In fact, results of a phase 1b study of the effects of autologous tolerogenic dendritic cells loaded with myelin and AQP-4 peptides, showed successful elicitation of antigen-specific IL-10 production by T regulatory cells in patients with NMOSD or MS. (openhealthgroup.com)
The micro ELISA plate provided in this kit has been pre-coated with an antigen specific to Human AQP-2(Aquaporin 2). (tzybiotech.com)
Then a biotinylated detection antigen specific for Human AQP-2(Aquaporin 2) and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. (tzybiotech.com)
Synaptic plasticity3
Aquaporin-4 is essential in the formation of memory as well as synaptic plasticity. (wikipedia.org)
Other performances that aquaporin-4 is involved in are synaptic plasticity, astrocyte migration, regulation of extracellular space volume, and the homeostasis of potassium. (wikipedia.org)
At physiological levels, ROS can improve cellular activities as they are involved in the control of the chemical balance and synaptic plasticity [ 4 ], whereas an excess amount of ROS can damage the endothelium, leading to alteration of the intracellular reduction-oxidation homeostasis [ 5 ]. (hindawi.com)
Neuromyelitis Optica Spectrum Disorder4
Neuromyelitis optica spectrum disorder (NMOSD) is one of the autoimmune demyelinating disorders, which is thought to be triggered by viral infection. (aku.edu)
Post herpes simplex virus (HSV) autoimmune encephalitis has been reported mainly in association with NMDA receptor antibodies, however, never with Caspr2 antibodies. (biomedcentral.com)
MOGAD is typically associated with acute disseminated encephalomyelitis (ADEM), optic neuritis (ON), and transverse myelitis (TM) and is less commonly associated with cerebral cortical encephalitis, brainstem or cerebellar symptoms, and clinical presentations including the combination of several phenotypes and sometimes accompanies other autoantibodies such as anti- N -methy-D aspartate receptor (NMDAR) autoantibodies with symptoms of autoimmune encephalitis. (encyclopedia.pub)
This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. (hindawi.com)
This notion has been challenged by the discovery of new membrane transport functions, especially those exerted by aquaporins (AQPs), a family of membrane channel proteins widespread in nature [ 10 , 11 ]. (hindawi.com)
20193
After novel coronavirus pandemic that emerged from Wuhan, China in December 2019, several cases of inflammatory and immune-mediated disorders have been reported, thought to be triggered by SARS-CoV-2 infection. (aku.edu)
The 71st Annual Meeting of the American Academy of Neurology (AAN) was held May 4-10, 2019 in Philadelphia, PA, drawing over 15,000 participants from around the globe. (openhealthgroup.com)
Indeed, astrocytic end feet, express the most AQP-4 channels in the entire CNS, playing a key role in brain activation and deactivation ( Mader and Brimberg, 2019 ). (raypeatforum.com)
Receptor1
This is supported by observing the beneficial effects of angiotensin receptor blockers and angiotensin converting enzyme inhibitors in both posttraumatic stress disorder and SARS-CoV-2 critical illness. (raypeatforum.com)
Prevalence2
2 3 4 5 6 ] However, a more recent population-based survey conducted in urban Mangalore has shown a prevalence of 8.3/100,000 for MS and 2.6/100,000 for neuromyelitis optic spectrum diseases (NMOSD). (lww.com)
As the prevalence rate of posttraumatic stress disorder in pandemic survivors exceeds that of the general and special populations, the virus may predispose to this disorder by directly interfering with the stress-processing pathways. (raypeatforum.com)
Channel2
Aquaporin-4, also known as AQP-4, is a water channel protein encoded by the AQP4 gene in humans. (wikipedia.org)
In the CNS, AQP4 is the most prevalent aquaporin channel, specifically located at the perimicrovessel astrocyte foot processes, glia limitans, and ependyma. (wikipedia.org)
Status1
the study designs varied with regard to inclusion criteria (eg, aquaporin-4 [AQP-4] status, background immunomodulatory therapy). (openhealthgroup.com)
Plasma2
The aquaporin-4 tetramers accumulate to transform into orthogonal arrays of particle (OAPs) in the cell plasma membrane. (wikipedia.org)
This ELISA kit applies to the in vitro quantitative determination of Human AQP-2(Aquaporin 2) concentrations in serum, plasma and other biological fluids. (tzybiotech.com)
Molecular2
We sought to delineate the molecular and phenotypic spectrum of LNPK-related disorder. (bvsalud.org)
In other words, learning from the virus, clarify the molecular underpinnings of stress related disorders, and design better therapies for these conditions. (raypeatforum.com)
Role1
Within the retina, the role of AQP-4 is to maintain homeostasis. (wikipedia.org)
Brain3
A limited number of aquaporins are found within the central nervous system (CNS): AQP1, 3, 4, 5, 8, 9, and 11, but more exclusive representation of AQP1, 4, and 9 are found in the brain and spinal cord. (wikipedia.org)
Aquaporin-4 is the most common aquaporin in the brain, spinal cord, and optic nerve. (wikipedia.org)
Recently, homozygous variants in LNPK were shown to cause a neurodevelopmental disorder (OMIM#618090) in four patients displaying developmental delay, epilepsy and nonspecific brain malformations including corpus callosum hypoplasia and variable impairment of cerebellum. (bvsalud.org)
Similar1
The assembly of AQP4 monomers into tetramers is similar to other aquaporin channels. (wikipedia.org)
Patients1
Over the years, extensive studies conducted in patients with MS have investigated the presence of anti-MOG autoantibodies using Western blotting and enzyme-linked immunosorbent assays targeting recombinant mouse MOG, without clear relation and specificity with MS [ 4 ] . (encyclopedia.pub)
AQP45
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathy against foot processes of aquaporin-4 (AQP4) water channels. (nih.gov)
Aquaporin-4, also known as AQP-4, is a water channel protein encoded by the AQP4 gene in humans. (wikipedia.org)
In the CNS, AQP4 is the most prevalent aquaporin channel, specifically located at the perimicrovessel astrocyte foot processes, glia limitans, and ependyma. (wikipedia.org)
The assembly of AQP4 monomers into tetramers is similar to other aquaporin channels. (wikipedia.org)
Pathologically, NMOSD includes AQP4-antibody-seropositive autoimmune astrocytopathic disease and MOG-antibody-seropositive inflammatory demyelinating disease. (nih.gov)
Antibody4
However, AQP-4-antibody-positive NMOSD coexisting with ankylosing spondylitis (AS) is rare. (nih.gov)
NMOSD encompassing brain syndrome as well as optic neuritis and acute myelitis is now classified into aquaporine-4 (AQP)-antibody-seropositive and aquaporine-4 (AQP)-antibody-seronegative diseases, detecting more patients earlier than before. (nih.gov)
Since the discovery of a specific serum marker for NMO in 2004, and its subsequent identification as an antibody to aquaporin-4 (AQP-4), various methods have been developed to test for the antibodies in patients sera. (ox.ac.uk)
Here, we demonstrate that subsequent to MRI-targeted focused ultrasound induced disruption of BBB, intravenously administered dopamine D(4) receptor-targeting antibody crossed the BBB and recognized its antigens. (researchgate.net)
Neuromyelitis5
Absence of aquaporin-4 expression in lesions of neuromyelitis optica but increased expression in multiple sclerosis lesions and normal-appearing white matter. (medscape.com)
The diagnostic criteria of neuromyelitis optica spectrum disorders (NMOSD) has been revised in the past 20 years and pathological and therapeutic data have been accumulated. (nih.gov)
Detection of anti-aquaporin-4 antibodies in neuromyelitis optica: current status of the assays. (ox.ac.uk)
OBJECTIVE: To assess the principal methods used to measure AQP-4 antibodies in patients sera, describe their contribution to neuromyelitis spectrum disease and examine their value in the early detection of disease. (ox.ac.uk)
CONCLUSIONS: The indirect immunofluorescence assay for NMO-IgG allows the detection of antibodies in routine screening, but the CBA for AQP-4 antibodies is the most sensitive. (ox.ac.uk)
This test uses a cell-based assay (CBA) to detect antibodies against aquaporin-4. (aruplab.com)
NMOSD1
Patients with NMOSD tend to have other coexisting autoimmune/connective tissue diseases. (nih.gov)
AQP11
A limited number of aquaporins are found within the central nervous system (CNS): AQP1, 3, 4, 5, 8, 9, and 11, but more exclusive representation of AQP1, 4, and 9 are found in the brain and spinal cord. (wikipedia.org)
Diseases4
Phytochemical modulation of AQP expression may provide new medical treatment options to improve the prognosis of several diseases. (frontiersin.org)
The ability of EV to modulate the immune system, the coagulation cascade, the angiogenetic process, and to drive endothelial dysfunction plays a crucial role in the pathophysiology of both autoimmune and renal diseases. (unicyte.ch)
We focused on EV-mediated interaction between the immune system and the kidney in autoimmune diseases displaying common renal damage, such as antiphospholipid syndrome, systemic lupus erythematosus, thrombotic microangiopathy, and vasculitis. (unicyte.ch)
Although further studies are needed to extend our knowledge on EV in renal pathology, a deeper investigation of the impact of EV in kidney autoimmune diseases may also provide insight into renal biological processes. (unicyte.ch)
Journal of Movement Disorders 2023;16(2):115-132. (e-jmd.org)
Optic2
Aquaporin-4 is the most common aquaporin in the brain, spinal cord, and optic nerve. (wikipedia.org)
Five out of nine seropositive but none of fourteen seronegative individuals who had experienced a single episode of LETM developed a relapse ( n = 4) or optic neuritis ( n = 1) within 12 months of presentation. (medscape.com)
Diagnostic2
In this review, we focus on adult-onset GLEs with movement disorders and offer a step-by-step diagnostic approach by clarifying the phenomenology of movement, advising investigations for acquired causes, describing the clinical and radiological clues to each disease, emphasizing the limitations of advanced molecular testing, and discussing the future application of artificial intelligence. (e-jmd.org)
This novel technology should be useful in delivering macromolecular therapeutic or diagnostic agents to the CNS for the treatment of various CNS disorders. (researchgate.net)
Common1
Movement disorders are among the most common symptoms, and their diversity makes diagnosis challenging. (e-jmd.org)
Provide2
Aquaporin-4's overall function is to provide fast water transportation as well as maintain homeostatic balance within the central nervous system. (wikipedia.org)
We provide a list summarizing the leukoencephalopathies associated with different categories of movement disorders. (e-jmd.org)
Aquaporins (AQPs), a family of membrane channel proteins involved in many body functions, are emerging among the targets of bioactive phytochemicals in imparting their beneficial actions. (frontiersin.org)
This review provides an update on the involvement of Aquaporins (AQPs), a family of membrane channel proteins with important role in many body functions, in the beneficial effects imparted by food polyphenols and herbal phytocompounds, both in health and disease. (frontiersin.org)
Central nervou1
Another confusing term is "leukodystrophies", which represent a group of inherited disorders that selectively impair the development or maintenance of central nervous system (CNS) myelin. (e-jmd.org)
Expression1
Expression, transport properties ( Agre, 2004 ), and pharmacological gating ( Soveral and Casini, 2017 ) of AQPs are object of strong interest and intense investigation in all body districts and a number of important roles have been already described, both in health and clinical disorders. (frontiersin.org)
Group1
INTRODUCTION: Neurodevelopmental disorders (NDD) are a diverse group of disorders that affect the development of the nervous system. (bvsalud.org)