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AcetyltransferasesHistone AcetyltransferasesCholine O-AcetyltransferaseChloramphenicol O-AcetyltransferaseAcetylationp300-CBP Transcription FactorsCarnitine O-AcetyltransferaseSerine O-AcetyltransferaseN-Terminal Acetyltransferase AN-Terminal Acetyltransferase EDihydrolipoyllysine-Residue AcetyltransferaseMolecular Sequence DataPromoter Regions, GeneticAcetyl Coenzyme ABase SequenceTranscription, GeneticHistonesCREB-Binding ProteinSaccharomyces cerevisiae ProteinsTransfectionPlasmidsAmino Acid SequenceE1A-Associated p300 ProteinN-Terminal AcetyltransferasesPyruvate Dehydrogenase ComplexN-Terminal Acetyltransferase BTranscription FactorsGene Expression RegulationSpermineCoenzyme ACloning, MolecularNuclear ProteinsVesicular Acetylcholine Transport ProteinsCell LineCholinergic FibersRegulatory Sequences, Nucleic AcidPolyaminesSpermidineTranscriptional ActivationLysineCysteine SynthaseDNA-Binding ProteinsAcetyl-CoA C-AcetyltransferaseRNA, MessengerTrans-ActivatorsRestriction MappingBinding SitesChromatinMutationEnhancer Elements, GeneticGene Expression Regulation, EnzymologicRecombinant Fusion ProteinsProtein BindingAnacardic AcidsAcetylcholinesteraseSaccharomyces cerevisiaeHeLa CellsChloramphenicol ResistanceGlucosamine 6-Phosphate N-AcetyltransferaseKineticsGenes, ReporterEscherichia coliDNASubstrate SpecificityGenes, RegulatorAcyltransferasesChloramphenicolRecombinant ProteinsPlatelet Activating FactorHistone DeacetylasesAmino-Acid N-AcetyltransferaseGenesSequence Homology, Amino AcidTumor Cells, CulturedCells, CulturedProtein Structure, TertiaryBiogenic PolyaminesCholineCell NucleusCarnitineEnzyme InductionNucleosomesCholinergic NeuronsSubstantia InnominataCell Cycle ProteinsGene ExpressionPutrescineAcetylcholineEuonymusPhosphate AcetyltransferaseGenes, BacterialGeobacillus stearothermophilusSequence DeletionOrnithine DecarboxylaseArylamine N-AcetyltransferaseMutagenesis, Site-DirectedAcetylcarnitineSequence Homology, Nucleic AcidDNA PrimersBlotting, Northern
ChloramphenicolP300EnzymesInhibitorsArylamineProteinNATsOrthologSubunitYeastHistonesKnockdownTransacetylaseAcetylationGeneActivityCatalyticProteinsCatalyzesAssayBiologicalBrainProductionEnzymeEnzymesP300 histone acetyltransferaseCholine acetyltransferase activityAcetylcholineLysineGcn5Histone deacetylasesInhibitorAcetyl groupTubulinRegulationUbiquitinationCharacterizationIrreversibleProtein calledMiceSignificantlyHumanExpression
Chloramphenicol2
  • antibodies to chloramphenicol acetyltransferase from abV Immune Response, Inc. (bio.net)
  • Last year, I ordered monoclonal antibodies to chloramphenicol acetyltransferase (CAT) at a company called abV Immune Response, Inc., Derry, New hamphire. (bio.net)
P3006
  • Citation: Ding Z, Cao J, Shen Y, Zou Y, Yang X, Zhou W, Guo Q and Huang C (2018) Resveratrol Promotes Nerve Regeneration via Activation of p300 Acetyltransferase-Mediated VEGF Signaling in a Rat Model of Sciatic Nerve Crush Injury. (vinomis.com)
  • In the affected ventral spinal cord, resveratrol enhanced the expression of several vascular endothelial growth factor family proteins (VEGFs) and increased the phosphorylation of p300 through Akt signaling, indicating activation of p300 acetyltransferase. (vinomis.com)
  • Inactivation of p300 acetyltransferase reversed the resveratrol-induced expression of VEGFs and motor repair in rats that had undergone sciatic nerve crush injury. (vinomis.com)
  • Resveratrol activated p300 acetyltransferase-mediated VEGF signaling in the affected ventral spinal cord, which may have thus contributed to the acceleration of nerve regeneration and motor repair. (vinomis.com)
  • The histone acetyltransferase (Head wear) p300/CBP is a transcriptional coactivator implicated in lots of gene regulatory pathways and protein acetylation events. (woofahs.com)
  • 1996). Within the ensuing years, p300/CBP provides been shown to be always a rather promiscuous acetyltransferase, with an increase of than 75 proteins substrates referred buy 1062159-35-6 to including p53, MyoD, and NFB (Gu et al. (woofahs.com)
Enzymes4
  • Histone acetyltransferase enzymes (HATs) are important therapeutic targets, but there are few cell-based assays available for evaluating the pharmacodynamics of HAT inhibitors. (nih.gov)
  • Arylamine N-acetyltransferases (NATs) are xenobiotic metabolizing enzymes that catalyze the acetyl-CoA-dependent acetylation of arylamines. (rcsb.org)
  • Arylamine N-acetyltransferases (NATs), a class of xenobiotic-metabolizing enzymes, catalyze the acetylation of aromatic amine compounds through a strictly conserved Cys-His-Asp catalytic triad. (pasteur.fr)
  • One challenge will be to develop specific inhibitors that discriminate between hARD1 and the many other enzymes, including the histone acetyltransferases, using acetyl-coenzyme A as acetyl donor. (umassmed.edu)
Inhibitors3
  • 2007). While research on histone deacetylases buy 1062159-35-6 possess resulted in the breakthrough of highly powerful compounds with scientific impact in tumor, the id of histone acetyltransferase inhibitors provides proved more difficult (Cole, 2008). (woofahs.com)
  • Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors. (reactionbiology.com)
  • Together with the powerful apoptotic effect (particularly notable if considering that anacardic acid and other KAT inhibitors are not cell permeable) appoint them as valuable biological tools to understand the mechanisms of lysine acetyltransferases. (cnr.it)
Arylamine4
  • Arylamine N-Acetyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • However, arylamine N-acetyltransferase should not be confused with the enzyme ARYLALKYLAMINE N-ACETYLTRANSFERASE which is also referred to as SEROTONIN ACETYLTRANSFERASE. (wakehealth.edu)
  • This graph shows the total number of publications written about "Arylamine N-Acetyltransferase" by people in this website by year, and whether "Arylamine N-Acetyltransferase" was a major or minor topic of these publications. (wakehealth.edu)
  • Below are the most recent publications written about "Arylamine N-Acetyltransferase" by people in Profiles. (wakehealth.edu)
Protein3
  • Link to all annotated objects annotated to protein acetyltransferase complex. (planteome.org)
  • Link to all direct and indirect annotations to protein acetyltransferase complex. (planteome.org)
  • Recently, several reports demonstrated that knockdown of the protein acetyltransferase hARD1 significantly reduced the growth rate of human cancer cell lines. (umassmed.edu)
NATs1
  • N terminal acetylation or CH3CO as epigenetic regulation of Anti- -Coenzyme A acetyltransferase 2 PAb by NATs.This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. (polabo.com)
Ortholog1
  • The CR3 regions of HAdV-3, 5, 9 and 40, but not HAdV-4 and 12 interact with the pCAF acetyltransferase, a mammalian ortholog of yeast Gcn5. (birmingham.ac.uk)
Subunit1
  • Orthologous to human NAA60 (N-alpha-acetyltransferase 60, NatF catalytic subunit). (nih.gov)
Yeast2
  • Acetylation of histone H3 lysine 56 (H3K56) by the fungal-specific histone acetyltransferase Rtt109 is important for yeast model organisms to survive DNA damage and maintain genome integrity. (umassmed.edu)
  • In yeast, transcriptional activation by several, but not all, of the CR3 regions requires the Gcn5 acetyltransferase component of SAGA. (birmingham.ac.uk)
Histones2
Knockdown1
  • N- acetyltransferase 10 knockdown significantly reduced both the total and ac4C acetylated levels of MMP1 mRNA and decreased its mRNA stability . (bvsalud.org)
Transacetylase1
  • Acetyltransferase (or transacetylase) is a type of transferase enzyme that transfers an acetyl group, a process called acetylation. (wikipedia.org)
Acetylation3
  • The main enzyme responsible for Nt-acetylation throughout the eukaryotic kingdom is the N-terminal acetyltransferase NatA. (lu.se)
  • N-acetyltransferase 10 promotes the progression of oral squamous cell carcinoma through N4-acetylcytidine RNA acetylation of MMP1 mRNA. (bvsalud.org)
  • N- acetyltransferase 10 (NAT10) is a crucial enzyme involved in mRNA acetylation , regulating target gene expression and biological functions of various diseases through mediating N4-acetylcytidine (ac4C) acetylation . (bvsalud.org)
Gene5
  • As part of a project on environmental disasters in minority populations, this study aimed to evaluate differences in the sequence of N-acetyltransferase 2 ( NAT2 ) as a metabolic susceptibility gene in yet unexplored ethnicities. (aacrjournals.org)
  • Lysine acetyltransferases (KATs) play a critical role in the regulation of central cellular functions such as gene expression and metabolism. (nih.gov)
  • The KAT6B gene provides instructions for making a type of enzyme called a histone acetyltransferase. (medlineplus.gov)
  • Little is known about the function of the histone acetyltransferase produced from the KAT6B gene. (medlineplus.gov)
  • Studies suggest that these mutations likely prevent the production of functional histone acetyltransferase from one copy of the KAT6B gene in each cell. (medlineplus.gov)
Activity3
  • E10 chick sympathetic ganglion cells display a cell contact-dependent rise in choline acetyltransferase (ChAT) specific activity over the first several days in culture. (rupress.org)
  • Histone acetyltransferase assays performed at Reaction Biology are radiometric activity assays using tritiated acetyl-Coenzyme A as a cofactor. (reactionbiology.com)
  • Variations of the alkyl chain length can change the activity profile from inhibition of both KAT3A/KAT2B (as derivative 2a) to the peculiar profile of pentadecylidenemalonate 1b, the first activator/inhibitor of histone acetyltransferases. (cnr.it)
Catalytic1
  • These findings overturn the conventional view, demonstrating that the catalytic triad of this family of acetyltransferases is plastic. (pasteur.fr)
Proteins1
  • With ~1750 lysine-acetylated proteins in the human proteome, Reaction Biology's histone acetyltransferase assays provide an important advantage in terms of assay flexibility as well as gold standard quality. (reactionbiology.com)
Catalyzes2
  • We previously showed that CD4 + T lymphocytes that express choline acetyltransferase (ChAT), which catalyzes the synthesis of the vasorelaxant acetylcholine, relay neural signals. (nih.gov)
  • Here, we show that the enzyme choline acetyltransferase (ChAT), which catalyzes the rate-limiting step of ACh production, is robustly induced in both CD4 + and CD8 + T cells during lymphocytic choriomeningitis virus (LCMV) infection in an IL-21-dependent manner. (lih.lu)
Assay4
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Choline Acetyltransferase (ChAT) in tissue homogenates, cell lysates and other biological fluids. (glideruniversity.org)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Choline Acetyltransferase (ChAT) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (glideruniversity.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Rat Choline Acetyltransferase (ChAT) in samples from tissue homogenates, cell lysates or other biological fluids. (glideruniversity.org)
  • All our histone acetyltransferase assay services are performed at our screening facility in Pennsylvania, US. (reactionbiology.com)
Biological1
  • Description: A sandwich ELISA kit for detection of Choline Acetyltransferase from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (glideruniversity.org)
Brain1
  • Estrogen Receptor Immunoreactivity in the Adult Primate Brain: Neuronal Distribution and Association with p75, trkA, and Choline Acetyltransferase. (bvsalud.org)
Production2
  • Arylalkylamine N-acetyltransferase) This enzyme is critical in the production of melatonin from serotonin. (myhappygenes.com)
  • These mutations lead to the production of a shortened histone acetyltransferase enzyme. (medlineplus.gov)
Enzyme7
  • The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland. (nih.gov)
  • For detailed information about [formate-C-acetyltransferase]-activating enzyme, go to the full flat file . (brenda-enzymes.org)
  • Choline acetyltransferase (ChAT), the acetylcholine synthesizing enzyme, is an important cholinergic marker whose levels/activity are reduced in aging and Alzheimer's disease (AD). (uwo.ca)
  • Solution of buffer used for diluting enzyme histone acetyltransferases (KAT). (signalchem.com)
  • The systematic name of this enzyme class is acetyl-CoA:taxan-10beta-ol O-acetyltransferase . (alchetron.com)
  • This enzyme is also called acetyl coenzyme A: 10-hydroxytaxane O-acetyltransferase . (alchetron.com)
  • In this study, we found that the E3 ligase Tom1 and deubiquitinating enzyme Ubp14 contributed to the regulation of ubiquitination and deubiquitination of acetyltransferase Gcn5, respectively, in Fusarium graminearum, the causal agent of Fusarium head blight of cereals . (bvsalud.org)
Enzymes3
  • Background: Histone acetyltransferase enzymes (HATs) are implicated in egulation of transcription. (diva-portal.org)
  • One challenge will be to develop specific inhibitors that discriminate between hARD1 and the many other enzymes, including the histone acetyltransferases, using acetyl-coenzyme A as acetyl donor. (umassmed.edu)
  • PmvE shares strong homologies with N(1)-spermidine/spermine acetyltransferase enzymes involved in the metabolism of polyamines. (unicatt.it)
P300 histone acetyltransferase1
  • Fig. 3: H3.3 phosphorylation stimulates p300 histone acetyltransferase activity in trans . (nature.com)
Choline acetyltransferase activity2
  • Brain region weights and choline acetyltransferase activity, an enzymatic marker for development of cholinergic nerve terminals, were within normal limits in the nicotine-exposed animals. (nih.gov)
  • The degree of reduction of choline acetyltransferase activity in cerebral cholinergic neurons is significantly correlated with the severity of dementia or cognitive impairments observed in Alzheimer's disease. (nih.gov)
Acetylcholine3
  • Here we show that choline acetyltransferase mediated by TAT protein transduction domain passes through the blood-brain barrier and enters the neurons in mice, increasing choline acetyltransferase and neurotransmitter acetylcholine contents. (nih.gov)
  • Choline acetyltransferase facilitates the production of a molecule called acetylcholine. (medlineplus.gov)
  • The mutations lead to decreased production of choline acetyltransferase or the production of a protein with decreased ability to aid in the production of acetylcholine. (medlineplus.gov)
Lysine4
Gcn55
  • Over the years, studies on Gcn5 structure-function have often formed the basis by which we understand the complex activities and regulation of the entire protein acetyltransferase family. (nih.gov)
  • This thesis describes the role of the conserved histone acetyltransferase (HAT) Gcn5 in transcriptional regulation in Schizosaccharomyces pombe. (diva-portal.org)
  • We also investigate the interactions between Gcn5 and other histone deacetylases and acetyltransferases and show overlapping functionality between Gcn5 and another histone acetyltransferase, Mst2, in stress response, regulation of subtelomeric genes and DNA damage repair. (diva-portal.org)
  • The histone acetyltransferase general control non-depressible 5 (Gcn5) plays a critical role in the epigenetic landscape and chromatin modification for regulating a wide variety of biological events. (bvsalud.org)
  • Our findings provide deep insights into the modification of acetyltransferase Gcn5 and its dynamic regulation via ubiquitination and deubiquitination. (bvsalud.org)
Histone deacetylases1
  • The key molecules involved in this dynamic process are histone acetyltransferase (HAT) and histone deacetylases (HDAC), which add acetyl group to histone and remove it from histone respectively [ 4 , 5 ]. (biomedcentral.com)
Inhibitor2
  • In this review, we provide an overview of our fundamental understanding of catalysis, regulation of activity and substrate selection, and inhibitor development for this archetypal acetyltransferase. (nih.gov)
  • NOC2 like nucleolar associated transcriptional repressor (NOC2L) was recently identified as a novel inhibitor of histone acetyltransferase (INHAT). (biomedcentral.com)
Acetyl group1
  • N-terminal acetyltransferases (NATs) transfer an acetyl group to the N-termini of proteins, and the major NATs in yeast and humans are NatA, NatB, and NatC. (hindawi.com)
Tubulin1
  • They watched how a protein called tubulin acetyltransferase (TAT) labels the inside of microtubules. (nih.gov)
Regulation1
  • Regulation of pineal serotonin N-acetyltransferase activity. (nih.gov)
Ubiquitination1
  • To our knowledge , this work is the most comprehensive analysis of a regulatory network of ubiquitination that impinges on acetyltransferase in filamentous pathogens. (bvsalud.org)
Characterization1
  • Characterization of rat hepatic acetyltransferase. (nih.gov)
Irreversible1
  • Krell, RD & Goldberg, AM 1973, ' The in vivo effects of irreversible inhibitors of choline acetyltransferase (CAT) ', Federation Proceedings , vol. 32, no. 3 (I). (johnshopkins.edu)
Protein called1
Mice1
  • The recombination TAT-choline acetyltransferase fusion protein injected intravenously improves the memory and cognitive dysfunction in Alzheimer's disease model mice induced by amyloid-beta peptide. (nih.gov)
Significantly1
  • Recently, several reports demonstrated that knockdown of the protein acetyltransferase hARD1 significantly reduced the growth rate of human cancer cell lines. (umassmed.edu)
Human2
  • We recently described the human protein acetyltransferase hARD1 (human Arrest Defective 1). (uib.no)
  • Conclusion: A human protein N-α-acetyltransferase is herein described. (uib.no)
Expression1
  • Violin plots show distribution of expression levels for N-acetyltransferase domain-containing protein (SMED30009746) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)