RadiofrequencyTumorsJournal for ImmunoTherapy of CancerChemotherapyRadiotherapyTherapiesThermalTreatmentsOncologyOutcomesSystemicSurgical resectionClinicalRadical nephrectomyUltrasoundCurativeCheckpoint inhibitorsBiomarkersTumor cellsPatientsTherapeuticHepatocellular2022TherapyPartialEfficacyDestroyImmunologicalLung cancerSurvivalTreatmentProstate tissueAblative techniquesLocalCancer cellsCombinationAdverse eventsTend
Radiofrequency8
- These ablation therapies can be combined with a systemic immunotherapy: Thermal ablation - local thermal ablation of tumor: Cryoablation Radiofrequency ablation High-intensity focused ultrasound ablation Laser ablation Photodynamic ablation Hyperthermia therapy Ablation with alpha radiation therapy A new type of ablation therapy that utilizes alpha radiation is now undergoing clinical trials for treatment of several types of solid tumors. (wikipedia.org)
- Combination therapy with radiofrequency ablation, cryoablation, and microwave ablation are all reviewed, and special attention has been paid to the addition of checkpoint blockades. (biomedcentral.com)
- This can be accomplished using extreme cold, known as cryoablation, or heat, known as radiofrequency ablation. (healthline.com)
- Radiofrequency ablation is done through the skin. (healthline.com)
- There have been multiple studies completed analyzing the outcomes of radiofrequency ablation (RFA) turbinate reduction. (medscape.com)
- Radiofrequency Ablation Beams of energy cause cancer cells to heat up and die. (cancerquest.org)
- At Premier Health, we use microwave ablation, radiofrequency ablation or NanoKnife® ablation. (premierhealth.com)
- If surgery is not an option, the tumor can be attacked using heat (radiofrequency ablation), cold (cryosurgery), or electricity (electrocoagulation), administered through a probe or needle. (sutterhealth.org)
Tumors11
- Combining ablation therapy of tumors with immunotherapy enhances the immunostimulating response and has synergistic effects for curative metastatic cancer treatment. (wikipedia.org)
- Thus, combinatorial ablation of tumors and immunotherapy is a way of achieving an autologous, in-vivo tumor lysate vaccine and treating metastatic disease. (wikipedia.org)
- Thermal ablation is an appealing modality to pair with such protocols, as tumors can be rapidly debulked (cell death occurring within minutes to hours), tumor antigens can be released locally, and treatment can be conducted and repeated without the concerns of radiation-based therapies. (jci.org)
- When the tumor burden was increased by implantation of 3 orthotopic tumors, successive primed ablation of 2 discrete lesions resulted in survival of 60% of treated mice as compared with 25% of mice treated with immunotherapy alone. (jci.org)
- There are a wide variety of ablation techniques designed to destroy solid organ tumors. (biomedcentral.com)
- Increasingly, renal cell cancers are diagnosed at an earlier stage, and nephron-sparing surgery, thermal ablation, and surveillance are gaining acceptance as a treatment of choice for smaller tumors. (medscape.com)
- However, ablation may be used for smaller tumors that cannot be removed with surgery, typically due to other medical conditions that are affecting your overall health. (healthline.com)
- In this report, the biologic functions of MDSC are defined and evidence linking MDSC with the response to cancer immunotherapies in solid tumors are reviewed. (iospress.com)
- We sought to determine whether neoadjuvant anti-CD20 immunotherapy with rituximab could reduce CD20+ B cell infiltration of prostate tumors in patients. (escholarship.org)
- It is shown that ultrasensitive single molecule arrays (Simoa) effectively detected proinflammatory biomarkers that are upregulated in response to the therapy in MN-sampled ISF, in plasma, and in tumors, supporting the feasibility of monitoring melanoma immunotherapy using MNs. (quanterix.com)
- However, not all patients respond to immunotherapy, acquired resistance remains a challenge, and responses are poor in certain tumors which are considered to be immunologically cold. (biomedcentral.com)
Journal for ImmunoTherapy of Cancer1
- Journal for ImmunoTherapy of Cancer (2023) 11 (8): e006608. (aacrjournals.org)
Chemotherapy3
- Treatment plan for early diagnosed patients include radiation therapy, tumor ablation, surgery, immunotherapy and chemotherapy. (intechopen.com)
- In addition, the review focuses on the current advanced therapeutic strategies for targeting PCSCs that are helping to prevent prostate cancer initiation and progression, such as microRNAs (miRNAs), nanotechnology, chemotherapy, immunotherapy, the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) gene-editing system, and photothermal ablation (PTA) therapy. (uaeu.ac.ae)
- Some patients also benefit from new chemotherapy and immunotherapy drugs. (premierhealth.com)
Radiotherapy1
- Lung cancer patients seem to be more prone to pneumonitis than patients with melanoma, Rohan commented, perhaps because lung cancer patients usually undergo radiotherapy before immunotherapy, and radiotherapy can itself cause pneumonitis. (medscape.com)
Therapies7
- Various local ablation therapies exist to induce necrosis of tumor cells and release tumor antigens to stimulate an immunological response. (wikipedia.org)
- Ablation and other local therapies. (rxwiki.com)
- I am looking into adjunct immunotherapy in combination with HIFU as it relates to enhancing tumoricidal effect of the combined therapies. (fusfoundation.org)
- PGEN ), a biopharmaceutical company specializing in the development of innovative gene and cell therapies to improve the lives of patients, today announces positive Phase 1 dose escalation and expansion cohort data as of the January 12, 2023 cutoff for the investigational, potential first-in-class PRGN-2012 off-the-shelf (OTS) AdenoVerse™ immunotherapy in patients with recurrent respiratory papillomatosis (RRP). (pipelinereview.com)
- The use of cell therapies, drivers of immune response, and trends in immunotherapy were the focus of the Immunotherapy Bridge (November 30th-December 1st, 2022), organized by the Fondazione Melanoma Onlus, Naples, Italy, in collaboration with the Society for Immunotherapy of Cancer. (biomedcentral.com)
- The use of cell therapies, drivers of immune response, and trends in immunotherapy were the focus of the Immunotherapy Bridge (November 30th-December 1st, 2022). (biomedcentral.com)
- Biological therapies, or immunotherapies , may be used to aid your body's immune system in fighting the disease. (sutterhealth.org)
Thermal13
- Nanotechnology in thermal ablation and immunotherapy Currently nanotechnologies has been continuously developed for cancer immunotherapy for their versatility in integration of therapeutic and diagnostic (or termed 'theranostic') multimodalities. (wikipedia.org)
- In a syngeneic model of epithelial cancer, we found that 7 days of immunotherapy (TLR9 agonist and checkpoint blockade), prior to thermal ablation, reduced macrophages and myeloid-derived suppressor cells and enhanced IFN-γ-producing CD8 + T cells, the M1 macrophage fraction, and PD-L1 expression on CD45 + cells. (jci.org)
- Alternatively, when immunotherapy was begun immediately after thermal ablation, the abscopal effect was diminished and none of the mice within the cohort exhibited a complete response. (jci.org)
- Two mechanisms have potential to impact the efficacy of immunotherapy when begun immediately after thermal ablation: mechanical changes in the tumor microenvironment and inflammatory-mediated changes in immune phenotype. (jci.org)
- A ) Regimen of thermal ablation in mice orthotopically transplanted with neu deletion line (NDL) tumor biopsies in the fourth and ninth mammary fat pad. (jci.org)
- B and C ) Magnetic resonance-guided focused ultrasound (MRgFUS) ablation protocol and temperature mapping for thermal ablation in vivo (white color indicates minimum threshold of 70°C). ( B ) T1w images of localized region to be ablated (red dotted circle). (jci.org)
- Thermal ablation did not reduce viable ( M ) contralateral tumor tissue ( n = 3). (jci.org)
- In particular, immune modulating drugs have the potential to enhance the systemic anticancer immune effects induced by locoregional thermal ablation. (biomedcentral.com)
- In clinical routine, therapeutic techniques such as thermal ablation and surgical resection are used to target local malignancies for destruction. (biomedcentral.com)
- Here we describe the development of FUS-activated therapeutic bacteria in which a brief thermal stimulus activates sustained release of anti-cancer immunotherapy. (nature.com)
- Whole gland TULSA-PRO and HIFU outcomes: Is it time to give up on thermal ablation for prostate cancer? (prostatecancer.news)
- Does thermal ablation completely ablate the cancer in the ablation zone? (prostatecancer.news)
- In about a third of favorable-risk patients, the cancer remained viable in spite of the thermal ablation. (prostatecancer.news)
Treatments3
- Immunotherapy These treatments are designed to overcome the immune system blocks created by cancer cells. (cancerquest.org)
- These new approaches are focused on patients with an inadequate response to current treatments, with emerging evidence of improved responses in various cancers with new immunotherapy agents, often in combinations with existing agents. (biomedcentral.com)
- While she emphasised the need to tackle the well-known preventable risk factors, she said that there is 'good news' on the horizon with the 'potentially game-changing' research into treatments such as immunotherapy. (medscape.com)
Oncology2
- As immunotherapy treatment continues to be utilized more frequently, the guidelines will be essential to helping nurses understand and mitigate the potential side effects," commented coauthor Anne Fraser, oncology nurse practitioner from New Zealand, who is chair of the IASLC Nurse and Allied Health Committee. (medscape.com)
- During the meeting, an expert noted the practical advice that is provided by the guidelines on managing immunotherapy toxicities produced by the European Society of Medical Oncology, which were published earlier this year in the Annals of Oncology . (medscape.com)
Outcomes3
- With increasing globalization and advancements in modern medicine, novel therapeutic approaches such as targeted molecular therapy [ 4 ], immunotherapy [ 5 ], and latent/residual tumor cell ablation have been used to improve clinical outcomes for cancer patients, but the prognosis for patients with gastric cancer remains poor. (hindawi.com)
- Numerous clinical trials and real-world experience provide evidence of improved response and survival outcomes with multiple immunotherapy agents and different combinations in various cancers. (biomedcentral.com)
- Here, MSC and peripheral blood mononuclear cells (PBMC) coculture is used to construct HCC organoid-on-a-chip mimicking original TME and provide a high-throughput drug-screening platform to predict outcomes of anti-HCC immunotherapies. (bvsalud.org)
Systemic1
- This aspect of ablation is responsible for its ability to trigger a systemic antitumor immune response where surgical resection would not [ 2 , 11 ]. (biomedcentral.com)
Surgical resection1
- Though the goals of ablation are similar to those of surgical resection, ablation differs in that the tumor material is left in situ. (biomedcentral.com)
Clinical5
- To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy, the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized, and clinical safety and efficacy also need to be proven. (nature.com)
- Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy, which will inspire further clinical investigations and eventually benefit cancer patients. (nature.com)
- Among tumor immunotherapies, neoantigen vaccines are in early human clinical trials and have demonstrated substantial efficiency. (wjgnet.com)
- Human clinical trials that investigate possible MDSC modulators are highlighted, and therapeutic strategies to leverage MDSC biology in bladder cancer immunotherapy are outlined. (iospress.com)
- Resistance to cancer immunotherapy continues to impair common clinical benefit. (nki.nl)
Radical nephrectomy1
- For patients with localized disease, partial or radical nephrectomy is the standard of care for most, and surveillance or ablation can be considered in a subset of patients with stage I disease. (onclive.com)
Ultrasound1
- Focused ultrasound ablation and delivery of nanoparticulate stimulator of interferon genes agonist are used as model immunotherapies. (quanterix.com)
Curative2
- Combining immunotherapy (ie: checkpoint inhibitors, CAR-T cell therapy) and vaccine adjuvants (ie: interferon, saponin) with ablation synergizes the immune reaction, and can treat metastatic disease with curative intent. (wikipedia.org)
- In summary, we found that immunotherapy begun before ablation can be curative and can enhance efficacy in the presence of a high tumor burden. (jci.org)
Checkpoint inhibitors2
- In this respect, the introduction of checkpoint inhibitors to unleash the activity of tumor-reactive T cells has been a milestone in cancer immunotherapy. (nature.com)
- This has led to the need for new immunotherapy-based approaches, including adoptive cell transfer (ACT), therapeutic vaccines, and novel immune checkpoint inhibitors. (biomedcentral.com)
Biomarkers1
- Here, a monitoring strategy for melanoma immunotherapy is investigated by longitudinal sampling of biomarkers in the skin ISF using Hyaluronic acid (HA)-based microneedles (MNs). (quanterix.com)
Tumor cells2
- Ablation involves destroying the tumor cells. (healthline.com)
- TSC2 ablation strongly augmented tumor cell sensitivity to CTL attack in vitro and in vivo, suggesting one of its functions is to critically protect tumor cells. (nki.nl)
Patients7
- The guidelines are aimed at nurses and clinicians who are treating lung cancer patients with immunotherapy, she said. (medscape.com)
- One problem is that some patients do not want to report adverse events, because they are concerned that the immunotherapy might then be stopped. (medscape.com)
- Another problem involves patients who travel some distance to receive the immunotherapy and then develop an adverse effect after returning home. (medscape.com)
- This is the first study to treat patients prior to surgical prostate removal with an immunotherapy that targets B-cells. (escholarship.org)
- Following the failure of TKIs in the adjuvant setting, pembrolizumab (Keytruda) was studied in the phase 3 KEYNOTE-564 trial (NCT03142334), randomizing 994 patients 1:1 to 1 year of adjuvant immunotherapy vs placebo. (onclive.com)
- Real-time monitoring of immune state and response to therapy can provide a means to stratify patients and increase the number of responders who will benefit from approved and emerging immunotherapies. (quanterix.com)
- In conclusion, the study successfully constructs microengineered organoid-on-a-chip to mimic TME for high-throughput drug screening, providing novel platform to predict immunotherapy response of HCC patients. (bvsalud.org)
Therapeutic2
- There is no approved therapeutic treatment for RRP and the current standard-of-care is repeated endoscopic debulking with ablation or excision of papillomatous lesions. (pipelinereview.com)
- This has resulted in the development of additional immunotherapy-based approaches, including adoptive cell transfer (ACT), therapeutic vaccines, and inhibitors of other immune checkpoints. (biomedcentral.com)
Hepatocellular1
- Background A better understanding of the molecular mechanisms that manifest in the immunosuppressive tumor microenvironment (TME) is crucial for developing more efficacious immunotherapies for hepatocellular carcinoma (HCC), which has a poor response to current immunotherapies. (bmj.com)
20221
- While the KEYNOTE-564 data were impressive, additional recent perioperative immunotherapy trials presented at the 2022 ESMO Congress have complicated the treatment landscape. (onclive.com)
Therapy6
- however, there is emerging evidence that focal therapy can have a positive or negative impact on the efficacy of immunotherapy. (jci.org)
- If you're at a high risk of recurrence, your doctor may recommend targeted therapy or immunotherapy after surgery. (healthline.com)
- There are also other options, such as immunotherapy or targeted therapy . (healthwise.net)
- A major breakthrough in cancer therapy is immune checkpoint inhibitor (CPI)-based immunotherapy which has been approved by the FDA for the treatment of multiple types of cancers ( 1 ). (frontiersin.org)
- There are number of potential advantages to ACT therapy compared with other immunotherapies. (biomedcentral.com)
- Another treatment option for liver cancer is to use ablation therapy. (premierhealth.com)
Partial1
- When these treatment options fail, surgical options such as corticosteroid injections, cryosurgery, electrocautery ablation, turbinate out-fracture, microdebrider-assisted inferior turbinoplasty (MAIT), submucous resection, and partial turbinate resection may be considered. (medscape.com)
Efficacy2
- Further studies are warranted to improve the efficacy of IL-15cx as an immunotherapy for breast cancer. (frontiersin.org)
- Long-term efficacy is identical between the two, though monopolar ablation is associated with less pain and earlier symptom improvement. (medscape.com)
Destroy1
- Ablation uses gas or electrical current to destroy the cancer calls. (rxwiki.com)
Immunological1
- We used mass cytometry (CyTOF) and orthotopic cancer mouse models to analyze overall immunological changes after growth differentiation factor 15 (GDF15) gene ablation in HCC. (bmj.com)
Lung cancer1
- YOKOHAMA, Japan ― New guidelines on how to deal with immunotherapy adverse events were launched here at the 18th World Conference on Lung Cancer (WCLC). (medscape.com)
Survival1
- IL-15 is considered superior to IL-2 for cancer immunotherapy due to its strong bioactivity in improving CD8 + T and natural killer (NK) cell survival, proliferation and cytotoxic function ( 8 ). (frontiersin.org)
Treatment7
- Combinatorial ablation and immunotherapy is an oncological treatment that combines various tumor-ablation techniques with immunotherapy treatment. (wikipedia.org)
- Continued treatment with immunotherapy alone or with immunotherapy combined with ablation (primed ablation) then resulted in a complete response in 80% of treated mice at day 90, and primed ablation expanded CD8 + T cells as compared with all control groups. (jci.org)
- D - F ) NDL tumor growth following MRgFUS ablation ( n = 7) compared with no-treatment (NT) control NDL tumor growth ( n = 34 total, 8 representative growth curves shown for this individual study). (jci.org)
- The less severe toxicities are coded green, to signify that treatment with immunotherapy should be continued. (medscape.com)
- [ 1 ] Medical treatment strategies include oral and intranasal antihistamines, intranasal corticosteroids, saline rinses, and allergen immunotherapy, as well as short-term agents such as oral and topical decongestants. (medscape.com)
- In mouse models, anti-CD20 antibody ablation of B-cells delayed PCa regrowth post-treatment. (escholarship.org)
- He studied whole-gland ablation because current FDA rules only permit ablation for removal of prostate tissue (like a TURP), but not for treatment of prostate cancer. (prostatecancer.news)
Prostate tissue1
- Q: How important is the FDA approval of HIFU for the ablation of prostate tissue? (fusfoundation.org)
Ablative techniques1
- Recently, interest has shifted towards exploring the potential synergy between ablative techniques and immunotherapies. (biomedcentral.com)
Local1
- MRgFUS ablation promotes local antitumor immune response. (jci.org)
Cancer cells1
- Ablation - using heat or the cold to kill cancer cells. (express.co.uk)
Combination1
- With this review, we will summarize the data gathered from the study of combination ablation immunotherapy in animal models (Table 1 ). (biomedcentral.com)
Adverse events1
- Timely evaluation of immunotherapy adverse events is essential, as they can become severe or even life-threatening," commented Hossein Borghaei, DO, medical oncologist at the Fox Chase Cancer Center in Philadelphia, Pennsylvania. (medscape.com)
Tend1
- The immune responses induced by ablation monotherapy are well documented, but independently they tend to be incapable of evoking a robust antitumor response. (biomedcentral.com)