• It has DNA helicase and ATPase activity. (nih.gov)
  • Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1. (umassmed.edu)
  • The origin recognition complex (ORC) is essential for initiation of eukaryotic chromosome replication as it loads the replicative helicase-the minichromosome maintenance (MCM) complex-at replication origins 1 . (nature.com)
  • The six subunit Origin Recognition Complex (ORC) together with Cdc6 and Cdt1, load the MCM replicative helicase as a double hexamer around double stranded DNA at origins. (crick.ac.uk)
  • During origin firing, the MCM helicase is activated, which involves a remodeling of the MCM ring to encircle single-stranded DNA, accompanied by assembly of a stable CMG (Cdc45-MCM-GINS) complex. (crick.ac.uk)
  • We are using this to understand the mechanism of MCM helicase loading and activation, how the replisome is assembled and regulated by protein kinases and how the DNA replication machinery interfaces with other aspects of chromosome biology. (crick.ac.uk)
  • We find that this type of non-canonical fork convergence in fission yeast is prone to trigger deletions between repetitive DNA sequences via a mechanism we call Inter-Fork Strand Annealing (IFSA) that depends on the recombination proteins Rad52, Exo1 and Mus81, and is countered by the FANCM-related DNA helicase Fml1. (elifesciences.org)
  • Proteins in the family to which SMBP2 belongs (known as the DNA helicase/ATPase family), are known to be involved in many cellular activities, including DNA replication, repair, and recombination. (sciencedaily.com)
  • Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. (nih.gov)
  • The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. (nih.gov)
  • In summary, our work provides fundamental insights into DDK structure, control and selective activation of the MCM2-7 helicase during DNA replication. (imperial.ac.uk)
  • Recombination and Pol ζ Rescue Defective DNA Replication upon Impaired CMG Helicase-Pol ε Interaction. (yeastgenome.org)
  • The papillomavirus E1 helicase is essential for viral DNA replication and plays a key role in controlling viral genome copy number. (biomedcentral.com)
  • The Bloom syndrome gene (BLM) encodes a RecQ-like DNA helicase. (lookformedical.com)
  • The papillomaviral DNA replication initiation protein E1 has origin recognition and ATP-dependent DNA melting and helicase activities, and it consists of a DNA-binding domain and an ATPase/helicase domain. (cshl.edu)
  • The loss of helicase function may prevent normal DNA replication and repair, causing widespread damage to a person's genetic information over time. (medlineplus.gov)
  • Association of the origin recognition complex (ORC) with a replication origin recruits the cell division cycle 6 protein (Cdc6) to form a platform for the loading of the minichromosome maintenance (Mcm 2-7) complex proteins, facilitated by the chromatin licensing and DNA replication factor 1 protein (Cdt1). (wikipedia.org)
  • Eukaryotic origins of replication control the formation of several protein complexes that lead to the assembly of two bidirectional DNA replication forks. (wikipedia.org)
  • The pre-RC formation involves the ordered assembly of many replication factors including the origin recognition complex (ORC), Cdc6 protein, Cdt1 protein, and minichromosome maintenance proteins (Mcm2-7). (wikipedia.org)
  • Download DNA or protein sequence, view genomic context and coordinates. (yeastgenome.org)
  • The precise regulations of pre-RC protein levels and assembly are effective ways to prevent reassembly of de novo MCM2-7 onto the replicated origins to re-license and re-replicate the genomic DNA in the subsequent phases of the same cell cycle ( Figure 1) . (intechopen.com)
  • The Neuron paper reports that the defective gene (designated Smbp2) in the neuromuscular disease mice encodes a DNA-binding protein (SMBP2, or immunoglobulin S-mu binding protein-2) on chromosome 19. (sciencedaily.com)
  • Within this research the hypothesis was explored that SNF2H protein might are likely involved in the excitement of MCM launching onto mobile replication origins which the Cdt1-SNF2H conversation is usually important in this context. (exposed-skin-care.net)
  • Unlike reversible disassembly, which requires ATP hydrolysis on V 1 to break protein-protein interactions, Oxr1p mediated disassembly of V-ATPase is ATP independent and therefore a novel mode of activity regulation. (upstate.edu)
  • The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. (nih.gov)
  • Diabetes mellitus impacts on expression of DNA mismatch repair protein PMS2 and tumor microenvironment in pancreatic ductal adenocarcinoma. (nih.gov)
  • The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. (nih.gov)
  • One such host protein, p97 or the valosin-containing protein (VCP), is a highly conserved AAA ATPase that facilitates replication of diverse RNA- and DNA-containing viruses. (bvsalud.org)
  • It is already known that such replication is controlled by a protein known as DnaA, a member of the AAA+ superfamily of ATPases. (lbl.gov)
  • Changing protein-DNA interactions promote ORC binding-site exchange during replication origin licensing. (yeastgenome.org)
  • Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex. (yeastgenome.org)
  • Structural changes in Mcm5 protein bypass Cdc7-Dbf4 function and reduce replication origin efficiency in Saccharomyces cerevisiae. (yeastgenome.org)
  • A single-stranded DNA-binding protein that is found in EUKARYOTIC CELLS. (lookformedical.com)
  • Cdc6p is definitely a member from the huge AAA+ superfamily of ATPases, which include Orc1p, Orc4p, Orc5p, MCM, protein and replication aspect C (42). (pkc-inhibitor.com)
  • The RECQL4 protein helps stabilize genetic information in the body's cells and plays a role in replicating and repairing DNA. (medlineplus.gov)
  • Some studies indicate that the antibacterial mechanism of the silver nanoparticles (AgNPs) relays on their ability to penetrate the bacterial cell wall, causing direct and indirect lipidic peroxidation, which damages the cell membrane, disrupts the DNA replication, and repairs and inhibits the respiratory protein 4,5 . (bvsalud.org)
  • Brg1 (Brahma-related gene 1) is an ATPase subunit of SWI2/SNF2-like chromatin-remodeling complexes that enable access of regulatory and effector proteins in transcription, DNA repair and DNA replication. (thermofisher.com)
  • The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. (nih.gov)
  • The foundation recognition complicated (ORC), a six-subunit initiator proteins (2), exists in both pre- and post-RCs (10), and among its functions is definitely to mark the positioning of replication roots in the genome. (pkc-inhibitor.com)
  • The vacuolar ATPase (V-ATPase) is a highly conserved rotary motor proton pump that plays an essential role in cellular housekeeping functions. (upstate.edu)
  • DNA replication, the process of copying one double stranded DNA molecule to form two identical copies, is highly conserved at the mechanistic level across evolution. (rsc.org)
  • To synthesize DNA, the double-stranded DNA is unwound by DNA helicases ahead of polymerases, forming a replication fork containing two single-stranded templates. (wikipedia.org)
  • Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity. (umassmed.edu)
  • Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. (lookformedical.com)
  • Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. (lookformedical.com)
  • Collapsed forks can be rescued by homologous recombination, which restarts replication. (elifesciences.org)
  • Eukaryotic DNA replication initiates at multiple origin sites along each chromosome and terminates when replication forks (RFs) from adjacent origins converge. (elifesciences.org)
  • The controlled assembly of replication forks is critical for genome stability. (imperial.ac.uk)
  • The replisome is responsible for copying the entirety of genomic DNA in each proliferative cell. (wikipedia.org)
  • We use a variety of human cell models to understand how the deregulation of normal replication control mechanisms leads to genomic instability and whether this plays a role in cancer biology. (crick.ac.uk)
  • In this chapter, we mainly discuss the coordination regulations between DNA replication initiation and other cell cycle events that ensure genomic integrity. (intechopen.com)
  • Problems that arise during DNA replication can drive genomic alterations that are instrumental in the development of cancers and many human genetic disorders. (elifesciences.org)
  • The involvement of viral DNA-binding proteins in the regulation of virulence genes, transcription, DNA replication, and repair make them significant targets. (mdpi.com)
  • A recent study from the Wilkens lab in collaboration with Seoul National University uncovered a novel mechanism of yeast V-ATPase regulation based on biochemical experiments and cryo electron microscopy (cryo-EM) structures of holo V-ATPase and Oxr1 bound V 1 subcomplex. (upstate.edu)
  • Interesting in its own right as a fascinating feat of biochemical regulation and coordination, DNA replication is at the heart of modern advances in molecular biology. (rsc.org)
  • This E1 phosphate map will provide a new tool to more fully understand viral replication and serve as a useful model for investigating regulation of viral and cellular DNA replication. (biomedcentral.com)
  • In this respect HBO1 (a MYST family members histone acetyltransferase that binds to ORC) originally determined through its physical connections with individual ORC1 (27) was lately discovered to associate with replication roots through relationship with Cdt1 also to enhance licensing and DNA replication through its acetylation activity GSK 525762A (28-30). (exposed-skin-care.net)
  • Biochemical experiments showed that Oxr1p binds and promotes V-ATPase disassembly. (upstate.edu)
  • The Origin Recognition Complex (ORC) binds to sites in chromosomes to specify the location of origins of DNA replication. (imperial.ac.uk)
  • The S. cerevisiae ORC binds to specific DNA sequences throughout the cell cycle but becomes active only when it binds to the replication initiator Cdc6. (imperial.ac.uk)
  • While monomeric in solution, E1 binds DNA as a dimer. (cshl.edu)
  • This so-called recombination-dependent replication (RDR) helps ensure that DNA is fully replicated prior to sister chromatid segregation, thereby avoiding mitotic catastrophes. (elifesciences.org)
  • In addition, Other study have found that DNA replication, recombination and repair are one of the reasons for the resistance of radiotherapy and chemotherapy in LACC [15]. (researchsquare.com)
  • For the first time, scientists have determined the structure of the initiator of bacterial DNA replication. (lbl.gov)
  • The structure reveals that Cdc6 contributes to origin DNA recognition via its winged helix domain (WHD) and its initiator-specific motif. (imperial.ac.uk)
  • Initiation of eukaryotic DNA replication is the first stage of DNA synthesis where the DNA double helix is unwound and an initial priming event by DNA polymerase α occurs on the leading strand. (wikipedia.org)
  • Eukaryotic DNA replication of chromosomal DNA is central for the duplication of a cell and is necessary for the maintenance of the eukaryotic genome. (wikipedia.org)
  • However, how this nucleosome organization is established and whether this organization is required for replication remain unknown. (nature.com)
  • Here, using genome-scale biochemical reconstitution with approximately 300 replication origins, we screened 17 purified chromatin factors from budding yeast and found that the ORC established nucleosome depletion over replication origins and flanking nucleosome arrays by orchestrating the chromatin remodellers INO80, ISW1a, ISW2 and Chd1. (nature.com)
  • Our results establish that ORC, in addition to its canonical role as the MCM loader, has a second crucial function as a master regulator of nucleosome organization at the replication origin, a crucial prerequisite for efficient chromosome replication. (nature.com)
  • Fig. 1: ORC is a master regulator of nucleosome organization at origins of replication. (nature.com)
  • Nucleosome-directed replication origin licensing independent of a consensus DNA sequence. (yeastgenome.org)
  • Please contact me if you are interested in doing a PhD in the area of genome stability and DNA repair. (lancaster.ac.uk)
  • Miller CLW and Winston F (2023) The conserved histone chaperone Spt6 is strongly required for DNA replication and genome stability. (yeastgenome.org)
  • Viral packaging ATPases utilize a glutamate switch to couple ATPase activity and DNA translocation. (umassmed.edu)
  • Not surprisingly, V-ATPase activity (or loss thereof) has been linked to several disease states including renal tubular acidosis, osteoporosis, neurodegeneration, and cancer. (upstate.edu)
  • The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. (nih.gov)
  • In contrast to other p97's cofactors, p37 uniquely increases the ATPase activity of p97. (bvsalud.org)
  • Disease-causing mutations in p97, including mutations that cause neurodegenerative diseases, increase cofactor association with its N-domain, ATPase activity and improper substrate processing. (bvsalud.org)
  • Conversely, ageing may be associated with loss of replication activity and restoring it to cells may moderate some of the diseases associated with old age. (rsc.org)
  • Among the origins of achlorhydria that are related to medical care, medications like proton pump inhibitors that block H+/K+ -ATPase activity can induce achlorhydria. (medscape.com)
  • Dukaj L and Rhind N (2021) The capacity of origins to load MCM establishes replication timing patterns. (yeastgenome.org)
  • the chorion gene loci in follicle cells (21 22 In pre-RC development the effective launching of multiple MCM complexes is necessary for the toleration of replication strains and activation of checkpoint pathways (23-25). (exposed-skin-care.net)
  • Previous studies have shown that ClpB-cyt/HSP100 gene belongs to the group class I Clp ATPase proteins and ClpB-cyt/HSP100 transcript is regulated by heat stress and developmental cues. (biomedcentral.com)
  • Rice class I Clp ATPase gene family is constituted of 9 members. (biomedcentral.com)
  • These changes may result in the accumulation of DNA errors and cell death, although it is unclear exactly how RECQL4 gene mutations lead to the specific features of RAPADILINO syndrome. (medlineplus.gov)
  • Multiple replicative proteins assemble on and dissociate from these replicative origins to initiate DNA replication. (wikipedia.org)
  • The major enzymatic functions carried out at the replication fork are well conserved from prokaryotes to eukaryotes, but the replication machinery in eukaryotic DNA replication is a much larger complex, coordinating many proteins at the site of replication, forming the replisome. (wikipedia.org)
  • Recent breakthroughs have uncovered more and more DNA replication licensing machinery proteins (ORC, Cdc6, Cdt1, geminin, etc.) functioning in other cell cycle events, including centrosome replication, mitotic events, transcription and so on. (intechopen.com)
  • From late mitosis to the G1 phase of the cell cycle ORC CDC6 and Cdt1 form the machinery necessary to load MCM2-7 complexes onto DNA. (exposed-skin-care.net)
  • DNA replication is one of the central processes in viral maintenance, and the machinery involved is an excellent target for the design of antiviral therapy. (cshl.edu)
  • DNA sequences containing these sites were initially isolated in the late 1970s on the basis of their ability to support replication of plasmids, hence the designation of autonomously replicating sequences (ARS). (wikipedia.org)
  • The molecular system that restricts firing of roots of replication to one time per cell routine invokes the purchased binding to and/or discharge of different replication proteins from particular DNA sequences (replicators) situated in the vicinity from the real roots of DNA replication. (pkc-inhibitor.com)
  • Priming of the DNA helix consists of the synthesis of an RNA primer to allow DNA synthesis by DNA polymerase α. (wikipedia.org)
  • Through a combination of biochemical analysis, using purified proteins and cell-free extracts of Xenopus laevis eggs, and in vivo cell biological analysis using established human cell lines, my group is identifying key targets of ubiquitin and SUMO modification in the DNA damage response. (lancaster.ac.uk)
  • Replication is, therefore, fundamental to a huge range of molecular biological and biochemical applications, and provides many potential targets for drug design. (rsc.org)
  • The results illuminate the molecular mechanism of a critical biochemical step in the licensing of eukaryotic replication origins. (imperial.ac.uk)
  • The Mitochondrial replication is diagrammed in the cartoon in the side bar and shown above in an electron micrograph. (cytochemistry.net)
  • Mitochondrial DNA and its function. (cytochemistry.net)
  • Each nucleoid may contain 4-5 copies of the mitochondrial DNA (mrDNA). (cytochemistry.net)
  • structure of mitochondrial DNA, we have to extract the proteins in the matrix and reveal the DNA (arrows in the figure to the right). (cytochemistry.net)
  • Mitochondrial circular DNA is shown in the following figure. (cytochemistry.net)
  • In mammals, 99.99% of mitochondrial DNA (mtDNA) is inherited from the mother. (cytochemistry.net)
  • It also covers mitochondrial DNA replication, and includes archaeal paradigms, which are proving increasingly relevant to the study of replication in higher eukaryotes. (rsc.org)
  • Besides its function in DNA replication, it could also be engaged inside a mitotic checkpoint control, because Cdc6-deprived candida cells that usually do not replicate DNA still go through a reductional mitosis (4, 47, 63). (pkc-inhibitor.com)
  • A family of structurally-related DNA helicases that play an essential role in the maintenance of genome integrity. (lookformedical.com)
  • In addition DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands. (lookformedical.com)
  • Helicases are enzymes that bind to DNA and temporarily unwind the two spiral strands (double helix) of the DNA molecule. (medlineplus.gov)
  • The H+/K+ -ATPase responsible for acid secretion resides in the apical microvillus membrane. (medscape.com)
  • Eukaryotic DNA replication is a conserved mechanism that restricts DNA replication to once per cell cycle. (wikipedia.org)
  • This mechanism is conserved from prokaryotes to eukaryotes and is known as semiconservative DNA replication. (wikipedia.org)
  • Structure and mechanism of the ATPase that powers viral genome packaging. (umassmed.edu)
  • Cisplatin is used to treat a variety of cancers, it interferes with the DNA repair mechanism and causes DNA damage, induces apoptosis of cancer cells [10]. (researchsquare.com)
  • Localization and sequence analysis of yeast origins of DNA replication. (nature.com)
  • Nieduszynski, C. A., Knox, Y. & Donaldson, A. D. Genome-wide identification of replication origins in yeast by comparative genomics. (nature.com)
  • used cryo-EM to obtain structures of yeast V-ATPase assembled from purified V 1 and V o subcomplexes. (upstate.edu)
  • Further experiments will be required to uncover the physiological role of the interaction suof Oxr1 with the V-ATPase, and whether the observations obtained for the yeast system are conserved in higher organisms, including humans. (upstate.edu)
  • Here we report the cryo-EM structure at 3.3 Å resolution of the yeast ORC-Cdc6 bound to an 85-bp ARS1 origin DNA. (imperial.ac.uk)
  • Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins. (yeastgenome.org)
  • Replication processes permit copying a single DNA double helix into two DNA helices, which are divided into the daughter cells at mitosis. (wikipedia.org)
  • In addition, the architecture indicates that this AAA+ superhelix will wrap coils of the DNA around its exterior, causing the DNA double helix to deform as a first step in the separation and unwinding of its strands. (lbl.gov)
  • DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). (lookformedical.com)
  • Replication starts at origins of replication. (wikipedia.org)
  • These events are initiated by the formation of the pre-replication complex (pre-RC) at the origins of replication. (wikipedia.org)
  • The pre-replication complex (pre-RC) assembly or the DNA replication licensing is the first step in DNA replication initiation, characterized by the sequential recruitment of ORCs, Cdc6, Cdt1 and MCMs to the DNA replication origins to form the pre-RC at the end of mitosis ( Bell and Dutta 2002 ). (intechopen.com)
  • Pursuing parting of sister chromatids at mitosis and through the following G1 stage, prereplication complexes (pre-RCs) are produced at roots of DNA replication. (pkc-inhibitor.com)
  • Cdc18+ may be the homologue of and performs equivalent features in regulating initiation of DNA replication and perhaps entrance into mitosis (28, 40, 43). (pkc-inhibitor.com)
  • Gross overexpression of Cdc18+ leads to repeated rounds of DNA replication in the lack of mitosis (23, 43). (pkc-inhibitor.com)
  • Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions. (umassmed.edu)
  • DNA replication in eukaryotic cells initiates from a large number of chromosomal sites known as origins. (crick.ac.uk)
  • A terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability. (lookformedical.com)
  • The identification of genes involved in replication, segregation, toxin-antitoxin systems and conjugation, would aid the design of drugs to prevent the survival or transmission of plasmids carrying pathogenic properties. (frontiersin.org)
  • The crystal structure of the ATPase module of FtsH has been solved, revealing an alpha/beta nucleotide binding domain connected to a four-helix bundle, similar to the AAA modules of proteins involved in DNA replication and membrane fusion. (rcsb.org)
  • Rather than simply "itemising" the replication steps and the proteins involved, replication is tackled from a novel perspective. (rsc.org)
  • Because efficient loading of excess MCM complexes is usually thought to be required for cells to tolerate replication tension Cdt1- and SNF2H-mediated advertising of MCM loading could be biologically relevant for the legislation of DNA replication. (exposed-skin-care.net)
  • Selecting catalytic ATPase subunits coupled with various other complicated elements defines the function of the complexes in a variety of nuclear occasions including transcription DNA replication and DNA fix. (exposed-skin-care.net)
  • While individual V 1 and V o subcomplexes are locked in specific rotary states, the in vitro assembled complexes populated three rotary states, similar to what was previously observed for native V-ATPase. (upstate.edu)
  • The book highlights new insights into the replication process, from the assembly of pre-replication complexes, through polymerisation mechanisms, to considering replication in the context of chromatin and chromosomes. (rsc.org)
  • The critical role of p97 in viral replication might be exploited as a target for development of pan-antiviral drugs that exceed the capability of virus-specific vaccines or therapeutics. (bvsalud.org)
  • The process of semiconservative replication for the site of DNA replication is a fork-like DNA structure, the replication fork, where the DNA helix is open, or unwound, exposing unpaired DNA nucleotides for recognition and base pairing for the incorporation of free nucleotides into double-stranded DNA. (wikipedia.org)
  • The priming event on the lagging strand establishes a replication fork. (wikipedia.org)
  • Replication fork barriers are a commonly encountered problem, which can cause fork collapse and act as hotspots for replication termination. (elifesciences.org)
  • However, replication restart is relatively slow and, therefore, replication termination may frequently occur by an active fork converging on a collapsed fork. (elifesciences.org)
  • Regardless of its precise form, collapse renders the fork incompetent for further DNA synthesis. (elifesciences.org)
  • RDR can initiate from a collapsed fork where the DNA is either broken or remains intact. (elifesciences.org)
  • In eukaryotes, the vast majority of DNA synthesis occurs during S phase of the cell cycle, and the entire genome must be unwound and duplicated to form two daughter copies. (wikipedia.org)
  • V-ATPase is made of two subcomplexes: a cytosolic V 1 that carries out ATP hydrolysis, and a membrane bound V o that is responsible for proton translocation. (upstate.edu)
  • Replication genes were not identified in some plasmids, a situation that has led to the possibility of host interaction involvement. (frontiersin.org)
  • Fig. 3: Effects of Orc1 mutations on cell viability, complex formation, origin DNA binding and MCM loading. (nature.com)
  • Fig. 4: Chromatin defects due to Orc1 mutations correlate with replication defects. (nature.com)
  • Cdc6 binding rearranges a short α-helix in the Orc1 AAA+ domain and the Orc2 WHD, leading to the activation of the Cdc6 ATPase and the formation of the three sites for the recruitment of Mcm2-7, none of which are present in ORC alone. (imperial.ac.uk)
  • On the basis of the data obtained we propose that SNF2H promotes MCM loading at cellular replication origins through conversation with Cdt1. (exposed-skin-care.net)
  • The large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain. (umassmed.edu)
  • A family of enzymes that catalyze the exonucleolytic cleavage of DNA. (lookformedical.com)
  • A cartoon of a section of chromatin in the nucleus with replication origins in three different states. (crick.ac.uk)
  • Furthermore SNF2H is certainly apparently recruited GSK 525762A towards the Epstein-Barr pathogen origins of plasmid replication ((37). (exposed-skin-care.net)
  • Insights into the process at the molecular level provide opportunities to modulate and intervene in replication. (rsc.org)
  • This transition involves the ordered assembly of additional replication factors to unwind the DNA and accumulate the multiple eukaryotic DNA polymerases around the unwound DNA. (wikipedia.org)