Cholesterol mobilization involves adipose tissue ATP-binding cassette transporter A1 (ABCA1), which has recently been shown to contribute to HDL biogenesis in vivo ( 9 , 10 ). (diabetesjournals.org)
ATP-binding cassette transporters ABCA1 and ABCG1 primarily mediate the efflux of cholesterol from peripheral cells. (diabetesjournals.org)
LXRs also transcriptionally regulate the cholesterol efflux transporters ABCA1 and ABCG1, and deficiency of ABCA1 is associated with decreased body weight ( 18 ), while ABCG1 deficiency protects against diet-induced obesity ( 19 ). (diabetesjournals.org)
We aimed to determine whether DNA methylation and mRNA levels of the ABCA1 and ABCG1 genes in EAT and subcutaneous adipose tissue (SAT) were associated with CAD. (biomedcentral.com)
ABCA1 and ABCG1 mRNA levels in EAT and SAT samples were analyzed using real time polymerase chain reaction, ABCA1 protein levels in EAT samples were assessed by western blotting. (biomedcentral.com)
ABCA1 and ABCG1 DNA methylation analysis was performed in 24 samples from the CAD group and 9 samples from the NCAD group via pyrosequencing. (biomedcentral.com)
CAD is associated with ABCA1 and ABCG1 DNA hypermethylation in EAT. (biomedcentral.com)
Cholesterol efflux from adipocytes is mediated by the cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and ATP-binding cassette G1 (ABCG1). (biomedcentral.com)
ABCA1 regulates the formation of nascent high-density lipoprotein (HDL) via cholesterol efflux to lipid free apolipoprotein A-1, whereas ABCG1 mediates cholesterol transport to the HDL fraction [ 13 ]. (biomedcentral.com)
However, whether ABCA1 and ABCG1 activity plays a role in EAT of CAD patients remains unknown. (biomedcentral.com)
ABCA1 and ABCG1 transporters are suspected to play a function in CCA lipid homeostasis. (scholarsresearchlibrary.com)
Methodology: The expression and localization of ABCA1 and ABCG1 were investigated via western blot analysis and immunocytochemistry, respectively. (scholarsresearchlibrary.com)
Correspondingly, localization of ABCA1 used to be exhibited around the nucleus while ABCG1 sample was greater scattered during cytoplasm. (scholarsresearchlibrary.com)
Cholesterol efflux capacity, especially ATP binding cassette transporter A1 (ABCA1) dependent capacity, has been proposed to be a likely mediator of arterial stiffness. (biomedcentral.com)
As the major cell-surface transporter, ABCA1 appears to be the main contributor to arterial stiffness changes in terms of structural and cellular function. (biomedcentral.com)
stream Reductions in the expression levels of these receptors resulted in decreased cholesterol efflux to apoA-I and HDL.163 Further, consistent with other studies,165-169 it was found that diabetes mellitus enhanced both atherosclerosis progression and impaired regression and that global deletion of RAGE overcame these defects by restoration of ABCA1 and ABCG1, promoting macrophage CEC despite ongoing hyperglycemia.163,170. (skanestugan.se)
ABCA1 and ABCG1 with subsequent delivery from peripheral tissues to the liver. (omicsdi.org)
Cholesterol content, cholesterol efflux, and ABCA1 and ABCG1 mRNA expression were measured. (omicsdi.org)
Kidney, spleen, and bone marrow-derived macrophages from APOL1-G1 and -G2 mice showed increased cholesterol accumulation and decreased ABCA1 and ABCG1 mRNA levels. (omicsdi.org)
In agreement with the reduced preβ-HDL particles, cholesterol efflux capacity mediated by the transporters ABCA1 and ABCG1 was reduced in AD patients' plasma. (biomedcentral.com)
Liver X receptor (LXR) agonism demonstrated active regulation of ABCA1 and ABCG1, but not ABCA5 or SCARB1, in human HFs and ORS keratinocytes via qPCR, in addition to LXR regulating cholesterol efflux to apolipoprotein A1 and high-density lipoprotein. (hud.ac.uk)
Lipid6
These transporters promote unidirectional cholesterol efflux to lipid-poor apolipoprotein A-I (apoA-I), apoE, or HDL particles, respectively, and are under the transcriptional control of liver X receptors (LXRs), master intracellular sensors that are activated in response to cholesterol biosynthetic intermediates and oxysterols ( 11 , 12 ). (diabetesjournals.org)
Mice lacking the ATP-binding cassette transporter G1 (ABCG1) develop chronic inflammation in the lungs, which is associated with the lipid accumulation (cholesterol, cholesterol ester, and phospholipid) and cholesterol crystal deposition that are characteristic of atherosclerotic lesions and pulmonary alveolar proteinosis. (ulpgc.es)
Indeed, despite chronic lipid accumulation and inflammation, hyperlipidemic mice lacking ABCG1 develop smaller atherosclerotic lesions compared with controls. (ulpgc.es)
PAP alveolar macrophages are foamy, lipid-filled cells with impaired surfactant clearance and markedly reduced expression of the transcription factor peroxisome proliferator-activated receptor gamma (PPARγ) and the PPARγ-regulated ATP binding cassette (ABC) lipid transporter, ABCG1. (ecu.edu)
Lipid transporters beam signals from cell membranes. (leejylab.org)
High-density lip1
The initial and rate-limiting step of cholesterol efflux is the transport of cellular free cholesterol to high-density lipoprotein (HDL) by cholesterol transporters, of which the best characterized are the ATP binding cassette transporter (ABC) A1, ABCG1 and scavenger receptor BI (SR-BI) [ 12 ]. (biomedcentral.com)
QN upregulated the mRNA levels of adenosine triphosphate (ATP)-binding cassette subfamily A1, ATP-binding cassette subfamily G1, and scavenger receptor class B type 1, which are related to cholesterol efflux. (pnfs.or.kr)
MRNA expression1
Results Mean PPARγ and ABCG1 mRNA expression increased 2.8 and 5.3-fold respectively (p ≤ 0.05) after treatment. (ecu.edu)
Proteins6
ATP-binding cassette (ABC) protein family encode for membrane proteins involved in the transport of various biomolecules through the cellular membrane. (biomedcentral.com)
The present study gives a comprehensive transcriptome analysis of ABC proteins from C. rogercresseyi, providing relevant information about transporter roles during ontogeny and in relation to delousing drug responses in salmon lice. (biomedcentral.com)
The ATP-binding cassette (ABC) proteins family is ubiquitous in the animal kingdom, and has even been found in plants. (biomedcentral.com)
Most of these ABC proteins are integral membrane proteins that use ATP to transport biomolecules through the plasma membrane [ 12 ]. (biomedcentral.com)
It is possible to divide ABC transporters into the following two groups: those present only in prokaryotes and which require substrate-binding proteins for transport, and those found only in eukaryotes and that bind directly to the substrate from the interior of the cell [ 15 ]. (biomedcentral.com)
Structural snapshot of the cholesterol-transport ATP-binding cassette proteins. (leejylab.org)
Protein9
ATP-binding cassette sub-family G member 1 is a protein that in humans is encoded by the ABCG1 gene. (wikipedia.org)
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. (wikipedia.org)
Each myosin motor protein possesses ATPase activity and functions in a cyclical manner that couples ATP binding and hydrolysis to a conformational change in the protein. (web.app)
From the transcriptome database of C. rogercresseyi , 57 putative members of ABC protein sequences were identified and phylogenetically classified into the eight subfamilies described for ABC transporters in arthropods. (biomedcentral.com)
One of the protein families which has shown detoxifying effects against drugs are the ABC transporters. (biomedcentral.com)
It binds to tachykinin receptors [neurokinin-1 receptor (NK1R), NK2R, NK3R] that belong, like most neuropeptide receptors, to the family of seven-transmembrane, G protein-coupled receptors. (niepokorny.org)
Phosphorylation by protein kinase C stabilizes ABCG1 and increases cholesterol efflux. (kyoto-u.ac.jp)
Soy protein peptic hydrolysate with bound phospholipids decreases micellar solubility and cholesterol absorption in rats and caco-2 cells. (cmdm.tw)
Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. (cmdm.tw)
Intracellular2
Mechanistically, KCTD4 binds to CLIC1 and disrupts its dimerization, thus increasing intracellular Ca2+ level to enhance NFATc1-dependent fibronectin transcription. (bvsalud.org)
Defects in at least one ATP binding cassette (ABC) transporter (ABCA5) alter intracellular cholesterol distribution, leading to congenital hypertrichosis. (hud.ac.uk)
Regulate1
2012-10-25 · This evolutionarily conserved CCT4 structural feature, together with the extreme sensitivity of the CCT4 ATP-binding pocket to any mutation, suggests that CCT4 is the key to regulate the ATP-driven conformational cycle, and may help to initiate the power stroke and/or dictate its directionality. (web.app)
Phospholipids2
In this article, we demonstrate that specific lipids, likely oxidized phospholipids and/or sterols, elicit a lung-specific immune response in Abcg1(-/-) mice. (ulpgc.es)
Loss of ABCG1 results in increased levels of specific oxysterols, phosphatidylcholines, and oxidized phospholipids, including 1-palmitoyl-2-(5'-oxovaleroyl)-sn-glycero-3-phosphocholine, in the lungs. (ulpgc.es)
Cholesterol transport1
Taken together, the evidence suggests that APOL1-G1 and -G2 risk variants impaired reverse cholesterol transport through decreased expression of cholesterol efflux transporters suggesting a possible mechanism to promote macrophage foam cell formation, driving inflammation in the glomerulus and renal interstitium. (omicsdi.org)
Apolipoprotein1
The liver and gut synthesize apolipoprotein (Apo) A-I which become discoid nascent HDL after interaction with the ATP-binding cassette transporter A-1 (ABCA-1). (encyclopedia.pub)
Cellular2
An embolic stroke refers to an arterial embolism (a blockage of an artery) by an embolus, a traveling particle 2018-04-19 · In a stroke or an ischemic event, there is a shortage of oxygen and/or nutrient delivery and hence reduction of cellular ATP. (web.app)
Snapshots of ABCG1 and ABCG5/G8: A Sterol's Journey to Cross the Cellular Membranes. (leejylab.org)
Expression2
Tissue expression profiling and ligandbinding properties of HarmOBP 16 of the cotton bollworm, Helicoverpa armigera (Lepidoptera: Noctuidae) [J]. , 2017, 60(8): 891-899. (insect.org.cn)
Immunofluorescence microscopy in human HF sections revealed differential expression of ABC transporters across the hair cycle. (hud.ac.uk)
Metabolism1
In animal models of stroke, the limited availability of glucose and oxygen directly impairs oxidative metabolism in severely ischemic regions of the affected tissue and leads to rapid changes in ATP and other energy-related metabolites. (web.app)
20201
ATP Lighting Stroke Studies 1 Modeling of Power Network by ATP-Draw for Lightning Stroke Studies J. Morales, A. Guzman Abstract- Protection rela Views 44 Downloads 1 File size 644KB 2020-07-08 · For the production of ATP through oxidative phosphorylation electrons are required so that they can pass down the electron transport. (web.app)
Conformational1
In vivo FRET analyses reveal a role of ATP hydrolysis-associated conformational changes in human P-glycoprotein. (kyoto-u.ac.jp)
Mice1
Collectively, these data demonstrate that the accumulation of lipids in Abcg1(-/-) mice induces the specific expansion and localization of B-1 B cells, which secrete NAbs that may help to protect against the development of atherosclerosis. (ulpgc.es)
Tissue2
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human ATP Binding Cassette Transporter G2 (ABCG2) in tissue homogenates, cell lysates and other biological fluids. (tissue-cell-culture.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human ATP Binding Cassette Transporter G2 (ABCG2) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (tissue-cell-culture.com)
Increases1
SDCBP increases the Kbu level and stability of HSP90 by binding competitively to HDAC11. (bvsalud.org)
20171
Gene cloning and subcellular localization of ATP-binding cassette transporter ABCG1 from Helicoverpa armigera (Lepidoptera: Noctuidae) and its relationship with Cry1Ac toxicity [J]. , 2017, 60(3): 297-308. (insect.org.cn)
Human2
Description: A sandwich ELISA kit for detection of ATP Binding Cassette Transporter G2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (tissue-cell-culture.com)
Crystal Structure of the Human Sterol Transporter ABCG5/ABCG8. (leejylab.org)
As such, ABCG1 plays a crucial role in the development of atherosclerosis in humans. (web.app)
Transport1
Leishmania LABCG2 transporter is involved in ATP-dependent transport of thiols. (kyoto-u.ac.jp)
Levels2
DNA methylation levels at the ABCG1 cg27243685 site positively correlated with plasma triglyceride concentration (r = 0.510, p = 0.008), body mass index (r = 0.556, p = 0.013) and waist-to-hip ratio (r = 0.504, p = 0.012) in SAT samples. (biomedcentral.com)
DNA methylation levels at the ABCG1 cg27243685 locus in SAT are associated with hypertriglyceridemia and obesity. (biomedcentral.com)
BACKGROUND1
Background- In brain blood vessels, electrophysiological studies proving the existence of ATP-sensitive potassium channels (KATP) are scarce. (web.app)
Analysis1
Data on structural analysis of cholesterol binding and sterol selectivity by ABCG5/G8. (leejylab.org)
Cycle1
This process is known as the 'powerstroke cycle' (reviewed in 10753125 10679363 19452133 ) and is outlined in During the recovery stroke, ATP binds to the _____ to recock it, beginning the cycle again. (web.app)
Body1
ATP) is the form of energy your body likes to use. (web.app)