects. (statpearls.com)

Acidosis is a process causing increased acidity in the blood and other body tissues (i.e., an increase in hydrogen ion concentration). (wikipedia.org)
For acidosis referring to acidity of the urine, see renal tubular acidosis . (iiab.me)

Identify the etiology of respiratory acidosis. (statpearls.com)
The frequency of respiratory acidosis in the United States and worldwide varies based on the etiology. (statpearls.com)
Lactic acidosis is the most common etiology in hospitalized patients and arises from increased anaerobic metabolism, which is triggered by either a defect in oxygen delivery to tissue, or a defect in oxygen utilization (at the level of the mitochondria). (openanesthesia.org)

The DelveInsight Metabolic Acidosis market report gives a thorough understanding of the Metabolic Acidosis by including details such as disease definition, symptoms, causes, pathophysiology, diagnosis and treatment. (marketresearch.com)
The diagnosis is made on biochemical analysis of blood (often initially on arterial blood gas samples), and once confirmed, generally prompts an investigation to establish the underlying cause to treat the acidosis. (diabetestalk.net)
The presence of metabolic acidosis with anion and osmolal gaps is an important clue to the diagnosis (Friedman et al. (cdc.gov)

In their classic 1976 monograph, Cohen and Woods classified the causes of lactic acidosis according to the presence or absence of adequate tissue oxygenation. (medscape.com)
Once oxygenation is restored, the acidosis clears quickly. (iiab.me)
Bicarbonate may be used to treat metabolic acidosis, and oxygenation and ventilation may be used to treat respiratory acidosis. (nucleusmedicalmedia.com)

https://www.doi.org/10.1007/s12325-020-01587-5 http://www.ncbi.nlm.nih.gov/pubmed/33367987?tool=bestpractice.com The acid retention or bicarbonate loss results in hyperchloremic metabolic acidosis marked by low serum bicarbonate and a normal anion gap. (bmj.com)
Conditions causing metabolic acidosis can include diabetes and kidney disease, ingestion of acidic drugs such as aspirin or toxins, alcoholism, and chronic diarrhea, resulting in significant bicarbonate loss. (nucleusmedicalmedia.com)
Proximal renal tubular acidosis (type 2) can also cause bicarbonate loss as its reabsorption from the urine is impaired. (openanesthesia.org)

Severe acute respiratory acidosis is a medical emergency. (medlineplus.gov)
In acute respiratory acidosis, there is a sudden elevation of PCO2 because of failure of ventilation. (statpearls.com)

People who have uncontrolled diabetes, or liver, kidney, or heart diseases are at a higher risk of developing lactic acidosis than those without these comorbidities. (healthnews.com)
Approximately 20% of patients with substantial chronic kidney disease (estimated glomerular filtration rate [eGFR] of 1,529) have metabolic acidosis. (medpagetoday.com)
According to a few small trials, treating metabolic acidosis in advanced chronic kidney disease (CKD) with sodium bicarbonate improves nutritional markers and slows progression to end-stage renal disease (ESRD). (medpagetoday.com)
Untreated renal (REE-nul) tubular acidosis can affect a child's growth, cause kidney stones , and other problems like bone or kidney disease . (teenshealth.org)
We found by growth factor quantitative PCR array that acidosis increases expression of mRNA encoding SDF1 (or CXCL12) in kidney cortex and isolated CCDs from mouse and rabbit kidney cortex. (jci.org)
When initiating treatment for metabolic acidosis, it's vital that the nurse reviews the results of ongoing lab testing, such as ABGs, electrolyte levels, ammonia levels, and kidney function. (nursetogether.com)
ROCKVILLE, Md. (October 22, 2020) - The American Kidney Fund (AKF) today announced a partnership with Tricida, Inc. to increase the understanding of chronic metabolic acidosis, a common complication of kidney disease that can cause serious effects, such as chronic kidney disease (CKD) progression, muscle atrophy and cardiac issues. (kidneyfund.org)
Complications of CKD, such as metabolic acidosis, create serious health problems, including patients' kidney disease getting worse," said LaVarne A. Burton, AKF president and CEO. (kidneyfund.org)
Tricida is honored to partner with the American Kidney Fund on this critical effort to increase awareness and understanding of metabolic acidosis in those with kidney disease," said Gerrit Klaerner, PhD, Tricida CEO and president. (kidneyfund.org)
We estimate that in the US, approximately 3 million patients with CKD have metabolic acidosis, and this initiative aligns with our goal to slow CKD progression by reducing the prevalence and severity of metabolic acidosis in these patients with kidney disease. (kidneyfund.org)
Metabolic acidosis is a buildup of acid in the body, which is common in people with kidney disease because their kidneys are not filtering their blood well enough. (kidneyfund.org)
Rising prevalence of kidney diseases in aging population and increased research & development for development of innovative therapies are expected to drive global metabolic acidosis treatment market growth. (reportsanddata.com)
Also, occurrence of chronic kidney diseases is increasing globally, that is eventually contributing in growth of the metabolic acidosis treatment market. (reportsanddata.com)
Acute Kidney Injury Interacts With Coma, Acidosis, and Impaired Perfusion to Significantly Increase Risk of Death in Children With Severe Malaria. (bvsalud.org)

The distinction may be relevant where a patient has factors causing both acidosis and alkalosis, wherein the relative severity of both determines whether the result is a high, low, or normal pH. (wikipedia.org)
To determine the effects of acute metabolic acidosis and alkalosis on leucine metabolism in vivo, mongrel dogs were infused with [1-14C]leucine for 8 h, along with NaCl, HCI, or NaHCO3 over the last 4 h. (nih.gov)
Total leucine carbon entry did not change from the basal value during saline infusion but increased (P less than .01) with acidosis and decreased (P less than .05) with alkalosis. (nih.gov)
During acidosis, total plasma essential and nonessential amino acid concentrations increased (P less than .05), whereas during alkalosis, total plasma essential and nonessential amino acid concentrations decreased (P less than .05). (nih.gov)
Is emphysema acidosis or alkalosis? (draftlessig.org)

[2] Kashoor I, Batlle D. Proximal renal tubular acidosis with and without Fanconi syndrome. (bmj.com)

Renal tubular acidosis is an illness that happens when the kidneys are damaged and can't remove a waste, called acid, from the blood. (teenshealth.org)
Decreased acid excretion in the kidneys can cause metabolic acidosis by two mechanisms. (openanesthesia.org)

Respiratory acidosis is a state in which there is usually a failure of ventilation and an accumulation of carbon dioxide. (statpearls.com)
Acidosis is caused by an overproduction of acid that builds up in the blood or an excessive loss of bicarbonate from the blood (metabolic acidosis) or by a buildup of carbon dioxide in the blood that results from poor lung function or depressed breathing (respiratory acidosis). (msdmanuals.com)
Metabolic acidosis is compensated for in the lungs, as increased exhalation of carbon dioxide promptly shifts the buffering equation to reduce metabolic acid. (iiab.me)

No clinical features are unique to lactic acidosis. (healthnews.com)
Since interventions aimed at correcting acidosis are either diet-based or over-the- counter, it is unlikely that a large randomized clinical trial will ever be sponsored by pharma. (medpagetoday.com)
It also helps to understand the Metabolic Acidosis clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug and the latest news and press releases. (marketresearch.com)
Renal tubular acidosis (RTA) is a clinical syndrome characterized by hyperchloremic metabolic acidosis with a normal serum anion gap. (bmj.com)

Does treating mild acidosis with either sodium bicarbonate or a diet rich in fruits and vegetables impact total mortality in patients with advanced CKD (eGFR of 1,530)? (medpagetoday.com)
Treatment therapy of metabolic acidosis particularly by sodium bicarbonate is not successful only in a few situations but likely harmful in other. (reportsanddata.com)

Signs and symptoms that may be seen in acidosis include headaches, confusion, feeling tired, tremors, sleepiness, flapping tremor, and dysfunction of the cerebrum of the brain which may progress to coma if there is no intervention. (wikipedia.org)
Severe metabolic acidosis can cause coma, shock, or death. (nursetogether.com)
AKI interacts with coma , acidosis , or impaired perfusion to significantly increase the risk of death in severe malaria . (bvsalud.org)

For example, having lactic acidosis due to sepsis means the doctor will take a targeted approach to managing sepsis. (healthnews.com)
Type A lactic acidosis - Associated with tissue hypoperfusion caused by circulatory failure from shock, which can be due to many things including sepsis, heart failure, hypovolemia, neurologic compromise, or respiratory failure. (logicalimages.com)

1. We have investigated the mechanisms responsible for the changes of systolic Ca2+ that occur in voltage-clamped rat ventricular myocytes during acidosis produced by application of the weak acid butyrate (30 mm). (manchester.ac.uk)
Metabolic acidosis can also occur as a result of abnormal metabolism. (msdmanuals.com)
Fetal death may occur due to fetal hypoxia and acidosis resulting from excessive maternal dehydration. (cdc.gov)

DelveInsight's "" Metabolic Acidosis- Market Insights, Epidemiology, and Market Forecast-2032 "" report delivers an in-depth understanding of the Metabolic Acidosis, historical and forecasted epidemiology as well as the Metabolic Acidosis market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan. (marketresearch.com)
The Metabolic Acidosis epidemiology division provide insights about historical and current Metabolic Acidosis patient pool and forecasted trend for every seven major countries. (marketresearch.com)
The disease epidemiology covered in the report provides historical as well as forecasted Metabolic Acidosis epidemiology scenario in the 7MM covering the United States, EU5 countries (Germany, Spain, Italy, France, and the United Kingdom), and Japan from 2019 to 2032. (marketresearch.com)
The epidemiology segment also provides the Metabolic Acidosis epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan. (marketresearch.com)

The project is titled "Association of Neurovascular Dysfunction with Fetal Acidosis and Mast Cell Activation. (wisc.edu)

The term congenital lactic acidosis (CLA) refers to a group of inborn errors of mitochondrial metabolism variably characterised by progressive neuromuscular deterioration and accumulation of lactate and hydrogen ions in blood, urine and/or cerebrospinal fluid, frequently resulting in early death. (bmj.com)
Metabolic acidosis refers to the increased hydrogen ion concentration and decreased bicarbonate that can result from one of three abnormalities: 1) Increased generation of acid, 2) Decreased excretion of acid, or 3) Loss of bicarbonate. (openanesthesia.org)

In work shared at the Western Canadian Dairy Seminar held in early March, researchers form the University of Alberta, set out to evaluate the variation in severity of SARA among lactating cows fed a high-grain diet and determine the factors characterizing acidosis tolerant and susceptible animals. (hoards.com)
Acidosis index, or the severity of SARA (pH below 5.8) divided by dry matter intake was determined for individual animals to assess the disease severity adjusted for feed consumption. (hoards.com)

With a persistent oxygen debt and overwhelming of the body's buffering abilities (whether from long-term dysfunction or excessive production), hyperlacticaemia and metabolic acidosis ensue, commonly referred to as lactic acidosis. (medscape.com)

Acidosis is any process that raises serum Hydrogen ion concentration, while overproduction of acid in bodily fluids is a condition known as metabolic acidosis. (reportsanddata.com)

Lactic acidosis, on the other hand, is associated with major metabolic dysregulation, tissue hypoperfusion, the effects of certain drugs or toxins, and congenital abnormalities in carbohydrate metabolism. (medscape.com)
Congenital lactic acidosis is secondary to inborn errors of metabolism, such as defects in gluconeogenesis, pyruvate dehydrogenase, the tricarboxylic acid (TCA) cycle, or the respiratory chain. (medscape.com)
On the other hand, lactic acidosis type B is a rare type resulting from altered metabolism by drugs or toxins. (healthnews.com)

Regarding ruminal acidosis, Chibisa, Beauchemin and Penner said, based on past research, there are indications that an increase in salivation could possibly compensate for a potential decrease in acid removal from the rumen via epithelial absorption during a bout of ruminal acidosis (abstract 1566/poster M280). (feedstuffs.com)
Severe rumen acidosis can be accompanied by systemic and often fatal acidosis. (extension.org)

Lactic acidosis is a medical condition characterized by the buildup of lactate (especially L-lactate) in the body, which results in an excessively low pH in the bloodstream. (diabetestalk.net)

Does treating mild acidosis result in delay in initiation of renal replacement therapy (RRT) for ESRD or result in an improved quality of life (QOL)? (medpagetoday.com)
Here, we employed whole-cell patch-clamp recordings to probe the effect of mild acidosis on the mechanosensitivity of the proprioceptive neurons of dorsal root ganglia (DRG) in mice. (myjournals.org)

How well you do depends on the disease causing the respiratory acidosis. (medlineplus.gov)

Several decades later, Huckabee's seminal work firmly established that lactic acidosis frequently accompanies severe illnesses and that tissue hypoperfusion underlies the pathogenesis. (medscape.com)

Numerous etiologies may be responsible for the presence of lactic acidosis, most commonly circulatory failure and hypoxia. (medscape.com)

In the moderately severe and severe forms of emphysema, the patient is likely to be hypoxemic and hypercarbic (respiratory acidosis). (draftlessig.org)

What Are the Signs & Symptoms of Renal Tubular Acidosis? (teenshealth.org)

A decrease in serum HCO3 of less than 24 mEq/L, is a sign of metabolic acidosis, which is caused by an increase in concentration of hydrogen ions in systemic circulation. (reportsanddata.com)

This will increase your "lactate threshold," making it less likely you'll get lactic acidosis. (webmd.com)
From stability constants it was calculated that the formation of Ca-lactate complexes accounts for the difference between lactic and hydrochloric acidosis. (uzh.ch)

The eventual development of status epilepticus, associated with a T(1) hypointense as well as T(2), fluid-attenuated inversion recovery, and diffusion-weighted hyperintense brain lesion led to pathologic and genetic testing that identified a A3243G mitochondrial DNA point mutation associated with mitochondrial, encephalomyopathy, lactic acidosis, and strokelike episodes. (nih.gov)
This case emphasizes that occipital epileptic seizures can be the only presenting and long-lasting sign in patients with mitochondrial, encephalomyopathy, lactic acidosis, and strokelike episodes. (nih.gov)
In rare chronic forms of lactic acidosis caused by mitochondrial disease, a specific diet or dichloroacetate may be used. (diabetestalk.net)

The ultimate goal in the management of metabolic acidosis is to correct and maintain a healthy balance of the body's acid-base levels. (nursetogether.com)
Metabolic acidosis is a serious disorder associated with an imbalance in the acid-base balance in the body. (nursetogether.com)

We present the case of a 4-year-old boy with medulloblastoma who presented with lactic acidosis in the setting of septic shock. (northwestern.edu)
Some medical conditions can also bring on lactic acidosis, including: Vitamin B deficiency Shock Some drugs, including metformin, a drug used to treat diabetes, and all nucleoside reverse transcriptase inhibitor (NRTI) drugs used to treat HIV/AIDS can cause lactic acidosis. (diabetestalk.net)

Review the history and physical exam findings typically seen in patients with respiratory acidosis. (statpearls.com)
Lactic acidosis is typically the result of an underlying acute or chronic medical condition, medication, or poisoning. (diabetestalk.net)

Furthermore, the symptomatic treatment is helping in preventing various patients from complications of the process of metabolic acidosis. (reportsanddata.com)

Anatomy2

Diseases14

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes3

Lactic acid11

Distal5

Severe acidosis4

Type B lactic acidosis4

Symptoms of lactic acidosis3

Development of lactic acidosis2

Respiratory and Metabolic Acidosis1

Forecasted Metabolic Acidosis market2

Occurs11

Anion gap metabolic2

Subacute ruminal acidosis2

Produce metabolic acidosis2

Chronic respiratory acidosis4

Acidity2

Etiology3

Diagnosis3

Oxygenation3

Bicarbonate loss3

Acute respiratory2

Kidney14

Alkalosis5

Proximal1

Kidneys2

Carbon dioxide3

Clinical4

Sodium bicarbonate2

Coma3

Sepsis2

Occur3

Epidemiology4

Fetal1

Refers2

Severity2

Excessive1

Hydrogen ion concentra1

Metabolism3

Rumen2

Buildup1

Mild2

Depends1

Tissue hypoperfusion1

Hypoxia1

Hypercarbic1

Signs1

Serum1

Lactate2

Mitochondrial3

Acid-base2

Shock2

Typically2

Complications1