- They originate in amine precursor uptake and decarboxylation (APUD) cells of the gastroenteropancreatic endocrine system and in adrenal or extra-adrenal neurogenic sites. (medscape.com)
- They were historically thought to be derived from neural crest cells, but this has since been shown to be untrue (see neuroendocrine tumor).The term dates back to at least 1975. (wikipedia.org)
- Neural crest cells are precursors of APUDoma and neurogenic cells. (medscape.com)
- This is a property of endocrine cells of neural and non-neural origin. (wakehealth.edu)
- [ 8 ] Approximately 5% of VIPomas are associated with multiple endocrine neoplasia (MEN) type 1 syndrome . (medscape.com)
- Because the label "apudoma" is very general, it is preferred to use a more specific term when possible. (wikipedia.org)
- In pathology, an apudoma is an endocrine tumour that arises from an APUD cell from structures such as the ampulla of Vater. (wikipedia.org)
- An apudoma is any endocrine tumor that arises from an APUD cell (APUD, meaning amine precursor uptake and decarboxylation) properties. (illnessopedia.org)
- 5. Production of calcitonin, adrenocorticotropic hormone, and beta-melanocyte-stimulating hormone in tumors derived from amine precursor uptake and decarboxylation cells. (nih.gov)
- APUDomas or APUD tumors arise from APUD cells which have the ability of amine precursors uptake and intracellular decarboxylation, before converting them into active amines, hence the name, amine precursor uptake, and decarboxylation cells. (statpearls.com)
- 14. A.P.U.D. type endocrine tumour of the prostate. (nih.gov)
- Cells with the capacity to take up and decarboxylate the amine precursors DIHYDROXYPHENYLALANINE or 5-HYDROXYTRYPTOPHAN. (nih.gov)
- [ 16 ] The term carcinoid was also used interchangeably with APUDoma, so named by Pearse in the 1960s, who developed the concept of the amine precursor uptake and decarboxylation (APUD) system after observing the ability of the secretory granules to take up and decarboxylate amino acid precursors of biogenic amines, such as serotonin and catecholamines. (medscape.com)
- Furthermore, neuroendocrine cells typically have neurosecretory granules. (statpearls.com)
- They originate in amine precursor uptake and decarboxylation (APUD) cells of the gastroenteropancreatic endocrine system and in adrenal or extra-adrenal neurogenic sites. (medscape.com)
- 7. [Content of endocrine cells of the APUD-system of the lungs in cancer of that organ]. (nih.gov)
- 10. [Changes in the APUD system of the large intestine as a risk factor for colorectal cancer]. (nih.gov)
- 12. [Morphofunctional state of the APUD-system cells of the lungs in hyaline membrane disease of newborn infants]. (nih.gov)
- [2] This was then disproven by the concept of the origin of APUD cells from multipotent stem cells before being implanted in different body organs, hence the diffuse endocrine system. (statpearls.com)
- Because the label "apudoma" is very general, it is preferred to use a more specific term when possible. (wikipedia.org)
- As such, most doctors and scientists prefer to use a more specific term when possible, such as apudoma of gall bladder. (illnessopedia.org)
- 8. [Apudoma of the prostate]. (nih.gov)
- 8] Approximately 5% of VIPomas are associated with multiple endocrine neoplasia (MEN) type 1 syndrome. (medscape.com)
- 18. [Possible causes for an increased content of blood peptide hormones in small-cell lung cancer]. (nih.gov)
- Well-differentiated NETs are composed of small cells organized in islets, gyriform, and trabeculae, with finely granular cytoplasm, commonly referred to as "salt and pepper" chromatin pattern. (statpearls.com)
- Between 1952 and 1953, serotonin [5-hydroxytryptamine (5-HT)] was identified as the secretory product of enterochromaffin cells (ECs) and isolated from a carcinoid tumor of the small bowel. (medscape.com)
- Aplastic anemia is a condition wherein the bone marrow does not produce enough new cells to replenish the blood cells. (illnessopedia.org)
- Anemia is the disorder that results in having lesser red blood cells than normal, which are needed to function properly. (illnessopedia.org)
- platelets, white blood cells and red blood cells. (illnessopedia.org)