Proton-translocating ATPases responsible for ADENOSINE TRIPHOSPHATE synthesis in the MITOCHONDRIA. (bvsalud.org)
Triphosphatase3
ATP is required by the actomyosin adenosine triphosphatase (ATPase) for contraction and relaxation of cardiomyocytes. (journalmc.org)
This study has found that Swr1, a Swi2/Snf2-related adenosine triphosphatase, is the catalytic core of a multisubunit, histone-variant exchanger that efficiently replaces conventional histone H2A with histone H2AZ in nucleosome arrays. (sdbonline.org)
Almost all enzymes involved in phosphorus reactions (eg, adenosine triphosphatase [ATPase]) require magnesium for activation. (medscape.com)
Diphosphate1
During the bonding, energy is released by the breaking down of ATP into adenosine diphosphate (ADP) and Pi at another site - the ATPase site - on the myosin cross-bridge (by the action of the enzyme ATPase). (ironmagazine.com)
Hydrolysis4
We present a mechanism for F 1 -ATPase in which hydrolysis of MgATP in the high-affinity catalytic site at the α/β interface drives rotation of the γ subunit via conformational changes in the α subunit. (ttu.edu)
Enzymes that catalyze the hydrolysis of adenosine triphosphate (ATPases) are ubiquitous in the liver, but are present in high concentrations in bile canaliculi (mostly N + ,K + -ATPase and Ca 2+ -ATPase). (histologyguide.com)
Since no SWI2/SNF2 ATPases have yet been captured bound to DNA in a state competent for ATP hydrolysis, we turn to structural examples from the DEAD-box RNA helicase family, and suggest that SWI2/SNF2-specific inserts may be poised to alter canonical duplex DNA structure. (johnshopkins.edu)
Arguments based mostly on mathematical modeling led to the conclusion that physiological concentrations of glutamate more than double astrocytic Na + /K + -ATPase activity, which should proportionally increase its ATP hydrolysis rate. (edu.sa)
Molecule4
This protein uses energy from a molecule called adenosine triphosphate (ATP) to transport charged atoms (ions) into and out of cells. (medlineplus.gov)
The source of energy for this bonding is the molecule adenosine triphosphate (ATP). (ironmagazine.com)
The ATPase site on the myosin cross-bridge must pick up another ATP molecule if it is to repeat the swiveling action further. (ironmagazine.com)
Adenosine triphosphate (ATP) is a key molecule that stores energy within cells, and is considered as the universal energy currency for all living organisms. (sigmaaldrich.com)
Oxidative phosphorylation3
Glucose utilization and blood flow are reduced in AD, and these changes are accompanied by downregulation of glucose transport, Na, K-ATPase, oxidative phosphorylation, and energy consumption. (iospress.com)
Thioretinaco ozonide, the complex formed from thioretinamide, cobalamin, ozone, and oxygen is proposed to constitute the active site of oxidative phosphorylation, catalyzing synthesis of adenosine triphosphate (ATP) from nicotinamide adenine dinucleotide (NAD+) and phosphate. (iospress.com)
Their major function is the provision of energy in terms of adenosine triphosphate (ATP) by the oxidative phosphorylation system (OXPHOS). (journalmc.org)
Enzymes3
Multisubunit enzymes that reversibly synthesize ADENOSINE TRIPHOSPHATE . (nih.gov)
Magnesium is also crucial for energy metabolism by the activation of enzymes known as ATPases, which are needed to generate ATP (adenosine triphosphate). (xendurance.eu)
To counteract constraints imposed by nucleosome structure, cells deploy two major classes of multiprotein enzymes, which covalently modify the nucleosome core histones or catalyze nucleosome mobility in an adenosine triphosphate (ATP)-dependent fashion. (sdbonline.org)
Subunit5
In the F-ATPase from Geobacillus stearothermophilus, conformational changes in the ε-subunit are influenced by intracellular ATP concentration and membrane potential. (rcsb.org)
The ATP1A3 gene provides instructions for making one part (the alpha-3 subunit) of a protein known as Na+/K+ ATPase or the sodium pump. (medlineplus.gov)
Na+/K+ ATPases that include the alpha-3 subunit are primarily found in nerve cells (neurons) in the brain and are critical for their normal function. (medlineplus.gov)
Most ATP1A3 gene mutations associated with alternating hemiplegia of childhood change single protein building blocks (amino acids) in the alpha-3 subunit of Na+/K+ ATPase. (medlineplus.gov)
Most of these mutations change single amino acids in the alpha-3 subunit of Na+/K+ ATPase. (medlineplus.gov)
Mitochondrial2
It is very similar to those of active mitochondrial and bacterial F1-ATPases. (rcsb.org)
Because magnesium is bound to adenosine triphosphate (ATP) inside the cell, shifts in intracellular magnesium concentration may help to regulate cellular bioenergetics, such as mitochondrial respiration. (medscape.com)
Adenine nucleotides1
Photometric reaction chamber designed to investigate the properties of the commercially available firefly bioluminescence assay for adenosine triphosphate (ATP) and, An investigation of the release of adenine nucleotides from a mammalian neuromuscular junction: suggestive evidence for a nerve terminal source of ATP. (epa.gov)
Sodium2
Studies suggest that the defective Na+/K+ ATPase is unable to transport sodium ions normally, which disrupts the electrical activity of neurons in the brain. (medlineplus.gov)
Both the principal and the MR cells possess the ability to actively transport sodium in the presence of ATP (Adenosine TriPhosphate) due to the presence of Na+-K+-ATPase on their basolateral surface. (courselink.org)
Chromatin2
These findings define a previously unknown role for the adenosine triphosphate-dependent chromatin remodeling machinery (Mizuguchi, 2004). (sdbonline.org)
We review structural features of the Chd1 chromatin remodeler regarding regulation of the ATPase motor, and discuss related strategies observed for other SF2 ATPases. (johnshopkins.edu)
Swi21
Hauk, G & Bowman, GD 2011, ' Structural insights into regulation and action of SWI2/SNF2 ATPases ', Current Opinion in Structural Biology , vol. 21, no. 6, pp. 719-727. (johnshopkins.edu)
Concentration2
Adenosine triphosphate (ATP), released from dying cells, has a high concentration within the cell. (spandidos-publications.com)
Changes in Lung ATP (Adenosine Triphosphate) Concentration in the Rat After Low-Level Phosgene Exposure (Journal Version). (epa.gov)
Inhibition3
Alkyltin Inhibition of ATPase Activities in Tissue Homogenates and Subcellular Fractions from Adult and Neonatal Rats (Journal Version). (epa.gov)
Inhibition of ATPase Activities of Brain and Liver Homogenates by Triethyltin (TET). (epa.gov)
Cold preservation studies showed a significant decrease in porcine hepatic PM Ca 2+ -ATPase activity after 4 hours of storage and near-total inhibition after 12 hours. (psu.edu)
Additionally2
Additionally, Na+/K+ ATPase helps regulate a process called neurotransmitter reuptake. (medlineplus.gov)
Additionally, membrane-bound ATPase utilizes ATP for depolarization and repolarization of cell membranes. (journalmc.org)
Liver6
Plasma membrane (PM) and endoplasmic reticulum (ER) Ca 2+ -adenosinetriphosphatases (ATPases) are the primary transporters that maintain [Ca 2+ ] i homeostasis in the liver. (psu.edu)
We hypothesized that the porcine liver is better than the rat liver as a model for the study of human liver Ca 2+ -ATPase activity. (psu.edu)
We also hypothesized that cold preservation would depress Ca 2+ -ATPase activity in the porcine liver. (psu.edu)
We conclude that the Ca 2+ -ATPase activity in the pig liver is equivalent to that of human liver, and thus, the pig liver is a better model than the rat liver. (psu.edu)
We conclude that cold ischemia at clinically relevant times depresses PM Ca 2+ -ATPase more than ER Ca 2+ -ATPase activity in pig liver homogenates. (psu.edu)
The antioxidant status was disturbed with the decrease in SOD, GST and catalase in the liver and membrane-ATPases as well. (nature.com)
Protein3
Porcine PM and ER Ca 2+ -ATPase activities were 0.47 ± 0.03 and 1.57 ± 0.10 nmol of Ca 2+ /mg of protein/min, respectively. (psu.edu)
Analysis of the data suggested that the point mutations in alpha-TM associated with hypertrophic or dilated cardiomyopathy caused abnormal changes in the affinity ofTM to actin and in the position of this protein on the thin filaments in the ATPase cycle. (ox.ac.uk)
Mutations in alpha-TM associated with HCM caused a shift of TM strands to the center of the thin filament and increased a range of tropomyosin motion and affinity of this protein to actin in the ATPase cycle. (ox.ac.uk)
Energy2
Adenosine triphosphate, or ATP, functions as a cell's main source of energy. (firebaseapp.com)
It is vital for energy metabolism by the activation of ATPase, which is required to produce ATP (adenosine triphosphate). (momarketplace.com)
Bound1
In the structure of the F1-ATPase from C. thermarum, ATP and a magnesium ion are bound to the α-helices in the down state. (rcsb.org)
Transporter1
The aim of this study was to test for the molecular and functional expression of the non-gastric H + /K + ATPase ATP12A/ATP1AL1 in unstimulated and butyrate-stimulated (1 and 10 mM) human myelomonocytic HL-60 cells, to unravel its potential role as putative apoptosis-counteracting ion transporter as well as to test for the effect of the H + /K + ATPase inhibitor SCH28080 in apoptosis. (karger.com)
Complex1
Isolation and properties of a DDT-sensitive adenosine triphosphate complex from rat brain. (epa.gov)
Activity4
The activity of Na+/K+ ATPase also helps regulate cell size (volume). (medlineplus.gov)
Ca 2+ -ATPase activity was measured after incubation with 45 Ca 2+ and adenosine triphosphate in the presence of specific Ca 2+ -ATPase inhibitors. (psu.edu)
Porcine hepatic ER Ca 2+ -ATPase activity showed a 45% decrease in activity by 12 hours and a 69% decrease by 18 hours. (psu.edu)
Unclear1
However, it is unclear how a malfunctioning Na+/K+ ATPase causes the movement abnormalities characteristic of rapid-onset dystonia parkinsonism. (medlineplus.gov)
Membrane1
Equivalence of Microbial Biomass Measures Based on Membrane Lipid and Cell Wall Components, Adenosine Triphosphate, and Direct Counts in Subsurface Aquifer Sediments (Journal Version). (epa.gov)
Function2
Immune Function in Mice Exposed to the Adenosine Deaminase Inhibitor 2'-Deoxycoformycin During Immune System Development. (epa.gov)
Abnormal tropomyosin function in ATPase cycle in hypertrophic and dilated cardiomyopathies]. (ox.ac.uk)
Resistance1
Host Resistance to Murine Malaria in Mice Exposed to the Adenosine Deaminase Inhibitor, 2'-Deoxycoformycin. (epa.gov)
Structure2
The crystal structure has been determined of the F1-catalytic domain of the F-ATPase from Caldalkalibacillus thermarum, which hydrolyzes adenosine triphosphate (ATP) poorly. (rcsb.org)
The structure of the α3β3-catalytic domain is likewise closely similar to those of active F1-ATPases. (rcsb.org)
Study1
In this study, we used lipopolysaccharide (LPS) and adenosine triphosphate (ATP) to simulate an inflammatory environment as the testing model. (spandidos-publications.com)