Polymorphism, GeneticPolymorphism, Single NucleotideProtein ConformationModels, MolecularGenetic Predisposition to DiseaseGene FrequencyAllelesMolecular Sequence DataPolymorphism, Single-Stranded ConformationalHaplotypesCase-Control StudiesAmino Acid SequenceProtein BindingBinding SitesGenotypePolymerase Chain ReactionProtein Structure, SecondaryProtein Structure, TertiaryBase SequenceCircular DichroismCrystallography, X-RayMolecular ConformationKineticsThermodynamicsGenetic Association StudiesMutationGenetic VariationLinkage DisequilibriumAsian Continental Ancestry GroupSpectrometry, FluorescenceAmino Acid SubstitutionProtein FoldingMagnetic Resonance SpectroscopyDNAMolecular Dynamics SimulationNucleic Acid ConformationSequence Analysis, DNALigandsNuclear Magnetic Resonance, BiomolecularGenetic MarkersHydrogen-Ion ConcentrationPhenotypeHomozygoteRisk FactorsProtein DenaturationStructure-Activity RelationshipModels, ChemicalTemperatureComputer SimulationEscherichia coliDNA PrimersHydrogen BondingEuropean Continental Ancestry GroupMethylenetetrahydrofolate Reductase (NADPH2)Promoter Regions, GeneticAmplified Fragment Length Polymorphism AnalysisChinaAbstracting and Indexing as TopicMutagenesis, Site-DirectedRecombinant ProteinsDNA Mutational AnalysisHeterozygoteCattleProtein Structure, QuaternaryProteinsExonsTryptophanPoint MutationSolutionsDimerizationAllosteric RegulationBacterial ProteinsPeptidesGlutathione TransferaseChromosome MappingCatalytic DomainOdds RatioFluorescence Resonance Energy TransferCatalysisMicrosatellite RepeatsAdenosine TriphosphateGenetic LinkageSpectrophotometry, UltravioletPeptide FragmentsEpitopesGenome-Wide Association StudySequence AlignmentPeptidyl-Dipeptidase ATime FactorsPhylogenyHydrolysisCysteineIntronsMutation, MissenseModels, GeneticGenetics, PopulationSolventsFluorescenceCatechol O-MethyltransferaseSubstrate Specificity