SchistosomiasisPrevalenceEndemicInfectionsJaponicumGenusSnailsIdentifying Schistosoma mansoniMorbidityPrevalentParasiticTana Delta District of KenyaBovis hybridsPraziquantel treatmentParasiteUrinaryInfestationHybridizationSchistosome speciesPopulationsCebio.orgGenomesExcretionKenyaParasitesMethodsWormsCercariaeMicroscopyAfricaSpecimensNecatorBulinusStoolEpidemiologyKenyan1991MalariaTreatmentCameroonHostsAdultGeneticDiagnosticEfficacy
Schistosomiasis24
- During ongoing surveillance of urogenital schistosomiasis in Chikhwawa District, Malawi, we encountered atypical S. haematobium eggs in urine samples from several infected children ( 5 ). (cdc.gov)
- In the second case, a 15 year old male presented with LUTS for a 1 year duration and was diagnosed to have schistosomiasis after eggs of Schistosoma haematobium were found in his urine. (biomedcentral.com)
- Urogenital schistosomiasis caused by Schistosoma haematobium is widely distributed across Africa and is increasingly being targeted for control. (biomedcentral.com)
- Several efforts are underway to control S. haematobium , including the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) program ( http://score.uga.edu/index.html ), which was established in 2008 to answer strategic questions about schistosomiasis control and elimination. (biomedcentral.com)
- BACKGROUND: The global distribution map of schistosomiasis shows a large overlap of Schistosoma haematobium- and S. mansoni-endemic areas in Africa. (itg.be)
- Diagnosis of schistosomiasis depends mainly on stool or urine microscopy for Schistosoma egg detection as well as immunoassays. (springeropen.com)
- The study aimed to detect the molecular prevalence of urine schistosomiasis and evaluate microscopic examination vs. PCR technique for detection of Schistosoma haematobium ( S. haematobium ) in urine of patients with suggestive symptoms or previous history of urine schistosomiasis coming from endemic regions. (springeropen.com)
- The current study aimed to assess the true (molecular) prevalence of S. haematobium in Sohag University Hospital, Governorate of Sohag, using the PCR assay to detect DNA of S. haematobium in urine vs. urine microscopy and to evaluate the diagnostic performance of microscopy and also to determine the associated variable that can be a predicator for the occurrence of urinary schistosomiasis. (springeropen.com)
- This cross-sectional study was performed for detection of S. haematobium for patients attending the Outpatient Clinic of Sohag University Hospital from August 2016 to July 2018, who had suggestive symptoms, previous history of urine schistosomiasis, or history of contact with water canals, or received Schistosoma treatment and were coming from endemic regions. (springeropen.com)
- This snail species acts as an intermediate host of Schistosoma haematobium and Schistosoma bovis, which cause human and animal schistosomiasis respectively. (africamuseum.be)
- Schistosoma haematobium , the agent of urogenital schistosomiasis, and related schistosomes are transmitted by members of the genus Bulinus . (unm.edu)
- The role of humans, animals and intermediate host snails in the parasites' epidemiology will be investigated, as previous studies revealed high prevalence of schistosomiasis and fascioliasis animals and schistosomiasis in humans, and the presence of Schistosoma haematobium / S. bovis hybrids. (swisstph.ch)
- ABSTRACT Schistosomiasis of the spinal cord is an uncommon but potentially curable form of schistosomiasis, if diagnosed and managed early. (who.int)
- Schistosomiasis is caused by several in areas known to be endemic for S. species of the genus Schistosoma . (who.int)
- Urogenital schistosomiasis (UGS) caused by Schistosoma haematobium is endemic in the South West Region of Cameroon. (bvsalud.org)
- This systematic review was conducted to identify gaps and recent progress on the efficacy of different regimens of praziquantel in treating schistosomiasis among children in sub-Saharan Africa where Schistosoma mansoni and S. haematobium are endemic. (biomedcentral.com)
- The review indicates that further investigations are necessary to conclusively determine efficacy of praziquantel on coinfection of S. haematobium and S. mansoni to formulate concrete guidelines on the use of repeated doses at 40 or 60 mg/kg for treating schistosomiasis. (biomedcentral.com)
- Schistosomiasis is a disease of great medical and veterinary importance in tropical and subtropical regions, caused by parasitic flatworms of the genus Schistosoma (subclass Digenea). (typeset.io)
- we evaluated praziquantel for therapy of active schistosoma mansoni infection in 15 rural egyptian males with hepatosplenic schistosomiasis. (liverpool.ac.uk)
- swamp rice farming: possible effects on endemicity of schistosomiasis mansoni and haematobia in a population in liberia. (liverpool.ac.uk)
- during a study in kenya of the relationships between schistosoma haematobium infection and anemia and growth, evidence was found to suggest that this infection was associated with splenomegaly in children, and that both splenomegaly and hepatomegaly regressed in children treated for urinary schistosomiasis, compared with a placebo group. (liverpool.ac.uk)
- Schistosomiasis is an acute and chronic parasitic disease caused by blood flukes (trematoda flat worms) of genus Schistosoma .FGS is mostly caused by the presence of S.haematobium eggs lodged in the female reproductive tract. (researchkey.net)
- Schistosomiasis (also called bilharzia) is a vector- borne disease caused by trematoda flat worms of the genus Schistosoma. (researchkey.net)
- Schistosoma haematobium and S. bovis are widespread schistosome species causing human and cattle schistosomiasis, respectively, in Africa. (imperial.ac.uk)
Prevalence7
- At baseline, the prevalence of S. haematobium was 34.3% (177/516). (biomedcentral.com)
- Surveys of 332 naturally infected bovines at eight abattoirs in Senegal, The Gambia and Mali were carried out to determine the prevalence of infection with Schistosoma bovis and S. curassoni and to pinpoint areas where the distribution of the species overlap. (typeset.io)
- Annual praziquantel treatment delivered to school children over 2 years significantly reduce prevalence, intensity of infection and reinfection of S. haematobium infection. (edctpalumninetwork.org)
- We measured prevalence of Schistosoma haematobium, Wuchereria bancrofti, Plasmodium falciparum, hookworm, and other geohelminths among school-aged children in four endemic villages in Kwale County, Kenya and explored the relationship between multiparasite burden, undernutrition, and anemia. (lshtm.ac.uk)
- A Spearman correlation coefficient matrix revealed an inverse relationship between site dT values for August 16, 1990 and February 14, 1991 and prevalence of Schistosoma mansoni in the 1935 and 1983 surveys. (lsu.edu)
- For S. haematobium, a positive association of site dT values and prevalence was seen for 1935 only. (lsu.edu)
- S. haematobium prevalence in 1935 was not correlated with the later surveys. (lsu.edu)
Endemic6
- The present study assessed Schistosoma haematobium and STH infection and morbidity patterns among school children in a hyper-endemic focus in the Tana River delta of coastal Kenya. (ac.ke)
- ABSTRACT Visceral leishmaniasis (VL) has shown endemic pattern and epidemic episodes in urban and rural areas, however, there are still gaps in knowledge with regards to disease transmission. (scielo.br)
- In parasite endemic areas, bacterial and parasitic co-infections may occur, however in Saint-Louis region which is a Schistosoma-endemic area, little is known about this association. (academicjournals.org)
- Thus, the evaluation of the impact bacterial and parasitic co-infection in the urinary tract should have a particular interest especially in Schistosoma endemic area and need further study to better understand the potential interactions. (academicjournals.org)
- relationships of s. haematobium, hookworm and malarial infections to growth 6 months after metrifonate treatment were studied in kenyan primary school children in an area where poor growth, s. haematobium and hookworm were common and malaria was endemic. (liverpool.ac.uk)
- Laboratory diagnosis are inadequate consequently, for women of reproductive age living in areas endemic for S. haematobium , FGS remains highly prevalent and under- diagnosed due to low index of suspicion among health-care professionals. (researchkey.net)
Infections13
- Atypical egg morphologies suggest a capacity for natural hybridization of S. haematobium with the bovine species S. mattheei , later confirmed with biochemical markers and experimental infections demonstrating viable progeny ( 3 ). (cdc.gov)
- Yet, little is known about the consequences of mixed Schistosoma infections for the human host. (itg.be)
- Here, we investigated the relationship between mixed Schistosoma infections and morbidity in the same population. (itg.be)
- CONCLUSIONS/SIGNIFICANCE: This is the first population-wide study on the relationship between mixed Schistosoma infections and morbidity. (itg.be)
- Reads were mapped against S. bovis and S. haematobium reference genomes to identify schistosome infections, and single nucleotide polymorphisms (SNPs) were scored using the Stacks pipeline. (africamuseum.be)
- The spinal cord is more frequently affected in Schistosoma mansoni or S. haematobium infections. (who.int)
- Ce sont les infections à Schistosoma mansoni ou à S. haematobium qui s'accompagnent le plus d'une atteinte de la moelle épinière. (who.int)
- Artesunate and praziquantel for the treatment of Schistosoma haematobium infections: a double blind, randomized, placebo-controlled study. (cermel.org)
- The search included studies published from 2008 to 2017 (August) with emphasis on the efficacy of praziquantel on S. haematobium and S. mansoni infections among preschool and school children. (biomedcentral.com)
- In the region of Saint-Louis, the urinary tract infections are dominated by bacterial infections including mainly E. coli and Klebsiella spp and may, for lesser extent, be caused by Schistosoma haematobium and Trichomonas vaginalis . (academicjournals.org)
- relationships of schistosoma haematobium, hookworm and malarial infections and metrifonate treatment to growth of kenyan school children. (liverpool.ac.uk)
- to obtain a better understanding of the possible influence of swamp rice farming on the patterns of schistosoma mansoni and schistosoma haematobium infections, the populations of two communities in rural liberia were studied. (liverpool.ac.uk)
- In the search for means to better prevent new Schistosoma infections, attention has returned to an older strategy for transmission control, i.e., chemical mollusciciding, to suppress intermediate host snail species responsible for S. mansoni and S. haematobium transmission. (scite.ai)
Japonicum5
- We assembled and aligned the S. haematobium sequences to the genomes of S. mansoni and S. japonicum , identifying microsatellite DNA loci across all three species and designing primers to amplify the loci in S. haematobium . (biomedcentral.com)
- Sequence conservation among S. haematobium, S. japonicum, and S. mansoni is relatively high, thus it should now be possible to identify markers that are universal among Schistosoma species (i.e., using DNA sequences conserved among species) , as well as other markers that are specific to species or species-groups (i.e., using DNA sequences that differ among species). (biomedcentral.com)
- Full genome-sequencing of additional species and specimens of S. haematobium, S. japonicum, and S. mansoni is desirable to better characterize differences within and among these species, to develop additional genetic markers, and to examine genes as well as conserved non-coding elements associated with drug resistance. (biomedcentral.com)
- There are three main species of Schistosoma that together infect over 200 million individuals, S. mansoni, S. haematobium and S. japonicum. (bibalex.org)
- The major causes of the disease are Schistosoma mansoni , Schistosoma japonicum and Schistosoma haematobium . (scialert.net)
Genus1
- Interactions between intermediate snail hosts of the genus Bulinus and schistosomes of the Schistosoma haematobium group. (ajtmh.org)
Snails4
- In West Africa, for example, species interactions with hybrid combinations of S. haematobium and the bovine or ovine species of S. bovis and S. curassoni are commonly encountered in humans and snails ( 3 ). (cdc.gov)
- In the present study, glucose, acid and alkaline phosphatases (ACP and ALP), α-amylase and lipase were measured for the first time in tissue homogenates of Biomphalaria arabica snails, molluscan intermediate host for Schistosoma mansoni in Saudi Arabia. (scialert.net)
- snails, and estimate its impact on local human Schistosoma infection.Methodology/Principal FindingsThe review was registered at inception with PROSPERO (CRD42013006869). (scite.ai)
- Eligible studies included published or unpublished mollusciciding field trials performed before January 2014 involving host snails for S. mansoni or S. haematobium, with a primary focus on the use of niclosamide. (scite.ai)
Identifying Schistosoma mansoni1
- We have now developed loop-mediated isothermal amplification (LAMP) assays for identifying Schistosoma mansoni and S. haematobium to facilitate large-scale evaluation of post-intervention transmission potential. (huji.ac.il)
Morbidity6
- Schistosoma-specific morbidity was assessed by ultrasound according to WHO guidelines. (itg.be)
- Schistosoma haematobium-specific bladder morbidity was observed in 83% and S. mansoni-specific hepatic fibrosis in 27% of the participants. (itg.be)
- Bladder morbidity was positively associated with S. haematobium infection intensity (OR = 1.9 (95% CI 1.3-2.9) for a 10-fold increase in intensity). (itg.be)
- They even tended to reduce the risk of S. haematobium-associated morbidity, suggesting a protective effect of S. mansoni infection on bladder morbidity. (itg.be)
- Assessment of morbidity in Schistosoma haematobium infection: current methods and future tools. (nih.gov)
- 8 ] speculated that IL-10 is important in regulating the human immune response to Schistosoma mansoni infection and that it is the main cytokine that plays part in the control of morbidity. (hindawi.com)
Prevalent2
- Both Schistosoma haematobium and Schistosoma mansoni are responsible for the burden of the disease although S. haematobium is more prevalent in the sub-Saharan region. (biomedcentral.com)
- This can be done in Ghana where S. haematobium is prevalent. (cancer.gov)
Parasitic1
- In the developing world, over 207 million people are infected with parasitic Schistosoma worms. (cdc.gov)
Tana Delta District of Kenya1
- Urinary cytokines in Schistosoma haematobium-infected schoolchildren from Tana Delta District of Kenya. (nih.gov)
Bovis hybrids1
- The recent emergence and persistent transmission of S. haematobium - bovis hybrids on the Mediterranean island of Corsica ( 4 ) demonstrates the public health impact of such genetic introgression. (cdc.gov)
Praziquantel treatment2
- One goal of the SCORE program is to understand and document whether changes in drug tolerance arise during different drug administration programs, and specific genetic assays are needed to better monitor population structure and potential changes in Schistosoma populations under praziquantel treatment. (biomedcentral.com)
- Inflammation dynamics after praziquantel treatment of Schistosoma haematobium reflected by urinary eosinophil cationic protein. (nih.gov)
Parasite3
- The distribution of Schistosoma bovis Sonsino, 1876 in relation to intermediate host mollusc-parasite relationship. (ajtmh.org)
- DESCRIPTION (provided by applicant): Bladder cancer in Africa is frequently associated with infection by the urinary trematode parasite, Schistosoma haematobium and has been the subject of several hospital-based studies. (cancer.gov)
- Schistosoma mansoni is one of the most widespread species, and its routine diag- nosis is based on microscopic detection of parasite eggs in stool samples. (cdc.gov)
Urinary1
- ABSTRACT An intervention study was conducted in Khamir, north of Sana'a, for control of urinary schis- tosomiasis using chemotherapy and health education. (who.int)
Infestation2
- La validité et le rapport coût-efficacité des bandelettes réactives comme outil de diagnostic rapide pour la recherche d'une infestation à Schistosoma haematobium ont également été évalués parallèlement à l'hématurie visible. (who.int)
- Un cas de triple infestation bilharzienne à Schistosoma mansoni. (parasite-journal.org)
Hybridization1
- The data provide indisputable evidence for the occurrence of bidirectional introgressive hybridization between a bovine and a human Schistosoma species. (typeset.io)
Schistosome species1
- Molecular analysis of atypical schistosome eggs retrieved from children in Malawi revealed genetic interactions occurring between human ( Schistosoma haematobium ) and livestock ( S. mattheei and S. bovis ) schistosome species. (cdc.gov)
Populations2
- Molecular tools, in particular, will allow researchers to determine whether changes in gene frequencies provide insight into the effectiveness of treatment, understand the impacts of treatment on the gene pool and population structure of Schistosoma parasites, and establish whether movement of humans from refugia or non-treated areas introduces new parasites into local populations [ 4 ]. (biomedcentral.com)
- This RD-PCR proved highly sensitive, detecting a single larval stage and as little as 0.78 ng of genomic DNA (gDNA) from an adult schistosome, providing a cost-effective, rapid and robust molecular tool for high-throughput screening of S. haematobium and S. bovis populations. (imperial.ac.uk)
Cebio.org1
- 13,790 primer pairs to amplify unique microsatellite loci in S. haematobium , (available at http://www.cebio.org/projetos/schistosoma-haematobium-genome ). (biomedcentral.com)
Genomes1
- The three Schistosoma genomes contained similar overall frequencies of microsatellites, but the frequency and length distributions of specific motifs differed among species. (biomedcentral.com)
Excretion1
- statistical methods analyzing changes in dispersion patterns of parasites among hosts were applied to schistosoma haematobium egg excretion data from a five-year study of a cohort of 1,400 boys in 3 villages in upper egypt. (liverpool.ac.uk)
Kenya1
- PCR-RFLP analysis of the ITS2 region to identify Schistosoma haematobium and S. bovis from Kenya. (ajtmh.org)
Parasites2
- Towards these ends, this thesis identifies bulinid species and the parasites they transmit and implicates certain species in the transmission of S. haematobium . (unm.edu)
- despite significant changes in mean density of the parasites in the first 4 years, the degree of aggregation of s. haematobium among the cohort did not change markedly in analysis of egg count data obtained semiannually. (liverpool.ac.uk)
Methods1
- METHODS: Schistosoma infection was assessed by microscopy. (itg.be)
Worms4
- After suprapubic aspiration, the cause of the obstructive uropathy was found to be several mature live worms of Schistosoma haematobium . (biomedcentral.com)
- A suprapubic puncture was done with extraction of several live worms which were confirmed to be S. haematobium in the laboratory (Fig. 1 ). (biomedcentral.com)
- This study aimed for assessment of antischistosomal properties of an antimalarial drug, mefloquine (MFQ), on juvenile and adult Schistosoma haematobium worms. (eg.net)
- S. were seen between 1997 and 2007 at The stools of al patients were positive haematobium worms are found in the the Neurosurgery Departments of the for S. mansoni eggs . (who.int)
Cercariae2
- We sequenced 1,058,114 random DNA fragments from clonal cercariae collected from a snail infected with a single Schistosoma haematobium miracidium. (biomedcentral.com)
- subcutaneous vaccination with cord factor (4.50 mg) and muramyl dipeptide (4.56 mg) 6 days before percutaneous exposure to 3000 schistosoma haematobium cercariae/baboon (c.p.b.) failed to protect naive baboons: baboons with a 7-month-old, 5000 c.p.b. s. haematobium primary infection had developed too strong a natural immunity to detect any protection attributable to vaccination. (liverpool.ac.uk)
Microscopy2
- Following a baseline study, S. haematobium egg load was determined using the urine filtration technique and microscopy. (biomedcentral.com)
- 2008) With predictions to colonize the lower pelvic venous system, especially the vesical plexus , eggs of S.haematobium are typically voided in urine and detected by urine microscopy ( Stothard et al ,2014). (researchkey.net)
Africa3
- Genetic analysis of S. haematobium group species in central and southern Africa is a high priority. (cdc.gov)
- HIV and Schistosoma haematobium prevalences correlate in sub-Saharan Africa. (yale.edu)
- Observations on natural and experimental interactions between Schistosoma bovis and S. curassoni from West Africa. (typeset.io)
Specimens2
- Urine specimens were analysed for Schistosoma haematobium ova. (digital-campus.org)
- no Schistosoma ova were detected in urine specimens. (cdc.gov)
Necator1
- In vitro viability assays were performed over a time course of 72 hours for Trichuris muris, Necator americanus, Ancylostoma ceylanicum, Heligmosomoides polygyrus, Strongyloides ratti, Schistosoma mansoni and Schistosoma haematobium. (unibas.ch)
Bulinus1
- Hybrid schistosomes recovered from the urine and faeces of children and the intermediate snail hosts of both parental species, Bulinus truncatus and B. globosus, presented a nuclear ITS rRNA sequence identical to S. haematobium, while the partial mitochondrial cox1 sequence was identified as S. bovis. (typeset.io)
Stool1
- Is PCR the Next Reference Standard for the Diagnosis of Schistosoma in Stool? (cdc.gov)
Epidemiology1
- Malaria in man : its epidemiology, clinical aspects and control , a review of recent abstracts from Tropical Diseases Bulletin and Abstracts on Hygiene and Communicable Diseases, January 1984-June 1986 / James Haworth. (who.int)
Kenyan1
- attempts to induce resistance to schistosoma mansoni and s. haematobium in kenyan baboons (papio anubis) using non-specific immunostimulants. (liverpool.ac.uk)
19911
- Idris, MA 1991, ' Diagnostic Mr 31/32000 proteins of Schistosoma mansoni (Sm31/32) and S. haematobium (Sh31/32): Stability and reaction conditions for prospective field tests ', Journal of Helminthology , vol. 65, no. 2, pp. 89-94. (elsevierpure.com)
Malaria1
- Fewer than 33% of refugees had evidence of an active infection known to cause splenomegaly at the time of assessment (via positive malaria antigen, hepatitis B antigen, or Schistosoma ova). (cdc.gov)
Treatment3
- Blood samples from the participants were assayed for total and S. haematobium (Sh13)-specific antibodies before and 2 years after annual rounds of treatment. (edctpalumninetwork.org)
- Schistosoma -infected children at baseline showed an increase in anti- Sh 13 IgG1 ( p = 0.005) and a decrease in Sh 13 IgG4 levels ( p = 0.012) following treatment. (edctpalumninetwork.org)
- Treatment was also observed to cause a reduction in schistosome-specific blocking IgG4 and an increase in Schistosoma -specific protecting IgG1. (edctpalumninetwork.org)
Cameroon1
- The aim of this study was to assess the efficacy and safety of praziquantel against Schistosoma haematobium among infected individuals in the Ikata-Likoko area of southwest Cameroon. (biomedcentral.com)
Hosts1
- This entailed mining available transcriptomic and/or genomic sequence datasets for the presence of homologues of known TIMPs, predicting secondary structures of defined protein sequences, systematic phylogenetic analyses and assessment of differential expression of genes encoding putative TIMPs in the developmental stages of A. suum , N. americanus and Schistosoma haematobium which infect the mammalian hosts. (biomedcentral.com)
Adult2
- The existence of adult Schistosoma haematobium worm proteins (Sh31/32) homologous to the diagnostic Sm3l/32 of S. mansoni is shown. (elsevierpure.com)
- Results concluded by this study elucidate promising MFQ antischistosomal efficacy on both juvenile and adult stages of S. haematobium with more evident effect on juvenile forms, which enforces the potential use of MFQ as an effective antischistosomal drug. (eg.net)
Genetic1
- Microsatellite DNA loci are genetic markers in wide use by Schistosoma researchers, but there are few primers available for S. haematobium . (biomedcentral.com)
Diagnostic4
- The validity and cost-effectiveness of reagent strips as a rapid diagnostic tool to screen for Schistosoma haematobium infection was also assessed along with visible haematuria. (who.int)
- RÉSUMÉ La schistosomiase médullaire est une forme rare mais potentiellement curable de la schistosomiase, lorsque le diagnostic a été posé au début de l'affection et que la prise en charge a été rapide. (who.int)
- Le présent article décrit les manifestations cliniques, le diagnostic et la prise en charge de la schistosomiase médullaire chez cinq patients admis dans les hôpitaux Shaab et Ibn Khaldoun de Khartoum entre 1997 et 2007. (who.int)
- A rapid diagnostic 'mulitplex' one-step polymerase chain reaction protocol (RD-PCR) was developed using cytochrome oxidase subunit 1 (COX1) mitochondrial DNA (mtDNA) to discriminate between S. haematobium and S. bovis. (imperial.ac.uk)
Efficacy1
- However, findings on efficacy of repeated doses in co-infection of S. mansoni and S. haematobium were not conclusive. (biomedcentral.com)