Production of the proteins, apolipoprotein A1 (ApoA1), the major component of HDL, and apolipoprotein B (ApoB), the main component of LDL, were studied. (chemistryviews.org)
Polyphenols from cocoa powder increased ApoA1 levels and decreased ApoB levels in both the liver and intestine. (chemistryviews.org)
Hepatic expression of fatty acid binding protein (FABP), very low density apolipoprotein II (ApoVLDL-II) and apolipoprotein B (ApoB) genes increased in both ad lib and restricted breeders following photo-stimulation, whereas apolipoprotein A1 (ApoA1) gene expression declined in both groups. (usda.gov)
Novel biomarkers of risk, such as apolipoprotein (Apo) A1 and ApoB (2), and the inflammatory markers C-reactive protein (CRP), fibrinogen, and homocysteine (3-5), have been proposed. (cdc.gov)
Accordingly, the ratio of apoB/apoA1 seems to reflect the status of pro- and anti-atherogenic lipoproteins in a simple manner, but the comparison with conventional lipid ratios is particularly complex. (biomedcentral.com)
An inverse association was also found between birth weight and the apoB/apoA1 ratio, a marker of cardiovascular risk. (lu.se)
Serum4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Apolipoprotein A1 (APOA1) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (elisastrip.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Apolipoprotein A1 (APOA1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (elisastrip.com)
Description: A sandwich ELISA kit for detection of Apolipoprotein A1 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (elisastrip.com)
[ 5 ] Only 10% of amyloidosis deposits consist of components such as glycosaminoglycans (GAGs), apolipoprotein-E (apoE), and serum amyloid P-component (SAP), while nearly 90% of the deposits consist of amyloid fibrils that are formed by the aggregation of misfolded proteins. (medscape.com)
ApoE2
Apolipoprotein E (apoE) plays an important role in the transport and uptake of cholesterol by way of its high affinity interaction with lipoprotein receptors, including the low-density lipoprotein (LDL) receptor. (wikipedia.org)
Recent findings with apoA1 and apoE suggest that the tertiary structures of these two members of the human exchangeable apolipoprotein gene family are related. (wikipedia.org)
Genes7
SREBPs attach to DNA and activate genes that boost ApoA1 levels, increasing "good" cholesterol. (chemistryviews.org)
The intracellular lipid level in hepatocytes from fish fed RO diet and DHA diet were higher, and the expressions of the genes for microsomal transfer protein (MTP) and apolipoprotein A1 (Apo A1) were lower, than those in fish fed the two other diets. (nofima.no)
Two genes, APOA1 and APOA4, have been associated with HDL-cholesterol levels in multiple studies with inconsistent results. (pitt.edu)
The cholesterol metabolism pathway was significantly enriched in the KEGG pathway analysis, and there was lower expression of three apolipoprotein genes (Apoa1, Apoa2, and Apoc3) at CT2 in the testes of Bmal1−/− mice than in those of WT mice. (tmu.edu.tw)
These decreases in Apoa1, Apoa2, and Apoc3 expression were verified by quantitative polymerase chain reaction analysis, which also revealed downregulation of the expression of the circadian clock (Per2, Dbp, and Nr1d1) and steroidogenic (StAR, Cyp11a1, and Hsd17b3) genes. (tmu.edu.tw)
The expression of circadian clock genes was relatively stable in WT mice over a 20-h period, whereas there was clear circadian rhythmic expression of Apoa1, Apoa2, Apoc3, StAR, Cyp11a1, Hsd3b2, and Hsd17b3. (tmu.edu.tw)
Bmal1−/− mice showed severely reduced expression of testicular circadian clock genes at three time points (CT4, CT12, and CT20), and a reduction in mRNA expression levels of Apo (Apoa1, Apoa2, and Apoc3) and steroidogenic (StAR, Cyp11a1, Hsd3b2, and Hsd17b3) genes. (tmu.edu.tw)
Apolipoprotein A-I (apoA1) is the major structural protein component of high-density lipoproteins (HDL), although it is present in other lipoproteins in smaller amounts. (wikipedia.org)
Apolipoprotein B plays a particularly important role in lipoprotein transport being the primary organizing protein of many lipoproteins. (wikipedia.org)
Apolipoprotein C-III (apoC3) plays an important role in lipid metabolism specific in regulating the metabolism of triglyceride-rich lipoproteins (TRLs). (wikipedia.org)
Apolipoproteins, the structural components of lipoproteins, play an essential role in lipid transportation and metabolism [ 1 ]. (biomedcentral.com)
Ratio2
Hemoglobin were also independently associated with unfavorable apolipoprotein B and apolipoprotein B/apolipoprotein A1 ratio both in men and women. (biomedcentral.com)
The Ratio of High-Density Lipoprotein Cholesterol to Apolipoprotein A-I Predicts Myocardial Injury Following Elective Percutaneous Coronary Intervention. (medscape.com)
Protein8
Apolipoprotein D (apoD) is a soluble carrier protein of lipophilic molecules in neurons and glial cells within the central and peripheral nervous system and apoD can also modulate the stability and oxidation status of these molecules. (wikipedia.org)
Apolipoprotein F (apoF) is one of the minor apolipoprotein in blood plasma and it is a lipid transfer inhibit protein to inhibit cholesteryl ester transfer protein-mediated transfers of cholesteryl esters and triglycerides. (wikipedia.org)
The APOA1 gene provides instructions for making a protein called apolipoprotein A-I (apoA-I). ApoA-I is a component of high-density lipoprotein (HDL). (medlineplus.gov)
In advanced stages of the condition, a protein called apolipoprotein A-1 (apoA-1) can form amyloid deposits, which are similar in structure to those associated with Alzheimer's disease. (sciencedaily.com)
One such protein called apolipoprotein A-1 (apoA-1) forms the scaffold of the so-called 'good cholesterol,' or high-density lipoprotein (HDL). (technologynetworks.com)
Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic? (technologynetworks.com)
Apolipoprotein A-I (Apo-A1) is a structural and functional protein that constitutes approximately 70% of the protein in high density lipoprotein (HDL). (medscape.com)
Apolipoprotein A-I Increases Insulin Secretion and Production From Pancreatic ß-Cells via a G-Protein-cAMP-PKA-FoxO1-Dependent Mechanism. (medscape.com)
ApoA46
Apo-AI and ApoA4 are part of the APOA1/C3/A4/A5 gene cluster on chromosome 11. (wikipedia.org)
A unique feature of APOA4 is that it is an intestinal apolipoprotein secreted on HDL and chylomicrons. (jci.org)
Tracer enrichments for APOA4 and APOA1 were determined by targeted mass spectrometry, and metabolic rates were derived by compartmental modeling. (jci.org)
In the initial sequence analysis, 54 variants were identified in APOA1 (25 of which were new), and 43 in APOA4 (21 of which were new). (pitt.edu)
According to preliminary analysis of the sequencing data for APOA1 and APOA4, no striking difference was noticed between the distribution of rare variants between high and low HDL groups in either population. (pitt.edu)
To date, screening data was compiled for the entire NHWs and Black samples for a total of seven common variants: 2 for APOA1 (rs5070 and rs5072), and 5 in APOA4 (rs5092, rs5100, rs5104, rs5106, and rs5109). (pitt.edu)
Cardiovascular2
Mutations in the APOA1 gene cause familial HDL deficiency, an inherited condition characterized by low levels of HDL in the blood and an elevated risk for early-onset cardiovascular disease, which often occurs before age 50. (medlineplus.gov)
Definition of human apolipoprotein A-I epitopes recognized by autoantibodies present in patients with cardiovascular diseases. (medscape.com)
Amyloidosis3
Mutations in the APOA1 gene can also cause a condition called familial visceral amyloidosis, which is characterized by an abnormal accumulation of proteins (amyloidosis) in internal organs (viscera). (medlineplus.gov)
Eriksson M, Schonland S, Yumlu S, Hegenbart U, von Hutten H, Gioeva Z, Lohse P, Buttner J, Schmidt H, Rocken C. Hereditary apolipoprotein AI-associated amyloidosis in surgical pathology specimens: identification of three novel mutations in the APOA1 gene. (medlineplus.gov)
A defect in the Apo-A1 gene ( APOA1 ) can cause HDL deficiency and systemic nonneuropathic amyloidosis. (medscape.com)
Participates1
Apolipoprotein M (apoM) participates in the lipid metabolism and exhibit anti‑atherosclerotic functions and it is presented in high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL). (wikipedia.org)
However, because of their detergent-like (amphipathic) properties, apolipoproteins and other amphipathic molecules (such as phospholipids) can surround the lipids, creating a lipoprotein particle that is itself water-soluble, and can thus be carried through body fluids (i.e., blood, lymph). (wikipedia.org)
Lipid4
In addition to stabilizing lipoprotein structure and solubilizing the lipid component, apolipoproteins interact with lipoprotein receptors and lipid transport proteins, thereby participating in lipoprotein uptake and clearance. (wikipedia.org)
Members of the apolipoprotein gene cluster (APOA1/C3/A4/A5) on human chromosome 11q23 play an important role in lipid metabolism. (doe.gov)
An assessment on the associations of iron status with apolipoproteins and lipid ratios would be informative for maintenance of metabolic homeostasis and hinderance of disease progression. (biomedcentral.com)
Pig apolipoprotein A1 (Apo-A1) ELISA Kit is Available at Gentaur Genprice with the fastest delivery. (joplink.net)
Oligomers1
There is a good link to oligomers from the apolipoprotein story. (alzforum.org)
Mutations1
Mutations encoding APOA1 are associated with HDL deficiencies and can confer a higher risk of coronary heart disease. (southtees.nhs.uk)
Clinical1
When applied to clinical placenta samples apolipoprotein A1 was found to be accumulated in the preeclamptic placenta, where it may either have a nutritional effect or act as a modifier of signal transduction. (hindawi.com)
Variants1
Daum U, Leren TP, Langer C, Chirazi A, Cullen P, Pritchard PH, Assmann G, von Eckardstein A. Multiple dysfunctions of two apolipoprotein A-I variants, apoA-I(R160L)Oslo and apoA-I(P165R), that are associated with hypoalphalipoproteinemia in heterozygous carriers. (medlineplus.gov)
Prevalence2
Logistic regression analyses were used to investigate the relationships between indicators of iron status and the prevalence of unfavorable apolipoprotein profiles. (biomedcentral.com)
Among men, Canadian Community Health Survey, the prevalence of factors were age, apolipoprotein A1 level, apolipoprotein B obesity among people who self-identified as Aboriginal level, and insulin resistance. (cdc.gov)
Odds1
LPA increased the odds by 13% while ApoA1 increased the odds by 29% of an FEV1 (cdc.gov)
Levels1
RESULTS: LPA and ApoA1 levels were higher in cases than controls and predictive of case status. (cdc.gov)
Detection1
Apolipoprotein AI is used in the evaluation of risk for atherosclerotic disease and the detection of Tangier disease. (southtees.nhs.uk)
Significantly2
The indicators of iron status are significantly associated with unfavorable apolipoprotein profiles. (biomedcentral.com)
CONCLUSIONS: Elevated LPA and ApoA1 are predictive of a significantly increased risk of developing an FEV1 (cdc.gov)
Risk1
Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: a nested case-control study. (cdc.gov)
Function1
Hundreds of genetic polymorphisms of the apolipoproteins have been described, and many of them alter their structure and function. (wikipedia.org)
Found1
women: OR 0.71, 95% CI 0.55-0.91) were found to be negatively associated with a decreased apolipoprotein A1. (biomedcentral.com)
Cell1
Chambenoit O, Hamon Y, Marguet D, Rigneault H, Rosseneu M, Chimini G. Specific docking of apolipoprotein A-I at the cell surface requires a functional ABCA1 transporter. (medlineplus.gov)