• When combined with chorea, as in cerebral palsy, the term "choreoathetosis" is frequently used. (wikipedia.org)
  • When chorea occurs in conjunction with athetosis, it is known as choreoathetosis. (abclawcenters.com)
  • Chorea is a continuous, random-appearing sequence of one or more discrete involuntary movements or movement fragments. (wikipedia.org)
  • Children with chorea appear fidgety and will often try to disguise the random movements by voluntarily turning the involuntary, abnormal movement into a seemingly more normal, purposeful motion. (wikipedia.org)
  • [2] Chorea , involuntary dance-like movement, is another very common symptom of neuroacanthocytosis. (wikidoc.org)
  • Patients may have difficulty walking due to muscle weakness and the involuntary and uncontrollable movement complications caused by parkinsonism and chorea. (wikidoc.org)
  • Many hyperkinetic movements are the result of improper regulation of the basal ganglia-thalamocortical circuitry. (wikipedia.org)
  • Although chorea consists of discrete movements, many are often strung together in time, thus making it difficult to identify each movement's start and end point. (wikipedia.org)
  • Unlike dystonic movements, chorea-associated movements are often more rapid, random and unpredictable. (wikipedia.org)
  • This subtype is the result of damage to the basal ganglia, the part of the brain responsible for regulating voluntary movements (14). (abclawcenters.com)
  • Glutaric acidemia I is an autosomal recessive metabolic disorder characterized by gliosis and neuronal loss in the basal ganglia and a progressive movement disorder that usually begins during the first year of life (Goodman et al. (beds.ac.uk)
  • Chorea is also the prominent movement featured in Huntington's disease. (wikipedia.org)
  • These syndromes, which include chorea acanthocytosis , McLeod syndrome , Huntington's disease-like 2 (HDL2) , and pantothenate kinase-associated neurodegeneration (PKAN), primarily affect the brain and the basal ganglia . (wikidoc.org)
  • Our findings suggest that there are differences in the perturbation of the basal ganglia-cortical circuits based on major clinical features. (e-jmd.org)
  • Excessive levels of these amino acids and their intermediate breakdown products can accumulate and cause damage to the brain, particularly the basal ganglia, which are regions that help control movement. (beds.ac.uk)
  • Chorea is also the prominent movement featured in Huntington's disease. (wikipedia.org)
  • According to the NIH , HD (aka Huntington's disease or Huntington's chorea) is a progressive brain disorder that causes uncontrolled movements, emotional problems, and loss of thinking ability (cognition). (trilinkbiotech.com)
  • However, we only had a handful of patients with underlying Huntington's chorea and Parkinson's disease. (medscape.com)
  • Chorea may result specifically from disorders of the basal ganglia, cerebral cortex, thalamus, and cerebellum. (wikipedia.org)
  • Overview of Movement and Cerebellar Disorders Voluntary movement requires complex interaction of the corticospinal (pyramidal) tracts, basal ganglia, and cerebellum (the center for motor coordination) to ensure smooth, purposeful movement. (msdmanuals.com)
  • Unlike dystonic movements, chorea-associated movements are often more rapid, random and unpredictable. (wikipedia.org)
  • And we found primarily chorea and athetosis , as well as eye movement abnormalities, like you mentioned - nystagmus and ophthalmoplegia , and even opsoclonus and myoclonus - in association with phenytoin. (medscape.com)
  • Although the function of this protein is unknown, it appears to play an important role in nerve cells (neurons) in the brain, primarily a group of nerve cells at the base of the brain known collectively as the basal ganglia. (trilinkbiotech.com)
  • CAG codes for glutamine, therefore an increase in the size of the CAG segment leads to the production of an abnormally long version of the huntingtin protein. (trilinkbiotech.com)
  • neurofibrillary tangles containing an abnormally phosphorylated tau protein are also present. (msdmanuals.com)
  • and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. (lookformedical.com)
  • When HD starts late in life, chorea tend to be a more prominent sign than slowness or stiffness. (hdscotland.org)
  • When this enzyme is lacking, purines are broken down but not recycled, producing abnormally high levels of uric acid. (medlineplus.gov)
  • And interestingly, about half of the patients who presented with this, for whom the levels were available, and also some other labs were available, had abnormally high creatinine. (medscape.com)
  • A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. (lookformedical.com)
  • When combined with chorea, as in cerebral palsy, the term "choreoathetosis" is frequently used. (wikipedia.org)